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Subthalamic deep brain stimulation sweet spots and hyperdirect cortical connectivity in Parkinson's disease

Harith Akram, Stamatios N. Sotiropoulos, Saad Jbabdi, Dejan Georgiev, Philipp Mahlknecht, Jonathan Hyam, Thomas Foltynie, Patricia Limousin, Enrico De Vita, Marjan Jahanshahi, Marwan Hariz, John Ashburner (+2 others)
2017 NeuroImage  
Firstly, to identify subthalamic region stimulation clusters that predict maximum improvement in rigidity, bradykinesia and tremor, or emergence of side-effects; and secondly, to map-out the cortical fingerprint  ...  , mediated by the hyperdirect pathways which predict maximum efficacy.  ...  Introduction Subthalamic nucleus (STN) high frequency stimulation is an established treatment in selected patients with advanced Parkinson's disease (PD) (Krack et al., 2003; Limousin et al., 1995; A.  ... 
doi:10.1016/j.neuroimage.2017.07.012 pmid:28711737 pmcid:PMC6581538 fatcat:hxrffwbmfrdjbhfu6u3i3w3pum

Correlation of active contact location with weight gain after subthalamic nucleus deep brain stimulation: a case series

Katsuki Eguchi, Shinichi Shirai, Masaaki Matsushima, Takahiro Kano, Kazuyoshi Yamazaki, Shuji Hamauchi, Toru Sasamori, Toshitaka Seki, Kenji Hirata, Mayumi Kitagawa, Mika Otsuki, Tohru Shiga (+3 others)
2021 BMC Neurology  
Methods We enrolled 14 patients with Parkinson's disease who underwent bilateral subthalamic deep brain stimulation between 2013 and 2019.  ...  The sweet spots for WG were bilateral, mainly located dorsally outside of the subthalamic nucleus (STN).  ...  Authors' contributions Availability of data and materials The dataset(s) used and/or analyzed during the current study are available from the corresponding author on reasonable request.  ... 
doi:10.1186/s12883-021-02383-6 pmid:34517835 fatcat:fa7ft76jpffq3kxfcfvz66tvdm

Functional segregation and integration within the human subthalamic nucleus from a micro- and meso-level perspective

Bernadette C.M. van Wijk, A. Alkemade, Birte U. Forstmann
2020 Cortex  
To a large extent, this hypothesis is used to motivate the choice of target coordinates for implantation of deep brain stimulation electrodes for treatment of neurological and psychiatric disorders.  ...  dorsolateral, putative sensorimotor, part of the STN for treatment of Parkinson's disease.  ...  Subthalamic deep brain stimulation sweet spots and hyperdirect cortical connectivity in Parkinson's disease. Neuroimage, 158, 332e345. https:// Albin, R.  ... 
doi:10.1016/j.cortex.2020.07.004 pmid:32823130 fatcat:7nooknoh4balviaxrqrmdddby4

Deep Brain Stimulation for Refractory Obsessive-Compulsive Disorder: Towards an Individualized Approach

Suhan Senova, Anne-Hélène Clair, Stéphane Palfi, Jérôme Yelnik, Philippe Domenech, Luc Mallet
2019 Frontiers in Psychiatry  
Deep brain stimulation (DBS) has been proposed as a reversible and controllable method to treat refractory patients, with meta-analyses showing 60% response rate following DBS, whatever the target: anterior  ...  VC/VS effective sites of stimulation were found within the VC and primarily connected to the medial orbitofrontal cortex (OFC) dorsomedial thalamus, amygdala, and the habenula.  ...  In 2002, in two patients suffering from Parkinson's disease and OCD, STN stimulation for motor symptoms of PD was found to improve preexisting OCD symptoms (11) .  ... 
doi:10.3389/fpsyt.2019.00905 pmid:31920754 pmcid:PMC6923766 fatcat:37tala6dn5errdu72cbrzots2e

Deep Brain Stimulation: Imaging on a group level [article]

Svenja Treu, Bryan Strange, Simon Oxenford, Andrea Kuehn, Ningfei Li, Andreas Horn
2020 bioRxiv   pre-print
Deep Brain Stimulation (DBS) is an established treatment option for movement disorders and is investigated to treat a growing number of other brain disorders.  ...  In the present article, we showcase the various processing streams of Lead Group in a retrospective cohort of 51 patients suffering from Parkinson's disease, who were implanted with DBS electrodes to the  ...  We show utility of the toolbox by presenting largely confirmatory results in a cohort of Parkinson's Disease patients that underwent deep brain stimulation surgery to the subthalamic nucleus.  ... 
doi:10.1101/2020.01.14.904615 fatcat:fmfqcztgzvgubfv3znxpszb5d4

The structural connectivity of subthalamic deep brain stimulation correlates with impulsivity in Parkinson's

Philip E Mosley, Saee Paliwal, Katherine Robinson, Terry Coyne, Peter Silburn, Marc Tittgemeyer, Klaas E Stephan, Alistair Perry, Michael Breakspear
2020 Brain  
Subthalamic deep brain stimulation (STN-DBS) for Parkinson's disease treats motor symptoms and improves quality of life, but can be complicated by adverse neuropsychiatric side-effects, including impulsivity  ...  Using a comprehensive neuropsychiatric battery and a virtual casino to assess impulsive behaviour in a naturalistic fashion, 55 patients with Parkinson's disease (19 females, mean age 62, mean Hoehn and  ...  The authors thank Till Dembek for assistance with modelling the field of stimulation in directional leads.  ... 
doi:10.1093/brain/awaa148 pmid:32568370 fatcat:wz537wxdbnhc5kxrfhhka6atle


2019 Stereotactic and Functional Neurosurgery  
Objectives: This was an open-label, phase I clinical trial to evaluate efficacy and safety of bilateral caudate nucleus neuromodulation by deep brain stimulation (DBS) for adults with chronic tinnitus  ...  Also, we did not experience any serious side effects of BBBD which can be associated with the bleeding or other brain tissue damage in the immediate and delayed MR imaging after BBBD.  ...  Sleep Disturbance in Parkinson's disease and its improvement after deep brain stimulation (DBS) are frequently reported for subthalamic nucleus (STN).  ... 
doi:10.1159/000501568 fatcat:pv2k5hzuindpdmffhvqlkl25ji

Deep Brain Stimulation Initiative: Toward Innovative Technology, New Disease Indications, and Approaches to Current and Future Clinical Challenges in Neuromodulation Therapy

Yanan Sui, Ye Tian, Wai Kin Daniel Ko, Zhiyan Wang, Fumin Jia, Andreas Horn, Dirk De Ridder, Ki Sueng Choi, Ausaf A. Bari, Shouyan Wang, Clement Hamani, Kenneth B. Baker (+9 others)
2021 Frontiers in Neurology  
We specifically addressed new clinical approaches and challenges in DBS for movement disorders (Parkinson's disease and dystonia), clinical application toward neurorehabilitation for stroke, and the progress  ...  Deep brain stimulation (DBS) is one of the most important clinical therapies for neurological disorders. DBS also has great potential to become a great tool for clinical neuroscience research.  ...  FIGURE 3 | 3 Connectivity predicts deep brain stimulation (DBS) outcome in Parkinson's disease (25).  ... 
doi:10.3389/fneur.2020.597451 pmid:33584498 pmcid:PMC7876228 fatcat:hqypmsxmpjaezfllq62zlyagje

17th Quadrennial Meeting of the World Society for Stereotactic and Functional Neurosurgery. Berlin, Germany, June 26-29, 2017: Abstracts

2017 Stereotactic and Functional Neurosurgery  
Abstract: Deep brain stimulation (DBS) of the subthalamic region is an established clinical therapy for the treatment of late stage Parkinson's disease.  ...  Conclusion: Deep Brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment option for patients with advanced Parkinson's disease (PD).  ...  This pattern includes reduced fiber connections between regions related to affective and associative dimensions of pain in TN patients, and enhanced fiber connections of regions related to both somatosensory  ... 
doi:10.1159/000478281 pmid:28641280 fatcat:ivcbjloukfgiriry65t37fccm4

Predicting optimal deep brain stimulation parameters for Parkinson's disease using functional MRI and machine learning

Alexandre Boutet, Radhika Madhavan, Gavin J. B. Elias, Suresh E. Joel, Robert Gramer, Manish Ranjan, Vijayashankar Paramanandam, David Xu, Jurgen Germann, Aaron Loh, Suneil K. Kalia, Mojgan Hodaie (+8 others)
2021 Nature Communications  
AbstractCommonly used for Parkinson's disease (PD), deep brain stimulation (DBS) produces marked clinical benefits when optimized.  ...  The model predicts optimal stimulation settings in unseen datasets: a priori clinically optimized and stimulation-naïve PD patients.  ...  The corresponding author confirms that he had full access to all the data in the study and had final responsibility for the decision to submit for publication.  ... 
doi:10.1038/s41467-021-23311-9 pmid:34031407 fatcat:6gjedt555fccbbp672nzyudvnu

Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies

Vinata Vedam-Mai, Karl Deisseroth, James Giordano, Gabriel Lazaro-Munoz, Winston Chiong, Nanthia Suthana, Jean-Philippe Langevin, Jay Gill, Wayne Goodman, Nicole R. Provenza, Casey H. Halpern, Rajat S. Shivacharan (+40 others)
2021 Frontiers in Human Neuroscience  
We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide.  ...  DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry.  ...  deep brain stimulation (aDBS) paradigms.  ... 
doi:10.3389/fnhum.2021.644593 pmid:33953663 pmcid:PMC8092047 fatcat:ixlexjcljjd7njuiuiphkjelz4