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Eliciting naturalistic cortical responses with a sensory prosthesis via optimized microstimulation

John S Choi, Austin J Brockmeier, David B McNiel, Lee M von Kraus, José C Príncipe, Joseph T Francis
2016 Journal of Neural Engineering  
Here we show that such optimization produces responses in the S1 cortex of the anesthetized rat that are highly similar to natural, tactile-stimulus-evoked counterparts.  ...  Perceptually, microstimulation of somatosensory brain regions produces localized, modality-specific sensations, and several spatiotemporal parameters have been studied for their discernibility.  ...  To this end, we have developed a model-based control method capable of eliciting naturalistic responses in the somatosensory cortex via optimized patterns of intra-thalamic microstimulation (ITMS).  ... 
doi:10.1088/1741-2560/13/5/056007 pmid:27518368 fatcat:em32xynwjba4rn6l6t4tg4yjx4

Whisker-Mediated Touch System in Rodents: From Neuron to Behavior

Mehdi Adibi
2019 Frontiers in Systems Neuroscience  
cortex.  ...  A key question in systems neuroscience is to identify how sensory stimuli are represented in neuronal activity, and how the activity of sensory neurons in turn is "read out" by downstream neurons and give  ...  ., head relative to environment and vice versa) at the level of neurons in the rat primary somatosensory cortex or secondary somatosensory cortex (Jacob et al., 2008) .  ... 
doi:10.3389/fnsys.2019.00040 pmid:31496942 pmcid:PMC6712080 fatcat:ndthvrmpn5e2zimv5p74fmpwly

Brain-Machine Interfaces: From Basic Science to Neuroprostheses and Neurorehabilitation

Mikhail A. Lebedev, Miguel A. L. Nicolelis
2017 Physiological Reviews  
Brain-machine interfaces (BMIs) combine methods, approaches, and concepts derived from neurophysiology, computer science, and engineering in an effort to establish real-time bidirectional links between  ...  Although theoretical propositions and some proof of concept experiments on directly linking the brains with machines date back to the early 1960s, BMI research only took off in earnest at the end of the  ...  This activity underwent a sigmoid transform to generate a microstimulation pattern, which was delivered to the somatosensory cortex of the decoder rat.  ... 
doi:10.1152/physrev.00027.2016 pmid:28275048 fatcat:26dy2lgh6nfppd3mjgoofyit6u


1988 The Hastings center report  
Louis 212 ENCODING IN RAT PRIMARY SOMATOSENSORY CORTEX OF ELECTRICAL STIMULATION IN VPL THALAMUS Shaohua Xu , John K.  ...  We measure the voltage power spectral density and impedance in layer IV-V pyramidal neurons of the rat somatosensory cortex at different holding potentials and with different pharmacological treatments  ...  which provide HRR representations of the deductive rule to be tested (Parsons and Osherson, 1998, 1999) ; and right inferior frontal cortex which combines VMPFC and HRR information to select and apply  ... 
doi:10.1002/j.1552-146x.1988.tb03932.x fatcat:bkotcyah2ngbfdk4kbx3xnf5v4

Can the brain use waves to solve planning problems? [article]

Henry Powell, Mathias Winkel, Alexander V. Hopp, Helmut Linde
2021 arXiv   pre-print
The neurons and synaptic connections in the model represent structures that can result from self-organization into a cognitive map via Hebbian learning, i.e. into a graph in which each neuron represents  ...  Graph traversal problems are solved by wave-like activation patterns which travel through the recurrent network and guide a localized peak of activity onto a path from some starting position to a target  ...  P. to undertake the work described in the above. We also thank Raul Mures , an and Robert Klassert for providing very valuable comments on early drafts of the paper.  ... 
arXiv:2110.05158v1 fatcat:v4rsm2t5xraa7cdvtn53auws4i

29th Annual Computational Neuroscience Meeting: CNS*2020

2020 BMC Neuroscience  
Selection starts in the primary visual cortex (V1), which creates a bottom-up saliency map to guide the fovea to selected visual locations via gaze shifts.  ...  This includes (i) how growing axons navigate to their targets by detecting and responding to molecular cues in their environment, (ii) the formation of maps in the visual cortex and how these are influenced  ...  Acknowledgments: The research reported here was supported, in part, by NSF grant #1544383 and in part by AFOSR grant #FA9550-16-1-0410.  ... 
doi:10.1186/s12868-020-00593-1 pmid:33342424 fatcat:edosycf35zfifm552a2aogis7a

30th Annual Computational Neuroscience Meeting: CNS*2021–Meeting Abstracts

2021 Journal of Computational Neuroscience  
One of the goals of neuroscience is to understand the computational principles that describe the formation of behaviorally relevant signals in the brain, as well as how these computations are realized  ...  The goal of the present study was to examine how PCs can recognise spatial patterns in the input. In a previous study the input was applied directly to PFs (Sajikumar et al., 2014 Aug 19 ).  ...  In particular, we wanted to explore the effect of the spatial extension, position and sparsity of the MF input , and in the next stage, the projection patterns from the GrCs to the PCs (Josselyn & Tonegawa  ... 
doi:10.1007/s10827-021-00801-9 pmid:34931275 pmcid:PMC8687879 fatcat:evpmmfpaivgpxdqpive5xdgmwu