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Subcortical shape and volume abnormalities in an elderly HIV+ cohort

Benjamin S. C. Wade, Victor Valcour, Edgar Busovaca, Pardis Esmaeili-Firidouni, Shantanu H. Joshi, Yalin Wang, Paul M. Thompson, Barjor Gimi, Robert C. Molthen
2015 Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging  
Our results show subcortical brain differences in HIV+ subjects in both shape and volumetric domains.  ...  With parametric surface-based shape analyses, we mapped the 3D profile of subcortical morphometry in 63 elderly HIV+ subjects (4 female; age=65.35 ± 2.21) and 31 uninfected elderly controls (2 female;  ...  Here we show the profile of subcortical volumetric and 3D surface-based shape abnormalities in a cohort of 63 elderly HIV+ subjects scanned with structural magnetic resonance imaging (MRI) as part of the  ... 
doi:10.1117/12.2082241 pmid:25844123 pmcid:PMC4382084 dblp:conf/mibam/WadeVBEJ0T15 fatcat:fzpl4biycvcwnmyhfzpzosygsm

Mapping abnormal subcortical brain morphometry in an elderly HIV+ cohort

Benjamin S. C. Wade, Victor G. Valcour, Lauren Wendelken-Riegelhaupt, Pardis Esmaeili-Firidouni, Shantanu H. Joshi, Yalin Wang, Paul M. Thompson
2015 2015 IEEE 12th International Symposium on Biomedical Imaging (ISBI)  
Using parametric surface-based shape analyses, we mapped the 3D profile of subcortical morphometry in 63 HIV+ participants and 31 uninfected controls.  ...  Over 50% of HIV+ individuals exhibit neurocognitive impairment and subcortical atrophy, but the pattern of brain abnormalities associated with HIV is still poorly understood.  ...  Here we report on both the subcortical volumetric and 3D surface-based shape abnormalities in a cohort of 63 elderly HIV+ subjects scanned with structural magnetic resonance imaging (MRI) as part of the  ... 
doi:10.1109/isbi.2015.7164033 pmid:26413207 pmcid:PMC4578225 dblp:conf/isbi/WadeVWEJWT15 fatcat:fmiwrapzczfozl5nj6aehflrxu

Mapping abnormal subcortical brain morphometry in an elderly HIV + cohort

Benjamin S.C. Wade, Victor G. Valcour, Lauren Wendelken-Riegelhaupt, Pardis Esmaeili-Firidouni, Shantanu H. Joshi, Boris A. Gutman, Paul M. Thompson
2015 NeuroImage: Clinical  
Using surface-based shape analyses, we mapped the 3D profile of subcortical morphometry in 63 elderly HIV+ participants and 31 uninfected controls.  ...  Over 50% of HIV+ individuals exhibit neurocognitive impairment and subcortical atrophy, but the profile of brain abnormalities associated with HIV is still poorly understood.  ...  Conclusions We have characterized patterns of abnormal brain morphometry in an elderly HIV + cohort.  ... 
doi:10.1016/j.nicl.2015.10.006 pmid:26640768 pmcid:PMC4625216 fatcat:dlh4sieo6ngz7gbzmgl4rig6ay

Mapping abnormal subcortical neurodevelopment in a cohort of Thai children with HIV

Benjamin S.C. Wade, Victor G. Valcour, Thanyawee Puthanakit, Arvin Saremi, Boris A. Gutman, Talia M. Nir, Christa Watson, Linda Aurpibul, Pope Kosalaraksa, Pradthana Ounchanum, Stephen Kerr, Netsiri Dumrongpisutikul (+8 others)
2019 NeuroImage: Clinical  
Alterations in subcortical brain structures have been reported in adults with HIV and, to a lesser extent, pediatric cohorts.  ...  Our findings corroborate reports in adult cohorts demonstrating a high predilection for HIV-mediated abnormalities in the basal ganglia, but suggest the effect of stable PaHIV infection on morphological  ...  Valcour) and R01MH102151 (T. Puthanakit and J.  ... 
doi:10.1016/j.nicl.2019.101810 pmid:31029050 pmcid:PMC6482384 fatcat:xq3ca26y3neuhegu4zpfyljpwe

The effects of HIV and aging on subcortical shape alterations: A 3D morphometric study

Taylor Kuhn, Daniel Schonfeld, Philip Sayegh, Alyssa Arentoft, Jacob D. Jones, Charles H. Hinkin, Susan Y. Bookheimer, April D. Thames
2016 Human Brain Mapping  
in predicting volume/ shape in each ROI.  ...  These findings may suggest that age and HIV infection conferred additional deleterious effects on subcortical shape abnormalities beyond the independent effects of these factors.  ...  We examined 1) the effects of HIV infection on volume and shape in each region of interest (ROI); 2) the association between age and volume/shape in each ROI; and 3) the interaction between age and HIV  ... 
doi:10.1002/hbm.23436 pmid:27778407 pmcid:PMC5225033 fatcat:75wpjdrw7vfp7d6gws4pf6ykhe

Brain mapping as a tool to study neurodegeneration

Liana G. Apostolova, Paul M. Thompson
2007 Neurotherapeutics  
Applications to AD and other dementias are discussed, with a brief review of related findings in other neurological and neuropsychiatric illnesses, including epilepsy, HIV/AIDS, schizophrenia, and disorders  ...  Neuroimaging and brain mapping techniques offer extraordinary power to understand AD, providing spatially detailed information on the extent and trajectory of the disease as it spreads in the living brain  ...  to identify systematic volume and shape differences in one subject group versus another.  ... 
doi:10.1016/j.nurt.2007.05.009 pmid:17599704 pmcid:PMC2634605 fatcat:ikodzcayofhfzp5yj3gf3as7bu

Evidence for a moderating effect of drinking severity but not HIV status on brain age in heavy episodic drinkers [article]

Jonathan C Ipser, John Joska, Tatum Sevenoaks, Hetta Gouse, Carla Freeman, Tobias Kaufmann, Ole Andreassen, Steve Shoptaw, Dan Stein
2021 medRxiv   pre-print
We predicted that BAG will be greater in PWH who engage in HED and that these effects will be particularly pronounced in frontoparietal and subcortical regions.  ...  Differences in BAG between patients and controls were observed subcortically, as for the cingulate and the parietal cortex.  ...  The observation of an interaction between age and HIV status in the shape of various subcortical .  ... 
doi:10.1101/2021.04.03.21254870 fatcat:2cno2d6xmnhnflnckchw63tzaa

Tracking Alzheimer's Disease

P. M THOMPSON, K. M HAYASHI, R. A DUTTON, M.-C. CHIANG, A. D LEOW, E. R SOWELL, G. DE ZUBICARAY, J. T BECKER, O. L LOPEZ, H. J AIZENSTEIN, A. W TOGA
2007 Annals of the New York Academy of Sciences  
We compare time-lapse maps of AD, MCI, and other dementias, correlate these changes with cognition, and relate them to similar timelapse maps of childhood development, schizophrenia, and HIV-associated  ...  A third technique, hippocampal surface modeling, plots the profile of shape alterations across the hippocampal surface.  ...  , and the National Institute for Child Health and Development (AG016570, LM05639, EB01651, RR019771 and HD050735 to P.M.T.).  ... 
doi:10.1196/annals.1379.017 pmid:17413023 pmcid:PMC3197831 fatcat:ztx5gpereze5fiujthiwuktr5q

3D maps localize caudate nucleus atrophy in 400 Alzheimer's disease, mild cognitive impairment, and healthy elderly subjects

S.K. Madsen, A.J. Ho, X. Hua, P.S. Saharan, A.W. Toga, C.R. Jack, M.W. Weiner, P.M. Thompson
2010 Neurobiology of Aging  
Compared to controls, caudate volumes were lower in MCI (2.64% left, 4.43% right) and AD (4.74% left, 8.47% right).  ...  Reduced right (but not left) volume was associated with MCI-to-AD conversion and CSF tau levels.  ...  Inc., Merck and Co., Inc., Novartis AG, Pfizer, Inc, F.  ... 
doi:10.1016/j.neurobiolaging.2010.05.002 pmid:20538376 pmcid:PMC2903198 fatcat:z5bm2s7avbgininteaz5fgqtma

Impact of HIV infection and alcohol on cognition: a review

Ola Selnes
2010 Neurobehavioral HIV Medicine  
In the context of HIV infection, very heavy alcohol use in individuals with advanced HIV disease appears to have synergistic effects.  ...  What they have in common is that the white matter of the brain is principally affected, and the direct neuronal injury does not appear to be a consequence of either HIV infection or alcohol use.  ...  Disclosure The author reports no conflicts of interest in this work.  ... 
doi:10.2147/nbhiv.s7364 fatcat:7kak2qvx2vcmdor33wbo6yqdti

ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide

Paul M. Thompson, Ole A. Andreassen, Alejandro Arias-Vasquez, Carrie E. Bearden, Premika S. Boedhoe, Rachel M. Brouwer, Randy L. Buckner, Jan K. Buitelaar, Kazima B. Bulayeva, Dara M. Cannon, Ronald A. Cohen, Patricia J. Conrod (+59 others)
2017 NeuroImage  
We discuss challenges and opportunities in applying these predictors to individual subjects and new cohorts, as well as lessons we have learned in ENIGMA's efforts so far.  ...  volumes.  ...  Funding for individual consortium authors is listed in Hibar et al., Nature, 2015 and in other papers cited here.  ... 
doi:10.1016/j.neuroimage.2015.11.057 pmid:26658930 pmcid:PMC4893347 fatcat:abs5uh3dmba2ze646vluqdujtu

Cerebral Small Vessel Disease: A Review Focusing on Pathophysiology, Biomarkers, and Machine Learning Strategies

Elisa Cuadrado-Godia, Pratistha Dwivedi, Sanjiv Sharma, Angel Ois Santiago, Jaume Roquer Gonzalez, Mercedes Balcells, John Laird, Monika Turk, Harman S. Suri, Andrew Nicolaides, Luca Saba, Narendra N. Khanna (+1 others)
2018 Journal of Stroke  
Cerebral small vessel disease (cSVD) has a crucial role in lacunar stroke and brain hemorrhages and is a leading cause of cognitive decline and functional loss in elderly patients.  ...  An important pathophysiological mechanism of cSVD is blood-brain barrier leakage and endothelium dysfunction which gives a clue in identification of the disease through circulating biological markers.  ...  In another report, correlation of arteriolar wall thickness was studied with many factors including HCV and human immunodeficiency virus (HIV) infection and concluded that HCV, not HIV establishes an independent  ... 
doi:10.5853/jos.2017.02922 pmid:30309226 pmcid:PMC6186915 fatcat:znrvqbctozc7hm2r3qrmcthqc4

Cortical metabolite alterations in abstinent cocaine and cocaine/alcohol-dependent subjects: proton magnetic resonance spectroscopic imaging

D. J. MEYERHOFF, C. BLOOMER, N. SCHUFF, F. EZEKIEL, D. NORMAN, W. CLARK, M. W. WEINER, G. FEIN
1999 Addiction Biology  
We pegormed MRI and multi-slice brain proton magnetic resonance spectroscopic imaging (MRSI) to assess neuronal viability (via N-acetylaspartate (NAA)) and white mutter metabolite status in 22 4-months-abstinent  ...  The MRSI findings suggest preferential neuronal damage to the frontal cortex of both cocaine-dependent samples and gliosis in frontal white matter of individQals dependent on both alcohol and cocaine,  ...  E) and AA10788 (D. J. M.). We are thankful for Mr Gilbert Salas' relentless efforts and expertise in recruiting subjects for this study.  ... 
doi:10.1080/13556219971399 pmid:20575809 pmcid:PMC2893339 fatcat:rli6ka3w4zgoxnpf5demznv63q

Magnetic resonance imaging for the diagnosis of Parkinson's disease

Beatrice Heim, Florian Krismer, Roberto De Marzi, Klaus Seppi
2017 Journal of neural transmission  
The differential diagnosis of parkinsonian syndromes is considered one of the most challenging in neurology and error rates in the clinical diagnosis can be high even at specialized centres.  ...  in the diagnostic work-up of Parkinson's disease.  ...  reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.  ... 
doi:10.1007/s00702-017-1717-8 pmid:28378231 pmcid:PMC5514207 fatcat:mijrauiwbvdw3cepks7qfj2e24

The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

Paul M. Thompson, Jason L. Stein, Sarah E. Medland, Derrek P. Hibar, Alejandro Arias Vasquez, Miguel E. Renteria, Roberto Toro, Neda Jahanshad, Gunter Schumann, Barbara Franke, Margaret J. Wright, Nicholas G. Martin (+277 others)
2014 Brain Imaging and Behavior  
Some ENIGMA investigators contributed to the design and implementation of ENIGMA or provided data but did not participate in the analysis or writing of this report.  ...  private agencies worldwide, listed in Stein et al. (2012) ; the funding for listed consortia is also itemized in Stein et al. (2012) .  ...  In general, the trend revealed a decrease in subcortical volumes throughout the brain in patients with bipolar disorder.  ... 
doi:10.1007/s11682-013-9269-5 pmid:24399358 pmcid:PMC4008818 fatcat:ujnpcizkpfdaxg6egpb43sskai
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