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Structural neuroimaging correlates of allelic variation of the BDNF val66met polymorphism
2014
NeuroImage
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The brain-derived neurotrophic factor (BDNF) val66met polymorphism is associated with altered activity dependent secretion of BDNF and a variable influence on brain morphology and cognition. ...
Although a met-dose effect is generally assumed, to date the paucity of met-homozygotes have limited our understanding of the role of the met-allele on brain structure. ...
We thank staff of the CBR and GSK Clinical Unit for assistance with volunteer recruitment. ...
doi:10.1016/j.neuroimage.2013.12.050
pmid:24384148
fatcat:c5du6qo5ejcxbeqwf4gybpqyuq
Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study
2020
Brain Structure and Function
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Current evidence supports the involvement of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and the ε4 allele of APOE gene in hippocampal-dependent functions. ...
We also investigated whether the association between APOE-ε4 allele and HSv were modified by BDNF Val66Met genotypes. BDNF Val66Met carriers showed larger bilateral volumes of the subiculum subfield. ...
The research leading to these results has received funding from "la Caixa" Foundation (LCF/PR/GN17/10300004) and the Health Department of the Catalan Government (Health Research and Innovation Strategic ...
doi:10.1007/s00429-020-02125-3
pmid:32804326
fatcat:sdrpqrbjqret5hn4nwqhgw3clm
Neuroprotective effect of Val variant of BDNF Val66Met polymorphism on hippocampus is modulated by the severity of menstrual pain
2021
NeuroImage: Clinical
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This study examined the associations among BDNF Val66Met polymorphisms, menstrual pain severity, and hippocampal volume among young PDM subjects. ...
Linear regression was used to test for BDNF Val66Met Val allele dosage-dependent effects. ...
We appreciate the assistance of Intan Low, Chou-Ming Cheng, Tzu-Ling Tzeng, Ching-Ju Yang, Chih-Che Chou, Dr. Lin-Chien Lee, Dr. ...
doi:10.1016/j.nicl.2021.102576
pmid:33561695
pmcid:PMC7873439
fatcat:p7asfkq4d5eqvomwoumbdiyci4
Interactions of BDNF Val66Met Polymorphism and Menstrual Pain on Brain Complexity
2018
Frontiers in Neuroscience
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Our results suggest that pain experience preponderantly affects the effect of BDNF Val66Met polymorphism on brain complexity. ...
Therefore, we aimed to examine the interactions of BDNF Val66Met polymorphism and long-term menstrual pain experience on brain complexity. ...
BDNF Genotype Distributions and Allele Frequency The Hardy-Weinberg equilibrium of the BDNF Val66Met genotype distributions and allele frequency were tested using chi-square tests of goodness-of-fit (p ...
doi:10.3389/fnins.2018.00826
pmid:30524221
pmcid:PMC6256283
fatcat:bdusapr5rrekref5dm4crpuk6y
Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression
2008
Molecular Psychiatry
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Complex genetic disorders such as depression likely exhibit epistasis, but neural mechanisms of such gene-gene interactions are incompletely understood. 5-HTTLPR and BDNF VAL66MET, functional polymorphisms ...
Our analyses revealed no effect of the 5-HTTLPR S allele on rAC volume in the presence of BDNF MET alleles, whereas a significant volume reduction (P < 0.001) was seen on BDNF VAL/VAL background. ...
Acknowledgments This study was supported by the National Institute of Mental Health Intramural Research Program. We thank JH Callicott for support of data acquisition.
Conflict of Interest ...
doi:10.1038/mp.2008.32
pmid:18347599
fatcat:4kozke27srczlpxpvb6smwdcfi
Imaging Genetics of Depression
[chapter]
2016
Neuroimaging Genetics
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For example, the Val66Met polymorphism that is targeted by neuroimaging genetics researchers is only one variant of the BDNF gene. ...
Only one study to date has examined the effects of the BDNF Val66Met polymorphism on functional activation in a sample of depressed individuals. ...
doi:10.1093/med/9780199920211.003.0013
fatcat:zdu4xjpphzavphdcuqwfy45pye
The functional epistasis of 5-HTTLPR and BDNF Val66Met on emotion processing: a preliminary study
2012
Brain and Behavior
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An epistatic interaction of 5-HTTLPR and BDNF Val66Met polymorphisms has been implicated in the structure of rostral anterior cingulate cortex (rACC) and amygdala (AMY): key regions associated with emotion ...
Region-of-interest analysis of the rACC and AMY revealed main effects of 5-HTTLPR and BDNF Val66Met, and an interaction of 5-HTTLPR and BDNF Val66Met. ...
Gene-gene epistatic interactions may better explain the complex differential brain and behavior correlates of the 5-HTTLPR and BDNF Val66Met polymorphisms. ...
doi:10.1002/brb3.99
pmid:23170240
pmcid:PMC3500464
fatcat:mevpdebn5zcxrj346tkeqhzst4
The Functional Epistasis of 5-HTTLPR and BDNF Val66Met on Emotion Processing: A Preliminary Study
2012
Frontiers in Human Neuroscience
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An epistatic interaction of 5-HTTLPR and BDNF Val66Met polymorphisms has been implicated in the structure of rostral anterior cingulate cortex (rACC) and amygdala (AMY): key regions associated with emotion ...
Region-of-interest analysis of the rACC and AMY revealed main effects of 5-HTTLPR and BDNF Val66Met, and an interaction of 5-HTTLPR and BDNF Val66Met. ...
Gene-gene epistatic interactions may better explain the complex differential brain and behavior correlates of the 5-HTTLPR and BDNF Val66Met polymorphisms. ...
doi:10.3389/conf.fnhum.2012.208.00076
fatcat:wazxf2xfefbs5n7lacko7maliq
Reduced hippocampal volumes in healthy carriers of brain-derived neurotrophic factor Val66Met polymorphism: Meta-analysis
2011
World Journal of Biological Psychiatry
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Converging evidence suggests that the brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects brain structure. ...
Healthy carriers of BDNF gene Val66Met polymorphism show bilateral hippocampal volume reduction. The effect size was small, but the same direction of effect was seen in all meta-analyzed studies. ...
None of the authors has any confl ict of interest to disclose.
Statement of Interest None of the authors has any confl ict of interest to declare. ...
doi:10.3109/15622975.2011.580005
pmid:21722019
pmcid:PMC4831902
fatcat:am7j5g2tsncvhn2xkjxtn6323u
Impact of the BDNF Val66Met Polymorphism on Regional Brain Gray Matter Volumes: Relevance to the Stress Response
2013
Psychiatry Investigation
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This study examined the effect of a polymorphism in the gene encoding brain-derived neurotrophic factor (BDNF) on regional gray matter (GM) volumes and the correlations between the dorsolateral prefrontal ...
MethodsaaSixty-one volunteers underwent genotyping for the BDNF Val66Met single nucleotide polymorphism (SNP) and completed the Stress Response Inventory (SRI). ...
DISCUSSION In this study, we aimed to elucidate the structural neural correlate of stress resilience in relation to the BDNF Val66Met polymorphism in normal subjects. ...
doi:10.4306/pi.2013.10.2.173
pmid:23798966
pmcid:PMC3687052
fatcat:6qizeukjind7rbg6c7bnbxvjki
BDNF Val66Met gene polymorphism modulates brain activity following rTMS-induced memory impairment
2022
Scientific Reports
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AbstractThe BDNF Val66Met gene polymorphism is a relevant factor explaining inter-individual differences to TMS responses in studies of the motor system. ...
We concluded that BDNF Val66Met gene polymorphism, known to exert a significant effect on neuroplasticity, modulates the impact of rTMS both at the cognitive as well as at the associated brain networks ...
the BDNF Val66Met genetic variation is associated with a decreased activity-dependent secretion of BDNF 18 . ...
doi:10.1038/s41598-021-04175-x
pmid:34997117
pmcid:PMC8741781
fatcat:3xuupnkndzbjrcgz6etyz37y7m
BDNF val66met association with serotonin transporter binding in healthy humans
2017
Translational Psychiatry
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We acknowledge the Simon Spies Foundation for the donation of the Siemens Trio MRI scanner. ...
We gratefully acknowledge The John and Birthe Meyer Foundation for the donation of the Cyclotron and PET scanner. ...
human studies indicate that BDNF affects the serotonin system. 5, 6 Within the human BDNF gene a common single-nucleotide polymorphism (BDNF val66met, rs6265) has been identified wherein the met-allele ...
doi:10.1038/tp.2016.295
pmid:28195567
pmcid:PMC5438027
fatcat:4rhjhom2w5fxdjd6ytawabgktq
BDNF polymorphism predicts the rate of decline in skilled task performance and hippocampal volume in healthy individuals
2011
Translational Psychiatry
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We found that val66met substitution in BDNF correlated longitudinally with the rate of decline in SFSS. ...
Our study suggests that val66met polymorphism in BDNF can be linked to the rate of decline in skilled task performance. ...
This research was supported by the Department of Veterans Affairs' War Related Illness and Injury Study Center (WRIISC), the Sierra-Pacific VA Advanced Fellowship Program in Mental Illness Research and ...
doi:10.1038/tp.2011.47
pmid:22833197
pmcid:PMC3309489
fatcat:qu6ysugyzbbpbbly3qxskyc6ha
Interactive effect of 5-HTTLPR and BDNF polymorphisms on amygdala intrinsic functional connectivity and anxiety
2019
Psychiatry Research : Neuroimaging
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FC was highest in carriers of the 5-HTTLPR short allele and BDNF Met allele. ...
Interactive genetic association with anxiety was observed such that effects of 5-HTTLPR depended on the BDNF Val66Met polymorphism (rs6265 variant), with higher anxiety scores in short and Met carriers ...
Acknowledgements The study was made possible by NIH grants MH086709 and MH088066 to C. J. Vaidya. The authors would like to thank Dr. Rebecca Ryan for advice on data analysis. ...
doi:10.1016/j.pscychresns.2019.01.010
pmid:30711709
pmcid:PMC6699775
fatcat:ydnvsazzhjfqhof4tcxvxghzfm
Imaging genetics paradigms in depression research: Systematic review and meta-analysis
2018
Progress in Neuro-psychopharmacology and Biological Psychiatry
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association of the BDNF Val66Met 'Met' risk allele and hippocampal volumes. ...
BDNF Val66Met 'Met' allele had larger grey matter volumes and hyperactivation of the right middle frontal gyrus compared to non-carriers. ...
of the impact of genetic variations on specific structural or functional neuroimaging abnormalities. ...
doi:10.1016/j.pnpbp.2018.05.012
pmid:29778546
pmcid:PMC6240165
fatcat:rkkfjd2d3zhrhfyh5fazqucw7u
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