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Toc64 is not required for import of proteins into chloroplasts in the moss Physcomitrella patens

Nancy Rosenbaum Hofmann, Steven M. Theg
2005 The Plant Journal  
To address this, we generated knockout mutants in the moss Physcomitrella patens using the moss's ability to perform homologous recombination with nuclear DNA.  ...  Isolation of DNA and RNA from moss plants; PCR to check targeting Genomic DNA was isolated from moss plants as described (Cove and Knight, 1999) .  ...  To confirm that Toc64 protein was located in moss chloroplasts, we generated an antibody that should react with both moss proteins (see Experimental procedures).  ... 
doi:10.1111/j.1365-313x.2005.02483.x pmid:16115065 fatcat:mnv6sog2zvf6bipie53dpg6wxu

Emerging vaccines: evidence and considerations for practice integration

Steven M Moss
2007 Canadian Family Physician  
FP Watch Surveillance médicale Emerging vaccines Evidence and considerations for practice integration Steven M. Moss MD FRCPC FAAP N ew vaccines are available to your patients.  ...  Dr Moss is a community pediatrician at North York General Hospital, an emergency physician at the Hospital for Sick Children, the Chair of the Evidence Based Practice Committee of the Child Health Network  ... 
pmid:18077758 pmcid:PMC2231559 fatcat:mzoqvblglbdotaitzxys7h7xmu

Renal Palliative Care

Lewis M. Cohen, Alvin H. Moss, Steven D. Weisbord, Michael J. Germain
2006 Journal of Palliative Medicine  
doi:10.1089/jpm.2006.9.977 pmid:16910813 fatcat:4oybkfshorc3bipzyza77n6owe

The Bioinformatics Template Library--generic components for biocomputing

W. R. Pitt, M. A. Williams, M. Steven, B. Sweeney, A. J. Bleasby, D. S. Moss
2001 Bioinformatics  
firstPDBFile secondPDBFile" << endl; exit(1); } // Create objects to represent each structure using one of the file processor classes from the BTL // Read information from PDB files (reading only chains M  ... 
doi:10.1093/bioinformatics/17.8.729 pmid:11524374 fatcat:6d4yqyy74rctjlblugagwmylmu

Understanding the U.S. Bioeconomy: A New Definition and Landscape

George B. Frisvold, Steven M. Moss, Andrea Hodgson, Mary E. Maxon
2021 Sustainability  
This article provides an overview of the U.S. bioeconomy, discussing how its definition has evolved and been formalized over time. The first attempts to conceptualize and define the U.S. bioeconomy began in the early 1990s. This was followed by a series of government and private efforts to develop methods to understand and evaluate it and to develop programs to promote it. These efforts culminated in the 2020 release of the National Academies of Science, Engineering, and Medicine (NASEM),
more » ... arding the Bioeconomy report. The report recommended a formal definition of the U.S. bioeconomy, providing the rationale for that particular definition in the U.S. context. Formally adopting a comprehensive definition of the U.S. bioeconomy would enable the U.S. government to better assess the bioeconomy's current state, to develop strategies to support its growth, and to promote strategies to safeguard it. Along with this recommendation, the NASEM Safeguarding report also discussed defining the "bioeconomy landscape," which involves more precise determination and quantification of which economic activities are part of and external to the U.S. economy. Defining this landscape could guide metric development and data collection needed to track the bioeconomy's growth, conduct economic assessments, and enable policy makers to keep abreast of advances that could potentially pose new national or economic security challenges. The report also includes an analysis of the broad range national bioeconomy strategies, identification of the four drivers of the U.S. bioeconomy, and the first of its kind, comprehensive estimate of the size and scope of the U.S. bioeconomy of USD 959B (valued in 2016 constant USD ).
doi:10.3390/su13041627 fatcat:3eluyumstnfotesbqorkwcpnr4

Ischemic Optic Neuropathy in Cardiac Surgery

Daniel S. Rubin, Monica M. Matsumoto, Heather E. Moss, Charlotte E. Joslin, Avery Tung, Steven Roth
2017 Anesthesiology  
Moss, Core Grant P30 EY001792 to the Department of Ophthalmology and Visual Sciences of the University of Illinois, the University of Chicago Pritzker School of Medicine Summer Research Program (Ms.  ... 
doi:10.1097/aln.0000000000001533 pmid:28244936 pmcid:PMC5395417 fatcat:75q3nlq7cjbwlchxuvggqf5mfq

Male rutting calls synchronize reproduction in Serengeti wildebeest

Justin M. Calabrese, Allison Moss Clay, Richard D. Estes, Katerina V. Thompson, Steven L. Monfort
2018 Scientific Reports  
The cows were initially held in a 30 × 60 m boma that was contained within a large 500 × 500 m (25 ha) fenced enclosure.  ...  To do this, we note that the calving (birth) time B is a random variable defined as = + B M G (2) where M and G are the time to mating and the gestation duration, respectively.  ... 
doi:10.1038/s41598-018-28307-y pmid:29976996 pmcid:PMC6033926 fatcat:l2xdqgm2ofaehhetdjqdmfffqa

Chemical Synthesis and Self-Assembly of a Ladderane Phospholipid

Jaron A. M. Mercer, Carolyn M. Cohen, Steven R. Shuken, Anna M. Wagner, Myles W. Smith, Frank R. Moss, Matthew D. Smith, Riku Vahala, Alejandro Gonzalez-Martinez, Steven G. Boxer, Noah Z. Burns
2016 Journal of the American Chemical Society  
Moss III, Matthew D. Smith, Riku Vahala, Alejandro Gonzalez- Martinez,* Steven G. Boxer,* and Noah Z.  ...  M. Mercer, Carolyn M. Cohen, Steven R. Shuken, Anna M. Wagner, Myles W. 1974, 96, 1137− 1144.  ...  The flask was purged with argon, and the solids were taken up in toluene (3.3 mL, 0.17 M, degassed with N 2 ) and water (1.12 mL, 0.5 M).  ... 
doi:10.1021/jacs.6b10706 pmid:27960308 pmcid:PMC5279923 fatcat:gohqlzptsnbs3jutl6jiv4pepu

GERD 2003 – A Consensus on the Way Ahead

Steven F. Moss, David Armstrong, Rudi Arnold, Peter Ferenci, Kwong M. Fock, Gerald Holtmann, Denis M. McCarthy, Joaquim P. Moraes-Filho, Ernst Mutschler, Raymond Playford, Stuart J. Spechler, Vincenzo Stanghellini (+1 others)
2003 Digestion  
Digestion 2003;67:111-117 Digestion 2003;67:111-117 Moss et al. Digestion 2003;67:111-117 Moss et al.  ... 
doi:10.1159/000071290 pmid:12853722 fatcat:6svqti62vffnvnbede74bcwqay

Maternal Periodontal Disease is Associated with Oxidative Stress during Pregnancy

M. Hickman, Kim Boggess, Kevin Moss, James Beck, Steven Offenbacher
2010 American Journal of Perinatology  
We sought to determine if maternal periodontal disease is associated with oxidative stress as measured by serum 8-isoprostane. A secondary analysis was conducted using prospective data from the Oral Conditions and Pregnancy Study. Healthy women enrolled at <26 weeks' gestational age underwent oral examination and serum sampling. Maternal periodontal disease status was categorized as healthy, mild, or moderate to severe by clinical criteria. Maternal serum was analyzed for 8-isoprostane using
more » ... rasensitive enzyme-linked immunosorbent assay. Elevated 8-isoprostane level was defined as ≥75th percentile. Maternal factors associated with elevated 8isoprostane were determined using chi-square or t test. Multivariable logistic regression was used to assess association between elevated 8-isoprostane and maternal factors. Seven hundred ninetyone women had complete data. Median (interquartile) 8-isoprostane serum level was 1806 (16 to 81,870) pg/dL. Using bivariate analysis, maternal age, race, marital status, utilization of public assistance, and mild or moderate to severe periodontal disease were associated with elevated serum 8-isoprostane. Using logistic regression, moderate to severe periodontal disease (adjusted odds ratio 2.9, 95% confidence interval: 1.7 to 5.0) remained significantly associated with an elevated serum 8-isoprostane level. Maternal periodontal disease is associated with oxidative stress during pregnancy. Further study is needed to determine the role of maternal oxidative stress in periodontal disease-associated adverse pregnancy outcomes. Oxidative stress is characterized by a state of imbalance between free radicals and antioxidant defenses. Free radicals are produced endogenously as part of the oxidative burst of phagocyte activation, and they are encountered via exogenous production from sources such as cigarette smoke. When an excess production of reactive oxygen species is formed, oxidative stress ensues. A member of the isoprostane family, 8-isoprostane PGF 2α (8-iso),
doi:10.1055/s-0030-1268706 pmid:21082538 pmcid:PMC4414032 fatcat:pmttnrzxzzfapimuo5bceyu43u

Dynamic Reorganization and Correlation among Lipid Raft Components

Mónica M. Lozano, Jennifer S. Hovis, Frank R. Moss, Steven G. Boxer
2016 Journal of the American Chemical Society  
× 35 and 50 μm × 50 μm.  ...  and 50 μm × 50 μm), oxidized silicon substrates by allowing them to rupture spontaneously and fill in the corralled regions created by the chrome grids.  ... 
doi:10.1021/jacs.6b05540 pmid:27447959 pmcid:PMC5007062 fatcat:cewmq46inrcazlvdklr7ltqgty

Ladderane phospholipids form a densely packed membrane with normal hydrazine and anomalously low proton/hydroxide permeability

Frank R. Moss, Steven R. Shuken, Jaron A. M. Mercer, Carolyn M. Cohen, Thomas M. Weiss, Steven G. Boxer, Noah Z. Burns
2018 Proceedings of the National Academy of Sciences of the United States of America  
(D) The logarithm of pH equilibration t 1/2 and straight-chain PC T m are correlated, while ladderane PCs deviate from this trend. Moss et al.  ...  Moss et al. PNAS | September 11, 2018 | vol. 115 | no. 37 | 9099 CHEMISTRY BIOPHYSICS AND COMPUTATIONAL BIOLOGY Fig. 4. pH equilibration assay.  ...  | www.pnas.org/cgi/doi/10.1073/pnas.1810706115 Moss et al.  ... 
doi:10.1073/pnas.1810706115 pmid:30150407 fatcat:nfnwsx3dnjdiljaohaplcguuu4

Priorities for Improving the Management of Gastroenteropancreatic Neuroendocrine Tumors

Irvin M. Modlin, Steven F. Moss, Daniel C. Chung, Robert T. Jensen, Elizabeth Snyderwine
2008 Journal of the National Cancer Institute  
A National Cancer Institute summit meeting on gastroenteropancreatic neuroendocrine and carcinoid tumors was held in September 2007 to present the currently accepted standards of care for patients with these tumors and to identify areas requiring investigation and development. These tumors are clinically and pathologically heterogeneous, present commonly with obscure symptoms that lead to delays in diagnosis of years, and have an incidence in the United States of 2.5 to 5 cases per 100 000. The
more » ... 5-year survival rates range between 15% and 95%, depending on the site and extent of disease. This report delineates the main conclusions of the meeting, including the best practice diagnosis and treatment strategies for gastropancreatic neuroendocrine tumors, and the identi fication of clinical and scientific areas that are most in need of attention. The most pressing needs were public and physician educa tion, identification of molecular markers for early diagnosis and therapeutic monitoring, improved imaging modalities and molecular prognostication, development of a standardized pathological classification system, and creation of regional centers of expertise with tumor and laboratory data banks. In addition, adequately validated neuroendocrine tumor models and cell lines should be established to investigate the molecular mechanisms involved in the control of their growth and secretion, and to facilitate the development of specific therapies that should be examined in well-designed multicenter studies of defined patient groups.
doi:10.1093/jnci/djn275 pmid:18780869 pmcid:PMC2538549 fatcat:zv2xd7v3hrcg5cs7sb3tjdswga

Gastrointestinal neuroendocrine (carcinoid) tumours: current diagnosis and management

Irvin M Modlin, Steven F Moss, Kjell Oberg, Robert Padbury, Rodney J Hicks, Bjorn I Gustafsson, Nicholas A Wright, Mark Kidd
2010 Medical Journal of Australia  
Irvin M Modlin, Steven F Moss, Kjell Oberg, Robert Padbury, Rodney J Hicks, Bjorn I Gustafsson, Nicholas A Wright and Mark Kidd ,8 This most likely reflects: Gastrointestinal neuroendocrine (carcinoid  ...  Clin Gastroenterol Hepatol 2006; g le -a g en t ch em o th er ap y C o m b in at io n ch em o th er ap y P ep ti d e re ce p to r ra d io th er ap y In te rf er o n (I N F ) ␣ IN F ␣ /h u m an le u ko  ... 
pmid:20618115 fatcat:43hvqiui6fd73oyg6uhoakwj2i

Analysis of Accredited Gastroenterology Fellowship Internet-Available Content: Twenty-Nine Steps Toward a Better Program Website

Jack H. Ruddell, Adam E. M. Eltorai, Mena Bakhit, Arman M. Lateef, Steven F. Moss
2019 Digestive Diseases and Sciences  
To assess publicly available content derived from official websites of accredited gastroenterology fellowship programs, specifically evaluating data pertinent to prospective applicants.
doi:10.1007/s10620-019-05579-6 pmid:30863954 fatcat:ppqz5gt7urccrjerehbadzqbcy
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