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Structural brain complexity and cognitive decline in late life — A longitudinal study in the Aberdeen 1936 Birth Cohort

Anca-Larisa Sandu, Roger T. Staff, Chris J. McNeil, Nazahah Mustafa, Trevor Ahearn, Lawrence J. Whalley, Alison D. Murray
2014 NeuroImage  
The purpose of this study is to examine changes over a five year period in brain structural complexity in late life, and to investigate cognitive correlates of any changes.  ...  Complexity of white matter is associated with higher fluid cognitive ability and, in a longitudinal study, predicts retention of cognitive ability within late life. 3  ...  Acknowledgement The authors would like to thank to the participants from the Aberdeen 1936 Birth Cohort studies for their voluntary contribution to these projects.  ... 
doi:10.1016/j.neuroimage.2014.06.054 pmid:24993896 fatcat:dlyyeztygfbphlktlpj5vhq6a4

Klotho, APOEε4, cognitive ability, brain size, atrophy, and survival: a study in the Aberdeen Birth Cohort of 1936

Clarisse F. de Vries, Roger T. Staff, Sarah E. Harris, Dorota Chapko, Daniel S. Williams, Polina Reichert, Trevor Ahearn, Christopher J. McNeil, Lawrence J. Whalley, Alison D. Murray
2017 Neurobiology of Aging  
However, its longitudinal effects on cognition and brain volumes, both global and regional, in late life are unclear.  ...  The longitudinal cognitive trajectories indicate that heterozygotes would have an advantage in very late life.  ...  M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT Klotho, APOEε4, cognitive ability, brain size, atrophy and survival  ... 
doi:10.1016/j.neurobiolaging.2017.02.019 pmid:28431289 fatcat:aqazwh23lzfczd33jveequ44qy

Cognitive Test Scores and Progressive Cognitive Decline in the Aberdeen 1921 and 1936 Birth Cohorts

Lawrence J. Whalley, Roger T. Staff, Helen Lemmon, Helen C. Fox, Chris McNeil, Alison D. Murray
2022 Brain Sciences  
The Aberdeen birth cohorts of 1921 and 1936 (ABC21 and ABC36) were subjected to IQ tests in 1932 or 1947 when they were aged about 11y.  ...  They were recruited between 1997–2001 among cognitively healthy community residents and comprehensively phenotyped in a long-term study of brain aging and health up to 2017.  ...  She was much loved by participants and the study team.  ... 
doi:10.3390/brainsci12030318 pmid:35326274 pmcid:PMC8946766 fatcat:gaiv5qsqmve2tgpyx466tw7rna

The balance between cognitive reserve and brain imaging biomarkers of cerebrovascular and Alzheimer's diseases

A. D. Murray, R. T. Staff, C. J. McNeil, S. Salarirad, T. S. Ahearn, N. Mustafa, L. J. Whalley
2011 Brain  
We found that educational attainment, but not occupation, has a measurable and positive effect, with a standardized regression weight of + 0.23, on late life cognitive ability in people without cognitive  ...  The effect of these measures of brain burden on life-long cognitive ageing from the age of 11 to 68 years was compared with the effect of educational attainment and occupational grade using structural  ...  The authors would like to thank the participants of the Aberdeen 1936 Birth Cohort, without whom this research would not have been possible.  ... 
doi:10.1093/brain/awr259 pmid:22102649 fatcat:e26tmfx2gbeerh2d362rxgqf4a

The association between polypharmacy and late life deficits in cognitive, physical and emotional capability: a cohort study

Mina Khezrian, Christopher J. McNeil, Phyo K. Myint, Alison D. Murray
2018 International Journal of Clinical Pharmacy  
Setting The Aberdeen 1936 Birth Cohort from 1999 to 2004. Method Recruited were 498 dementia free participants around 64 years old and recruited into wave one.  ...  A triad of impairment was defined as a composite measure of impairment in cognitive, physical and emotional function.  ...  Acknowledgements We thank the participants of the Aberdeen Birth Cohort of 1936. Conflicts of interest The authors declare that they have no conflicts of interest.  ... 
doi:10.1007/s11096-018-0761-2 pmid:30499028 fatcat:acyh6e7kqvgc7dxygjvium6gku

Early Life Socioeconomic Circumstance and Late Life Brain Hyperintensities – A Population Based Cohort Study

Alison D. Murray, Christopher J. McNeil, Sima Salarirad, Lawrence J. Whalley, Roger T. Staff, Sonia Brucki
2014 PLoS ONE  
Design: Cohort study Setting: Community Participants: 227 community dwelling members of the 1936 Aberdeen Birth Cohort aged 68 years, who were free from dementia.  ...  Hyperintensities on brain magnetic resonance imaging are associated with vascular risk factors, cognitive decline, dementia and death.  ...  Acknowledgments The authors would like to thank the participants of the Aberdeen 1936 Birth Cohort (ABC36), without whom this research would not have been possible.  ... 
doi:10.1371/journal.pone.0088969 pmid:24558456 pmcid:PMC3928340 fatcat:d6t3guflwveynjoyxazxxpphvi

Healthy cognitive ageing in the Lothian Birth Cohort studies: marginal gains not magic bullet

J. Corley, S. R. Cox, I. J. Deary
2017 Psychological Medicine  
The Lothian Birth Cohorts of 1921 (LBC1921, n = 550) and 1936 (LBC1936, n = 1091) are longitudinal studies of cognitive and brain ageing based in Scotland.  ...  about and promote a multivariate recipe for healthy cognitive and brain ageing.  ...  Other SMS follow-up studies were conducted in Aberdeen, known as the Aberdeen Birth Cohort of 1921 (ABC1921) and 1936 (ABC1936) Whalley et al. 2011) .  ... 
doi:10.1017/s0033291717001489 pmid:28595670 fatcat:sltmdmvlvja3taz4m66vf7kiga

The Impact of Childhood Intelligence on Later Life: Following Up the Scottish Mental Surveys of 1932 and 1947

Ian J. Deary, Martha C. Whiteman, John M. Starr, Lawrence J. Whalley, Helen C. Fox
2004 Journal of Personality and Social Psychology  
This research, using the surveys' data, examined (a) the stability of intelligence differences across the life span, (b) the determinants of cognitive change from childhood to old age, and (c) the impact  ...  The Scottish Mental Surveys of 1932 and 1947 collected valid IQ-type test scores for almost everyone born in 1921 and 1936 and attending school on June 1, 1932 (N ϭ 89,498) and June 4, 1947 (N ϭ 70,805  ...  The Aberdeen Birth Cohorts of 1921 and 1936 provide a rare opportunity to examine this dedifferentiation hypothesis of cognitive aging.  ... 
doi:10.1037/0022-3514.86.1.130 pmid:14717632 fatcat:7nawhj7qdfhejg3jzfcijbgw7a

Solvent exposure and cognitive ability at age 67: a follow-up study of the 1947 Scottish Mental Survey

F. D. Dick, V. J. Bourne, S. E. Semple, H. C. Fox, B. G. Miller, I. J. Deary, L. J. Whalley
2009 Occupational and Environmental Medicine  
67: a follow-up study of the 1947 Scottish Solvent exposure and cognitive ability at age Updated information and services can be found at: These include: References  ...  We acknowledge the contribution of Jen Herbert who recruited most of the subjects and Nachaat Tahmaz who assessed some of the work histories.  ...  Acknowledgements We gratefully acknowledge the assistance of local community physicians with subject recruitment.  ... 
doi:10.1136/oem.2009.047977 pmid:19910296 fatcat:7sx63wqz3bepze3kwkreqb6zeq

A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing

G Davies, S E Harris, C A Reynolds, A Payton, H M Knight, D C Liewald, L M Lopez, M Luciano, A J Gow, J Corley, R Henderson, C Murray (+23 others)
2012 Molecular Psychiatry  
Cognitive decline is a feared aspect of growing old. It is a major contributor to lower quality of life and loss of independence in old age.  ...  Imputation and conditional analyses in the discovery and replication cohorts strongly suggest that this effect is due to APOE (rs429358).  ...  ACKNOWLEDGEMENTS We thank the cohort participants who contributed to these studies. We thank Martha Pollard for Lothian Birth Cohort 1921 data collection.  ... 
doi:10.1038/mp.2012.159 pmid:23207651 pmcid:PMC7321835 fatcat:oftwpgj5mza2ne5mcg47nk6mdy

Abstracts of the UK Molecular Epidemiology Group Winter Meeting on The Ageing World: employing molecular epidemiology to advance lifelong health. Newcastle University, Research Beehive, Newcastle upon Tyne, UK. December 1, 2015

2016 Mutagenesis  
Hypertension predicts the accumulation of vascular pathologies in the brain and cognition in late life. Hypertension variability predicts hippocampus size in late life.  ...  Early life socioeconomic position influences the accumulation of late life vascular pathologies in the brain.  ...  A higher level of spermatozoa DNA alkylation, in the form of N7-methylguanine, has been associated with infertile males and suggests DNA alkylation could be a significant contributor to male infertility  ... 
doi:10.1093/mutage/gew004 fatcat:txlde2kf5jgojbehkknlsrdlyu

Inter-individual Differences in fMRI Entropy Measurements in Old Age

M. O. Sokunbi, R. T. Staff, G. D. Waiter, T. S. Ahearn, H. C. Fox, I. J. Deary, J. M. Starr, L. J. Whalley, A. D. Murray
2011 IEEE Transactions on Biomedical Engineering  
from 40 participants of the Aberdeen Birth Cohort 1936 (ABC1936) while undergoing a visual information processing task: inspection time (IT).  ...  We investigated the association between individual differences in cognitive performance in old age and the approximate entropy (ApEn) measured from functional magnetic resonance imaging (fMRI) data acquired  ...  About age 64, survivors were recruited to a longitudinal study of health and cognitive ageing, the Aberdeen Birth Cohort 1936 (ABC1936).  ... 
doi:10.1109/tbme.2011.2164793 pmid:21859598 fatcat:5tlk45odszd6tk4xlr3mj7pmjq

Neurogenetic effects on cognition in aging brains: a window of opportunity for intervention?

Ivar Reinvang
2010 Frontiers in Aging Neuroscience  
changes in brain structure and cognition.  ...  Progress in understanding the neural basis of cognitive aging also requires a better understanding of the neurogenetics of cognition.  ...  Birth Cohort 1936.  ... 
doi:10.3389/fnagi.2010.00143 pmid:21103005 pmcid:PMC2987509 fatcat:hp6um7dqpfawxkzsoiipye734u

Is retaining the youthful functional anatomy underlying speed of information processing a signature of successful cognitive ageing? An event-related fMRI study of inspection time performance

Gordon D. Waiter, Helen C. Fox, Alison D. Murray, John M. Starr, Roger T. Staff, Victoria J. Bourne, Lawrence J. Whalley, Ian J. Deary
2008 NeuroImage  
The functional anatomy of inspection time: an event-related fMRI study. NeuroImage 22, 1466NeuroImage 22, -1479. The group of cognitive decliners lacked these clear neural networks.  ...  cognitive decliners' (n = 15).  ...  Earlier waves (1 and 2) of data collection on the Aberdeen Birth Cohort 1936 mentioned here were supported, respectively, by the UK's Biotechnology and Biological Sciences Research Council and the Wellcome  ... 
doi:10.1016/j.neuroimage.2008.02.045 pmid:18395472 fatcat:dj2vnqm6bfbd5nvc3dt4omfgsm

Complex Variation in Measures of General Intelligence and Cognitive Change

Suzanne J. Rowe, Amy Rowlatt, Gail Davies, Sarah E. Harris, David J. Porteous, David C. Liewald, Geraldine McNeill, John M. Starr, Ian J. Deary, Albert Tenesa, Huiping Zhang
2013 PLoS ONE  
Measures of crystallised (g c ) and fluid intelligence (g f ) in late adulthood (64-79 years) were available for 1806 individuals genotyped for 549,692 autosomal single nucleotide polymorphisms (SNPs).  ...  of these uniquely informative cohorts.  ...  Acknowledgments We thank the cohort participants who contributed to these studies.  ... 
doi:10.1371/journal.pone.0081189 pmid:24349040 pmcid:PMC3865348 fatcat:kbvqvks3eng4le4qytp3k6rtci
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