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Feasibility assessment of yttrium-90 liver radioembolization imaging using amplitude-based gated PET/CT
2018
Nuclear medicine communications
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Purpose The usage of PET/computed tomography (CT) to monitor hepatocellular carcinoma patients following yttrium-90 ( 90 Y) radioembolization has increased. ...
This work examines the use of amplitude-based gating on 90 Y-PET/CT and its potential impact on diagnostic integrity. ...
Some results of this work have been presented at the Society of Nuclear Medicine and Molecular Imaging over the last 2 years.
Conflicts of interest There are no conflicts of interest. ...
doi:10.1097/mnm.0000000000000794
pmid:29351124
pmcid:PMC5882249
fatcat:ia46z2zlmfbdjmjxelre7tbxwe
Theranostic Imaging of Yttrium-90
2015
BioMed Research International
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This paper overviews Yttrium-90 (90Y) as a theranostic and nuclear medicine imaging of90Y radioactivity with bremsstrahlung imaging and positron emission tomography. ...
Although challenges remain for90Y imaging, continued clinical demand for predictive imaging response assessment and target/nontarget dosimetry will drive research and technical innovation to provide greater ...
Table 2 details some of the acquisition and image reconstruction parameters used for clinical 90 Y internal pair production PET imaging studies. In 2013, Kao et al. ...
doi:10.1155/2015/481279
pmid:26106608
pmcid:PMC4464848
fatcat:uha56qq66ffg3larg6qauxblkm
Radionuclide therapy: current status and prospects for internal dosimetry in individualized therapeutic planning
2019
Clinics
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Its limitations include technical aspects related to image acquisition and processing and the lack of randomized clinical trials demonstrating the impact of dosimetry on patient therapy. ...
A more widespread use of dosimetry in therapeutic planning involves the development of user-friendly dosimetric protocols and confirmation that dose estimation implies good efficacy and low treatment-related ...
Yttrium-90 microsphere therapy for hepatic lesions. ...
doi:10.6061/clinics/2019/e835
pmid:31365617
pmcid:PMC6644503
fatcat:ifcatsihzzcy7m3fcrifos2tdq
Emission of β+ Particles Via Internal Pair Production in the 0+ – 0+ Transition of 90Zr: Historical Background and Current Applications in Nuclear Medicine Imaging
2013
Atoms
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An overview of most recent studies that exploit β + particles emitted from 90 Y for PET acquisitions is also provided. ...
To date, this topic is gaining increasing interest in the radiation dosimetry community, as the possibility of detecting β + emissions from 90 Y by PET scanners may pave the way for an accurate patient-specific ...
Recent studies performed by D'Arienzo et al. [17] and Willowson et al. [18] confirmed the feasibility of dosimetry and quantitative image reconstruction following 90 Y PET, respectively. ...
doi:10.3390/atoms1010002
fatcat:sexlowcfoba7nkorbzwferat5m
EANM dosimetry committee series on standard operational procedures: a unified methodology for 99mTc-MAA pre- and 90Y peri-therapy dosimetry in liver radioembolization with 90Y microspheres
2021
EJNMMI Physics
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AbstractThe aim of this standard operational procedure is to standardize the methodology employed for the evaluation of pre- and post-treatment absorbed dose calculations in 90Y microsphere liver radioembolization ...
Basic assumptions include the permanent trapping of microspheres, the local energy deposition method for voxel dosimetry, and the patient–relative calibration method for activity quantification.The identity ...
Marco Maccauro gave an extraordinary help with discussions, but, above all, he introduced twocompartment treatment planning in clinics. ...
doi:10.1186/s40658-021-00394-3
pmid:34767102
pmcid:PMC8589932
fatcat:cus3naantrc3lae6xzn5nofrgm
Evaluation of qualitative and quantitative data of Y-90 imaging in SPECT/CT and PET/CT phantom studies
2021
PLoS ONE
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This indicates that PET/CT might become the method of choice in Y-90 post radioembolization imaging for visualisation of both necrotic and hot lesions in the liver. ...
For PET studies all hot spheres were visible, regardless of the background activity. Conclusions PET Y-90 imaging provided better results than Bremsstrahlung based SPECT imaging. ...
Utilising the post-treatment PET/CT imaging for quantitative dosimetry analysis may give better treatment results enabling recognition of liver tumours with sufficient Y-90 microspheres deposition and ...
doi:10.1371/journal.pone.0246848
pmid:33566845
fatcat:4n6ps2bezjfopbeomfk2lj3k6a
Assessment of acquisition protocols for routine imaging of Y-90 using PET/CT
2013
EJNMMI Research
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The aim of this work was to determine the minimum detectable activity (MDA) of 90 Y by PET imaging and the impact of time-of-flight (TOF) reconstruction on detectability and quantitative accuracy according ...
Despite the early theoretical prediction of the 0 + -0 + transition of 90 Zr, 90 Y-PET underwent only recently a growing interest for the development of imaging radioembolization of liver tumors. ...
The first clinical applications of PET imaging with 90 Y have been tested recently in the context of radioembolization [15, 16] , PRRT [17] , and RAIT for lymphoma [18] . ...
doi:10.1186/2191-219x-3-11
pmid:23414629
pmcid:PMC3614476
fatcat:7lxu4kk5bvdt5brhqpqa3cnv3u
New Radionuclides and Technological Advances in SPECT and PET Scanners
2021
Cancers
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Positron Emission Tomography—PET-devices with silicon photomultipliers), design (total body PET) and configuration (ring-shaped, Single-Photon Emission Computed Tomography (SPECT), Compton camera). ...
On the other end of spectrum, further developments of PET technology have seen a resurgence in its use in nuclear cardiology, with rubidium-82 from strontium-82/rubidium-82 generators being the radionuclide ...
Evaluation
of qualitative and quantitative data of Y-90 imaging in SPECT/CT and PET/CT phantom studies. PLoS ONE 2021, 16, e0246848.
[CrossRef]
37. ...
doi:10.3390/cancers13246183
pmid:34944803
pmcid:PMC8699425
fatcat:gkpa72jlcjcojlnh5cfhwapyhq
Theranostics in Interventional Oncology: Versatile Carriers for Diagnosis and Targeted Image-Guided Minimally Invasive Procedures
2019
Frontiers in Pharmacology
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In parallel, medical imaging and image-guided therapies are rapidly developing fields with new interventions and procedures entering constantly in clinical practice. ...
The aim is to develop more personalized procedures able to identify cancer cells, selectively reach and treat them, and to assess drug delivery and uptake in real-time in order to perform adjustments in ...
ND and RD assembled and designed the figures. ...
doi:10.3389/fphar.2019.00450
pmid:31143114
pmcid:PMC6521126
fatcat:dphoynxmx5gohctg6f4xsal4ye
32nd International Austrian Winter Symposium
2016
EJNMMI Research
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This study was designed for comparison of detection rate between PSMA and 18F-fluoromethylcholine (FCH) PET/CT scan in pre or postop prostate cancer patients. ...
Methods: In this prospective study 15 consecutive prostate cancer patients (mean age 67.9, range 57-83) underwent both PSMA and FCH PET/CT with a maximum interval of 4 weeks without any treatment in between ...
for post-therapy quantitative dosimetry. ...
doi:10.1186/s13550-016-0168-9
pmid:27090254
pmcid:PMC4835428
fatcat:zzlj3cwqh5ebvheulibvsveko4
Oral Communications
2013
Clinical and translational imaging
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[ 18 F]FDG PET/CT is an important nuclear medicine imaging tool for the diagnosis, staging, restaging, therapy monitoring and radiotherapy planning of malignant lesions, in particular those located in ...
Thus, the aims of this study were to assess the clinical impact of MET-PET on RT planning of primary brain tumors, and to evaluate how treatment modification might influence the outcome of patients. ...
RADIONUCLIDE THERAPY AND DOSIMETRY 2 Radioembolization with Yttrium-90 glass microspheres in patients with HCC: a prospective phase II study M. Maccauro 1 , C. Chiesa 1 , R. Romito 3 , C. ...
doi:10.1007/s40336-013-0001-7
fatcat:a5ef5xekf5fi5ngovjb373sc7a
Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems
2015
Annual Review of Biomedical Engineering
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PET imaging has also become an important tool in preclinical studies, particularly for investigating murine models of disease and other small-animal models. ...
The physics of the emission, and the detection of the coincident photons, give PET imaging unique capabilities for both very high sensitivity and accurate estimation of the in vivo concentration of the ...
ACKNOWLEDGMENTS We thank our collaborators and our colleagues at the Universidad Carlos III de Madrid and the University of Washington for many helpful discussions. ...
doi:10.1146/annurev-bioeng-071114-040723
pmid:26643024
pmcid:PMC5299095
fatcat:5mwg2in42bcr7eic3qiii7utci
Advanced Monte Carlo simulations of emission tomography imaging systems with GATE
2021
Physics in Medicine and Biology
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In this paper, we reviewed the recent developments that have been proposed to simulate modern detectors and provide a comprehensive report on imaging systems that have been simulated and evaluated in GATE ...
Additionally, some methodological developments that are not specific for imaging but that can improve detector modelling and provide computation time gains, such as Variance Reduction Techniques and Artificial ...
Acknowledgments The Opengate collaboration would like to warmly thanks the Geant4 collaboration for their great support and fruitful discussions. ...
doi:10.1088/1361-6560/abf276
pmid:33770774
fatcat:7hboqolvz5cexnelzhib7euru4
Posters
2013
Clinical and translational imaging
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Two-tailed Student's t-test was applied to analyze differences in PET semi-quantitative parameters between the groups. ...
PET studies were qualitatively classified as positive or negative, and additional semi-quantitative parameters, such as SUVmax, tumor-to-contralateral background ratio and tumor-tocontralateral basal ganglia ...
A one-year experience in the use of PVC for the measurement of SUV on 18 F-FDG PET studies is here presented, showing the impact of PVC on the diagnostic, prognostic and treatment monitoring value of SUV ...
doi:10.1007/s40336-013-0002-6
fatcat:jfrptu6wuvhjvfss4iobwqfk2q
Minimisation of Acquisition Time in a TOF PET/CT Scanner Without Compromising Image Quality
[chapter]
2017
Lecture Notes in Computational Vision and Biomechanics
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Liver radioembolization (RE) is a clinical practice to treat primary and metastatic tumors via injecting Yttrium-90 ( 90 Y) microspheres (MS) into the hepatic artery. ...
MAA SPECT with post-treatment MS PET maps for patientpersonalized voxel-dosimetry. ...
doi:10.1007/978-3-319-68195-5_4
fatcat:wuvwnijoobfv5lvo5dc4tqdfue
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