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., 2016; Das and Sarkar, 2019b; Wang and Eisner, 2018) , target-language independent perturba-tion (Das and Sarkar, 2019a) , training a word orderinsensitive parser model (Ahmad et al., 2019) or imposing ... Das et al. (2012) compares performance of a grammar driven parser and a modified MALT parser. ...arXiv:2002.12097v1 fatcat:6stj5e7zuvc7hgi77fn5q7h7ji
Transverse layering of molecular gyration spheres in spin-coated atactic polystyrene (aPS) films, for film thickness R ≤ 4R_g (R_g = unperturbed gyration radius), causes an increase in free energy that does not follow the (R_g/R)^-2 dependence of planar confinement and is explained by invoking a fixed-range, repulsive, modified Pöschl-Teller intermolecular potential, its strength decreasing with increase in R. Vacuum ultraviolet spectroscopy reveals a change in 'physical dimers' of adjacentarXiv:cond-mat/0610138v1 fatcat:433r65dsvnakpfpjhjsz5wdz7y
more »... ant benzene rings of aPS from 'oblique' to 'head-to-tail' configuration as film thickness goes from 9R_g to 2R_g. This reduces cohesion by reducing dimer dipole moment. Thus a new phase of aPS, the nanoconfined phase, ordered but with lower cohesion than bulk, is formed.
Leiomyosarcoma of the kidney is a rare type of adult renal sarcoma. Here, we presented a case of a 68-year-old female who had a past history of bilateral renal calculi 3 years back with hydronephrotic changes, now presented to the OPD with complaints of abdominal pain for the past few months. On further evaluation, a heterogeneously enhancing necrotic mass was identified in the right kidney measuring 7.5 cm in the greatest dimension. A right radical nephrectomy with left Double J stenting wasdoi:10.32677/ijcr.v7i11.3156 fatcat:2ibmt24x2bdvdp2uwvhsbik2vi
more »... ne. From histopathological and immunohistochemical staining, it was diagnosed as leiomyosarcoma.
We have implemented an iterative algorithm for the identification of diagnostic patterns from sets of multipledomain proteins, where domains need not be common to all the proteins in the defining set. Our algorithm was applied to sequences gathered using a variety of methods, including BLAST, common keywords, and common E.C. numbers. In all cases, useful diagnostic patterns were obtained, possessing both high sensitivity and specificity. The patterns were found to correlate in several casesdoi:10.1002/pro.5560050703 pmid:8819157 pmcid:PMC2143450 fatcat:fhhwlyoszbewxldk6uk4xkfucq
more »... both functional and structural domains. Patterns generated from a large number of sequence families were analyzed for probable multiple-domain structure.
Brahmaputra river has ironically been both a 'boon and bane' for the north eastern part of India. Brahmaputra's immense natural potential has provided life and fodder for generations. On the other hand, Brahmaputra's periodic raging form forces a number of families in Brahmaputra basin to change their place of permanent residence almost every year. Taking Brahmaputra Valley as a case, the impact of a river (and it basin) on the neighbouring spatial extent is discussed in this paper. Thedoi:10.5281/zenodo.2345062 fatcat:ceh242436fem5l6qqst3m5elaa
more »... linkage of Brahmaputra with the North East India forms the basis of this paper. The geographic impact of Brahmaputra is also discussed keeping in mind the socio-political factors. This paper also puts focus on the major problems caused by Brahmaputra in the North East India and implication of the same on the demographic profile. The environmental conditions thus created by the river are a concern of utmost interest, especially to the development authorities which bear the responsibility of ensuring a balanced and sustainable growth to its citizens. The paper finally discusses the major factors responsible for the population distribution in north eastern states due to Brahmaputra Valley. These factors are namely natural course, natural disasters, socio-cultural factors, institutional mechanism and land use pressure. The aim of this paper is to understand the factors responsible for population distribution due to the presence of an important source of life . . . WATER
AbstractMost two-group statistical tests are implicitly looking for a broad pattern such as an overall shift in mean, median or variance between the two groups. Therefore, they operate best in settings where the effect of interest is uniformly affecting everyone in one group versus the other. In real-world applications, there are many scenarios where the effect of interest is heterogeneous. For example, a drug that works very well on only a proportion of patients and is equivalent to a placebodoi:10.1101/2020.03.23.002972 fatcat:glu3bluq2fhz7njhlpmtj7vhkm
more »... n the remaining patients, or a disease associated gene expression dysregulation that only occurs in a proportion of cases whereas the remaining cases have expression levels indistinguishable from the controls for the considered gene. In these examples with heterogeneous effect, we believe that using classical two-group statistical tests may not be the most powerful way to detect the signal. In this paper, we developed a statistical test targeting heterogeneous effects and demonstrated its power in a controlled simulation setting compared to existing methods. We focused on the problem of finding meaningful associations in complex genetic diseases using omics data such as gene expression, miRNA expression, and DNA methylation. In simulated and real data, we showed that our test is complementary to the traditionally used statistical tests and is able to detect disease-relevant genes with heterogeneous effects which would not be detectable with previous approaches.
For example, the perception of the male-derived sex pheromone cVA in female flies underlies modulation by mating as well as feeding (Das et al. 2017; Lebreton et al. 2014 Lebreton et al. , 2015 . ... Such a neuronal network organization is similar to the AL, where OSNs and PNs both transmit and receive input from various local interneurons (Das et al. 2017; Liu and Wilson 2013; Mohamed et al. 2019b ...doi:10.1007/s00441-020-03392-6 pmid:33475851 fatcat:2ofnznv6vfh2dgd4cybvpcyooi
Open appendicectomy has been safe and effective for acute appendicitis for more than a century. Recently, several authors proposed that the new technique of laparoscopic appendicectomy should be the treatment for acute appendicitis. Therefore, the aim of this study is to evaluate and compare laparoscopic appendicectomy with open appendicectomy in general surgical practice. Methods: This prospective randomized controlled study was carried out over a period from October 2012 to October 2015 indoi:10.18203/2349-2902.isj20160905 fatcat:qh2puwzp6rcrhfurnrbptstkay
more »... department of general surgery K.P.C. Medical College and Hospital, Kolkata. Patients between 18 years and 60 years of age were candidates for randomization. The total population group included 144 patients with a mean age of 39 years. Results: Comparative studies of laparoscopic and open appendicectomy shows that hospital stay and wound infection rates are significantly lower after laparoscopic appendicectomy. As compared to laparoscopic appendicectomy prevalence of intra-abdominal abscess was less in open appendicectomy. Similarly, shorter operating time was found in patients randomized to open appendicectomy compared with laparoscopic appendicectomy. There were shorter period of convalescence and better cosmesis observed in the laparoscopic group. However, no single case of pneumonia was reported in the post-operative period in both appendicectomy. Conclusions: From the present study, we can conclude that laparoscopic appendicectomy has been shown to be both feasible and safe in comparison with open appendicectomy. However, because of the competition of laparoscopic and open appendicectomy, open appendicectomy has improved greatly. The benefit of laparoscopic appendicectomy over the open appendicectomy will be a question.
Let us first define the key words of this topic... Communication: Communication is the interaction between two or more animate or inanimate things. Communication (from Latin "communis", meaning to share) is the activity of conveying information through the exchange of thoughts, messages, or information, as by speech, visuals, signals, writing, or behavior.(1) Skills: Skills, in context of communication is the art of exchanging thoughts or ideas from mind to mind or soul to soul of individualsdoi:10.9790/0837-19177477 fatcat:yfemqhdjwfbyficvmg67cdr5ri
more »... th equal reciprocation. Education: Education generally means imparting information in a systematic and scheduled manner. Education in its general sense is a form of learning in which knowledge, skills, and habits of a group of people are transferred from one generation to the next through teaching, training, research, or simply through autodidacticism. Generally, it occurs through any experience that has a formative effect on the way one thinks, feels, or acts.(2) Summing up these definitions, the role of communication skills in education in today"s context is, teaching and training a child with the basic skills of communication, that is listening, speaking, reading and writing to establish himself successfully in the society and make an affluent livelihood. One of the drawback of the above aim of education is this that it considers all human beings having same potential and ignores the individuality of an individual being. It considers human beings as a dead rock which can be carved as per the prevailing market demand. It fails to consider human beings as a living soul which grows and evolves as per his own potential. This attitude of guardians or teachers generates a conflict in the childs"s mind. In my years of teaching experience, one thing generally observed is that many students are pursuing great professional courses not because they are interested, but because their parents think these courses will make them successful professionals. Once they realize that this profession might not be self fulfilling or not their cup of tea, they don"t hesitate to leave the same and join some other. Many times it is at the cost of their livelihood, comfort and affluence. Hope the readers will agree to my view. However, only looking forward towards earning livelihood may be a too shallow aim of education. To me the purpose of education is much wider as well as deeper, as explained in the following sentence "The chief aim of education should be to help the growing soul to draw out that in itself which is best and make it perfect for a noble use".(3)Here comes the role of communication skills of a teacher and guardian, how they can bring out the best in a child. Discussion And Reasons: Swami Vivekananda in one of his writings has mentioned that one cannot have mangoes on a neem tree. But certainly a good care taken by a gardener can grow an excellent neem tree. In Swamiji"s words, "Thus Vedanta says that within man is all knowledge even in a boy it is so, and it requires only an awakening and that much is the work of a teacher". To drive his point home, he refers to the growth of a plant. Just as in case of a plant, one cannot do anything more than supplying it with water, air and manure, while it grows from within its own nature, so is the case of human child. (4) I strongly believe in this view, that what is within comes out and manifests externally. Keeping this view in mind one can say that the prime responsibility of a teacher is to identify, what is there hidden in a child. To bring out the hidden man in us or what is termed as Atmagyan. Here comes the role of the teacher as a communicator or a facilitator or a gardener, to bring out the hidden potential of the child and give it a right direction. Once the potential and area of interest has been identified in a child, the child gets the direction of learning and educating himself. By communicating to the students and understanding them, a teacher plays a dual role of understanding and gauging the real interest of the child and making him realize his direction . It"s the duty of the teacher and guardian to communicate it to the individual, make him realize his potential and show the right of interest. This can be done only by communicating all the time, apart from a formal
<p>Corticosteroids, since their introduction have become one of the most widely prescribed class of drugs. They belong to a class of chemicals that includes steroid hormones that are produced naturally in the adrenal cortex of vertebrates and analogous to those that are synthesized in laboratories. They have been used extensively in managing many oral lesions due to their excellent anti-inflammatory and immunemodulators effects. However, considering their potential and significant side effects,doi:10.3329/updcj.v6i1.29221 fatcat:f2a42vdjfzdwzbf66lfagv3kaq
more »... they are sometimes termed as the "double –edge sword" in the field of medicine. Their successful use depends upon the comprehension of the disease process. This includes an appropriate diagnosis, a clear view of the desirable treatment outcome and understanding of whether the treatment is aimed at the management of a chronic disease or enhanced resolution of a short – term condition. The possible side effects of systemic corticosteroids must be weighed against probable risks. This article is aimed at reviewing the use of corticosteroids in the treatment of various oral lesions, and deriving a certain protocol for the same.</p><p>Update Dent. Coll. j: 2016; 6 (1): 52-58</p>
Parkinson's disease is characterized by dopaminergic neurodegeneration in the substantia nigra. Although dopaminergic drugs are the mainstay of Parkinson's treatment, their putative disease-modifying properties remain controversial. We explored whether prescription of dopaminergic stimulants for attention-deficit hyperactivity disorder (ADHD) might affect Parkinson's incidence. We performed Cox survival analyses for outpatient Parkinson's diagnosis among ADHD-diagnosed seniors in the Optumdoi:10.1101/2020.05.06.20089748 fatcat:n335ozxkfbbjtckvyesxr7cqga
more »... ormatics Data Mart de-identified administrative claims database, correcting for diverse demographic and socio-economic status covariates. We compared 5,683 sustained users (≥ 90 days) of dopaminergic stimulants to 252 sustained users of atomoxetine, a noradrenergic first-line ADHD medication. Parkinson's incidence was reduced among sustained dopaminergic stimulant users compared to atomoxetine users (adjusted hazard ratio [HR] 0.15, 95% confidence interval [CI] 0.04-0.56, p = 0.005). Effect sizes were comparable between derivatives of amphetamine (adjusted HR 0.12, 95% CI 0.03-0.48, p = 0.003) and methylphenidate (adjusted HR 0.27, 95% CI 0.04-1.76, p = 0.2). In sensitivity analyses, similar trends were observed when other psychotropics (SSRIs, gabapentin) were used as comparators instead of atomoxetine, or when the threshold for sustained use was defined as 45, 180 or 360 days instead of 90. Thus, sustained dopaminergic stimulant use was associated with lower Parkinson's incidence among seniors with ADHD. Our results are consistent with a protective effect of dopaminergic stimulants on the development of Parkinson's, and support a re-examination of certain dopaminergics, particularly rasagiline and other selective monoamine oxidase B inhibitors, as potential disease-modifying agents.
Automated disease detection in medical images using deep learning holds promise to improve the diagnostic ability of radiologists, but routinely collected clinical data frequently contains technical and demographic confounding factors that differ between hospitals, negatively affecting the robustness of diagnostic deep learning models. Thus, there is a critical need for deep learning models that can train on imbalanced datasets without overfitting to site-specific confounding factors. In thisarXiv:2205.02885v1 fatcat:lomijmg2n5hmpapd5na2bql32e
more »... rk, we developed a novel deep learning architecture, MUCRAN (Multi-Confound Regression Adversarial Network), to train a deep learning model on highly heterogeneous clinical data while regressing demographic and technical confounding factors. We trained MUCRAN using 16,821 clinical T1 Axial brain MRIs collected from Massachusetts General Hospital before 2019 and tested it using post-2019 data to distinguish Alzheimer's disease (AD) patients, identified using both prescriptions of AD drugs and ICD codes, from a non-medicated control group. In external validation tests using MRI data from other hospitals, the model showed a robust performance of over 90% accuracy on newly collected data. This work shows the feasibility of deep learning-based diagnosis in real-world clinical data.
Sudeshna Das and Anna Goldenberg supervised the work, offered precious support and guidance, and contributed to improving the writing through multiple rounds of reviews. ...doi:10.1186/s13073-021-00864-4 pmid:33892787 pmcid:PMC8066476 fatcat:4hpubv2kyfbazkonrlxyyee25m
Cutaneous leiomyomas, also known as pilar leiomyomas, arise from the arrectores pilorum muscles and are made up of a poorly circumscribed proliferation of haphazardly arranged smooth muscle fibers located in the dermis that appears to infiltrate the surrounding tissue and may extend into the subcutis. Cutaneous leiomyomas are rare, benign, smooth muscle tumors. The most common type of cutaneous leiomyoma, angioleiomyoma arise from the tunica media of blood vessels. The other subtypes,doi:10.32677/ijcr.2021.v07.i02.008 fatcat:vgmo2r6uava5bpq7dre57z3ogm
more »... omas and genital leiomyomas arise from the arrector pili musculature of the hair follicle and from the smooth muscle found in the scrotum, labia, or nipple, respectively. Here, we presented a case of cutaneous leiomyoma, in a young male presenting with a swelling in the arm.
modifier screen identifies chromosomal intervals harboring potential midline interacting genes Sudeshna Das, Deepak Kumar, Katie Warren, Sandra Leal University of Southern Mississippi, Hattiesburg, MS, ...doi:10.1016/j.ydbio.2011.05.320 fatcat:jq26ufnwhnbjpgqxog5maljnku
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