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Autistic-spectrum disorders: lessons from neuroimaging

Fiona Toal, Declan G. M. Murphy, Kieran C. Murphy
2005 British Journal of Psychiatry  
Autistic-spectrum disorder is approximately half as common as schizophrenia but its cause remains unknown.  ...  In the past decade, great advances have been made in our understanding of the neurobiological basis of autism.  ...  with study of the brain in individuals with autistic-spectrum disorder.  ... 
doi:10.1192/bjp.187.5.395 pmid:16260811 fatcat:lpatfthoxnaurbqg23jxuszgzm

Women with autistic-spectrum disorder: magnetic resonance imaging study of brain anatomy

Michaelc. Craig, Shahid H. Zaman, Eileen M. Daly, William J. Cutter, Dene M. W. Robertson, Brian Hallahan, Fiona Toal, Suzie Reed, Anita Ambikapathy, Mick Brammer, Clodagh M. Murphy, Declan G. M. Murphy
2007 British Journal of Psychiatry  
Aims To study regional grey-matter and white-matter differences in the brains of women with autistic-spectrum disorder.  ...  Method We compared the brain anatomy of 14 adult women with autistic-spectrum disorder with 19 controls using volumetric magnetic resonance imaging and voxel-based morphometry Results Women with autistic-spectrum  ...  ACKNOWLEDGEMENTS ACKNOWLEDGEMENTS The authors thank the people with autistic-The authors thank the people with autisticspectrum disorder who took part in the study, the spectrum disorder who took part  ... 
doi:10.1192/bjp.bp.106.034603 pmid:17766762 fatcat:545sjfwyjjf3jlbwutp5aoc6ve

Brief Report: Biochemical Correlates of Clinical Impairment in High Functioning Autism and Asperger's Disorder

Natalia M. Kleinhans, Todd Richards, Kurt E. Weaver, Olivia Liang, Geraldine Dawson, Elizabeth Aylward
2009 Journal of Autism and Developmental Disorders  
The current study investigated biochemical abnormalities in the amygdala in 20 high functioning adults with autistic disorder or Asperger's disorder and 19 typically developing adults matched on age and  ...  Keywords amygdala; autism; Asperger's disorder; MRS Social deficits are a core feature of individuals with autism that persist throughout the lifespan.  ...  be critical to mediating the severity of social deficits in individuals with autism spectrum disorders (ASD).  ... 
doi:10.1007/s10803-009-0707-6 pmid:19234776 pmcid:PMC4114770 fatcat:i5oevweqhbbk7hx36bne5bvlei

Brain Anatomy and Its Relationship to Behavior in Adults With Autism Spectrum Disorder

Christine Ecker
2012 Archives of General Psychiatry  
We also observed spatially distributed reductions in white matter volume in participants with ASD.  ...  Context: There is consensus that autism spectrum disorder (ASD) is accompanied by differences in neuroanatomy.  ...  - Figure 3 . 3 Brain map (voxel-based morphometry) of significant white matter differences in autism spectrum disorder (ASD) (P = .005).  ... 
doi:10.1001/archgenpsychiatry.2011.1251 pmid:22310506 fatcat:ly3nhs2x2bby3ehxfzex2gd6o4

Cognitive-Behavioral Therapy for Obsessive–Compulsive Disorder with and without Autism Spectrum Disorder: Gray Matter Differences Associated with Poor Outcome

Aki Tsuchiyagaito, Yoshiyuki Hirano, Kenichi Asano, Fumiyo Oshima, Sawako Nagaoka, Yoshitake Takebayashi, Koji Matsumoto, Yoshitada Masuda, Masaomi Iyo, Eiji Shimizu, Akiko Nakagawa
2017 Frontiers in Psychiatry  
Second, to investigate how the structural abnormality profile of the brain at pretreatment influenced CBT outcomes, we performed a structural MRI comparison focusing on the gray matter volume of the whole  ...  Cognitive behavioral therapy (CBT) is an effective treatment for obsessive-compulsive disorder (OCD) and is also applicable to patients with both OCD and autism spectrum disorder (ASD).  ...  A high prevalence of autistic traits has been found in OCD samples both in adults (2, 3) and in children (4) .  ... 
doi:10.3389/fpsyt.2017.00143 pmid:28861007 pmcid:PMC5559438 fatcat:jx5pf4qbknfpbktpn7ven7ikci

Meynert's Nucleus Complex White Matter Abnormalities in Autism Spectrum Disorders: An MRI Study

Leonardo Gialloreti, Matteo Pardini, Francesco Garaci, Laszlo Zaborszky, Filadelfo Coniglione, Gianluca Serafini, Martina Martina, Francesca Benassi
2017 Journal of Intellectual Disability - Diagnosis and Treatment  
Methods: Twenty-five low-functioning, non-verbal males with Autism Spectrum Disorders (ASD) and 25 controls were enrolled in the study.  ...  Cholinergic dysfunction has been proposed to play a role in autistic symtomatology. However, to date, its structural correlates are poorly understood.  ...  We showed a significant structural integrity reduction of those white matter bundles included in the Meynert's nucleus complex (MN) in subjects with low-functioning Autism Spectrum Disorders (ASD), compared  ... 
doi:10.6000/2292-2598.2016.04.04.1 fatcat:ithaep5ajnch7g75bbwmaskc7e

Autism Spectrum Disorder as Early Neurodevelopmental Disorder: Evidence from the Brain Imaging Abnormalities in 2–3 Years Old Toddlers

Zhou Xiao, Ting Qiu, Xiaoyan Ke, Xiang Xiao, Ting Xiao, Fengjing Liang, Bing Zou, Haiqing Huang, Hui Fang, Kangkang Chu, Jiuping Zhang, Yijun Liu
2014 Journal of Autism and Developmental Disorders  
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that occurs within the first 3 years of life, which is marked by social skills and communication deficits along with stereotyped  ...  Structural magnetic resonance imaging was applied to assess overall gray matter (GM) and white matter (WM) volumes, and regional alterations were assessed by voxel-based morphometry.  ...  Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s)  ... 
doi:10.1007/s10803-014-2033-x pmid:24419870 pmcid:PMC4057630 fatcat:qnj7x7aegzhnrfhe5bj6vcorwa

Comparative Multimodal Meta-analysis of Structural and Functional Brain Abnormalities in Autism Spectrum Disorder and Obsessive-Compulsive Disorder

Christina O. Carlisi, Luke J. Norman, Steve S. Lukito, Joaquim Radua, David Mataix-Cols, Katya Rubia
2017 Biological Psychiatry  
Waiter GD, Williams JH, Murray AD, Gilchrist A, Perrett DI, Whiten A (2004): A voxel-based investigation of brain structure in male adolescents with autistic spectrum disorder.  ...  Itahashi T, Yamada T, Nakamura M, Watanabe H, Yamagata B, Jimbo D, et al. (2015): Linked alterations in gray and white matter morphology in adults with high-functioning autism spectrum disorder: A multimodal  ...  -S4) for further details Abbreviations: ASD, autism spectrum disorders; fMRI, functional magnetic resonance imaging; OCD, obsessive compulsive disorder; SD, standard deviation; VBM, voxel-based morphometry  ... 
doi:10.1016/j.biopsych.2016.10.006 pmid:27887721 fatcat:y6xefxbyj5cqdjut2zxbliacy4

Candidate Biomarkers in Children with Autism Spectrum Disorder: A Review of MRI Studies

Dongyun Li, Hans-Otto Karnath, Xiu Xu
2017 Neuroscience Bulletin  
Magnetic resonance imaging (MRI) provides a non-invasive and powerful tool for investigating changes in the structure, function, maturation, connectivity, and metabolism of the brain of children with ASD  ...  Searching for effective biomarkers is one of the most challenging tasks in the research field of Autism Spectrum Disorder (ASD).  ...  Introduction Autism spectrum disorder (ASD) is a neurodevelopmental disorder that has a strong genetic basis, a heterogeneous etiology, and various clinical presentations.  ... 
doi:10.1007/s12264-017-0118-1 pmid:28283808 pmcid:PMC5360855 fatcat:zkgvhz7iirgd7hc3mqi3g6g2zu

Changes in grey matter development in autism spectrum disorder

Ellen Greimel, Barbara Nehrkorn, Martin Schulte-Rüther, Gereon R. Fink, Thomas Nickl-Jockschat, Beate Herpertz-Dahlmann, Kerstin Konrad, Simon B. Eickhoff
2012 Brain Structure and Function  
Results on grey matter (GM) structural alterations in autism spectrum disorder (ASD) are inconclusive.  ...  Moreover, while GM volume in the right precentral gyrus decreased linearly with age in ASD individuals, GM volume development in controls followed a U-shaped pattern.  ...  Acknowledgments We are grateful to all participants with their families who took part in this study.  ... 
doi:10.1007/s00429-012-0439-9 pmid:22777602 pmcid:PMC3695319 fatcat:ncdgunytezcmdcfazqk2khrzq4

Increased Putamen Volume in Adults with Autism Spectrum Disorder

Wataru Sato, Yasutaka Kubota, Takanori Kochiyama, Shota Uono, Sayaka Yoshimura, Reiko Sawada, Morimitsu Sakihama, Motomi Toichi
2014 Frontiers in Human Neuroscience  
The increased volume of the putamen found in high-functioning adults with ASD suggests that structural or histological abnormalities of the putamen may underlie the pathologies of ASD, such as repetitive  ...  Basal ganglia (BG) abnormalities are implicated in the pathophysiology of autism spectrum disorder (ASD).  ...  ACKNOWLEDGMENTS The authors thank Emi Yokoyama, Akemi Inoue, and Kazusa Minemoto for help with subject recruitment.  ... 
doi:10.3389/fnhum.2014.00957 pmid:25505401 pmcid:PMC4243557 fatcat:jkai7jm2zzgurdba6qupo5ufp4

Connectivity Theory of Autism: Use of Connectivity Measures in Assessing and Treating Autistic Disorders

Robert Coben, Thomas E. Myers
2008 Journal of Neurotherapy  
McAlonan et al. (2005) investigated brain structural changes linked to Autism using voxel-based MRI.  ...  Research utilizing two-dimensional voxel-based morphometry to identify white matter density as an index of neural connectivity indicated that Autism is associated with reduced white matter concentration  ... 
doi:10.1080/10874200802398824 fatcat:dby2ejd74zfkzcqr2ctbo7i5cq

White Matter Microstructure Predicts Autistic Traits in Attention-Deficit/Hyperactivity Disorder

Miriam Cooper, Anita Thapar, Derek K. Jones
2014 Journal of Autism and Developmental Disorders  
Traits of autism spectrum disorder (ASD) in children with attention-deficit/hyperactivity disorder (ADHD) have previously been found to index clinical severity.  ...  No case-control differences were found for the diffusion parameters investigated. This is the first report of a WM microstructural signature of autistic traits in ADHD.  ...  Introduction Attention-deficit/hyperactivity disorder (ADHD) is the most common childhood-onset neurodevelopmental disorder, with a male:female prevalence bias of 2-3:1 in general population samples (  ... 
doi:10.1007/s10803-014-2131-9 pmid:24827086 pmcid:PMC4194020 fatcat:ox4qxycinfhhvfombdxh6y5kp4

Structural connectivity of the amygdala in young adults with autism spectrum disorder

Clare R. Gibbard, Juejing Ren, David H. Skuse, Jonathan D. Clayden, Chris A. Clark
2017 Human Brain Mapping  
Autism spectrum disorder (ASD) is characterized by impairments in social cognition, a function associated with the amygdala.  ...  The brains of 51 high-functioning young adults (25 with ASD; 26 controls) were scanned using MRI.  ...  This warrants further investigation. Our study has some limitations. The study sample was high functioning, with high IQ scores.  ... 
doi:10.1002/hbm.23915 pmid:29265723 pmcid:PMC5838552 fatcat:wncv5kdzlbe3jeoqkjzhbib4ba

Structural MRI in Autism Spectrum Disorder

2011 Pediatric Research  
Magnetic resonance (MR) examination provides a powerful tool for investigating brain structural changes in children with autism spectrum disorder (ASD).  ...  We review recent advances in the understanding of structural MR correlates of ASD.  ...  A utism spectrum disorder (ASD) (1,2) is a heterogeneous disorder (or collection of related disorders) of multifactorial etiology, with great range in severity of symptoms.  ... 
doi:10.1203/pdr.0b013e318212c2b3 pmid:21289538 pmcid:PMC3081653 fatcat:cbpc5hsctndmjkyoee6bap4wwe
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