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Amyloid Fiber Precursors in Native and Denaturing MD Simulations of an IG Light Chain Domain

Nina Pastor, Cesar Millan-Pacheco, Francisco Murphy-Perez, Daniel Alejandro Fernandez-Velasco
2010 Biophysical Journal  
Immunoglobulin variable light chain domains are prominent in primary systemic amyloidoses; in particular, class 6a appears iñ 40% of clinical cases, despite being expressed only in~2% of B-cells under  ...  unfolded coillike conformation. 1042-Plat Amyloid Fiber Precursors in Native and Denaturing MD Simulations of an IG Light Chain Domain Nina Pastor 1 , Cesar Millan-Pacheco 1 , Francisco Murphy-Perez  ... 
doi:10.1016/j.bpj.2009.12.1069 fatcat:4hd74mrdqrfspb54q7vflrabrm

Characterization of circulating myeloma tumor cells by next generation flowcytometry in scleromyxedema patient: a case report

Ruba Y. Taha, Saba Hasan, Firyal Ibrahim, Yannick Chantran, Hesham El Sabah, Siveen Sivaraman, Issam Al Bozom, Ahmad Al Sabbagh, Laurent Garderet, Halima El Omri
2020 Medicine  
Serum protein electrophoresis and immunofixation showed monoclonal band of 14.5 g/L typed as IgG lambda.  ...  NGF analysis revealed approximately 0.25% Lambda monotypic plasma cells in the bone marrow expressing CD38, CD138, and CD27 with aberrant expression of CD56 and were negative for CD45, CD19, CD117, and  ...  The authors have no funding and conflicts of interests to disclose. The authors report no conflicts of interest.  ... 
doi:10.1097/md.0000000000020726 pmid:32629647 pmcid:PMC7337479 fatcat:zapqkmq6bbhr5frzickapnxhv4

Protein Folding Landscapes for Alpha- and Beta-Miniproteins Using All-Atom Simulations with an Optimized Force-Field

Jeetain Mittal, Robert B. Best
2010 Biophysical Journal  
Immunoglobulin variable light chain domains are prominent in primary systemic amyloidoses; in particular, class 6a appears iñ 40% of clinical cases, despite being expressed only in~2% of B-cells under  ...  unfolded coillike conformation. 1042-Plat Amyloid Fiber Precursors in Native and Denaturing MD Simulations of an IG Light Chain Domain Nina Pastor 1 , Cesar Millan-Pacheco 1 , Francisco Murphy-Perez  ... 
doi:10.1016/j.bpj.2009.12.1068 fatcat:zd4gvjkqqfhfnebafacypue6ua

Residue Specific Analysis of Frustration in Folding Landscape of Repeat Alpha/Beta Protein Apoflavodoxin

Antonios Samiotakis, Loren Stagg, Dirar Homouz, Margaret S. Cheung, Pernilla Wittung-Stafshede
2010 Biophysical Journal  
Immunoglobulin variable light chain domains are prominent in primary systemic amyloidoses; in particular, class 6a appears iñ 40% of clinical cases, despite being expressed only in~2% of B-cells under  ...  unfolded coillike conformation. 1042-Plat Amyloid Fiber Precursors in Native and Denaturing MD Simulations of an IG Light Chain Domain Nina Pastor 1 , Cesar Millan-Pacheco 1 , Francisco Murphy-Perez  ... 
doi:10.1016/j.bpj.2009.12.1066 fatcat:3ht56ow54jgqddnbnobvdw6dem

Folding Kinetics of IkB: Excursions Through the Energy Landscape

Ryan M.B. Hoffman, Patricio O. Craig, Ingrid L. DeVries, Elizabeth A. Komives, Peter G. Wolynes
2010 Biophysical Journal  
Immunoglobulin variable light chain domains are prominent in primary systemic amyloidoses; in particular, class 6a appears iñ 40% of clinical cases, despite being expressed only in~2% of B-cells under  ...  unfolded coillike conformation. 1042-Plat Amyloid Fiber Precursors in Native and Denaturing MD Simulations of an IG Light Chain Domain Nina Pastor 1 , Cesar Millan-Pacheco 1 , Francisco Murphy-Perez  ... 
doi:10.1016/j.bpj.2009.12.1067 fatcat:ptybf4cs5jdqrdswdb74fltiey

Stability and uniqueness of clonal immunoglobulin CDR3 sequences for MRD tracking in multiple myeloma

Even H Rustad, Kristine Misund, Elsa Bernard, Eivind Coward, Venkata D Yellapantula, Malin Hultcrantz, Caleb Ho, Dickran Kazandjian, Neha Korde, Sham Mailankody, Jonathan J Keats, Theresia Akhlaghi (+15 others)
2019 American Journal of Hematology  
Next, we establish somatic hypermutation and non-templated insertions as the most important determinants of light chain clonal uniqueness, identifying a potentially trackable sequence in the majority of  ...  Taken together, we show that dominant clonal sequences identified at baseline are reliable biomarkers for long-term tracking of the malignant clone, including both IGH and the majority of light chain clones  ...  A, Schematic of the immunoglobulin heavy (above) and light (below) chain genes.  ... 
doi:10.1002/ajh.25641 pmid:31571261 fatcat:xsdyhg6f55ghtawkqd42nnvujm

Exploration of the Conformational Landscape of an Amyloidogenic Ig Domain

Nina Pastor, César Millán-Pacheco, D. Alejandro Fernández-Velasco
2011 Biophysical Journal  
In this particular case, variable light chain immunoglobulin domains are expressed in excess, due to a B-cell dyscrasia, and form fibers that deposit primarily in the kidneys and heart.  ...  This is the underlying cause of a large group of misfolding diseases, such as light chain amyloidosis.  ...  In this particular case, variable light chain immunoglobulin domains are expressed in excess, due to a B-cell dyscrasia, and form fibers that deposit primarily in the kidneys and heart.  ... 
doi:10.1016/j.bpj.2010.12.1366 fatcat:u5ibcrg7z5ei5jmq23lnc7dh2y

Epigenetic and 3-dimensional regulation of V(D)J rearrangement of immunoglobulin genes

Stephanie C. Degner-Leisso, Ann J. Feeney
2010 Seminars in Immunology  
V(D)J recombination is a crucial component of the adaptive immune response, allowing for the production of a diverse antigen receptor repertoire (Ig and TCR).  ...  Taken together, the many epigenetic and 3-D layers of control ensure that Ig loci are only rearranged at appropriate stages of B-cell development.  ...  We thank all present and former members of the Feeney lab for the contributions to the research summarize in this review.  ... 
doi:10.1016/j.smim.2010.08.002 pmid:20833065 pmcid:PMC2981695 fatcat:oylatun3nrgmxnc24dpjrythvy

Trp Cage Folding in Confinement

Kristen A. Marino, Peter G. Bolhuis
2011 Biophysical Journal  
In this particular case, variable light chain immunoglobulin domains are expressed in excess, due to a B-cell dyscrasia, and form fibers that deposit primarily in the kidneys and heart.  ...  This is the underlying cause of a large group of misfolding diseases, such as light chain amyloidosis.  ...  In this particular case, variable light chain immunoglobulin domains are expressed in excess, due to a B-cell dyscrasia, and form fibers that deposit primarily in the kidneys and heart.  ... 
doi:10.1016/j.bpj.2010.12.1367 fatcat:nfkbt6hjebfxxlwm2er2itep7u

Early-Aggregation Studies of Diabetic Amyloid in Solution and Membranes

Sadanand Singh, Chi-Cheng Chiu, Kyle Q. Hoffmann, Allam S. Reddy, M. Zanni, J.L. Skinner, Juan J. de Pablo
2011 Biophysical Journal  
In this particular case, variable light chain immunoglobulin domains are expressed in excess, due to a B-cell dyscrasia, and form fibers that deposit primarily in the kidneys and heart.  ...  This is the underlying cause of a large group of misfolding diseases, such as light chain amyloidosis.  ...  In this particular case, variable light chain immunoglobulin domains are expressed in excess, due to a B-cell dyscrasia, and form fibers that deposit primarily in the kidneys and heart.  ... 
doi:10.1016/j.bpj.2010.12.1363 fatcat:sdtdhu6kd5gubnvzqj2ejoyumq

Diffusion of Unfolded Acyl-Coenzyme A-Binding Protein Over a Complete Range of Denaturant

Yujie Chen, Vincent A. Voelz, Olgica Bakajin, Vijay S. Pande, Lisa J. Lapidus
2011 Biophysical Journal  
In this particular case, variable light chain immunoglobulin domains are expressed in excess, due to a B-cell dyscrasia, and form fibers that deposit primarily in the kidneys and heart.  ...  This is the underlying cause of a large group of misfolding diseases, such as light chain amyloidosis.  ...  In this particular case, variable light chain immunoglobulin domains are expressed in excess, due to a B-cell dyscrasia, and form fibers that deposit primarily in the kidneys and heart.  ... 
doi:10.1016/j.bpj.2010.12.1362 fatcat:44p3xuk4qnamxa4gccg3ywdfmq

Early Closure of Loops in the Refolding of Adenylate Kinase: A Possible Key Role for Non Local Interactions in the Initial Folding Steps

Eldad Ben-Ishai, tomer Orevi, Gil Rahamim, Sivan Gershanov, Gershon Hazan, Dan Amir, Elisha Haas
2011 Biophysical Journal  
In this particular case, variable light chain immunoglobulin domains are expressed in excess, due to a B-cell dyscrasia, and form fibers that deposit primarily in the kidneys and heart.  ...  This is the underlying cause of a large group of misfolding diseases, such as light chain amyloidosis.  ...  In this particular case, variable light chain immunoglobulin domains are expressed in excess, due to a B-cell dyscrasia, and form fibers that deposit primarily in the kidneys and heart.  ... 
doi:10.1016/j.bpj.2010.12.1364 fatcat:rlpldsfseje2rczjfj4o3vh7lu

Exome sequencing in high and low fetal haemoglobin Arab–Indian haplotype sickle cell disease

Awatif N. Alnafie, Suad A. Alateeq, Fahad A. Al‐Muhanna, Ahmed M. Alsulaiman, Mohammed Alfarhan, Waleed Buali, Chitti Babu Vatte, Cyril Cyrus, Brendan Keating, Amein K. Al‐Ali, Martin H Steinberg
2021 British Journal of Haematology  
were involved in the design of the project, patient selection, patients' data collection, analysis and review of the manuscript.  ...  SAA, CBV, CC, BK, AKA and MHS were involved in the design of the project, sequencing, analysis and preparation of the manuscript.  ...  Whole-genome sequence analysis of light-chain-sorted cells in biclonal CLL may provide insight into the genomic landscape of each and set a light on the genealogy of the clonal evolution.  ... 
doi:10.1111/bjh.17542 pmid:34041755 fatcat:cd33nvesnjdzxiklqyos65rf7a

Equilibrium Studies of Protein Denaturation by Urea - Examining Backbone and Sidechain Contributions

Deepak R. Canchi, Angel E. Garcia
2011 Biophysical Journal  
In this particular case, variable light chain immunoglobulin domains are expressed in excess, due to a B-cell dyscrasia, and form fibers that deposit primarily in the kidneys and heart.  ...  This is the underlying cause of a large group of misfolding diseases, such as light chain amyloidosis.  ... 
doi:10.1016/j.bpj.2010.12.1365 fatcat:pc6jrxhbczapra4cvhijr7kvhq

Association of Immune Marker Changes With Progression of Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma

Ola Landgren, Jonathan N. Hofmann, Charlene M. McShane, Loredana Santo, Malin Hultcrantz, Neha Korde, Sham Mailankody, Dickran Kazandjian, Kazunori Murata, Katie Thoren, Lakshmi Ramanathan, Ahmet Dogan (+9 others)
2019 JAMA Oncology  
Serum protein and monoclonal immunoglobulin levels, serum free light chains, and serum light chains within each immunoglobulin class were measured.  ...  Similar results were found for light-chain MGUS. The findings of evolving risk patterns support annual blood testing and risk assessment for patients with MGUS or light-chain MGUS.  ...  chain. 439 440 441 Variable Adverse marker Points M-spike isotype IgA 1 M-spike concentration ≥15 g/L 1 sFLC ratio (kappa/lambda) <0.1 or >10 1 Immunoparesis Uninvolved immunoglobulins  ... 
doi:10.1001/jamaoncol.2019.1568 pmid:31318385 pmcid:PMC6646992 fatcat:jgxgxnthwnampbg5ths276bk7u
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