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The Biology of Forgetting—A Perspective

Ronald L. Davis, Yi Zhong
2017 Neuron  
/synapse structure.  ...  The currently known mechanisms for active forgetting include neurogenesis-based forgetting, interference-based forgetting, and intrinsic forgetting, the latter term describing the brain's chronic signaling  ...  Thus, forgetting neurons are not unique to Drosophila.  ... 
doi:10.1016/j.neuron.2017.05.039 pmid:28772119 pmcid:PMC5657245 fatcat:mv4gzs6ad5apfadjnqjtdclxka

BlastNeuron for Automated Comparison, Retrieval and Clustering of 3D Neuron Morphologies

Yinan Wan, Fuhui Long, Lei Qu, Hang Xiao, Michael Hawrylycz, Eugene W. Myers, Hanchuan Peng
2015 Neuroinformatics  
Our approach was able to accurately and efficiently retrieve morphologically and functionally similar neuron structures from large morphology database, identify the local common structures, and find clusters  ...  Characterizing the identity and types of neurons in the brain, as well as their associated function, requires a means of quantifying and comparing 3D neuron morphology.  ...  We thank Zhi Zhou for providing some neuron reconstructions for testing in Fig. 8 .  ... 
doi:10.1007/s12021-015-9272-7 pmid:26036213 fatcat:zbuu2yr5ijepllz63wfnizsham

Electrical synapses between mushroom body neurons are critical for consolidated memory retrieval in Drosophila

Wei-Huan Shyu, Wang-Pao Lee, Meng-Hsuan Chiang, Ching-Ching Chang, Tsai-Feng Fu, Hsueh-Cheng Chiang, Tony Wu, Chia-Lin Wu, Liliane Schoofs
2019 PLoS Genetics  
Altogether, our results suggest INX5 gap junction channels in αβ neurons for ARM retrieval and also provide a more detailed neuronal mechanism for consolidated memory in Drosophila.  ...  Whole-mount brain immunohistochemistry indicated that INX5 protein was preferentially expressed in the somas, calyxes, and lobes regions of the MB neurons.  ...  We also thank Ann-Shyn Chiang, Bloomington Drosophila Stock Center, Vienna Drosophila RNAi Center, Vienna Tile (VT) Library and Fly Core in Taiwan for providing fly stocks.  ... 
doi:10.1371/journal.pgen.1008153 pmid:31071084 pmcid:PMC6529013 fatcat:2qsj6fi3q5ezrkmkv73n6etlnq

Neurobiology of behaviour

John H Byrne, Wendy A Suzuki
2006 Current Opinion in Neurobiology  
Liu and Davis review studies that apply this technique to reveal that synaptic transmission from the mushroom body neurons is required only during retrieval for normal behavioral memory performance, whereas  ...  The breakthrough in recording came with the development and application of functional optical imaging that employs protein-based optical reporters expressed in specific neurons with the GAL4-UAS expression  ... 
doi:10.1016/j.conb.2006.10.011 pmid:17098418 fatcat:u6s3dmupdvc5tpep5nppeorm3q

Chapter 18 Olfactory memory traces in Drosophila [chapter]

Jacob Berry, William C. Krause, Ronald L. Davis
2008 Progress in Brain Research  
These molecular, physiological or structural changes in neurons, induced by pairing odor and shock, regulate behavior by altering the neurons' response to the learned environment.  ...  In Drosophila the fruit fly, coincident exposure to an odor and an aversive electric shock can produce robust behavioral memory.  ...  Olfactory processing circuit in Drosophila. A diagram of the important structures in olfactory learning and memory in the fruit fly (one hemisphere of the brain).  ... 
doi:10.1016/s0079-6123(07)00018-0 pmid:18394482 pmcid:PMC2692900 fatcat:bcehhfsu2naabe5kkpahv2hk6q

Circuits that encode and predict alcohol associated preference [article]

Kristin M. Scaplen, Mustafa Talay, Sarah Salamon, Kavin M. Nuñez, Amanda G. Waterman, Sydney Gang, Sophia L. Song, Gilad Barnea, Karla R. Kaun
2019 bioRxiv   pre-print
Using neurogenetic tools available in Drosophila melanogaster we define how circuits required for alcohol associated preference shift from population level dopaminergic activation to select dopamine neurons  ...  Transsynaptic tracing of these output neurons revealed at least two regions of convergence: 1) a center of memory consolidation within the MB implicated in arousal, and 2) a structure outside the MB implicated  ...  We also thank the Drosophila community, particularly Yoshinori Aso and Gerry Rubin, the Bloomington Stock Center, and the Vienna Drosophila RNAi Center for sharing fly stocks.  ... 
doi:10.1101/578401 fatcat:vosqpc5axrgwvj4na5tdxjaurq

Do the right thing: neural network mechanisms of memory formation, expression and update in Drosophila

Paola Cognigni, Johannes Felsenberg, Scott Waddell
2018 Current Opinion in Neurobiology  
Individual network components in the mushroom bodies of the fruit fly Drosophila melanogaster represent cues, learning signals and behavioral outcomes of learned experience.  ...  When animals learn, plasticity in brain networks that respond to specific cues results in a change in the behavior that these cues elicit.  ...  gene product is expressed in two neurons in the Drosophila brain that are critical for memory.  ... 
doi:10.1016/j.conb.2017.12.002 pmid:29258011 pmcid:PMC5981003 fatcat:7jxmouei75eatacq44qz2uhs3q

Deconstructing Memory in Drosophila

Carla Margulies, Tim Tully, Josh Dubnau
2005 Current Biology  
MTM was postulated to exist, based on the assumption that STM, MTM and ARM act additively to produce the observed memory retention curve.  ...  In this essay, we have not attempted to review the entire Drosophila memory field.  ...  One of the most obvious structures in the insect brain is the mushroom body (MB).  ... 
doi:10.1016/j.cub.2005.08.024 pmid:16139203 pmcid:PMC3044934 fatcat:povtxko2vfclxp6byk4u6jtjwu

The Fruit Fly Brain Observatory: From Structure to Function [article]

Nikul H. Ukani, Chung-Heng Yeh, Adam Tomkins, Yiyin Zhou, Dorian Florescu, Carlos Luna Ortiz, Yu-Chi Huang, Cheng-Te Wang, Mehmet K. Turkcan, Tingkai Liu, Paul Richmond, Chung-Chuan Lo (+3 others)
2019 bioRxiv   pre-print
that end we developed the Fruit Fly Brain Observatory (FFBO), the next generation open-source platform to support open, collaborative Drosophila neuroscience research.  ...  Tools are provided to extract the function inherent in these structural maps. All applications can be accessed with any modern browser.  ...  For example, staining-based cell type classification has led to the FlyBrain, the very first online atlas of the Drosophila brain [4] .  ... 
doi:10.1101/580290 fatcat:udubxzazlfct3beks2onuaduje

A Programmable Ontology Encompassing the Functional Logic of the Drosophila Brain [article]

Aurel A Lazar, Mehmet Kerem Turkcan, Yiyin Zhou
2021 bioRxiv   pre-print
The Drosophila brain has only a fraction of the number of neurons of higher organisms such as mice.  ...  Furthermore, we describe a methodology for modeling the functional logic of the antennal lobe circuit consisting of massive local feedback loops, a characteristic feature observed across Drosophila brain  ...  A Programmable Ontology Encompassing the Functional Logic of the Fruit Fly Brain Circuits Traditionally, ontologies formally define the classification of the anatomical structure of the Drosophila nervous  ... 
doi:10.1101/2021.12.28.474399 fatcat:lqwf5nvj7zdmroln7ofsngg63i

A Systematic Nomenclature for the Insect Brain

Kei Ito, Kazunori Shinomiya, Masayoshi Ito, J. Douglas Armstrong, George Boyan, Volker Hartenstein, Steffen Harzsch, Martin Heisenberg, Uwe Homberg, Arnim Jenett, Haig Keshishian, Linda L. Restifo (+5 others)
2014 Neuron  
Ambiguous definitions of brain regions and fiber bundles have contributed to the variation of names used to describe the same structure.  ...  This nomenclature is intended to serve as a standard of reference for the study of the brain of Drosophila and other insects.  ...  Figure 2 . 2 Summary of the Nomenclature System of the Insect Brain Structures (A) Overview of the Drosophila brain. 3D reconstruction of the brain (top panel) and a 3D model with the defined synaptic  ... 
doi:10.1016/j.neuron.2013.12.017 pmid:24559671 fatcat:w5bs4apb2ngw7lw2ovubw2buei

Thirty years of olfactory learning and memory research in Drosophila melanogaster

Sean E. McGuire, Mitch Deshazer, Ronald L. Davis
2005 Progress in Neurobiology  
brain regions as well as in the physiology underlying the acquisition, storage, and retrieval of memory.  ...  With these advances in our understanding of the genes, neurons, and circuits involved in learning and memory, the field of Drosophila memory research is nearing a state of integration of the bottom up  ...  are detected and subsequently channeled via specific neurons to higher centers of the brain, based upon the subset of neurons activated in response to a particular odor (Vosshall et al., 1999; Clyne  ... 
doi:10.1016/j.pneurobio.2005.09.003 pmid:16266778 fatcat:klajgh6rqrca5gpjzgvrjhrrre

Reward from bugs to bipeds: a comparative approach to understanding how reward circuits function

Kristin M. Scaplen, Karla R. Kaun
2016 Journal of neurogenetics  
In part, this is a result of the sheer diversity of neurons, the heterogeneity of their responses and the complexity of neural circuits within which they are found.  ...  We argue that general features of reward circuitry are common across model organisms, and thus principles learned from invertebrate model organisms can inform research across species.  ...  For instance, Drosophila central brain neurons are unipolar; as such the cell body is physically separated from its processes.  ... 
doi:10.1080/01677063.2016.1180385 pmid:27328845 pmcid:PMC4926782 fatcat:7hmttjpjcnhthnjw24lkrrlbmu

A Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster

Zhihao Zheng, J. Scott Lauritzen, Eric Perlman, Camenzind G. Robinson, Matthew Nichols, Daniel Milkie, Omar Torrens, John Price, Corey B. Fisher, Nadiya Sharifi, Steven A. Calle-Schuler, Lucia Kmecova (+11 others)
2018 Cell  
A Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster Graphical Abstract Highlights d A complete adult Drosophila brain was imaged with EM and has been made publicly available  ...  Its 100,000-neuron brain is a large but tractable target for comprehensive neural circuit mapping.  ...  Projection of tracing across alignments With each new alignment, the CATMAID PostgreSQL database containing all neuronal skeleton coordinates (Schneider-Mizell et al., 2016) is dumped to retrieve their  ... 
doi:10.1016/j.cell.2018.06.019 pmid:30033368 pmcid:PMC6063995 fatcat:me3wn3utfrbuhi6byynila624a

SNT: A Unifying Toolbox for Quantification of Neuronal Anatomy [article]

Cameron Arshadi, Mark Eddison, Ulrik A Gunther, Kyle I Harrington, Tiago A Ferreira
2020 bioRxiv   pre-print
Quantification of neuronal morphology is essential for understanding neuronal connectivity and many software tools have been developed for neuronal reconstruction and morphometry.  ...  With an open and scriptable architecture, a large user base, and thorough community-based documentation, SNT is an accessible and scalable resource for the broad neuroscience community that synergizes  ...  Special thanks to all the labs, teams, institutions and initiatives that facilitate public sharing of neuronal data, including 3D InsectBrain, BigNeuron (Allen Institute for Brain Science), Blue Brain,  ... 
doi:10.1101/2020.07.13.179325 fatcat:hblbhhxfcbecphetan5rbktinq
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