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Mucosal epithelial cells: the initial sentinels and responders controlling and regulating immune responses to viral infections

Jingyi Yang, Huimin Yan
2021 Cellular & Molecular Immunology  
in the laboratory of Christoph Bock published the paper "Structural cells are key regulators of organ-specific immune responses" in Nature.  ...  Structural cells exhibit organ-specific patterns of immune activity and seem to modulate many interactions with hematopoietic immune cells.  ... 
doi:10.1038/s41423-021-00650-7 pmid:33927362 pmcid:PMC8082051 fatcat:phjt5de2rjbztjgsumgfzkhyge

RUFY4: Immunity piggybacking on autophagy?

Seigo Terawaki, Voahirana Camosseto, Philippe Pierre, Evelina Gatti
2016 Autophagy  
To fulfill this function, DC display particular regulation of their endocytic and autophagy pathways in response to the immune environment.  ...  DCs orchestrate the eradication of pathogens by coordinating the action of the different cell types involved in microbe recognition and destruction during the immune response.  ...  RUFY4 is therefore the first example of a positive regulator of autophagy, whose activity is restricted to specific immune conditions, suggesting that other factors are likely to exist and regulate autophagy  ... 
doi:10.1080/15548627.2015.1136772 pmid:26760128 pmcid:PMC4836005 fatcat:jc4cmvdobbatngxhxk5nv6nfju

The intestinal barrier function and its involvement in digestive disease

Eloisa Salvo Romero, Carmen Alonso Cotoner, Cristina Pardo Camacho, Maite Casado Bedmar, Maria Vicario
2015 Revista Espanola de Enfermedades Digestivas  
However, epithelial cells are also responsible for the absorption of nutrients and electrolytes, hence a semipermeable barrier is required that selectively allows a number of substances in while keeping  ...  Disturbances in the mechanisms of the barrier function favor the development of exaggerated immune responses; while exact implications remain unknown, changes in intestinal barrier function have been associated  ...  GI tract immune cells make up the so-called gut-associated lymphoid tissue (GALT), which comprises two compartments: Organized GALT, which induces immune responses, and diffuse GALT, effector of immune  ... 
doi:10.17235/reed.2015.3846/2015 pmid:26541659 fatcat:aoezyqrygbfx3b2jtzcimnwvy4

Immunology in China: the past, present and future

Xuetao Cao
2008 Nature Immunology  
For example, one Key Program (1999) (2000) (2001) (2002) (2003) investigated the immune regulation and organ transplantation, and another Key Program (2004-2008) is for the investigation of the structural  ...  A key issue in this field is how to balance the immune response and immune (negative) regulation.  ... 
doi:10.1038/ni0408-339 pmid:18349809 fatcat:cwe64j2tofffhaefax3ajvghy4

Immune Regulation in Time and Space: The Role of Local- and Long-Range Genomic Interactions in Regulating Immune Responses

Liam P. Devenish, Musa M. Mhlanga, Yutaka Negishi
2021 Frontiers in Immunology  
Importantly, immune cells are heterogeneous due to various factors relating to cytokine exposure and cell-cell interaction.  ...  Therefore, the fine control of immune effector functions to provide for a rapid, robust response to challenge is essential.  ...  Specific transcription factors (TFs) are one such example. Key to immune cells specifically is NFkB -known to induce most inflammatory genes while suppressing a cohort of metabolic genes.  ... 
doi:10.3389/fimmu.2021.662565 pmid:34046034 pmcid:PMC8144502 fatcat:6igy4fjojjelloupvusbmxsvae

Inflammation, Innate Immunity, and the Intestinal Stromal Cell Niche: Opportunities and Challenges

Benjamin M. J. Owens
2015 Frontiers in Immunology  
Thus, stroma is used within medicine as a term to describe the structural or connective tissue of organs, comprised of cells that act in a supportive capacity to the parenchymal cells performing specific  ...  IL-1β, TNFα, GM-CSF) and chemokines to localize cells to and within tissue Provide a structural framework for immune cell organization model systems.  ... 
doi:10.3389/fimmu.2015.00319 pmid:26150817 pmcid:PMC4471728 fatcat:g6qdjfsvcvbnpm6uzbofubrgty

MOESM3 of Impaired B cell immunity in acute myeloid leukemia patients after chemotherapy

Meghali Goswami, Gabrielle Prince, Angelique Biancotto, Susan Moir, Lela Kardava, Brian Santich, Foo Cheung, Yuri Kotliarov, Jinguo Chen, Rongye Shi, Huizhi Zhou, Hana Golding (+7 others)
2017 Figshare  
response to external biotic stimulus response to other organism regulation of anatomical structure morphogenesis regulation of cell adhesion response to oxygen levels myeloid cell development positive  ...  of immune system process cell activation involved in immune response leukocyte activation involved in immune response Gene ontology analysis using Toppgene of up--regulated genes in AML--NR versus HD.  ... 
doi:10.6084/m9.figshare.c.3823162_d3.v1 fatcat:jghf7jk2bvga5d4ektippogofq

Rho GTPases at the crossroad of signaling networks in mammals

Jean Claude Hervé, Nicolas Bourmeyster
2015 Small GTPases  
Invadosomes are, therefore, considered as key structures of cell invasion.  ...  Effective immune response against pathogenic agents requires rapid and specific threat detection and intercellular communication.  ... 
doi:10.1080/21541248.2015.1044811 pmid:26110743 pmcid:PMC4601364 fatcat:u5aejk7fsrbifi5w2u7q5ch2hq

Neutrophils: multitasking first responders of immunity and tissue homeostasis

Craig N. Jenne, Shan Liao, Baljit Singh
2018 Cell and Tissue Research  
From an evolutionary perspective, neutrophils are one of oldest immune cell types and represent a key first responder to infection and tissue injury (Leiding 2017).  ...  Importantly, we now know that neutrophils play key roles in the initiation, modulation, and resolution of the host immune response.  ...  structures and the function of these traps within the organism.  ... 
doi:10.1007/s00441-018-2802-5 pmid:29392468 fatcat:acvvrzyzb5cb7n3ovpzyxvgroi

Control of Immune Cell Homeostasis and Function by lncRNAs

Walter K. Mowel, Jonathan J. Kotzin, Sam J. McCright, Vanessa D. Neal, Jorge Henao-Mejia
2018 Trends in immunology  
Thus, lncRNAs have emerged as key regulatory molecules of immune cell gene expression programs in response to microbial and tissue-derived cues.  ...  The immune system is comprised of diverse cell types that coordinate responses to infection and maintain tissue homeostasis.  ...  It is becoming clear that the diverse cell types of the innate and adaptive immune system are no exception, and that lncRNAs are key regulatory molecules of immune cell gene expression programs in response  ... 
doi:10.1016/ pmid:28919048 pmcid:PMC5748345 fatcat:ogqbij6s2nfall6h7d4g35jyz4

Synthetic Biology in Cell and Organ Transplantation

Sean Stevens
2016 Cold Spring Harbor Perspectives in Biology  
Progress in the understanding of host immune responses to donor cells and organs, combined with the rapid advancement in synthetic biology applications, allows the rational engineering of more effective  ...  The speed and efficiency of the human immune system evolved to rapidly recognize and remove pathogens; the human immune system also serves as a barrier against the transplant of cells and organs from even  ...  Although the immune mechanisms involved are similar, overall rejection responses to cells and organs differ.  ... 
doi:10.1101/cshperspect.a029561 pmid:28003184 fatcat:xn7g77emfrbxjklkqakc24d5ji

A special collection of reviews on frontiers in immunology

Chenqi Xu, Hua-Bing Li, Richard A. Flavell
2020 Cell Research  
understanding of the structural basis of inflammasome activation. 8 In a specific organ, unique populations of immune cells are present to interplay with other tissue-resident cells and environmental  ...  . 3 Innate immune response is an essential arm of antitumor immunity and its roles are less understood than the arm of adaptive immune response.  ... 
doi:10.1038/s41422-020-00403-7 pmid:32859992 fatcat:tyyn2znj2rc7nhu5rxknjkx2ey

Regulating DCs in Innate Immune Response and Infection by Cytoskeletal Proteins

Wei Lin, Xin Wang
2017 Journal of Immunobiology  
Dendritic cells (DCs) are important antigen-presenting cells of innate immune system. Their main function is to take up antigen and present it to T-cells to active adaptive immune response.  ...  Regulating the specific cytoskeletal proteins of DCs would be a potential therapeutic strategy for preventing viral infection.  ...  Acknowledgement This work was supported by the grants of the National Nature Science Foundation of China (Grant No. 81601757 and 81500710), and the Innovation Project of Shandong Academy of Medical Sciences  ... 
doi:10.4172/2476-1966.1000124 fatcat:qaqsenwivrdi7ddtt7g6xchvzu

Cochlin-cleaved LCCL is a dual-armed regulator of the innate immune response in the cochlea during inflammation

Hyeong-Jun Rhyu, Seong Hoon Bae, Jinsei Jung, Young-Min Hyun
2020 BMB Reports  
The exact mechanism how the inner ear's immune response, specifically the innate immunity, is regulated was unknown.  ...  Cochlin regulates innate immunity by physically entrapping pathogens within scala tympani and recruiting innate immune cells.  ...  The inner ear is a delicate structure enclosing the key auditory structure, organ of Corti.  ... 
doi:10.5483/bmbrep.2020.53.9.104 fatcat:6fkzffnr55bexaif5vpvog4pxe

Transcriptional regulation in the immune system: a status report

Stephen T. Smale
2014 Trends in immunology  
Regulated changes in transcription play a central role in virtually all events that accompany the development of the immune system and its response to microbial and environmental cues.  ...  is regulated in key immunological settings.  ...  immune cell types and their response to a broad range of stimuli.  ... 
doi:10.1016/ pmid:24703179 pmcid:PMC4041609 fatcat:m4ibg4xzpvbsdpsgrzs4jve3va
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