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Structural neuroimaging correlates of allelic variation of the BDNF val66met polymorphism

Natalie J. Forde, Lisa Ronan, John Suckling, Cathy Scanlon, Simon Neary, Laurena Holleran, Alexander Leemans, Roger Tait, Catarina Rua, Paul C. Fletcher, Ben Jeurissen, Chris M. Dodds (+5 others)
2014 NeuroImage  
The brain-derived neurotrophic factor (BDNF) val66met polymorphism is associated with altered activity dependent secretion of BDNF and a variable influence on brain morphology and cognition.  ...  Although a met-dose effect is generally assumed, to date the paucity of met-homozygotes have limited our understanding of the role of the met-allele on brain structure.  ...  We thank staff of the CBR and GSK Clinical Unit for assistance with volunteer recruitment.  ... 
doi:10.1016/j.neuroimage.2013.12.050 pmid:24384148 fatcat:c5du6qo5ejcxbeqwf4gybpqyuq

Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study

Natalia Vilor-Tejedor, for the ALFA Study, Grégory Operto, Tavia E. Evans, Carles Falcon, Marta Crous-Bou, Carolina Minguillón, Raffaele Cacciaglia, Marta Milà-Alomà, Oriol Grau-Rivera, Marc Suárez-Calvet, Diego Garrido-Martín (+6 others)
2020 Brain Structure and Function  
Current evidence supports the involvement of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and the ε4 allele of APOE gene in hippocampal-dependent functions.  ...  We also investigated whether the association between APOE-ε4 allele and HSv were modified by BDNF Val66Met genotypes. BDNF Val66Met carriers showed larger bilateral volumes of the subiculum subfield.  ...  The research leading to these results has received funding from "la Caixa" Foundation (LCF/PR/GN17/10300004) and the Health Department of the Catalan Government (Health Research and Innovation Strategic  ... 
doi:10.1007/s00429-020-02125-3 pmid:32804326 fatcat:sdrpqrbjqret5hn4nwqhgw3clm

Neuroprotective effect of Val variant of BDNF Val66Met polymorphism on hippocampus is modulated by the severity of menstrual pain

Wei-Chi Li, Hsiang-Tai Chao, Ming-Wei Lin, Horng-Der Shen, Li-Fen Chen, Jen-Chuen Hsieh
2021 NeuroImage: Clinical  
This study examined the associations among BDNF Val66Met polymorphisms, menstrual pain severity, and hippocampal volume among young PDM subjects.  ...  Linear regression was used to test for BDNF Val66Met Val allele dosage-dependent effects.  ...  We appreciate the assistance of Intan Low, Chou-Ming Cheng, Tzu-Ling Tzeng, Ching-Ju Yang, Chih-Che Chou, Dr. Lin-Chien Lee, Dr.  ... 
doi:10.1016/j.nicl.2021.102576 pmid:33561695 pmcid:PMC7873439 fatcat:p7asfkq4d5eqvomwoumbdiyci4

Interactions of BDNF Val66Met Polymorphism and Menstrual Pain on Brain Complexity

Intan Low, Po-Chih Kuo, Cheng-Lin Tsai, Yu-Hsiang Liu, Ming-Wei Lin, Hsiang-Tai Chao, Yong-Sheng Chen, Jen-Chuen Hsieh, Li-Fen Chen
2018 Frontiers in Neuroscience  
Our results suggest that pain experience preponderantly affects the effect of BDNF Val66Met polymorphism on brain complexity.  ...  Therefore, we aimed to examine the interactions of BDNF Val66Met polymorphism and long-term menstrual pain experience on brain complexity.  ...  BDNF Genotype Distributions and Allele Frequency The Hardy-Weinberg equilibrium of the BDNF Val66Met genotype distributions and allele frequency were tested using chi-square tests of goodness-of-fit (p  ... 
doi:10.3389/fnins.2018.00826 pmid:30524221 pmcid:PMC6256283 fatcat:bdusapr5rrekref5dm4crpuk6y

Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression

L Pezawas, A Meyer-Lindenberg, A L Goldman, B A Verchinski, G Chen, B S Kolachana, M F Egan, V S Mattay, A R Hariri, D R Weinberger
2008 Molecular Psychiatry  
Complex genetic disorders such as depression likely exhibit epistasis, but neural mechanisms of such gene-gene interactions are incompletely understood. 5-HTTLPR and BDNF VAL66MET, functional polymorphisms  ...  Our analyses revealed no effect of the 5-HTTLPR S allele on rAC volume in the presence of BDNF MET alleles, whereas a significant volume reduction (P < 0.001) was seen on BDNF VAL/VAL background.  ...  Acknowledgments This study was supported by the National Institute of Mental Health Intramural Research Program. We thank JH Callicott for support of data acquisition. Conflict of Interest  ... 
doi:10.1038/mp.2008.32 pmid:18347599 fatcat:4kozke27srczlpxpvb6smwdcfi

Imaging Genetics of Depression [chapter]

Matthew D. Sacchet, Lara C. Foland-Ross, Ian H. Gotlib
2016 Neuroimaging Genetics  
For example, the Val66Met polymorphism that is targeted by neuroimaging genetics researchers is only one variant of the BDNF gene.  ...  Only one study to date has examined the effects of the BDNF Val66Met polymorphism on functional activation in a sample of depressed individuals.  ... 
doi:10.1093/med/9780199920211.003.0013 fatcat:zdu4xjpphzavphdcuqwfy45pye

The functional epistasis of 5-HTTLPR and BDNF Val66Met on emotion processing: a preliminary study

Tim Outhred, Pritha Das, Carol Dobson-Stone, Kristi Griffiths, Kim L. Felmingham, Richard A. Bryant, Gin Malhi, Andrew H. Kemp
2012 Brain and Behavior  
An epistatic interaction of 5-HTTLPR and BDNF Val66Met polymorphisms has been implicated in the structure of rostral anterior cingulate cortex (rACC) and amygdala (AMY): key regions associated with emotion  ...  Region-of-interest analysis of the rACC and AMY revealed main effects of 5-HTTLPR and BDNF Val66Met, and an interaction of 5-HTTLPR and BDNF Val66Met.  ...  Gene-gene epistatic interactions may better explain the complex differential brain and behavior correlates of the 5-HTTLPR and BDNF Val66Met polymorphisms.  ... 
doi:10.1002/brb3.99 pmid:23170240 pmcid:PMC3500464 fatcat:mevpdebn5zcxrj346tkeqhzst4

The Functional Epistasis of 5-HTTLPR and BDNF Val66Met on Emotion Processing: A Preliminary Study

Kemp Andrew
2012 Frontiers in Human Neuroscience  
An epistatic interaction of 5-HTTLPR and BDNF Val66Met polymorphisms has been implicated in the structure of rostral anterior cingulate cortex (rACC) and amygdala (AMY): key regions associated with emotion  ...  Region-of-interest analysis of the rACC and AMY revealed main effects of 5-HTTLPR and BDNF Val66Met, and an interaction of 5-HTTLPR and BDNF Val66Met.  ...  Gene-gene epistatic interactions may better explain the complex differential brain and behavior correlates of the 5-HTTLPR and BDNF Val66Met polymorphisms.  ... 
doi:10.3389/conf.fnhum.2012.208.00076 fatcat:wazxf2xfefbs5n7lacko7maliq

Reduced hippocampal volumes in healthy carriers of brain-derived neurotrophic factor Val66Met polymorphism: Meta-analysis

Tomas Hajek, Miloslav Kopecek, Cyril Höschl
2011 World Journal of Biological Psychiatry  
Converging evidence suggests that the brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects brain structure.  ...  Healthy carriers of BDNF gene Val66Met polymorphism show bilateral hippocampal volume reduction. The effect size was small, but the same direction of effect was seen in all meta-analyzed studies.  ...  None of the authors has any confl ict of interest to disclose. Statement of Interest None of the authors has any confl ict of interest to declare.  ... 
doi:10.3109/15622975.2011.580005 pmid:21722019 pmcid:PMC4831902 fatcat:am7j5g2tsncvhn2xkjxtn6323u

Impact of the BDNF Val66Met Polymorphism on Regional Brain Gray Matter Volumes: Relevance to the Stress Response

Sung Nyun Kim, Do-Hyung Kang, Je-Yeon Yun, Tae Young Lee, Wi Hoon Jung, Joon Hwan Jang, Jun Soo Kwon
2013 Psychiatry Investigation  
This study examined the effect of a polymorphism in the gene encoding brain-derived neurotrophic factor (BDNF) on regional gray matter (GM) volumes and the correlations between the dorsolateral prefrontal  ...  MethodsaaSixty-one volunteers underwent genotyping for the BDNF Val66Met single nucleotide polymorphism (SNP) and completed the Stress Response Inventory (SRI).  ...  DISCUSSION In this study, we aimed to elucidate the structural neural correlate of stress resilience in relation to the BDNF Val66Met polymorphism in normal subjects.  ... 
doi:10.4306/pi.2013.10.2.173 pmid:23798966 pmcid:PMC3687052 fatcat:6qizeukjind7rbg6c7bnbxvjki

BDNF Val66Met gene polymorphism modulates brain activity following rTMS-induced memory impairment

Kilian Abellaneda-Pérez, Pablo Martin-Trias, Catherine Cassé-Perrot, Lídia Vaqué-Alcázar, Laura Lanteaume, Elisabeth Solana, Claudio Babiloni, Roberta Lizio, Carme Junqué, Núria Bargalló, Paolo Maria Rossini, Joëlle Micallef (+11 others)
2022 Scientific Reports  
AbstractThe BDNF Val66Met gene polymorphism is a relevant factor explaining inter-individual differences to TMS responses in studies of the motor system.  ...  We concluded that BDNF Val66Met gene polymorphism, known to exert a significant effect on neuroplasticity, modulates the impact of rTMS both at the cognitive as well as at the associated brain networks  ...  the BDNF Val66Met genetic variation is associated with a decreased activity-dependent secretion of BDNF 18 .  ... 
doi:10.1038/s41598-021-04175-x pmid:34997117 pmcid:PMC8741781 fatcat:3xuupnkndzbjrcgz6etyz37y7m

BDNF val66met association with serotonin transporter binding in healthy humans

P M Fisher, B Ozenne, C Svarer, D Adamsen, S Lehel, W F C Baaré, P S Jensen, G M Knudsen
2017 Translational Psychiatry  
We acknowledge the Simon Spies Foundation for the donation of the Siemens Trio MRI scanner.  ...  We gratefully acknowledge The John and Birthe Meyer Foundation for the donation of the Cyclotron and PET scanner.  ...  human studies indicate that BDNF affects the serotonin system. 5, 6 Within the human BDNF gene a common single-nucleotide polymorphism (BDNF val66met, rs6265) has been identified wherein the met-allele  ... 
doi:10.1038/tp.2016.295 pmid:28195567 pmcid:PMC5438027 fatcat:4rhjhom2w5fxdjd6ytawabgktq

BDNF polymorphism predicts the rate of decline in skilled task performance and hippocampal volume in healthy individuals

M Millan Sanchez, D Das, J L Taylor, A Noda, J A Yesavage, A Salehi
2011 Translational Psychiatry  
We found that val66met substitution in BDNF correlated longitudinally with the rate of decline in SFSS.  ...  Our study suggests that val66met polymorphism in BDNF can be linked to the rate of decline in skilled task performance.  ...  This research was supported by the Department of Veterans Affairs' War Related Illness and Injury Study Center (WRIISC), the Sierra-Pacific VA Advanced Fellowship Program in Mental Illness Research and  ... 
doi:10.1038/tp.2011.47 pmid:22833197 pmcid:PMC3309489 fatcat:qu6ysugyzbbpbbly3qxskyc6ha

Interactive effect of 5-HTTLPR and BDNF polymorphisms on amygdala intrinsic functional connectivity and anxiety

Joshua Loewenstern, Xiaozhen You, Junaid Merchant, Evan M. Gordon, Melanie Stollstorff, Joseph Devaney, Chandan J. Vaidya
2019 Psychiatry Research : Neuroimaging  
FC was highest in carriers of the 5-HTTLPR short allele and BDNF Met allele.  ...  Interactive genetic association with anxiety was observed such that effects of 5-HTTLPR depended on the BDNF Val66Met polymorphism (rs6265 variant), with higher anxiety scores in short and Met carriers  ...  Acknowledgements The study was made possible by NIH grants MH086709 and MH088066 to C. J. Vaidya. The authors would like to thank Dr. Rebecca Ryan for advice on data analysis.  ... 
doi:10.1016/j.pscychresns.2019.01.010 pmid:30711709 pmcid:PMC6699775 fatcat:ydnvsazzhjfqhof4tcxvxghzfm

Imaging genetics paradigms in depression research: Systematic review and meta-analysis

Lícia P. Pereira, Cristiano A. Köhler, Brendon Stubbs, Kamilla W. Miskowiak, Gerwyn Morris, Bárbara P. de Freitas, Trevor Thompson, Brisa S. Fernandes, André R. Brunoni, Michael Maes, Diego A. Pizzagalli, André F. Carvalho
2018 Progress in Neuro-psychopharmacology and Biological Psychiatry  
association of the BDNF Val66Met 'Met' risk allele and hippocampal volumes.  ...  BDNF Val66Met 'Met' allele had larger grey matter volumes and hyperactivation of the right middle frontal gyrus compared to non-carriers.  ...  of the impact of genetic variations on specific structural or functional neuroimaging abnormalities.  ... 
doi:10.1016/j.pnpbp.2018.05.012 pmid:29778546 pmcid:PMC6240165 fatcat:rkkfjd2d3zhrhfyh5fazqucw7u
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