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Amyloid Fiber Precursors in Native and Denaturing MD Simulations of an IG Light Chain Domain
2010
Biophysical Journal
Preserved Fulltext
Immunoglobulin variable light chain domains are prominent in primary systemic amyloidoses; in particular, class 6a appears iñ 40% of clinical cases, despite being expressed only in~2% of B-cells under ...
unfolded coillike conformation.
1042-Plat Amyloid Fiber Precursors in Native and Denaturing MD Simulations of an IG Light Chain Domain Nina Pastor 1 , Cesar Millan-Pacheco 1 , Francisco Murphy-Perez ...
doi:10.1016/j.bpj.2009.12.1069
fatcat:4hd74mrdqrfspb54q7vflrabrm
Characterization of circulating myeloma tumor cells by next generation flowcytometry in scleromyxedema patient: a case report
2020
Medicine
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Serum protein electrophoresis and immunofixation showed monoclonal band of 14.5 g/L typed as IgG lambda. ...
NGF analysis revealed approximately 0.25% Lambda monotypic plasma cells in the bone marrow expressing CD38, CD138, and CD27 with aberrant expression of CD56 and were negative for CD45, CD19, CD117, and ...
The authors have no funding and conflicts of interests to disclose. The authors report no conflicts of interest. ...
doi:10.1097/md.0000000000020726
pmid:32629647
pmcid:PMC7337479
fatcat:zapqkmq6bbhr5frzickapnxhv4
Protein Folding Landscapes for Alpha- and Beta-Miniproteins Using All-Atom Simulations with an Optimized Force-Field
2010
Biophysical Journal
Preserved Fulltext
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Immunoglobulin variable light chain domains are prominent in primary systemic amyloidoses; in particular, class 6a appears iñ 40% of clinical cases, despite being expressed only in~2% of B-cells under ...
unfolded coillike conformation.
1042-Plat Amyloid Fiber Precursors in Native and Denaturing MD Simulations of an IG Light Chain Domain Nina Pastor 1 , Cesar Millan-Pacheco 1 , Francisco Murphy-Perez ...
doi:10.1016/j.bpj.2009.12.1068
fatcat:zd4gvjkqqfhfnebafacypue6ua
Residue Specific Analysis of Frustration in Folding Landscape of Repeat Alpha/Beta Protein Apoflavodoxin
2010
Biophysical Journal
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Immunoglobulin variable light chain domains are prominent in primary systemic amyloidoses; in particular, class 6a appears iñ 40% of clinical cases, despite being expressed only in~2% of B-cells under ...
unfolded coillike conformation.
1042-Plat Amyloid Fiber Precursors in Native and Denaturing MD Simulations of an IG Light Chain Domain Nina Pastor 1 , Cesar Millan-Pacheco 1 , Francisco Murphy-Perez ...
doi:10.1016/j.bpj.2009.12.1066
fatcat:3ht56ow54jgqddnbnobvdw6dem
Folding Kinetics of IkB: Excursions Through the Energy Landscape
2010
Biophysical Journal
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The file type is application/pdf.
Immunoglobulin variable light chain domains are prominent in primary systemic amyloidoses; in particular, class 6a appears iñ 40% of clinical cases, despite being expressed only in~2% of B-cells under ...
unfolded coillike conformation.
1042-Plat Amyloid Fiber Precursors in Native and Denaturing MD Simulations of an IG Light Chain Domain Nina Pastor 1 , Cesar Millan-Pacheco 1 , Francisco Murphy-Perez ...
doi:10.1016/j.bpj.2009.12.1067
fatcat:ptybf4cs5jdqrdswdb74fltiey
Stability and uniqueness of clonal immunoglobulin CDR3 sequences for MRD tracking in multiple myeloma
2019
American Journal of Hematology
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Next, we establish somatic hypermutation and non-templated insertions as the most important determinants of light chain clonal uniqueness, identifying a potentially trackable sequence in the majority of ...
Taken together, we show that dominant clonal sequences identified at baseline are reliable biomarkers for long-term tracking of the malignant clone, including both IGH and the majority of light chain clones ...
A, Schematic of the immunoglobulin heavy (above) and light (below) chain genes. ...
doi:10.1002/ajh.25641
pmid:31571261
fatcat:xsdyhg6f55ghtawkqd42nnvujm
Exploration of the Conformational Landscape of an Amyloidogenic Ig Domain
2011
Biophysical Journal
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In this particular case, variable light chain immunoglobulin domains are expressed in excess, due to a B-cell dyscrasia, and form fibers that deposit primarily in the kidneys and heart. ...
This is the underlying cause of a large group of misfolding diseases, such as light chain amyloidosis. ...
In this particular case, variable light chain immunoglobulin domains are expressed in excess, due to a B-cell dyscrasia, and form fibers that deposit primarily in the kidneys and heart. ...
doi:10.1016/j.bpj.2010.12.1366
fatcat:u5ibcrg7z5ei5jmq23lnc7dh2y
Epigenetic and 3-dimensional regulation of V(D)J rearrangement of immunoglobulin genes
2010
Seminars in Immunology
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V(D)J recombination is a crucial component of the adaptive immune response, allowing for the production of a diverse antigen receptor repertoire (Ig and TCR). ...
Taken together, the many epigenetic and 3-D layers of control ensure that Ig loci are only rearranged at appropriate stages of B-cell development. ...
We thank all present and former members of the Feeney lab for the contributions to the research summarize in this review. ...
doi:10.1016/j.smim.2010.08.002
pmid:20833065
pmcid:PMC2981695
fatcat:oylatun3nrgmxnc24dpjrythvy
Trp Cage Folding in Confinement
2011
Biophysical Journal
Preserved Fulltext
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In this particular case, variable light chain immunoglobulin domains are expressed in excess, due to a B-cell dyscrasia, and form fibers that deposit primarily in the kidneys and heart. ...
This is the underlying cause of a large group of misfolding diseases, such as light chain amyloidosis. ...
In this particular case, variable light chain immunoglobulin domains are expressed in excess, due to a B-cell dyscrasia, and form fibers that deposit primarily in the kidneys and heart. ...
doi:10.1016/j.bpj.2010.12.1367
fatcat:nfkbt6hjebfxxlwm2er2itep7u
Early-Aggregation Studies of Diabetic Amyloid in Solution and Membranes
2011
Biophysical Journal
Preserved Fulltext
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The file type is application/pdf.
In this particular case, variable light chain immunoglobulin domains are expressed in excess, due to a B-cell dyscrasia, and form fibers that deposit primarily in the kidneys and heart. ...
This is the underlying cause of a large group of misfolding diseases, such as light chain amyloidosis. ...
In this particular case, variable light chain immunoglobulin domains are expressed in excess, due to a B-cell dyscrasia, and form fibers that deposit primarily in the kidneys and heart. ...
doi:10.1016/j.bpj.2010.12.1363
fatcat:sdtdhu6kd5gubnvzqj2ejoyumq
Diffusion of Unfolded Acyl-Coenzyme A-Binding Protein Over a Complete Range of Denaturant
2011
Biophysical Journal
Preserved Fulltext
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The file type is application/pdf.
In this particular case, variable light chain immunoglobulin domains are expressed in excess, due to a B-cell dyscrasia, and form fibers that deposit primarily in the kidneys and heart. ...
This is the underlying cause of a large group of misfolding diseases, such as light chain amyloidosis. ...
In this particular case, variable light chain immunoglobulin domains are expressed in excess, due to a B-cell dyscrasia, and form fibers that deposit primarily in the kidneys and heart. ...
doi:10.1016/j.bpj.2010.12.1362
fatcat:44p3xuk4qnamxa4gccg3ywdfmq
Early Closure of Loops in the Refolding of Adenylate Kinase: A Possible Key Role for Non Local Interactions in the Initial Folding Steps
2011
Biophysical Journal
Preserved Fulltext
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The file type is application/pdf.
In this particular case, variable light chain immunoglobulin domains are expressed in excess, due to a B-cell dyscrasia, and form fibers that deposit primarily in the kidneys and heart. ...
This is the underlying cause of a large group of misfolding diseases, such as light chain amyloidosis. ...
In this particular case, variable light chain immunoglobulin domains are expressed in excess, due to a B-cell dyscrasia, and form fibers that deposit primarily in the kidneys and heart. ...
doi:10.1016/j.bpj.2010.12.1364
fatcat:rlpldsfseje2rczjfj4o3vh7lu
Exome sequencing in high and low fetal haemoglobin Arab–Indian haplotype sickle cell disease
2021
British Journal of Haematology
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were involved in the design of the project, patient selection, patients' data collection, analysis and review of the manuscript. ...
SAA, CBV, CC, BK, AKA and MHS were involved in the design of the project, sequencing, analysis and preparation of the manuscript. ...
Whole-genome sequence analysis of light-chain-sorted cells in biclonal CLL may provide insight into the genomic landscape of each and set a light on the genealogy of the clonal evolution. ...
doi:10.1111/bjh.17542
pmid:34041755
fatcat:cd33nvesnjdzxiklqyos65rf7a
Equilibrium Studies of Protein Denaturation by Urea - Examining Backbone and Sidechain Contributions
2011
Biophysical Journal
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
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In this particular case, variable light chain immunoglobulin domains are expressed in excess, due to a B-cell dyscrasia, and form fibers that deposit primarily in the kidneys and heart. ...
This is the underlying cause of a large group of misfolding diseases, such as light chain amyloidosis. ...
doi:10.1016/j.bpj.2010.12.1365
fatcat:pc6jrxhbczapra4cvhijr7kvhq
Association of Immune Marker Changes With Progression of Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma
2019
JAMA Oncology
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Serum protein and monoclonal immunoglobulin levels, serum free light chains, and serum light chains within each immunoglobulin class were measured. ...
Similar results were found for light-chain MGUS. The findings of evolving risk patterns support annual blood testing and risk assessment for patients with MGUS or light-chain MGUS. ...
chain.
439
440
441
Variable
Adverse marker
Points
M-spike isotype
IgA
1
M-spike concentration
≥15 g/L
1
sFLC ratio (kappa/lambda)
<0.1 or >10
1
Immunoparesis
Uninvolved immunoglobulins ...
doi:10.1001/jamaoncol.2019.1568
pmid:31318385
pmcid:PMC6646992
fatcat:jgxgxnthwnampbg5ths276bk7u
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