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Surface-based characteristics of the cerebellar cortex visualized with ultra-high field MRI

Yohan Boillat, Pierre-Louis Bazin, Kieran O'Brien, Mário João Fartaria, Guillaume Bonnier, Gunnar Krueger, Wietske van der Zwaag, Cristina Granziera
2018 NeuroImage  
In this study, we used quantitative T 1 and T 2 * mapping at ultra-high field (7T) MRI to investigate the tissue characteristics of the cerebellar gray matter surface and its layers.  ...  T 1 surfaces showed an alternation of lower and higher T 1 values when going from the median to the lateral part of the cerebellar hemispheres.  ...  This work was supported by the Centre d'Imagerie BioM edicale of the UNIL, UNIGE, HUG, CHUV, and EPFL and the Leenaards and Jeantet Foundations and the Swiss National Science Foundation Grants 31003A_153070  ... 
doi:10.1016/j.neuroimage.2018.01.016 pmid:29339314 fatcat:vzhbj5zvwvecjklnl4xuwn6vd4

The human cerebellum has almost 80% of the surface area of the neocortex

Martin I. Sereno, Jörn Diedrichsen, Mohamed Tachrount, Guilherme Testa-Silva, Helen d'Arceuil, Chris De Zeeuw
2020 Proceedings of the National Academy of Sciences of the United States of America  
The surface of the human cerebellar cortex is much more tightly folded than the cerebral cortex.  ...  It was computationally reconstructed for the first time to the level of all individual folia from multicontrast high-resolution postmortem MRI scans.  ...  We thank Alex de Crespigny for providing the macaque monkey scan and Anders Dale for writing the core of the original FreeSurfer code that was extended here.  ... 
doi:10.1073/pnas.2002896117 pmid:32723827 fatcat:utfk2ybjebcllmzynpg57w6ltq

Laminar analysis of the cerebellar cortex shows widespread damage in early MS patients: A pilot study at 7T MRI

Riccardo Galbusera, Katrin Parmar, Yohan Boillat, Mario Joao Fartaria, Alexandra-Ramona Todea, Kieran O' Brien, Anna Smolinski, Ludwig Kappos, Wietske van der Zwaag, Cristina Granziera
2020 Multiple Sclerosis Journal - Experimental, Translational and Clinical  
T1 values correlated with EDSS, SDMT and PASAT. Conclusions We found MRI evidence of damage in the normal-appearing cerebellar cortex at early MS stages and before volumetric changes.  ...  Objective The aims of this study were to (i) investigate microstructural changes in the normal-appearing cerebellar cortex of early MS patients by using 7 T MRI and (ii) evaluate the influence of those  ...  In conclusion, our pilot study showed that quantitative T 1 imaging at ultra-high-field MRI is sensitive to alterations in the normal-appearing cortex of the cerebellum in early-MS patients, which are  ... 
doi:10.1177/2055217320961409 pmid:33149930 pmcid:PMC7586276 fatcat:ipy4mvw5qveorhozqvd2pecdfu

Ultra-high field (7T) functional magnetic resonance imaging in amyotrophic lateral sclerosis [article]

Robert Barry, Suma Babu, Sheeba Anteraper, Christina Triantafyllou, Boris Keil, Olivia Rowe, D Rangaprakash, Sabrina Paganoni, Robert Lawson, Christina Dheel, Paul Cernasov, Bruce Rosen (+2 others)
2020 bioRxiv   pre-print
Herein we report on twelve participants with ALS and nine age-matched healthy controls who underwent high-resolution resting state functional magnetic resonance imaging at an ultra-high field of 7 Tesla  ...  Our observation of the involvement of cerebellar lobule VI adds to the growing number of studies implicating the cerebellum in ALS.  ...  Acknowledgments The authors acknowledge the generosity of our participants and their families. We also thank Dr.  ... 
doi:10.1101/2020.12.02.408278 fatcat:bcruawvoxraypjawwmt7fxhp5i

Ultra-high field (7T) functional magnetic resonance imaging in amyotrophic lateral sclerosis: a pilot study

Robert L. Barry, Suma Babu, Sheeba Arnold Anteraper, Christina Triantafyllou, Boris Keil, Olivia E. Rowe, D. Rangaprakash, Sabrina Paganoni, Robert Lawson, Christina Dheel, Paul M. Cernasov, Bruce R. Rosen (+2 others)
2021 NeuroImage: Clinical  
field of 7 Tesla.  ...  Herein we report on a pilot study involving twelve participants with ALS and nine age-matched healthy controls who underwent high-resolution resting state functional magnetic resonance imaging at an ultra-high  ...  The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.  ... 
doi:10.1016/j.nicl.2021.102648 pmid:33872993 pmcid:PMC8060594 fatcat:xfcho7pj7fhn5o6lwn3ylwy2gi

Functional correlates of motor control impairments in multiple sclerosis: A 7 Tesla task functional MRI study

Myrte Strik, Camille J Shanahan, Anneke van der Walt, Frederique M C Boonstra, Rebecca Glarin, Mary P Galea, Trevor J Kilpatrick, Jeroen J G Geurts, Jon O Cleary, Menno M Schoonheim, Scott C Kolbe
2021 Human Brain Mapping  
Systems Scores ≤ 2) and 17 healthy controls (HC) using ultra-high field 7-Tesla fMRI, allowing us to visualise sensorimotor network activity in high detail.  ...  We investigated brain activation during visually guided force matching of hand or foot in 28 minimally disabled pwMS (Expanded Disability Status Scale (EDSS) < 4 and pyramidal and cerebellar Kurtzke Functional  ...  | Methodological considerations and limitations In this study, we used ultra-high field MRI with the goal of detecting more specific activation loci with better accuracy due to high sensitivity.  ... 
doi:10.1002/hbm.25389 pmid:33666314 pmcid:PMC8090767 fatcat:oftilgvjcnbxxkctnzydquyfjm

Mapping fine-scale anatomy of gray matter, white matter, and trigeminal-root region applying spherical deconvolution to high-resolution 7-T diffusion MRI

Ralf Lützkendorf, Robin M. Heidemann, Thorsten Feiweier, Michael Luchtmann, Sebastian Baecke, Jörn Kaufmann, Jörg Stadler, Eike Budinger, Johannes Bernarding
2018 Magnetic Resonance Materials in Physics, Biology and Medicine  
Objectives We assessed the use of high-resolution ultra-high-field diffusion magnetic resonance imaging (dMRI) to determine neuronal fiber orientation density functions (fODFs) throughout the human brain  ...  In cortical GM, additional evidence was found that in parts of primary somatosensory cortex, fODFs seem to be oriented less perpendicular to the cortical surface than in GM of motor, premotor, and secondary  ...  a decade of experimental ultra-high-field MRI 7-T, MR scanners are now being introduced into clinical routine with the expectation that advantages of 7-T, such as increased signal-to-noise ratio (SNR)  ... 
doi:10.1007/s10334-018-0705-9 pmid:30225801 fatcat:7ybzzpnlzbg7bhss7hrbqpd4ye

Cartography and Connectomes

David C. Van Essen
2013 Neuron  
The transition to an atlas based on high-resolution MRI scans occurred a decade later with the introduction of the surface-based ''F99'' macaque atlas (Van Essen, 2002a) (see Figure 1B ).  ...  The cerebellar atlas surfaces shown in Figure 1 are useful for surface-based visualization but unfortunately not for surface-based analysis (e.g., smoothing or intersubject alignment).  ... 
doi:10.1016/j.neuron.2013.10.027 pmid:24183027 pmcid:PMC3855872 fatcat:nsrernbfkvctlbgaigmef7bedy

A review of the use of magnetic resonance imaging in Parkinson's disease

Nadya Pyatigorskaya, Cécile Gallea, Daniel Garcia-Lorenzo, Marie Vidailhet, Stéphane Lehericy
2013 Therapeutic Advances in Neurological Disorders  
Other quantitative biomarkers such as susceptibility-weighted imaging for iron load, magnetization transfer and ultra-high-field MRI have shown great potential.  ...  However, major advances have occurred in the development of magnetic resonance imaging (MRI) biomarkers for PD in the past decade.  ...  Structural imaging Techniques for visualization and segmentation of brain regions MRI sequences for visualization of the basal ganglia and the cortex.  ... 
doi:10.1177/1756285613511507 pmid:25002908 pmcid:PMC4082302 fatcat:bxgvmd2eqbay5bjce6trzngy5a

Anatomic & metabolic brain markers of the m.3243A>G mutation: A multi-parametric 7T MRI study

Roy A.M. Haast, Dimo Ivanov, Rutger J.T. IJsselstein, Suzanne C.E.H. Sallevelt, Jacobus F.A. Jansen, Hubert J.M. Smeets, Irenaeus F.M. de Coo, Elia Formisano, Kâmil Uludağ
2018 NeuroImage: Clinical  
In this study, ultra-high field MRI at 7 Tesla and volume-and surface-based data analyses approaches were used to highlight morphology (i.e. atrophy)-, microstructure (i.e. myelin and iron concentration  ...  The use of quantitative MRI at 7 Tesla allowed us to detect subtle changes of biophysical processes in the brain with high accuracy and sensitivity, in addition to typically assessed lesions and atrophy  ...  Uludag and Blinder (2017) have theoretically estimated that the SNR of fMRI at high spatial resolution scales approximately quadratically with magnetic field strength.  ... 
doi:10.1016/j.nicl.2018.01.017 pmid:29868447 pmcid:PMC5984598 fatcat:ia7ucvseprdspo5nmfttedul6a

The impact of ultra-high field MRI on cognitive and computational neuroimaging

Federico De Martino, Essa Yacoub, Valentin Kemper, Michelle Moerel, Kâmil Uludağ, Peter De Weerd, Kamil Ugurbil, Rainer Goebel, Elia Formisano
2018 NeuroImage  
The impact of ultra-high field MRI on cognitive and computational neuroimaging. Neuroimage, 168, 366-382. https://doi.  ...  Compared to lower fields (3 T and below), ultra high field MRI has an increased sensitivity, which can be used to acquire functional images with greater spatial resolution, and greater specificity of the  ...  Acknowledgements This work was supported by the Netherlands Organization for Scientific Research (NWO; VIDI grant 864-13-012 to F.D.M., VENI grant 451-15-012 to M.M. and VICI grant 453-12-002 to E.F).  ... 
doi:10.1016/j.neuroimage.2017.03.060 pmid:28396293 fatcat:i6hjieismrfqnfjh3a53q7e624

Mapping Small-World Properties through Development in the Human Brain: Disruption in Schizophrenia

Dardo Tomasi, Nora D. Volkow, Gaolang Gong
2014 PLoS ONE  
frontal) and lower negative connectivity in auditory, visual, motor, premotor and somatosensory cortices for schizophrenia patients than for controls, consistent with prior findings of thalamic disconnection  ...  Here we propose novel ultra-fast methodology for mapping local properties of brain network topology such as local C, L and S (lC, lL and lS) in the human brain at 3-mm isotropic resolution from 'resting-state  ...  Region-of-interest (ROI) analyses The population-average landmark-and surface-based atlas of the cerebral cortex [32] and the Automated Anatomical Labeling (AAL) atlas [33] provided in the installation  ... 
doi:10.1371/journal.pone.0096176 pmid:24788815 pmcid:PMC4005771 fatcat:rksbt5f6ezg57bxxi2n6mufx3y

Imaging: What can it tell us about parkinsonian gait?

Nicolaas I. Bohnen, Klaus Jahn
2013 Movement Disorders  
The direct, stereotyped locomotor loop from the primary motor cortex to the spinal cord with rhythmic cerebellar input appears preserved and may contribute to the unflexible gait pattern in parkinsonian  ...  First, imaging of blood flow functions has identified a supraspinal locomotor network that includes the (frontal) cortex, basal ganglia, brainstem tegmentum and the cerebellum.  ...  Department of Veterans Affairs and the Michael J.  ... 
doi:10.1002/mds.25534 pmid:24132837 pmcid:PMC3801220 fatcat:pftct47etnbxdh7zdqecig5mvi

Histological correlates of postmortem ultra-high-resolution single-section MRI in cortical cerebral microinfarcts

Deniz Yilmazer-Hanke, Theresa Mayer, Hans-Peter Müller, Hermann Neugebauer, Alireza Abaei, Angelika Scheuerle, Joachim Weis, Karin M. E. Forsberg, Katharina Althaus, Julia Meier, Albert C. Ludolph, Kelly Del Tredici (+3 others)
2020 Acta Neuropathologica Communications  
Here, we matched pathological changes in the microvasculature of cortical cerebral microinfarcts to MRI signals using single 100 μm-thick histological sections scanned with ultra-high-resolution 11.7 T  ...  While postmortem ultra-high-resolution single-section imaging improved MRI-histological matching and the structural characterization of chronic cortical cerebral microinfarcts, miniscule microinfarcts  ...  ultra-high-resolution MRI.  ... 
doi:10.1186/s40478-020-00900-1 pmid:32169123 fatcat:ebzfkwsqfbgvvoinqyo75toq5q

Recent advancements in diffusion MRI for investigating cortical development after preterm birth—potential and pitfalls

J. Dudink, K. Pieterman, A. Leemans, M. Kleinnijenhuis, A. M. van Cappellen van Walsum, F. E. Hoebeek
2015 Frontiers in Human Neuroscience  
When using more advanced acquisition settings such as high-angular resolution diffusion imaging (HARDI), more advanced reconstruction methods can be applied to investigate the cortical microstructure with  ...  We will review the current understanding of abnormal preterm cortical development, novel approaches in dMRI, and the pitfalls in scanning vulnerable preterm infants.  ...  ACKNOWLEDGMENTS The research of A. Leemans is supported by VIDI Grant 639.072.411 from the Netherlands Organisation for Scientific Research (NWO). The research of F. E.  ... 
doi:10.3389/fnhum.2014.01066 pmid:25653607 pmcid:PMC4301014 fatcat:g4j7tr3f7naytfqdjuo2hanp4m
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