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Subcellular protein expression models for microsatellite instability in colorectal adenocarcinoma tissue images
2016
BMC Bioinformatics
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We then develop models for six proteins which are important colorectal cancer biomarkers and are associated with microsatellite instability, namely MLH1, PMS2, MSH2, MSH6, P53 and PTEN. ...
To the best of our knowledge, this is the first model for expression of multiple proteins in anatomically intact tissue, rather than within cells in culture. ...
To the best of our knowledge, this is the first model for subcellular expression of multiple proteins in anatomically intact tissue, as opposed to existing models for protein expression within cells in ...
doi:10.1186/s12859-016-1243-y
pmid:27770786
pmcid:PMC5075203
fatcat:w37ihtnke5enxegu3gdh2gxjyi
MYO1A (myosin IA)
2014
Atlas of Genetics and Cytogenetics in Oncology and Haematology
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Review on MYO1A, with data on DNA/RNA, on the protein encoded and where the gene is This article should be referenced as such: ...
(C) Localization of additional mutations found in colorectal tumors without microsatellite instability. ...
Mazzolini et al. reported MYO1A frame-shift mutations in 32% (37 of 116) of the colorectal tumors with microsatellite instability. ...
doi:10.4267/2042/54010
fatcat:34qhult25febjjcxqiq5s4b5w4
Differential expression of DHHC9 in microsatellite stable and instable human colorectal cancer subgroups
2007
British Journal of Cancer
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The upregulation was more striking in microsatellite stable (MSS), than in microsatellite instable (MSI), tumours. ...
In conclusion, DHHC9 is a gastrointestinal-related protein highly expressed in MSS colon tumours. ...
ACKNOWLEDGEMENTS We thank Pamela Celis, Susanne Bruun and Jette Jensen for their excellent technical assistance as well as to Jeppe Praetorius, Institute of Anatomy, University of Aarhus, for confocal ...
doi:10.1038/sj.bjc.6603818
pmid:17519897
pmcid:PMC2359975
fatcat:4uqqytt36bdutogppbof262fgu
Parkin protein expression and its impact on survival of patients with advanced colorectal cancer
2018
Cancer Biology and Medicine
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parameters, and expression of known proteins involved in colorectal cancer. ...
Although alterations in parkin protein expression have been described in colorectal cancer, the functional significance of this protein remains unknown. ...
non-neoplastic
mucosa
0.409 1.04
0.94-1.15
Table S1 S1 Immunohistochemical analysis of microsatellite instability markers expression in colorectal cancer patients Protein
Positive/negative ...
doi:10.20892/j.issn.2095-3941.2017.0136
pmid:29545969
pmcid:PMC5842336
fatcat:fjxkatrllrb6hao4yfrptx7rrm
MSH2missense mutations and HNPCC syndrome: pathogenicity assessment in a human expression system
2008
Human Mutation
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Functional assays results were correlated with clinical and genetic features indicative of HNPCC as MicroSatellite-Instability (MSI), abnormalities of MMR gene expression in tumour tissue (IHC) and familial ...
Missense alterations, were assessed in a human system for expression/stability and for the ability to heterodimerize with MSH6 and correctly localize into the nucleus. ...
Index patient MSI analysis resulted in a high degree of instability (80%). Normal staining for MLH1 and the lack of MSH2 and MSH6 expression were observed in the tumour tissue. ...
doi:10.1002/humu.20875
pmid:18781619
fatcat:xdzhaohd3vfzppg5yuhgfjt7y4
Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro
2007
Molecular Oncology
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In conclusion, Keratin23 expression is a novel and important difference between microsatellite-stable and microsatellite-instable colon cancers. ...
Immunohistochemical analyses demonstrated that 88% of microsatellite-instable tumors were negative for Keratin23 protein, while 70% of MSS tumors and metastases derived from MSS-tumors showed high Keratin23 ...
Acknowledgments We are grateful to Pamela Celis and Susanne Bruun for their excellent technical assistance and Jeppe Praetorius, Institute of Anatomy, University of Aarhus, for confocal microscopy. ...
doi:10.1016/j.molonc.2007.05.005
pmid:19383294
pmcid:PMC5543893
fatcat:zwc6lzvcbfge5otzicdfcipblq
Brush border Myosin Ia has tumor suppressor activity in the intestine
2012
Proceedings of the National Academy of Sciences of the United States of America
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MYO1A frame-shift mutations were observed in 32% (37 of 116) of the colorectal tumors with microsatellite instability analyzed, and evidence of promoter methylation was observed in a significant proportion ...
Moreover, MYO1A tumor expression was found to be an independent prognostic factor for colorectal cancer patients. ...
Results
Frequent MYO1A Mutations in Colorectal Tumors with Microsatellite Instability. ...
doi:10.1073/pnas.1108411109
pmid:22307608
pmcid:PMC3277176
fatcat:lccbdaupnjdwfj66uoszr6hfey
Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression
2010
Gut
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Tissue microarrays from a subset of 64 cases were used for immunohistochemical analysis of DNMT3B expression. ...
and aims Although aberrant methylation of key genes in the progression of colorectal neoplasia has been reported, no model-based analysis of the incremental changes through the intermediate adenoma stage ...
We also acknowledge the help of the Tissue Bank facility in Addenbrooke's hospital funded through the NIHR Biomedical Research Centre. ...
doi:10.1136/gut.2010.223602
pmid:21068132
fatcat:tt464vbkb5anlo6gzoparzbvva
Tumor-Associated Alterations in Caspase-14 Expression in Epithelial Malignancies
2005
Clinical Cancer Research
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Experimental Design: Tumor-associated alterations in caspase-14 expression were observed for cervical, ovarian, breast, gastric, and colon cancers. ...
Conclusions: The findings reveal tumor-specific alterations in caspase-14 expression and suggest that differences in its expression may define subsets of epithelial cancers with distinct clinical behaviors ...
Guy Salvesen from the Burnham Institute, La Jolla, CA for providing the caspase-14 recombinant protein for antibodies production and Wei-Soon Kwon for technical assistance. ...
doi:10.1158/1078-0432.ccr-04-2527
pmid:16061862
fatcat:6lrbxlbnlvdxvbcvz4d6ppjo2i
Expression of ERalpha, ERbeta and co-regulator PELP1/MNAR in colorectal cancer: prognostic significance and clinicopathologic correlations
2009
Cellular Oncology
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ERalpha, ERbeta and PELP1/MNAR protein expression were evaluated by immunohistochemistry in colorectal normal mucosa, adenomas and adenocarcinomas from 113 patients with colorectal cancer. ...
Estrogen receptor beta (ERbeta) is abundantly expressed in colorectal tissue, but its role in colorectal carcinogenesis remains elusive. ...
Study sponsors had no involvement in the study design, in the collection, analysis and interpretation of data; in the writing of the manuscript; in the decision to submit the manuscript for publication ...
doi:10.3233/clo-2009-0467
pmid:19478391
pmcid:PMC4618984
fatcat:fruybzmoxfbsbaxyq5vd63xxle
Interplay between SOX9, β-catenin and PPARγ activation in colorectal cancer
2013
BBA - Molecular Cell Research
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tumor tissue and age (p = 0.04) and microsatellite instability (MSI), in particular with MSI-H (p = 0.0002). ...
In CRC tissues SOX9 resulted up-regulated at both mRNA and protein levels when compared to matched normal mucosa, β-catenin resulted up-regulated at protein levels, while PPARG mRNA and PPARγ protein levels ...
Stefano Ferrari for excellent support in the cell-cycle experiment, and Dr. Rosa Di Paola and Dr. Antonella Marucci for technical contribution. ...
doi:10.1016/j.bbamcr.2013.04.004
pmid:23583560
fatcat:niime4mkhfdlvgbg6yo2va5nby
Organoid modelling identifies that DACH1 functions as a tumour promoter in colorectal cancer by modulating BMP signalling
2020
EBioMedicine
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Dachshund homologue 1 (DACH1) is highly expressed in LGR5+ intestinal stem cells and colorectal tumours. ...
We used immunohistochemistry, western blotting and quantitative real-time PCR to analyse DACH1 expression in colorectal cancer (CRC) samples. ...
; MSS, microsatellite
stability; MSI, microsatellite instability. ...
doi:10.1016/j.ebiom.2020.102800
pmid:32512510
pmcid:PMC7281795
fatcat:mg4hyvguzfcifcb6qncope3rjq
Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: implications for therapeutic targeting
2018
Cancer Metastasis Review
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APC encodes a 312-kDa protein that localizes to multiple subcellular compartments and performs diverse functions. ...
Individuals with FAP inherit a loss-of-function mutation in a single allele of APC, followed by an additional acquired mutation in the second allele of APC in the adenomas and adenocarcinomas that develop ...
responsible for normal homeostasis of the colorectal epithelium and other tissues [88, 148] . ...
doi:10.1007/s10555-017-9725-6
pmid:29318445
pmcid:PMC5803335
fatcat:arnxpedybfcptngwx6qpfa7574
Molecular Pathogenesis of Colorectal Cancer with an Emphasis on Recent Advances in Biomarkers, as Well as Nanotechnology-Based Diagnostic and Therapeutic Approaches
2022
Nanomaterials
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The formation of colorectal adenomas and invasive adenocarcinomas is the consequence of a succession of genetic and epigenetic changes in the normal colonic epithelium. ...
It also provides conceptual knowledge of nanotechnology-based diagnostic techniques and therapeutic approaches for malignant colorectal cancer. ...
Colorectal carcinogenesis has been linked to three distinct molecular pathways, including chromosomal instability (CIN), microsatellite instability (MSI), and chromosomal mismatch repair (CIMP) (Figure ...
doi:10.3390/nano12010169
pmid:35010119
pmcid:PMC8746463
fatcat:v2jclhpxsvc65jup7rxyqzpssu
Parallel Sessions (Proffered Papers)
2010
Analytical Cellular Pathology
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Neuroblastoma is the most common extracranial solid tumor in childhood and shows notable heterogeneity with regard to both histology and clinical behavior. ...
DNA content in colon adenocarcinomas measured by image cytometry is an independent predictor of prognosis in our patients operated for colon adenocarcinoma. ...
No nonsense mutations were found. 33% of non CD-related SBA showed microsatellite instability, whereas 67% of CD-related SBA were microsatellite instable. ...
doi:10.1155/2010/531968
fatcat:xfboajtlebgtvcnqkej5olrncm
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