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Anatomy Based Networks and Topology Alteration in Seizure-Related Cognitive Outcomes

Qian Wu, Charlie W. Zhao, Zhe Long, Bo Xiao, Li Feng
2018 Frontiers in Neuroanatomy  
In this review article, we survey structural, network changes and topological alteration in different regions of the brain and in different epilepsy and epileptic syndromes, and discuss what these changes  ...  Damage to these structures and their substructures results in worsening of epilepsy symptoms and cognitive dysfunction.  ...  transcranial magnetic stimulation SMA Supplemental motor area STP Short term potentiation TLE Temporal lobe epilepsy WM White matter TABLE 2 | 2 Structural and functional anatomic changes  ... 
doi:10.3389/fnana.2018.00025 pmid:29681801 pmcid:PMC5898178 fatcat:a7lzlw3qhfgktalrl2pntv3yb4

Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction

Ethan M. Goldberg, Douglas A. Coulter
2013 Nature Reviews Neuroscience  
Recent work has yielded important conceptual advances in this field. We suggest that such insights into the mechanisms of epileptogenesis converge at the level of cortical circuit dysfunction.  ...  The process that links brain injury or other predisposing factors to the subsequent emergence of epilepsy is termed epileptogenesis.  ...  predisposition of temporal lobe structures to epileptogenesis 132, 133 .  ... 
doi:10.1038/nrn3482 pmid:23595016 pmcid:PMC3982383 fatcat:krfnkeu5hfcz5ncdpk4qov5mfu

A perfect storm: Converging paths of epilepsy and Alzheimer's dementia intersect in the hippocampal formation

Jeffrey Noebels
2011 Epilepsia  
in validated mouse models of AD implicates a new level of circuit-based pathophysiology that could lead to the appearance of epilepsy and further aggravate memory loss.  ...  Co-morbid conditions such as epilepsy that interfere with memory formation and retrieval in the temporal lobe further complicate the goal of preserving normal cognition.  ...  Acknowledgments The author would like to thank the NIH and the Blue Bird Circle Foundation for generous support.  ... 
doi:10.1111/j.1528-1167.2010.02909.x pmid:21214538 pmcid:PMC3058398 fatcat:tbmfqn4pprcibeamhgeyvybbhm

Metabotropic Glutamate Receptors and Interacting Proteins in Epileptogenesis

Feng Qian, Feng-Ru Tang
2016 Current Neuropharmacology  
In this paper, we reviewed metabotropic glutamate receptors (mGluRs) and their related signal transduction pathways or interacting proteins in status epilepticus and temporal lobe epilepsy, and proposed  ...  some novel therapeutical drug targets for controlling epilepsy and epileptogenesis.  ...  Temporal lobe epilepsy associated up-regulation of metabotropic glutamate receptors: correlated changes in mGluR1 mRNA and protein expression in experimental animals and human patients. J.  ... 
doi:10.2174/1570159x14666160331142228 pmid:27030135 pmcid:PMC4983745 fatcat:wqwmvarw6zfazlhi7vgyckfk3i

Contributions of Adult-Generated Granule Cells to Hippocampal Pathology in Temporal Lobe Epilepsy: A Neuronal Bestiary

Steve C. Danzer, Bryan W. Luikart
2018 Brain Plasticity  
During the development of temporal lobe epilepsy, newly-generated hippocampal granule cells integrate abnormally into the brain.  ...  Changes in granule cell position and dendritic structure fundamentally alter the types of inputs these cells are able to receive, as well as the relative proportions of remaining inputs.  ...  Conclusions Here, we reviewed the key somatic and dendritic abnormalities exhibited by newly-generated hippocampal granule cells in models of temporal lobe epilepsy.  ... 
doi:10.3233/bpl-170056 pmid:30151341 pmcid:PMC6091048 fatcat:nakkjz73u5amjioxll43nbclfy

Pathological Targets for Treating Temporal Lobe Epilepsy: Discoveries From Microscale to Macroscale

Jing You, Haiyan Huang, Clement T. Y. Chan, Lin Li
2022 Frontiers in Neurology  
Temporal lobe epilepsy (TLE) is one of the most common and severe types of epilepsy, characterized by intractable, recurrent, and pharmacoresistant seizures.  ...  new potential targets in the diagnosis and treatment of TLE.  ...  In the intrahippocampal kainic acid model of mesial temporal lobe epilepsy (mTLE) (21) , hippocampal neuronal loss and fiber sprouting play a critical role in the temporal lobe epileptogenesis.  ... 
doi:10.3389/fneur.2021.779558 pmid:35069411 pmcid:PMC8777077 fatcat:s5o3lqdqs5gn3h4bfc76lyuoli

MRI changes and complement activation correlate with epileptogenicity in a mouse model of temporal lobe epilepsy

Irina Kharatishvili, Zuyao Y. Shan, David T. She, Samuel Foong, Nyoman D. Kurniawan, David C. Reutens
2013 Brain Structure and Function  
of figures: 9 The number of tables: 2 1 Abstract The complex pathogenesis of temporal lobe epilepsy (TLE) includes neuronal and glial pathology, synaptic reorganization and an immune response.  ...  However, the spatio-temporal pattern of structural changes in the brain that provide a substrate for seizure generation and modulate the seizure phenotype is yet to be completely elucidated.  ...  Acknowledgments We would like to thank the National Imaging Facility (NIF) and the Queensland NMR Network  ... 
doi:10.1007/s00429-013-0528-4 pmid:23474541 fatcat:argg7bobpfhtbcnrigaoaot7h4

Expressional analysis of the astrocytic Kir4.1 channel in a pilocarpine–induced temporal lobe epilepsy model

Yuki Nagao, Yuya Harada, Takahiro Mukai, Saki Shimizu, Aoi Okuda, Megumi Fujimoto, Asuka Ono, Yoshihisa Sakagami, Yukihiro Ohno
2013 Frontiers in Cellular Neuroscience  
Here, we performed expressional analysis of Kir4.1 in a pilocarpine-induced rat model of temporal lobe epilepsy (TLE) to explore the role of Kir4.1 channels in modifying TLE epileptogenesis.  ...  Recent studies have shown that loss-of-function mutations in the human gene KCNJ10 encoding Kir4.1 cause epileptic seizures, suggesting a close relationship between the Kir4.1 channel function and epileptogenesis  ...  ACKNOWLEDGMENTS This work was partly supported by a Grant in Aid for Scientific Research (22590092) from the Ministry of Education, Science, Sports and Culture of Japan and a research grant from the Japan  ... 
doi:10.3389/fncel.2013.00104 pmid:23922547 pmcid:PMC3734973 fatcat:jmm7rf7xvffa7kd3u743fx3u7a

Drug Resistant Epilepsy and the hypothesis of intrinsic severity: What about the High‐Frequency Oscillations?

Cesar E. Santana‐Gomez, Jerome Engel, Richard Staba
2021 Epilepsia Open  
Understanding the mechanisms of DRE is critical for producing breakthroughs in the development and testing of novel strategies for treatment.  ...  Based on experimental findings from animal models and brain tissue from patients with DRE, different hypotheses have been proposed to explain the cause(s) of drug resistance.  ...  Large-scale 3-5 Hz oscillation constrains the expression of neocortical fast ripples in a mouse model of Mesial temporal lobe epilepsy. eNeuro. 2019;6(1):1-13. 66.  ... 
doi:10.1002/epi4.12565 pmid:34861102 pmcid:PMC9340307 fatcat:w5olfyvsyja5vh4muxlhthw6ri

Astrocyte Role in Temporal Lobe Epilepsy and Development of Mossy Fiber Sprouting

Carolyn Twible, Rober Abdo, Qi Zhang
2021 Frontiers in Cellular Neuroscience  
Epilepsy affects approximately 50 million people worldwide, with 60% of adult epilepsies presenting an onset of focal origin. The most common focal epilepsy is temporal lobe epilepsy (TLE).  ...  The role of astrocytes in the presentation and development of TLE has been increasingly studied and discussed within the literature.  ...  A., and Amaral, D. G. (2004). Functional neuroanatomy of the medial temporal lobe memory system.  ... 
doi:10.3389/fncel.2021.725693 pmid:34658792 pmcid:PMC8514632 fatcat:k4koeann5ndc3j5vii3bdu4qpq

Is Mossy Fiber Sprouting a Potential Therapeutic Target for Epilepsy?

Clarissa F. Cavarsan, Jackeline Malheiros, Clement Hamani, Imad Najm, Luciene Covolan
2018 Frontiers in Neurology  
recurrent seizures in models of TLE (temporal lobe epilepsy).  ...  Mesial temporal lobe epilepsy (MTLE) caused by hippocampal sclerosis is one of the most frequent focal epilepsies in adults.  ...  ACKNOWLEDGMENTS The authors would like to thank Katharina Quinlan (University of Rhode Island) for her assistance proof reading the article. This work was supported by CNPq (200970/2015-1) (Brazil).  ... 
doi:10.3389/fneur.2018.01023 pmid:30555406 pmcid:PMC6284045 fatcat:wxscazykkzf4pd6jrvagyjumpi

Curing epilepsy: Progress and future directions

Margaret P. Jacobs, Gabrielle G. Leblanc, Amy Brooks-Kayal, Frances E. Jensen, Dan H. Lowenstein, Jeffrey L. Noebels, Dennis D. Spencer, John W. Swann
2009 Epilepsy & Behavior  
During the past decade, substantial progress has been made in delineating clinical features of the epilepsies and the basic mechanisms responsible for these disorders.  ...  Eleven human epilepsy genes have been identified and many more are now known from animal models.  ...  Imaging has revealed acute alterations that may be associated with later risk of temporal lobe epilepsy, including abnormal hippocampal T2 signals on MRI (at 72 hours post-seizure) and medial temporal  ... 
doi:10.1016/j.yebeh.2009.02.036 pmid:19341977 pmcid:PMC2822433 fatcat:hwp7c4m5nzetdgm4vlxjcds6ou

Pten-less Dentate Granule Cells Make Fits

Alison L. Althaus, Jack M. Parent
2012 Neuron  
Seizure initiation and spread in temporal lobe epilepsy (TLE), one of the most common and intractable epilepsies in adolescents and adults, is thought to involve medial temporal structures, such as the  ...  in the ability of seizure-like activity to spread easily (B) In rodent TLE models, DGCs developing during or after epileptogenic insults display multiple structural abnormalities.  ...  Asleep at the Switch: MEK Kinases Control Transit to Gliogenesis in Developing Cortex Jing Zhou 1 and Charles D. Stiles 1, *  ... 
doi:10.1016/j.neuron.2012.09.008 pmid:22998860 fatcat:qbam7np3gbbgvemhgmpi2pt6ba

Disrupted hippocampal network physiology following PTEN deletion from newborn dentate granule cells

Candi L. LaSarge, Raymund Y.K. Pun, Michael B. Muntifering, Steve C. Danzer
2016 Neurobiology of Disease  
Abnormal hippocampal granule cells are present in patients with temporal lobe epilepsy, and are a prominent feature of most animal models of the disease.  ...  other models of temporal lobe epilepsy.  ...  Acknowledgments This work was supported by the National Institute of Neurological Disorders and Stroke (SCD, Awards R01NS065020 and R01NS062806; CLL, F32NS083239).  ... 
doi:10.1016/j.nbd.2016.09.004 pmid:27597527 pmcid:PMC5102799 fatcat:y34uikurijgaflb3yswg7ljtf4

Managing epilepsy by modulating glia

Medine Gülçebi İdrizoğlu, Nihan Carcak, Filiz Yılmaz Onat
2016 Anatomy (International Journal of Experimental and Clinical Anatomy)  
The understanding of links between astrocyte functions and neuronal signaling in epileptogenesis will be one of the top epilepsy research advances in the future.  ...  This review underlies the participation of reactive astrocytes, glia modulating approaches and the roles of inflammatory cytokines in the modulation of convulsive and non-convulsive forms of epilepsy.  ...  Acknowledgements This study was supported by The Scientific and Technological Research Council of Turkey (TUBITAK), Project No: 111S209 and Marmara University Research Council.  ... 
doi:10.2399/ana.15.041 fatcat:rqcpynw4hvdkhfgfwsfnsvbf7q
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