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Structural and Functional MRI Evidence for Distinct Medial Temporal and Prefrontal Roles in Context-dependent Relational Memory

Hillary Schwarb, Curtis L. Johnson, Michael R. Dulas, Matthew D. J. McGarry, Joseph L. Holtrop, Patrick D. Watson, Jane X. Wang, Joel L. Voss, Brad Sutton, Neal J. Cohen
2019 Journal of Cognitive Neuroscience  
Here, we present data from a context-dependent relational memory task in which participants learned that individuals belonged in a single room in each of two buildings.  ...  Declarative memory is supported by distributed brain networks in which the medial-temporal lobes (MTLs) and pFC serve as important hubs.  ...  NIH/NIMH grant R01-MH062500 and Silvio O. Conte Center Award MH094263 provided partial support for the work presented in Experiment 2.  ... 
doi:10.1162/jocn_a_01454 pmid:31393232 pmcid:PMC7028347 fatcat:h2vgo34b2bepji2gtduwrdvj6i

Page 3683 of Psychological Abstracts Vol. 87, Issue 10 [page]

2000 Psychological Abstracts  
The most general and distinctive function of the dorsolateral prefrontal cortex is the temporal organization of goal-directed actions.  ...  The dorsolat- eral prefrontal cortex interacts with other cortical and subcortical structures in those 2 time-bridging functions at the basis of the temporal organization of behavior. 28843.  ... 

Neural Response during Preference and Memory Judgments for Subliminally Presented Stimuli: A Functional Neuroimaging Study

Rebecca Elliott, Raymond J. Dolan
1998 Journal of Neuroscience  
Memory judgments were associated with activation of left frontopolar cortex and parietal areas, whereas preference judgments were associated with activation of medial prefrontal cortex and regions of occipital  ...  Dissociable activations within this system implicate a frontopolar involvement in explicit retrieval attempt and right lateral prefrontal cortex involvement in implicit memory expressed in preference judgments  ...  Furthermore, we predicted a role for medial temporal lobe structures in response to stimulus novelty (Dolan and Fletcher, 1997) . MATERIALS AND METHODS Subjects.  ... 
doi:10.1523/jneurosci.18-12-04697.1998 pmid:9614244 pmcid:PMC6792681 fatcat:jlje57x2zfhnvay2zwuokcu4mm

Frontal cortex contributes to human memory formation

Randy L. Buckner, William M. Kelley, Steven E. Petersen
1999 Nature Neuroscience  
These results, taken in the context of other studies, suggest that memory formation depends on joint participation of frontal and medial temporal lobe structures.  ...  311 Primate models of memory and multiple lines of evidence from neuropsychology suggest that medial temporal lobe brain structures are essential for memory formation.  ...  These results, taken in the context of other studies, suggest that memory formation depends on joint participation of frontal and medial temporal lobe structures.  ... 
doi:10.1038/7221 pmid:10204536 fatcat:iov6thx2bzc3vhpwkzcu6xasdu

The Episodic Memory System: Neurocircuitry and Disorders

Bradford C Dickerson, Howard Eichenbaum
2009 Neuropsychopharmacology  
A growing body of evidence is converging on a functional organization of the cortical, subcortical, and MTL structures that support the fundamental features of episodic memory in humans and animals.  ...  Structures within the MTL, and particularly the hippocampus, have distinct functions in combining information from multiple cortical streams, supporting our ability to encode and retrieve details of events  ...  ACKNOWLEDGEMENTS This work was generously supported by the National Institute on Aging (R01-AG29411, R21-AG29840) and the Alzheimer's Association.  ... 
doi:10.1038/npp.2009.126 pmid:19776728 pmcid:PMC2882963 fatcat:z6qkg2igg5aj3nxv5of6dca6qe

Influence of functional connectivity and structural MRI measures on episodic memory

Jing He, Owen Carmichael, Evan Fletcher, Baljeet Singh, Ana-Maria Iosif, Oliver Martinez, Bruce Reed, Andy Yonelinas, Charles DeCarli
2012 Neurobiology of Aging  
Age-related memory decline is the consequence of multiple biological factors that lead to brain structural and functional change, including gray matter atrophy, white matter injury, and loss of functional  ...  We found that GM, WMH, and connectivity between left inferior parietal and medial prefrontal cortex (MPF_LIP) were independently associated with episodic memory performance.  ...  While activity in these regions tends to increase during memory task performance, activity in an additional set of brain regions in the prefrontal, parietal, precuneus, posterior cingulate, and medial  ... 
doi:10.1016/j.neurobiolaging.2011.12.029 pmid:22285758 pmcid:PMC3353006 fatcat:neefixloujhjtj5dunw4zm4g3a

Epistatic interactions of AKT1 on human medial temporal lobe biology and pharmacogenetic implications

H Y Tan, A G Chen, Q Chen, L B Browne, B Verchinski, B Kolachana, F Zhang, J Apud, J H Callicott, V S Mattay, D R Weinberger
2011 Molecular Psychiatry  
Here, we report that an AKT1 variant (rs1130233) previously associated with AKT1 protein expression, prefrontal function and schizophrenia, affects human MTL structure and memory function.  ...  AKT1 controls important processes in medial temporal lobe (MTL) development and plasticity, but the impact of human genetic variation in AKT1 on these processes is not known in healthy or disease states  ...  and associated prefrontal structure and function. 11, 12 Aberrant development and plasticity of the medial temporal lobe (MTL) is also critically implicated in schizophrenia and may involve genes controlling  ... 
doi:10.1038/mp.2011.91 pmid:21788944 pmcid:PMC3449232 fatcat:4ppo5245nvdubmm22mhdjh7htu

The default network and self-generated thought: component processes, dynamic control, and clinical relevance

Jessica R. Andrews-Hanna, Jonathan Smallwood, R. Nathan Spreng
2014 Annals of the New York Academy of Sciences  
Because of this task-related variability, we instead define the DN on the basis of its patterns of temporal correlations using resting-state functional connectivity (RSFC) MRI. 14,51,242 In a comprehensive  ...  A growing theme highlights the DN as playing a key role in internally directed or self-generated thought.  ...  Acknowledgments The authors wish to thank several people for providing helpful discussion or feedback on prior versions of the manuscript: Randy  ... 
doi:10.1111/nyas.12360 pmid:24502540 pmcid:PMC4039623 fatcat:4xqbqbqecrcmnify34575jdz4a

Thalamo-Cortical Disruption Contributes to Short-Term Memory Deficits in Patients with Medial Temporal Lobe Damage

Natalie L. Voets, Ricarda A. L. Menke, Saad Jbabdi, Masud Husain, Richard Stacey, Katherine Carpenter, Jane E. Adcock
2015 Cerebral Cortex  
Short-term (STM) and long-term memory (LTM) have largely been considered as separate brain systems reflecting frontoparietal and medial temporal lobe (MTL) functions, respectively.  ...  Whereas thalamo-temporal functional connectivity reflected LTM performance, thalamo-prefrontal functional connectivity specifically predicted STM performance.  ...  Such evidence for thalamic atrophy raises the possibility that, in the context of MTL injury, altered integrity of thalamic nuclei, and disruption of their associated respective thalamo-cortical functional  ... 
doi:10.1093/cercor/bhv109 pmid:26009613 pmcid:PMC4816801 fatcat:sgrh66tm7bewlopk4uznq7blri

Page 3425 of Psychological Abstracts Vol. 92, Issue 10 [page]

2005 Psychological Abstracts  
the role of medial temporal lobe (MTL) structures in mem- ory and perception’’.  ...  of MTL structures in memory and perception. 28461.  ... 

Page 525 of Journal of Cognitive Neuroscience Vol. 22, Issue 3 [page]

2010 Journal of Cognitive Neuroscience  
Prefrontal cortex and recognition memory. Functional-MRI evidence for context-dependent retrieval processes. Brain, 121, 1985-2002. Wagner, A. D., Maril, A., Bjork, R. A., & Schacter, D. L. (2001).  ...  Prefrontal contributions to executive control: fMRI evidence for functional distinctions within lateral prefrontal cortex. Neuroimage, 14, 1337-1347.  ... 

The Regulatory Role of the Human Mediodorsal Thalamus

Giulio Pergola, Lola Danet, Anne-Lise Pitel, Giovanni A. Carlesimo, Shailendra Segobin, Jérémie Pariente, Boris Suchan, Anna S. Mitchell, Emmanuel J. Barbeau
2018 Trends in Cognitive Sciences  
Recent studies emphasize its function in many cognitive tasks related to the prefrontal cortex.  ...  Although it was at first proposed to play a role in long-term memory, a set of recent studies in animals and humans has revealed a more complex, and broader, role in several cognitive functions.  ...  its relation with the medial temporal lobes.  ... 
doi:10.1016/j.tics.2018.08.006 pmid:30236489 pmcid:PMC6198112 fatcat:zijb7iozcvb63bkwtjdipdudpy

Hippocampal function, declarative memory, and schizophrenia: Anatomic and functional neuroimaging considerations

Alison R. Preston, Daphna Shohamy, Carol A. Tamminga, Anthony D. Wagner
2005 Current Neurology and Neuroscience Reports  
At the neurobiologic level, it is well established that the hippocampus and surrounding medial temporal lobe (MTL) cortices play an essential role in declarative memory (ie, long-term memory for general  ...  The presence of declarative memory impairments and correlated abnormalities in hippocampal function as revealed by functional neuroimaging suggest a clear role for the hippocampus and surrounding MTL structures  ... 
doi:10.1007/s11910-005-0067-3 pmid:15987607 fatcat:vgfwspnotvehtpiedxrotd2isq

Effect of handedness on fMRI activation in the medial temporal lobe during an auditory verbal memory task

Jennifer L. Cuzzocreo, Michael A. Yassa, Guillermo Verduzco, Nancy A. Honeycutt, David J. Scott, Susan Spear Bassett
2009 Human Brain Mapping  
We used a paired-associates verbal memory task to elicit activation of neural areas related to declarative memory, examining the hypothesis that there are differences in activation in the medial temporal  ...  Functional and structural imaging data were acquired and analyzed for group differences within MTL subregions.  ...  It has been established that medial temporal lobe structures as well as prefrontal cortical structures play an essential role in declarative memory processes [Cohen and Eichenbaum, 1993; Gabrieli et al  ... 
doi:10.1002/hbm.20596 pmid:18570207 pmcid:PMC2672821 fatcat:s5m6xhggwzajvmrirlyy7pvpu4

Cognitive neuroscience of episodic memory encoding

Randy L Buckner, Jessica Logan, David I Donaldson, Mark E Wheeler
2000 Acta Psychologica  
Convergent evidence from multiple brain imaging studies using positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) suggests a role for frontal cortex in episodic memory encoding  ...  Activity levels within speci®c frontal and medial temporal regions can even predict, on an item by item basis, whether an episodic memory is likely to form.  ...  Acknowledgements We thank Laura Williams for help in preparing this manuscript.  ... 
doi:10.1016/s0001-6918(00)00057-3 pmid:11194408 fatcat:lb5wq567zbhanovvw36ymv2ycm
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