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Supporting precision medicine by data mining across multi-disciplines: an integrative approach for generating comprehensive linkages between single nucleotide variants (SNVs) and drug-binding sites

Amrita Roy Choudhury, Tiejun Cheng, Lon Phan, Stephen H Bryant, Yanli Wang, John Hancock
2017 Bioinformatics  
Results: An integrated approach was taken involving data mining across multiple information resources including databases containing drugs, drug targets, chemical structures, protein-ligand structure complexes  ...  Identifying single nucleotide variants (SNVs) that contribute to differences in drug response and understanding their underlying mechanisms are fundamental to successful implementation of the precision  ...  Funding This work has been supported by the Intramural Research Program of the National Library of Medicine, National Institutes of Health. Conflict of Interest: none declared.  ... 
doi:10.1093/bioinformatics/btx031 pmid:28158543 pmcid:PMC5856083 fatcat:6wt6lvpwwfgabbvmptxrdwnxmi