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Mucosal epithelial cells: the initial sentinels and responders controlling and regulating immune responses to viral infections
2021
Cellular & Molecular Immunology
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in the laboratory of Christoph Bock published the paper "Structural cells are key regulators of organ-specific immune responses" in Nature. ...
Structural cells exhibit organ-specific patterns of immune activity and seem to modulate many interactions with hematopoietic immune cells. ...
doi:10.1038/s41423-021-00650-7
pmid:33927362
pmcid:PMC8082051
fatcat:phjt5de2rjbztjgsumgfzkhyge
RUFY4: Immunity piggybacking on autophagy?
2016
Autophagy
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To fulfill this function, DC display particular regulation of their endocytic and autophagy pathways in response to the immune environment. ...
DCs orchestrate the eradication of pathogens by coordinating the action of the different cell types involved in microbe recognition and destruction during the immune response. ...
RUFY4 is therefore the first example of a positive regulator of autophagy, whose activity is restricted to specific immune conditions, suggesting that other factors are likely to exist and regulate autophagy ...
doi:10.1080/15548627.2015.1136772
pmid:26760128
pmcid:PMC4836005
fatcat:jc4cmvdobbatngxhxk5nv6nfju
The intestinal barrier function and its involvement in digestive disease
2015
Revista Espanola de Enfermedades Digestivas
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However, epithelial cells are also responsible for the absorption of nutrients and electrolytes, hence a semipermeable barrier is required that selectively allows a number of substances in while keeping ...
Disturbances in the mechanisms of the barrier function favor the development of exaggerated immune responses; while exact implications remain unknown, changes in intestinal barrier function have been associated ...
GI tract immune cells make up the so-called gut-associated lymphoid tissue (GALT), which comprises two compartments: Organized GALT, which induces immune responses, and diffuse GALT, effector of immune ...
doi:10.17235/reed.2015.3846/2015
pmid:26541659
fatcat:aoezyqrygbfx3b2jtzcimnwvy4
Immunology in China: the past, present and future
2008
Nature Immunology
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For example, one Key Program (1999) (2000) (2001) (2002) (2003) investigated the immune regulation and organ transplantation, and another Key Program (2004-2008) is for the investigation of the structural ...
A key issue in this field is how to balance the immune response and immune (negative) regulation. ...
doi:10.1038/ni0408-339
pmid:18349809
fatcat:cwe64j2tofffhaefax3ajvghy4
Immune Regulation in Time and Space: The Role of Local- and Long-Range Genomic Interactions in Regulating Immune Responses
2021
Frontiers in Immunology
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Importantly, immune cells are heterogeneous due to various factors relating to cytokine exposure and cell-cell interaction. ...
Therefore, the fine control of immune effector functions to provide for a rapid, robust response to challenge is essential. ...
Specific transcription factors (TFs) are one such example. Key to immune cells specifically is NFkB -known to induce most inflammatory genes while suppressing a cohort of metabolic genes. ...
doi:10.3389/fimmu.2021.662565
pmid:34046034
pmcid:PMC8144502
fatcat:6igy4fjojjelloupvusbmxsvae
Inflammation, Innate Immunity, and the Intestinal Stromal Cell Niche: Opportunities and Challenges
2015
Frontiers in Immunology
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Thus, stroma is used within medicine as a term to describe the structural or connective tissue of organs, comprised of cells that act in a supportive capacity to the parenchymal cells performing specific ...
IL-1β, TNFα,
GM-CSF) and chemokines to localize
cells to and within tissue
Provide a structural framework for
immune cell organization
model systems. ...
doi:10.3389/fimmu.2015.00319
pmid:26150817
pmcid:PMC4471728
fatcat:g6qdjfsvcvbnpm6uzbofubrgty
MOESM3 of Impaired B cell immunity in acute myeloid leukemia patients after chemotherapy
2017
Figshare
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response to external biotic stimulus response to other organism regulation of anatomical structure morphogenesis regulation of cell adhesion response to oxygen levels myeloid cell development positive ...
of immune system process cell activation involved in immune response leukocyte activation involved in immune response Gene ontology analysis using Toppgene of up--regulated genes in AML--NR versus HD. ...
doi:10.6084/m9.figshare.c.3823162_d3.v1
fatcat:jghf7jk2bvga5d4ektippogofq
Rho GTPases at the crossroad of signaling networks in mammals
2015
Small GTPases
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Invadosomes are, therefore, considered as key structures of cell invasion. ...
Effective immune response against pathogenic agents requires rapid and specific threat detection and intercellular communication. ...
doi:10.1080/21541248.2015.1044811
pmid:26110743
pmcid:PMC4601364
fatcat:u5aejk7fsrbifi5w2u7q5ch2hq
Neutrophils: multitasking first responders of immunity and tissue homeostasis
2018
Cell and Tissue Research
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From an evolutionary perspective, neutrophils are one of oldest immune cell types and represent a key first responder to infection and tissue injury (Leiding 2017). ...
Importantly, we now know that neutrophils play key roles in the initiation, modulation, and resolution of the host immune response. ...
structures and the function of these traps within the organism. ...
doi:10.1007/s00441-018-2802-5
pmid:29392468
fatcat:acvvrzyzb5cb7n3ovpzyxvgroi
Control of Immune Cell Homeostasis and Function by lncRNAs
2018
Trends in immunology
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Thus, lncRNAs have emerged as key regulatory molecules of immune cell gene expression programs in response to microbial and tissue-derived cues. ...
The immune system is comprised of diverse cell types that coordinate responses to infection and maintain tissue homeostasis. ...
It is becoming clear that the diverse cell types of the innate and adaptive immune system are no exception, and that lncRNAs are key regulatory molecules of immune cell gene expression programs in response ...
doi:10.1016/j.it.2017.08.009
pmid:28919048
pmcid:PMC5748345
fatcat:ogqbij6s2nfall6h7d4g35jyz4
Synthetic Biology in Cell and Organ Transplantation
2016
Cold Spring Harbor Perspectives in Biology
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Progress in the understanding of host immune responses to donor cells and organs, combined with the rapid advancement in synthetic biology applications, allows the rational engineering of more effective ...
The speed and efficiency of the human immune system evolved to rapidly recognize and remove pathogens; the human immune system also serves as a barrier against the transplant of cells and organs from even ...
Although the immune mechanisms involved are similar, overall rejection responses to cells and organs differ. ...
doi:10.1101/cshperspect.a029561
pmid:28003184
fatcat:xn7g77emfrbxjklkqakc24d5ji
A special collection of reviews on frontiers in immunology
2020
Cell Research
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understanding of the structural basis of inflammasome activation. 8 In a specific organ, unique populations of immune cells are present to interplay with other tissue-resident cells and environmental ...
. 3 Innate immune response is an essential arm of antitumor immunity and its roles are less understood than the arm of adaptive immune response. ...
doi:10.1038/s41422-020-00403-7
pmid:32859992
fatcat:tyyn2znj2rc7nhu5rxknjkx2ey
Regulating DCs in Innate Immune Response and Infection by Cytoskeletal Proteins
2017
Journal of Immunobiology
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Dendritic cells (DCs) are important antigen-presenting cells of innate immune system. Their main function is to take up antigen and present it to T-cells to active adaptive immune response. ...
Regulating the specific cytoskeletal proteins of DCs would be a potential therapeutic strategy for preventing viral infection. ...
Acknowledgement This work was supported by the grants of the National Nature Science Foundation of China (Grant No. 81601757 and 81500710), and the Innovation Project of Shandong Academy of Medical Sciences ...
doi:10.4172/2476-1966.1000124
fatcat:qaqsenwivrdi7ddtt7g6xchvzu
Cochlin-cleaved LCCL is a dual-armed regulator of the innate immune response in the cochlea during inflammation
2020
BMB Reports
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The exact mechanism how the inner ear's immune response, specifically the innate immunity, is regulated was unknown. ...
Cochlin regulates innate immunity by physically entrapping pathogens within scala tympani and recruiting innate immune cells. ...
The inner ear is a delicate structure enclosing the key auditory structure, organ of Corti. ...
doi:10.5483/bmbrep.2020.53.9.104
fatcat:6fkzffnr55bexaif5vpvog4pxe
Transcriptional regulation in the immune system: a status report
2014
Trends in immunology
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Regulated changes in transcription play a central role in virtually all events that accompany the development of the immune system and its response to microbial and environmental cues. ...
is regulated in key immunological settings. ...
immune cell types and their response to a broad range of stimuli. ...
doi:10.1016/j.it.2014.03.003
pmid:24703179
pmcid:PMC4041609
fatcat:m4ibg4xzpvbsdpsgrzs4jve3va
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