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Anti-Cancer Properties of Stevia rebaudiana; More than a Sweetener

Nikos Iatridis, Anastasia Kougioumtzi, Katerina Vlataki, Styliani Papadaki, Angeliki Magklara
2022 Molecules  
Stevia rebaudiana Bertoni is a perennial shrub from Paraguay that is nowadays widely cultivated, since it is increasingly being utilized as a sugar substitute in various foodstuffs due to its sweetness and minimal caloric content. These properties of the plant's derivatives have spurred research on their biological activities revealing a multitude of benefits to human health, including antidiabetic, anticariogenic, antioxidant, hypotensive, antihypertensive, antimicrobial, anti-inflammatory and
more » ... antitumor actions. To our knowledge, no recent reviews have surveyed and reported published work solely on the latter. Consequently, our main objective was to present a concise, literature-based review of the biological actions of stevia derivatives in various tumor types, as studied in in vitro and in vivo models of the disease. With global cancer estimates suggesting a 47% increase in cancer cases by 2040 compared to 2020, the data reviewed in this article should provide a better insight into Stevia rebaudiana and its products as a means of cancer prevention and therapy within the context of a healthy diet.
doi:10.3390/molecules27041362 pmid:35209150 pmcid:PMC8874712 fatcat:btnxucrbhnenlknfbvobu35u6a

Transcriptional Profiling of Tumorspheres Reveals TRPM4 as a Novel Stemness Regulator in Breast Cancer

John Verigos, Dimitris Kordias, Styliani Papadaki, Angeliki Magklara
2021 Biomedicines  
Cancer stem cells (CSCs) have been implicated in the development of chemoresistance, tumor recurrence and metastasis in breast cancer, thus emerging as a promising target for novel therapies. To identify novel stemness regulators that could potentially be targeted in luminal ER+ tumors, we performed RNA-sequencing (RNA-seq) in MCF-7 adherent monolayer cells and tumorspheres enriched in breast CSCs (bCSCs). We identified 1421 differentially expressed genes (DEGs), with 923 of them being
more » ... ed and 498 downregulated in tumorspheres. Gene ontology and pathway enrichment analyses revealed that distinct gene networks underlie the biology of the two cell systems. We selected the transient receptor potential cation channel subfamily M member 4 (TRPM4) gene that had not been associated with cancer stemness before for further investigation. We confirmed that TRPM4 was overexpressed in tumorspheres and showed that its knock-down affected the stemness properties of bCSCs in vitro. TRPM4 inhibition revealed potential anti-tumor effects by directly targeting the bCSC subpopulation. We suggest that TRPM4 plays a key role in stemness mediation, and its inhibition may represent a novel therapeutic modality against bCSCs contributing in the improvement of breast cancer treatments.
doi:10.3390/biomedicines9101368 pmid:34680485 fatcat:fissvbmp65dvzgefkztarh5f7a

Microalgae based innovative animal fat and proteins replacers for application in functional baked products

Maria-Styliani-Georgia Kafyra, Sofia Papadaki, Marios Chronis, Magdalini Krokida
2018 Open Agriculture  
Animal fat and proteins, such as milk butter and eggs, are the main ingredients of baked products, and are frequently blamed for food allergies, obesity, cancer and type II diabetes. Therefore, there is an urgent need to replace these ingredients with healthier ones without degrading the organoleptic characteristics of the final product. Microalgae are a great source of protein, minerals and lipids such as omega-3 and omega-6 fatty acids, which are beneficial for human health, offering multiple
more » ... health benefits such as antioxidant and anti-aging activity. In this study, Chlorella vulgaris microalgae were the selected raw material for the innovative replacers because of their high content in proteins and polyunsaturated fatty acids. The obtained microalgal oil was colour corrected and used to produce brioche-type baked products with 100% animal fat substitution. For protein recovery, the aquatic extract was freeze-dried, producing a dry protein powder that fully substituted the animal protein in the baked products. Finally, the development of bakery products with 100% replacement of both animal fat and protein was achieved. These innovative bakery products showed equal performance to the commercial ones, and even improved organoleptic characteristics according to the sensorial analysis that occurred.
doi:10.1515/opag-2018-0047 fatcat:6llyzzhnmjbohfokgumxled43a

Do platelet mediators and coagulation factors affect the formation of neutrophil extracellular traps?

Iraklis C. Moschonas, Styliani Papadaki, Sofia Sidiropoulou, Alexandros D. Tselepis
2020 Journal of Atherosclerosis Prevention and Treatment  
Aim: To investigate the effect of factor Xa (FXa), thrombin and platelets, under activation or resting conditions, on neutrophil extracellular traps (NETs) formation (NETosis). Materials and Methods: Neutrophils, isolated from apparently healthy volunteers, were challenged with 25-50 nM FXa, 0.2-8 U/mL thrombin, 5-100 μM adenosine diphosphate (ADP), 0.1-0.5 mM arachidonic acid (AA), 5-15 μg/mL collagen, 100 μM protease-activated receptor (PAR)-4 activating peptide, 10-100 μM PAR-2 activating
more » ... tide or 25-100 nM phorbol 12-myristate 13-acetate (PMA). Moreover, neutrophils were challenged with platelet-rich plasma (PRP), activated with ADP (at a concentration of either 20 μM, in an aggregometer, or of 50 μM, in situ). Neutrophils were incubated for 3.5 h at 37οC and 5% CO2 and an immunofluorescence protocol followed, in order to stain neutrophils and NETs for myeloperoxidase and DNA. Finally, NETs and neutrophils were microscopically visualized and the percentage of NET-releasing neutrophils of each of the above experimental conditions was evaluated. Results and Conclusion: Among the agonists studied, only PMA and AA, induced robust NETosis, at a threshold concentration of 25 nM and 0.25 mM, respectively. Furthermore, platelets pre-activated with ADP, but not resting platelets induce the formation of NETs, a phenomenon that is also observed when platelets were activated with ADP in situ, in the presence of neutrophils. The present results provide an additional mechanism through which platelets contribute to various pathophysiological conditions in which NETs are implicated, such as inflammation and thrombosis. The whole spectrum of platelet mediators that are implicated in NETosis needs to be further investigated.
doi:10.53590/japt.02.1013 fatcat:ax2s2wgdmjdhzaa4ed6ry4zfa4

Plasma Brain Natriuretic Peptide Levels in Children with Chronic Kidney Disease and Renal Transplant Recipients: A Single Center Study

Anastasia Garoufi, Aikaterini Koumparelou, Varvara Askiti, Panagis Lykoudis, Andromachi Mitsioni, Styliani Drapanioti, Georgios Servos, Maria Papadaki, Dimitrios Gourgiotis, Antonios Marmarinos
2022 Children  
Pediatric chronic kidney disease (CKD) patients, as well as kidney transplant patients, are at an increased risk of developing cardiovascular disease. BNP measurement, as a biomarker of cardiovascular risk, has been recommended to this high-risk population. Plasma BNP levels were measured in 56 CKD children in either pre-dialysis stage, hemodialysis (HD) or renal transplant recipients (RTRs) and in 76 sex- and age-matched healthy controls. BNP levels were investigated in HD children, before and
more » ... after the completion of their HD session. BNP levels in total CKD population, in pre-dialysis stage patients and on HD were significantly higher, compared to the respective controls. HD children had higher BNP levels compared to CKD patients in the pre-dialysis stage. Moreover, post-HD BNP concentration was slightly higher than pre-HD, with the difference being marginally statistically significant. BNP was positively correlated with eGFR, creatinine, cystatin-C and parathormone and negatively with albumin and 25-hydroxyvitamin D. A positive correlation between BNP concentration and the ratio of E/A in pulse-wave Doppler echocardiography was also observed. In conclusion, CKD pediatric patients, mainly those undergoing HD, have high plasma BNP levels which do not decrease after the HD session. This is indicative of a greater risk for future cardiovascular disease.
doi:10.3390/children9060916 fatcat:akr45v7njrcj5b6yex2pkdvvty

Quantification of effective orbital volume and its association with axial length of the eye. A 3D-MRI study

Georgios Bontzos, Efrosini Papadaki, Michael Mazonakis, G Thomas Maris, Zoi Kapsala, Styliani Blazaki, E Eleni Drakonaki, T Efstathios Detorakis
2019 Romanian Journal of Ophthalmology  
Objective: To measure the effective orbital volume (EOV) from magnetic resonance images, and investigate its relationship with axial length (AL) in those parameters. Methods: Cross-sectional, 3D-MRI study. 54 eyes of 54 patients (25 males) were included in this work. Patient weight, height and head circumference were also measured. Orbital and eyeball volumes were calculated after image segmentation. The difference between those values volume was assessed, estimating the EOV for each eye.
more » ... s: Mean eyeball volume was 7.83 ± 2.27 mm3, mean orbital volume 26.81 ± 0.59 mm3 and EOV 21.64 ± 0.19 mm3. The orbital volume was significantly higher in the male group (Wilcoxon signed-rank tests Z=-1.51, p<0.001; Z=-3.57, p<0.001 respectively). EOV was significantly correlated with AL in both males (r=-0.71, p<0.001) and females (r=-0.73, p<0.001), whereas it was also significantly associated with patient height (r=0.261, p=0.03). Associations between EOV and other age, axial and anthropometric characteristics were not statistically significant. Conclusions: Findings of this study could be of valuable importance in various clinical situations in which quantification of orbital volume is needed, such as orbital decompression in Graves' orbitopathy, volume restoration in orbital fractures or other orbital reconstructive surgery. In surgical interventions, clinical relationships should be carefully taken under consideration to avoid iatrogenic injury. Abbreviations: EOV = Effective orbital volume, AL = Axial length, ROI = Region of interest.
pmid:31915734 pmcid:PMC6943286 fatcat:no5u26kowrdb5mjcqrux75pfa4

Expanded national database collection and data coverage in the FINDbase worldwide database for clinically relevant genomic variation allele frequencies

Emmanouil Viennas, Angeliki Komianou, Clint Mizzi, Maja Stojiljkovic, Christina Mitropoulou, Juha Muilu, Mauno Vihinen, Panagiota Grypioti, Styliani Papadaki, Cristiana Pavlidis, Branka Zukic, Theodora Katsila (+4 others)
2016 Nucleic Acids Research  
FINDbase ( is a comprehensive data repository that records the prevalence of clinically relevant genomic variants in various populations worldwide, such as pathogenic variants leading mostly to monogenic disorders and pharmacogenomics biomarkers. The database also records the incidence of rare genetic diseases in various populations, all in well-distinct data modules. Here, we report extensive data content updates in all data modules, with direct implications to clinical
more » ... pharmacogenomics. Also, we report significant new developments in FINDbase, namely (i) the release of a new version of the ETHNOS software that catalyzes development curation of national/ethnic genetic databases, (ii) the migration of all FINDbase data content into 90 distinct national/ethnic mutation databases, all built around Microsoft's PivotViewer ( software (iii) new data visualization tools and (iv) the interrelation of FINDbase with DruGeVar database with direct implications in clinical pharmacogenomics. The abovementioned updates further enhance the impact of FIND-base, as a key resource for Genomic Medicine applications.
doi:10.1093/nar/gkw949 pmid:27924022 pmcid:PMC5210643 fatcat:blq746iqefdeti4ush75ki3aw4

Immunohistochemical Analysis of IL-6, IL-8/CXCR2 Axis, Tyrp-STAT-3, and SOCS-3 in Lymph Nodes from Patients with Chronic Lymphocytic Leukemia: Correlation between Microvascular Characteristics and Prognostic Significance

Georgia Levidou, Sotirios Sachanas, Gerassimos A. Pangalis, Christina Kalpadakis, Xanthi Yiakoumis, Maria Moschogiannis, Athanasia Sepsa, Eleftheria Lakiotaki, Vassilis Milionis, Marie-Christine Kyrtsonis, Theodoros P. Vassilakopoulos, Pantelis Tsirkinidis (+9 others)
2014 BioMed Research International  
A number of studies have looked into the pathophysiological role of angiogenesis in CLL, but the results have often been inconsistent. We aimed to gain direct insight into the angiogenic process in lymph nodes involved by CLL, focusing on proangiogenic cytokines and microvessel morphometry. The tissue levels of VEGF, Th-2 cytokines IL-6 and IL-8, IL-8 receptor CXCR2, and tyrosine p-STAT-3/SOCS-3 axis modulating cytokine expression were evaluated immunohistochemically in 62 CLL/SLL cases.
more » ... scular characteristics were evaluated by image analysis. Results were analyzed with regard to clinicopathological characteristics. Proliferation centers (PCs) were less well vascularised compared to non-PC areas. IL-8 and CXCR2 expression was distinctly uncommon as opposed to IL-6, VEGF and SOCS-3, which were detected in the vast majority of cases. The latter two molecule expressions were more pronounced in the PCs in∼40% of the cases. p-STAT-3 immunoreactivity was recorded in 66.67% of the cases with a predilection for PCs. Microvessel morphometry was unrelated to proangiogenic cytokines, p-STAT-3, SOCS-3, or survival. Microvascular caliber and VEGF expression were higher in Binet stage A, whereasIL-6 expression was higher in stage C. VEGF and p-STAT-3 exerted a favorable effect on progression, which remained significant in multivariate analysis, thereby constituting potential outcome predictors in CLL patients.
doi:10.1155/2014/251479 pmid:24883303 pmcid:PMC4026921 fatcat:5qz3ai2hqzeo3imr6z63fqehnu

Die Modernisierung Griechenlands im 20. Jahrhundert am Beispiel der Gesetzgebung unter Eleftherios Venizelos [chapter]

S.-E. Vetsika
2015 Konflikt und Koexistenz  
Jahrhundert Styliani-Eirini Vetsika Styliani-Eirini Vetsika Styliani-Eirini Vetsika b) 1917-1920.Es ist eine Periode, die noch stark vom Konflikt zwischen Venizelos und dem König Konstantin charakterisiert  ...  Styliani-Eirini Vetsika Styliani-Eirini Vetsika 7 Nach einer ersten sechsjährigen verfassungsrechtlichen Erfahrung wurde die Verfassung von Troizina nicht mehr wie die zwei vorigen als vorläufig qualifiziert  ...  Styliani-Eirini  ... 
doi:10.5771/9783465142461-331 fatcat:hmbzmeltfjczdluthsft5rcvp4

Program in chronological order

2018 2018 IEEE EMBS International Conference on Biomedical & Health Informatics (BHI)  
Hellas); Maris, Thomas (Dept. of Radiology, Medical School -University of Crete, H); Karantanas, Apostolos (Radiology, University of Crete, Chairman, Dept. of Medical); Papadaki, Efrosini (Dept. of Radiology  ...  .................................................... 235-238 Leandrou, Stephanos (European University Cyprus); Mamais, Ioannis (National and Kapodistrian University of Athens, Dept. of Hy); Petroudi, Styliani  ... 
doi:10.1109/bhi.2018.8333344 fatcat:gr5gtf3yb5h2vkaryq43chpcau

Oscar Wilde's Social Comedies in Modern Greek Theatre (1908-1945)

Constantina Georgiadi
2015 Studii si Cercetari de Istoria Artei : Teatru, Muzică, Cinematografie  
One can also cite the PhD thesis of Styliani Platskou, The Irish drama in Greece: fifty years of theatre productions was doomed to remain unknown in Greece.  ...  Both performances followed the pattern established by the star theatre, with Katina Paxinou and Eleni Papadaki or Vasso Manolidou, among the divas of the time, in the main roles. 16 Although successful  ... 
doaj:06197463bce24c69bf300d80282a196d fatcat:okseqtkw6vfhvaitrv52tew7re

Metabolic syndrome is common among middle-to-older aged Mediterranean patients with rheumatoid arthritis and correlates with disease activity: a retrospective, cross-sectional, controlled, study

S A Karvounaris, P I Sidiropoulos, J A Papadakis, E K Spanakis, G K Bertsias, H D Kritikos, E S Ganotakis, D T Boumpas
2006 Annals of the Rheumatic Diseases  
We also thank Dr Styliani Maragaki, Charalambos Linardakis, Irini Flouri, Argyro Dimaka, RN, Zacharenia Papadopoulou, RN and Stauroula Lanara, RN, for patient care.  ... 
doi:10.1136/ard.2006.053488 pmid:16793841 pmcid:PMC1798406 fatcat:ve7prqbjp5gendff5toocjdgrm

Acknowledgement to Reviewers of IJERPH in 2018

2019 International Journal of Environmental Research and Public Health  
, Angeliki Papadakis, Stamatis Papadakis, Raffaello Papadopoulos, Andrew Papadopoulos, Nikos Papantoniou, Panagiotis Papapostolou, Vasileios Paparusso, Angela Papassotiriou, Ioannis G.  ...  Passannante, Marian Pasti, Luisa Pastor Vicedo, Juan Carlos Pastore, Luisa Patchay, Sandhiran Patel, Riya Patel, Minal Patel, Deven Pateraki, Styliani Pathak, Ram D.  ... 
doi:10.3390/ijerph16010160 fatcat:oehkay77qrgvnit7jniucknawy

Acknowledgement to Reviewers of Applied Sciences in 2019

Applied Sciences Editorial Office
2020 Applied Sciences  
Papacharalampopoulos, Alexios Papadakis, Manos Papadakis, Nikolaos M.  ...  Nikos Papastefanatos, George Papastergiou, Maria Papathanasopoulou, Vasileia Papathanassiou, George Papatzani, Styliani Papini, Marcello Papoulis, Dimitris Papoutsidakis, Michail G.  ... 
doi:10.3390/app10020725 fatcat:j7pcmb6esbafpa6vqkqs5apsye

Acknowledgement to Reviewers of Sensors in 2019

Sensors Editorial Office
2020 Sensors  
Dhruba Pantoli, Leonardo Panzardi, Enza Paolanti, Marina Paolicelli, Federica Paolini, Christopher Paolini, Riccardo Paolo, Bollella Paolo, Favali Paolozzi, Antonio Paone, NICOLA Pap, László Papa, Paolo Papadakis  ...  Vojtisek-Lom, Michal Volkov, Valentyn Volmer, Marius Volná, Eva Volosencu, Constantin Volpati, Diogo Volpp, Joerg Von Wangenheim, Aldo Vos, Steven Voß, Stefan Voué, Michel Voutetaki, Maria-Styliani  ... 
doi:10.3390/s20020576 fatcat:yjjvds6ndvdx5dp6gfcsvyfar4
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