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Subthreshold voltage noise due to channel fluctuations in active neuronal membranes

P N Steinmetz, A Manwani, C Koch, M London, I Segev
Journal of Computational Neuroscience  
Voltage-gated ion channels in neuronal membranes fluctuate randomly between different conformational states due to thermal agitation.  ...  Here we study subthreshold voltage fluctuations due to active voltage-gated Na+ and K+ channels as predicted by two commonly used kinetic schemes: the Mainen et al. (1995) (MJHS) kinetic scheme, which  ...  Acknowledgments This work was funded by NSF, NIMH, and the Sloan Center for Theoretical Neuroscience to C.K. and by the Israeli Academy of Science and the ONR to I.S.  ... 
pmid:11030518 fatcat:brrpau2ferh55pck2yx5it7hle

Modeling electromagnetic fields detectability in a HH-like neuronal system: stochastic resonance and window behavior

Matteo Giannì, Micaela Liberti, Francesca Apollonio, Guglielmo D'Inzeo
2005 Biological cybernetics  
Here, an HH-like neuronal model is set up and accurate channels stochastic models are adopted to investigate possible noise-induced enhancements in the detection of EM fields.  ...  Recently, attention has been devoted to channel noise which plays a significant role in neuronal processing, being at the basis of some well-known behaviors like response unreliability, missing spikes  ...  The additive EM voltage term over membrane potential perturbs the activity of the voltage-dependent ion channels, whose gating is modulated by the membrane voltage.  ... 
doi:10.1007/s00422-005-0029-5 pmid:16369796 fatcat:t4bh2czlxzdrzl42a2utt2mgji

Quasicycles in the stochastic hybrid Morris-Lecar neural model

Heather A. Brooks, Paul C. Bressloff
2015 Physical Review E  
Study of classical neuron models with stochastic ion channels is becoming increasingly important, especially in understanding a cell's ability to produce subthreshold oscillations and to respond to weak  ...  Intrinsic noise arising from the stochastic opening and closing of voltage-gated ion channels has been shown experimentally and mathematically to have important effects on a neuron's function.  ...  Ion channel noise has also been implicated in subthreshold membrane potential oscillations (STOs).  ... 
doi:10.1103/physreve.92.012704 pmid:26274200 fatcat:eicg2cl2s5de7gnkzwnblq76te

Ion Channel Stochasticity May Be Critical in Determining the Reliability and Precision of Spike Timing

Elad Schneidman, Barry Freedman, Idan Segev
1998 Neural Computation  
Channel fluctuations, together with the inherent bistability in the HH equations, give rise to three additional experimentally observed phenomena: subthreshold oscillations in the membrane voltage for  ...  We suggest that the noise inherent in the operation of ion channels enables neurons to act as "smart" encoders.  ...  Acknowledgments We are grateful to our friends and colleagues, Miki London, Yosi Yarom, John Rinzel, David Hansel, Shimon Marom, Zach Mainen, Henry Markram, Tali Tishby, and Moshe Abeles, for their insightful  ... 
doi:10.1162/089976698300017089 pmid:9744892 fatcat:sonvjqkm75gt5gaj4u5odaduku

Detection of subthreshold pulses in neurons with channel noise

Yong Chen, Lianchun Yu, Shao-Meng Qin
2008 Physical Review E  
In the case of single pulse detection, we show that channel noise enables one neuron to detect the subthreshold signals and an optimal membrane area (or channel noise intensity) exists for a single neuron  ...  In addition to synaptic noise, the stochastic opening and closing of ion channels represents an intrinsic source of noise that affects the signal processing properties of the neuron.  ...  Voltage-gated ion channels in neuronal membranes fluctuate randomly between different conformational states due to thermal agitation.  ... 
doi:10.1103/physreve.78.051909 pmid:19113157 fatcat:qv3lmevk3zbmjln4xy2xa6tzcm

Subthreshold voltage noise of rat neocortical pyramidal neurones

Gilad A. Jacobson, Kamran Diba, Anat Yaron-Jakoubovitch, Yasmin Oz, Christof Koch, Idan Segev, Yosef Yarom
2005 Journal of Physiology  
Our results imply that ion channel noise contributes significantly to membrane voltage fluctuations at the subthreshold voltage range, and that Na + conductance plays a key role in determining the amplitude  ...  The increase in voltage noise is accompanied by an increase in the cell impedance, due to voltage dependence of Na + conductance.  ...  While most voltage fluctuations in cell-attached configuration arise from external current sources, there can still be some voltage fluctuations due to ion channel fluctuations in the membrane patch under  ... 
doi:10.1113/jphysiol.2004.080903 pmid:15695244 fatcat:a5gxj2qrxrb53k2xlkbhoae44a

Using computer simulations to determine the limitations of dynamic clamp stimuli applied at the soma in mimicking distributed conductance sources

Risa J. Lin, Dieter Jaeger
2011 Journal of Neurophysiology  
To simulate variability in neuronal responses to repeated stimuli, we added a somatic white current noise to reproduce subthreshold fluctuations in the membrane potential.  ...  We were able to replicate our dynamic clamp results with respect to spike rates and spike precision for different patterns of background synaptic activity.  ...  ACKNOWLEDGMENTS We acknowledge Volker Gauck's contribution to this work by recording some of the physiological data.  ... 
doi:10.1152/jn.00968.2010 pmid:21325676 pmcid:PMC3094164 fatcat:47pkpwjdg5erddwzwohwpx7ei4

White-noise susceptibility and critical slowing in neurons near spiking threshold

D. A. Steyn-Ross, Moira L. Steyn-Ross, M. T. Wilson, J. W. Sleigh
2006 Physical Review E  
If confirmed, then the proximity of a neuron to its spike-transition point can be judged by measuring its subthreshold susceptibility to white-noise stimulation.  ...  When stimulated with a low-intensity white noise superimposed on a dc control current, both membrane types generate voltage fluctuations that exhibit critical slowing down-that is, the voltage responsiveness  ...  Provided that the noise intensities are sufficiently weak, the noise-evoked subthreshold fluctuations in recovery variable R and membrane voltage V will be rather small, so a linear analysis of the Wilson  ... 
doi:10.1103/physreve.74.051920 pmid:17279952 fatcat:wjcda3ypurce5m7ecwzljlb4bm

Stochastic and deterministic dynamics of intrinsically irregular firing in cortical inhibitory interneurons

Philipe RF Mendonça, Mariana Vargas-Caballero, Ferenc Erdélyi, Gábor Szabó, Ole Paulsen, Hugh PC Robinson
2016 eLife  
sodium and fast-inactivating potassium channels just below spike threshold, amplifying channel noise.  ...  This active irregularity may help IS cells synchronize with each other at gamma range frequencies, while resisting synchronization to lower input frequencies.  ...  Thus these strong subthreshold membrane potential 300 fluctuations appear to be actively-amplified channel noise, somewhat like noise-driven 301 subthreshold oscillations, as described in entorhinal stellate  ... 
doi:10.7554/elife.16475 pmid:27536875 pmcid:PMC5030087 fatcat:mylv23r3hbadnopd2a5qni7kpu

Channel noise in neurons

John A. White, Jay T. Rubinstein, Alan R. Kay
2000 Trends in Neurosciences  
The contribution of the ganglionic eminence to the neuronal cell types of the cerebral cortex.  ...  Cortex 9, 646-654 55 Wu, W. et al. (1999) Directional guidance of neuronal migration in the olfactory system by the protein Slit.  ...  Scand. 107, 343-363 e Chow, C.C. and White, J.A. (1996) Spontaneous action potentials due to channel fluctuations. Biophys.  ... 
doi:10.1016/s0166-2236(99)01521-0 pmid:10675918 fatcat:nv5xxwcv3fb73h7q76giunt5na

Neuronal noise as an origin of sleep arousals and its role in sudden infant death syndrome

Hila Dvir, Idan Elbaz, Shlomo Havlin, Lior Appelbaum, Plamen Ch. Ivanov, Ronny P. Bartsch
2018 Science Advances  
In addition to regular sleep/wake cycles, humans and animals exhibit brief arousals from sleep.  ...  Because neuronal noise decreases with increasing temperature, our model predicts arousal frequency to decrease as well.  ...  There are two main sources of neuronal subthreshold voltage fluctuations (11) : one is due to stochastic openings and closings of voltagegated membrane channels (mainly potassium channels); the other  ... 
doi:10.1126/sciadv.aar6277 pmid:29707639 pmcid:PMC5916514 fatcat:v6wistpj6vhi5b5fwckqxf6vkq

Noise Enhances Subthreshold Oscillations in Injured Primary Sensory Neurons

Yu-Ying Wang, Zhi-Hong Wen, Jian-Hong Duan, Jun-Ling Zhu, Wen-Ting Wang, Hui Dong, Hui-Ming Li, Guo-Dong Gao, Jun-Ling Xing, San-Jue Hu
2011 Neurosignals  
Recently some experimental and computational studies have reported that channel noise can be a major contributor to electrical membrane noise in neurons, and stochastic behavior of the persistent sodium  ...  In neurons, electrical membrane noise arises from different sources, such as the quasi-random release of neurotransmitters from the synapses and the random switching of ion channels [4, 6, 10] .  ...  Second, due to the augmentation of amplitude of subthreshold oscillation during the noise application, the arising slope of membrane potential fluctuation increases obviously.  ... 
doi:10.1159/000324519 pmid:21422753 fatcat:w3jhtywvjrbntdth2x7ddw4m4e

Kv7 channels regulate pairwise spiking covariability in health and disease

Gabriel Koch Ocker, Brent Doiron
2014 Journal of Neurophysiology  
This reduction is beyond that explained by the lowering of firing rates and involves an active cancellation of common fluctuations in the membrane potentials of the cell pair.  ...  Our theory shows that the excess covariance reduction is due to a Kv7-induced shift from low-pass to band-pass filtering of the single neuron spike train response.  ...  In this equilibrium state, the membrane potential spent the majority of its time in the subthreshold voltage range.  ... 
doi:10.1152/jn.00084.2014 pmid:24790164 fatcat:laathnr7fbhddow33qwpgduyyq

Correlation Detection and Resonance in Neural Systems with Distributed Noise Sources

Michael Rudolph, Alain Destexhe
2001 Physical Review Letters  
This frequency change directly impacted on the amplitude of the internal membrane voltage fluctuations (Fig. 1A) .  ...  Given that, on average, cortical neurons fire tonically at frequencies up to 20 Hz in awake animals [10], these neurons are subject to a tremendous synaptic background activity [11, 12] .  ...  due to the background activity.  ... 
doi:10.1103/physrevlett.86.3662 pmid:11328048 fatcat:4dwup4f6bbcmjez67cr2psaz7e

Inferring network activity from synaptic noise

Michael Rudolph, Alain Destexhe
2004 Journal of Physiology - Paris  
During intense network activity in vivo, cortical neurons are in a high-conductance state, in which the membrane potential (V m ) is subject to a tremendous fluctuating activity.  ...  For example, the global excitatory and inhibitory conductances can be extracted from synaptic noise, and can be related to the mean activity of presynaptic neurons.  ...  They found, that the intense synaptic inputs due to network activity result in seemingly random fluctuations of the membrane potential.  ... 
doi:10.1016/j.jphysparis.2005.09.015 pmid:16289550 fatcat:ykmp6k7ymjdhzkaqtqrx74lzbm
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