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Feasibility assessment of yttrium-90 liver radioembolization imaging using amplitude-based gated PET/CT

Dustin R. Osborne, Shelley N. Acuff, Melissa L. Neveu, Mumtaz Syed, Austin D. Kaman, Yitong Fu
2018 Nuclear medicine communications  
Purpose The usage of PET/computed tomography (CT) to monitor hepatocellular carcinoma patients following yttrium-90 ( 90 Y) radioembolization has increased.  ...  This work examines the use of amplitude-based gating on 90 Y-PET/CT and its potential impact on diagnostic integrity.  ...  Some results of this work have been presented at the Society of Nuclear Medicine and Molecular Imaging over the last 2 years. Conflicts of interest There are no conflicts of interest.  ... 
doi:10.1097/mnm.0000000000000794 pmid:29351124 pmcid:PMC5882249 fatcat:ia46z2zlmfbdjmjxelre7tbxwe

Theranostic Imaging of Yttrium-90

Chadwick L. Wright, Jun Zhang, Michael F. Tweedle, Michael V. Knopp, Nathan C. Hall
2015 BioMed Research International  
This paper overviews Yttrium-90 (90Y) as a theranostic and nuclear medicine imaging of90Y radioactivity with bremsstrahlung imaging and positron emission tomography.  ...  Although challenges remain for90Y imaging, continued clinical demand for predictive imaging response assessment and target/nontarget dosimetry will drive research and technical innovation to provide greater  ...  Table 2 details some of the acquisition and image reconstruction parameters used for clinical 90 Y internal pair production PET imaging studies. In 2013, Kao et al.  ... 
doi:10.1155/2015/481279 pmid:26106608 pmcid:PMC4464848 fatcat:uha56qq66ffg3larg6qauxblkm

Radionuclide therapy: current status and prospects for internal dosimetry in individualized therapeutic planning

Marcelo Tatit Sapienza, José Willegaignon
2019 Clinics  
Its limitations include technical aspects related to image acquisition and processing and the lack of randomized clinical trials demonstrating the impact of dosimetry on patient therapy.  ...  A more widespread use of dosimetry in therapeutic planning involves the development of user-friendly dosimetric protocols and confirmation that dose estimation implies good efficacy and low treatment-related  ...  Yttrium-90 microsphere therapy for hepatic lesions.  ... 
doi:10.6061/clinics/2019/e835 pmid:31365617 pmcid:PMC6644503 fatcat:ifcatsihzzcy7m3fcrifos2tdq

Emission of β+ Particles Via Internal Pair Production in the 0+ – 0+ Transition of 90Zr: Historical Background and Current Applications in Nuclear Medicine Imaging

Marco D'Arienzo
2013 Atoms  
An overview of most recent studies that exploit β + particles emitted from 90 Y for PET acquisitions is also provided.  ...  To date, this topic is gaining increasing interest in the radiation dosimetry community, as the possibility of detecting β + emissions from 90 Y by PET scanners may pave the way for an accurate patient-specific  ...  Recent studies performed by D'Arienzo et al. [17] and Willowson et al. [18] confirmed the feasibility of dosimetry and quantitative image reconstruction following 90 Y PET, respectively.  ... 
doi:10.3390/atoms1010002 fatcat:sexlowcfoba7nkorbzwferat5m

EANM dosimetry committee series on standard operational procedures: a unified methodology for 99mTc-MAA pre- and 90Y peri-therapy dosimetry in liver radioembolization with 90Y microspheres

Carlo Chiesa, Katarina Sjogreen-Gleisner, Stephan Walrand, Lidia Strigari, Glenn Flux, Jonathan Gear, Caroline Stokke, Pablo Minguez Gabina, Peter Bernhardt, Mark Konijnenberg
2021 EJNMMI Physics  
AbstractThe aim of this standard operational procedure is to standardize the methodology employed for the evaluation of pre- and post-treatment absorbed dose calculations in 90Y microsphere liver radioembolization  ...  Basic assumptions include the permanent trapping of microspheres, the local energy deposition method for voxel dosimetry, and the patient–relative calibration method for activity quantification.The identity  ...  Marco Maccauro gave an extraordinary help with discussions, but, above all, he introduced twocompartment treatment planning in clinics.  ... 
doi:10.1186/s40658-021-00394-3 pmid:34767102 pmcid:PMC8589932 fatcat:cus3naantrc3lae6xzn5nofrgm

Evaluation of qualitative and quantitative data of Y-90 imaging in SPECT/CT and PET/CT phantom studies

Agata Kubik, Anna Budzyńska, Krzysztof Kacperski, Maciej Maciak, Michał Kuć, Piotr Piasecki, Maciej Wiliński, Marcin Konior, Mirosław Dziuk, Edward Iller, Pradeep K. Garg
2021 PLoS ONE  
This indicates that PET/CT might become the method of choice in Y-90 post radioembolization imaging for visualisation of both necrotic and hot lesions in the liver.  ...  For PET studies all hot spheres were visible, regardless of the background activity. Conclusions PET Y-90 imaging provided better results than Bremsstrahlung based SPECT imaging.  ...  Utilising the post-treatment PET/CT imaging for quantitative dosimetry analysis may give better treatment results enabling recognition of liver tumours with sufficient Y-90 microspheres deposition and  ... 
doi:10.1371/journal.pone.0246848 pmid:33566845 fatcat:4n6ps2bezjfopbeomfk2lj3k6a

Assessment of acquisition protocols for routine imaging of Y-90 using PET/CT

Thomas Carlier, Thomas Eugène, Caroline Bodet-Milin, Etienne Garin, Catherine Ansquer, Caroline Rousseau, Ludovic Ferrer, Jacques Barbet, Frédéric Schoenahl, Françoise Kraeber-Bodéré
2013 EJNMMI Research  
The aim of this work was to determine the minimum detectable activity (MDA) of 90 Y by PET imaging and the impact of time-of-flight (TOF) reconstruction on detectability and quantitative accuracy according  ...  Despite the early theoretical prediction of the 0 + -0 + transition of 90 Zr, 90 Y-PET underwent only recently a growing interest for the development of imaging radioembolization of liver tumors.  ...  The first clinical applications of PET imaging with 90 Y have been tested recently in the context of radioembolization [15, 16] , PRRT [17] , and RAIT for lymphoma [18] .  ... 
doi:10.1186/2191-219x-3-11 pmid:23414629 pmcid:PMC3614476 fatcat:7lxu4kk5bvdt5brhqpqa3cnv3u

New Radionuclides and Technological Advances in SPECT and PET Scanners

Nicholas P. van der Meulen, Klaus Strobel, Thiago Viana Miranda Lima
2021 Cancers  
Positron Emission Tomography—PET-devices with silicon photomultipliers), design (total body PET) and configuration (ring-shaped, Single-Photon Emission Computed Tomography (SPECT), Compton camera).  ...  On the other end of spectrum, further developments of PET technology have seen a resurgence in its use in nuclear cardiology, with rubidium-82 from strontium-82/rubidium-82 generators being the radionuclide  ...  Evaluation of qualitative and quantitative data of Y-90 imaging in SPECT/CT and PET/CT phantom studies. PLoS ONE 2021, 16, e0246848. [CrossRef] 37.  ... 
doi:10.3390/cancers13246183 pmid:34944803 pmcid:PMC8699425 fatcat:gkpa72jlcjcojlnh5cfhwapyhq

Theranostics in Interventional Oncology: Versatile Carriers for Diagnosis and Targeted Image-Guided Minimally Invasive Procedures

Nils Degrauwe, Arnaud Hocquelet, Antonia Digklia, Niklaus Schaefer, Alban Denys, Rafael Duran
2019 Frontiers in Pharmacology  
In parallel, medical imaging and image-guided therapies are rapidly developing fields with new interventions and procedures entering constantly in clinical practice.  ...  The aim is to develop more personalized procedures able to identify cancer cells, selectively reach and treat them, and to assess drug delivery and uptake in real-time in order to perform adjustments in  ...  ND and RD assembled and designed the figures.  ... 
doi:10.3389/fphar.2019.00450 pmid:31143114 pmcid:PMC6521126 fatcat:dphoynxmx5gohctg6f4xsal4ye

32nd International Austrian Winter Symposium

W Langsteger, A Rezaee, W Loidl, HS Geinitz, F Fitz, M Steinmair, G Broinger, L Pallwien-Prettner, M Beheshti, L Imamovic, M Beheshti, G Rendl (+256 others)
2016 EJNMMI Research  
This study was designed for comparison of detection rate between PSMA and 18F-fluoromethylcholine (FCH) PET/CT scan in pre or postop prostate cancer patients.  ...  Methods: In this prospective study 15 consecutive prostate cancer patients (mean age 67.9, range 57-83) underwent both PSMA and FCH PET/CT with a maximum interval of 4 weeks without any treatment in between  ...  for post-therapy quantitative dosimetry.  ... 
doi:10.1186/s13550-016-0168-9 pmid:27090254 pmcid:PMC4835428 fatcat:zzlj3cwqh5ebvheulibvsveko4

Oral Communications

2013 Clinical and translational imaging  
[ 18 F]FDG PET/CT is an important nuclear medicine imaging tool for the diagnosis, staging, restaging, therapy monitoring and radiotherapy planning of malignant lesions, in particular those located in  ...  Thus, the aims of this study were to assess the clinical impact of MET-PET on RT planning of primary brain tumors, and to evaluate how treatment modification might influence the outcome of patients.  ...  RADIONUCLIDE THERAPY AND DOSIMETRY 2 Radioembolization with Yttrium-90 glass microspheres in patients with HCC: a prospective phase II study M. Maccauro 1 , C. Chiesa 1 , R. Romito 3 , C.  ... 
doi:10.1007/s40336-013-0001-7 fatcat:a5ef5xekf5fi5ngovjb373sc7a

Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems

Juan José Vaquero, Paul Kinahan
2015 Annual Review of Biomedical Engineering  
PET imaging has also become an important tool in preclinical studies, particularly for investigating murine models of disease and other small-animal models.  ...  The physics of the emission, and the detection of the coincident photons, give PET imaging unique capabilities for both very high sensitivity and accurate estimation of the in vivo concentration of the  ...  ACKNOWLEDGMENTS We thank our collaborators and our colleagues at the Universidad Carlos III de Madrid and the University of Washington for many helpful discussions.  ... 
doi:10.1146/annurev-bioeng-071114-040723 pmid:26643024 pmcid:PMC5299095 fatcat:5mwg2in42bcr7eic3qiii7utci

Advanced Monte Carlo simulations of emission tomography imaging systems with GATE

David Sarrut, Mateusz Bala, Manuel Bardies, Julien Bert, Maxime Chauvin, Konstantinos Chatzipapas, Mathieu Dupont, Ane Etxebeste, Louise M Fanchon, Sebastien Jan, Gunjan Kayal, Assen S Kirov (+22 others)
2021 Physics in Medicine and Biology  
In this paper, we reviewed the recent developments that have been proposed to simulate modern detectors and provide a comprehensive report on imaging systems that have been simulated and evaluated in GATE  ...  Additionally, some methodological developments that are not specific for imaging but that can improve detector modelling and provide computation time gains, such as Variance Reduction Techniques and Artificial  ...  Acknowledgments The Opengate collaboration would like to warmly thanks the Geant4 collaboration for their great support and fruitful discussions.  ... 
doi:10.1088/1361-6560/abf276 pmid:33770774 fatcat:7hboqolvz5cexnelzhib7euru4

Posters

2013 Clinical and translational imaging  
Two-tailed Student's t-test was applied to analyze differences in PET semi-quantitative parameters between the groups.  ...  PET studies were qualitatively classified as positive or negative, and additional semi-quantitative parameters, such as SUVmax, tumor-to-contralateral background ratio and tumor-tocontralateral basal ganglia  ...  A one-year experience in the use of PVC for the measurement of SUV on 18 F-FDG PET studies is here presented, showing the impact of PVC on the diagnostic, prognostic and treatment monitoring value of SUV  ... 
doi:10.1007/s40336-013-0002-6 fatcat:jfrptu6wuvhjvfss4iobwqfk2q

Minimisation of Acquisition Time in a TOF PET/CT Scanner Without Compromising Image Quality [chapter]

J. Oliveira, R. Parafita, S. Branco
2017 Lecture Notes in Computational Vision and Biomechanics  
Liver radioembolization (RE) is a clinical practice to treat primary and metastatic tumors via injecting Yttrium-90 ( 90 Y) microspheres (MS) into the hepatic artery.  ...  MAA SPECT with post-treatment MS PET maps for patientpersonalized voxel-dosimetry.  ... 
doi:10.1007/978-3-319-68195-5_4 fatcat:wuvwnijoobfv5lvo5dc4tqdfue
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