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Harri-Augstein, of Self-Organised Learning. 8 Steven J. ... . $79.50 ($108.50, Canada) Steven J. Trierweiler Fay Fransella, executive director of the Centre for Personal Construct Psychology (London, England), is coauthor, with D. ...doi:10.1037/028249 fatcat:zll4zaftmnfgziumzkb24w3bhi
Kellys citrus thrips (Pezothrips kellyanus) (KCT) has recently been identified as the most serious pest affecting citrus production in New Zealand A literature survey was undertaken to determine previous ... Stevens & K. Froud, unpubl. data) . This gradual build-up in the population would indicate that the thrips are mainly breeding on citrus. ... Stevens, unpubl. data) . In spring and early summer it has been observed that there is a predominance of New Zealand flower thrips inhabiting citrus flowers. ...doi:10.30843/nzpp.2001.54.3732 fatcat:h3s6fm4uonfrtl4qyv2rugkid4
The genome sequence of Mycobacterium tuberculosis (and also M. leprae) revealed a significant number of homologies to Saccharomyces cerevisiae sterol biosynthetic enzymes. We addressed the hypothesis of a potential sterol biosynthetic pathway existing in Mycobacterium using cultures of Mycobacterum smegmatis. Non-saponifiable lipid extracts subjected to analysis by gas chromatography-mass spectrometry (GC-MS) showed cholesterol was present. Sterol synthesis by M. smegmatis was confirmed usingdoi:10.1016/s0014-5793(98)01218-6 pmid:9804188 fatcat:jec6zzgdtzgenepkx3uctisj3e
more »... C-radiolabelled mevalonic acid and incorporation into C4-desmethyl sterol co-migrating with authentic cholesterol on TLC. The sterol biosynthetic pathway has provided a rich source of targets for commercially important bioactive molecules and such agents represent new opportunities for Mycobacteria chemotherapy. z 1998 Federation of European Biochemical Societies.
Widely used methods include OrthoMCL (Li et al. 2003) , OMA (Train et al. 2017) , Hieranoid (Kaduk and Sonnhammer 2017) , OrthoFinder (Emms and Kelly 2015) , and SonicParanoid (Cosentino and Iwasaki ... A set of commonly used orthogroup inference methods comprising OrthoFinder (Emms and Kelly 2019), SonicParanoid (Cosentino and Iwasaki 2019), OrthoMCL (Li et al. 2003) , Hieranoid (Kaduk and Sonnhammer ... Associate editor: Martin Embley Emms and Kelly ...doi:10.1101/2020.07.09.195586 fatcat:5b3tirfrubh7ffoa7tbphouylm
Although numerous medications have been associated with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in HIV-infected patients, 1 sulphonamide drugs are the most common cause, with ...doi:10.1016/s0140-6736(98)24008-6 pmid:9492778 fatcat:w4uh6ib6r5ajbbn2tpfkm33paa
It is possible that 242 250 study (Emms and Kelly 2017). This consisted of a diverse set of species sampled from throughout 251 the eukaryotic domain. ... It has been designed to 202 integrate with OrthoFinder (Emms and Kelly 2015), which is a method for inferring the set of 203 orthogroups for all genes in a set of species. ...doi:10.1101/267914 fatcat:jggdl43ehnallfgom4e2xr2dyu
CYP61 was revealed in the sequencing of the yeast genome on chromosome XIII and was the last member of the CYP superfamily in yeast to be discovered. We show here that besides the housekeeping role in 22-desaturation during ergosterol biosynthesis the enzyme is also that responsible for benzo(a)pyrene metabolism/proniutagen activation by yeast in genotoxicity assays. This enzyme may represent an ancestral activity for the superfamily which allowed xenobiotic metabolism for the first time.doi:10.1016/s0014-5793(97)00785-0 pmid:9257726 fatcat:3qjgytsy3zh5ro67tjzw3fzipa
Kelly et al. intermediate stage report on deletion of 2026 openreading frames Table 1 . 1 Hierarchy of Eurofan consortia. Level A: service or material resources for the whole of Eurofan. ...doi:10.1002/cfg.95 pmid:18628917 pmcid:PMC2447215 fatcat:uffrsspttrbybgkmdn3ylue7sq
The Saccharomyces cerevisiae strain XL16-5B exhibited a fungicidal response to treatment with ketoconazole. Cell death became apparent during prolonged treatment over 72 h following an initial period over 24 h where viable cells were found and limited cell division occurred. Sterol analysis showed some differences between XL16-5B and the strain XY729-5a, which had a fungistatic response to ketoconazole. In particular, the level of ergosterol was higher in XL16-5B and remained high during treatment.doi:10.1111/j.1574-6968.1994.tb06641.x pmid:8138136 fatcat:wdlnz2uoerddzi5tr2x53vyh4a
PURPOSE. Metabotropic receptor agonists that signal through G q -coupled pathways increase Ca 2ϩ in mammalian Müller cells by release from intracellular stores and Ca 2ϩ influx pathways that have not been well described. The authors examined the involvement of voltage-dependent and non-voltage-dependent Ca 2ϩ channels in metabotropic muscarinic receptor-activated Ca 2ϩ increases and store-operated Ca 2ϩ influx in cultured mouse Müller cells. METHODS. Intracellular Ca 2ϩ was measured usingdoi:10.1167/iovs.07-1118 pmid:18316702 fatcat:cvt2oq4ltvbtvoc7jqnop3n4je
more »... scence imaging with the ratiometric dye fura-2. Currents were recorded using the whole-cell patch-clamp recording method. mRNA and protein were identified using reverse transcriptase polymerase chain reaction (RT-PCR) and immunocytochemical approaches. RESULTS. The muscarinic receptor agonist carbachol (3-20 M) produced increases in Ca 2ϩ that were blocked by the muscarinic receptor antagonists atropine and pirenzepine. RT-PCR confirmed mRNA for metabotropic M1 muscarinic receptors. Depletion of Ca 2ϩ stores by the sarcoplasmic/endoplasmic Ca 2ϩ ATPase (SERCA) inhibitors thapsigargin and cyclopiazonic acid or the inhibition of phospholipase C occluded the carbachol-activated increase in Ca 2ϩ . Carbachol-activated Ca 2ϩ increases in Müller cells were enhanced by the diacylglycerol derivative 1-oleyl-2-acetyl-sn-glycerol and were blocked by transient receptor potential (TRP) channel blockers Gd 3ϩ , La 3ϩ , 2-APB, and flufenamic acid. Both muscarinic receptor activation and thapsigargin treatment depleted Ca 2ϩ stores and produced Ca 2ϩ entry that was attenuated by La 3ϩ , 2-APB, Gd 3ϩ , and flufenamic acid. mRNA and protein for TRPC1 and TRPC6 were present in mouse Müller cells, and carbachol activated a Gd 3ϩ -sensitive, TRP-like cation channel. CONCLUSIONS. Metabotropic muscarinic receptor-activated Ca 2ϩ increases in mouse Müller cells require the release of Ca 2ϩ from intracellular stores and the activation of Ca 2ϩ entry that involves TRP-like cation channels but is independent of voltage-dependent Ca 2ϩ channels. (Invest Ophthalmol Vis Sci.
Kellys citrus thrips (Pezothrips kellyanus) (KCT) is a key pest of citrus in New Zealand Many insecticides used to control KCT cause outbreaks of secondary pests or market restrictions due to chemical ... INTRODUCTION Kelly's citrus thrips (Pezothrips kellyanus) (KCT) is a key pest of citrus in New Zealand (Pyle & Stevens 2004) , Australia (Baker et al. 2001) and Sicily (Conti et al. 2002) . ...doi:10.30843/nzpp.2006.59.4514 fatcat:tklc36bh35dbbfn6zq5rczfs2y
The phenotype of a strain of Saccharomyces cerevisiaecontaining a disruption of the gene encoding NADPH cytochrome P-450 oxidoreductase (CPR) was quantified biochemically and microbiologically, as were those of various transformants of this strain after expression of native CPR, cytochrome P-45051 (CYP51), and a fusion protein of CYP51-CPR (FUS). Only a 4-fold decrease in ergosterol biosynthesis was observed for the cpr strain, but ketoconazole sensitivity increased 200-fold, indicatingdoi:10.1128/aac.42.7.1756 fatcat:utmsuj4h6zca3cbtxpxjjbrixq
more »... sitivity to the alternative electron donor system incpr strains. Both phenotypes could be reversed in transformants expressing the CPR and FUS, indicating the availability of the CPR in FUS as well as the expressed native CPR for monoxygenase-associated reactions. The complementation of function was observed both in vitro and in vivo for the monoxygenases squalene epoxidase, CYP51, and CYP61 in the ergosterol biosynthesis pathway with which CPR is coupled. Overexpression of CYP51 and FUS produced different levels of ketoconazole resistance in wild-type cells, indicating that the availability of CPR may limit the potential of overproduction of CYP51 as a mechanism of resistance to azole antifungal agents.
doi:10.1007/s00586-012-2340-x pmid:22581191 pmcid:PMC3535230 fatcat:kuiftv5zrramzampue5xnbh72i
Another example of health as an ethical project is given by Kelly and Colquhoun (2003) . ... Author biographies STEVEN ALLENDER is a senior researcher with the BHF Health Promotion Research Group at the University of Oxford. ...doi:10.1177/1363459306058989 pmid:16322044 fatcat:discev7nn5cg5pn7sue27kbof4
Lecture Notes in Computer Science
Modelling and version control both play key roles in industrial-scale software development, yet their integration has proved difficult. Significant effort has been expended on improving file-based merging of modellers' work, but empirical research shows the results of that approach still leave much to be desired in practice. Approaches based on multi-user modelling databases have often foundered by locking too broadly, thus preventing work on different elements in the same model, or by handlingdoi:10.1007/978-3-319-74730-9_3 fatcat:kmvzvniokzgqnequcgtqn7wdg4
more »... versioning themselves, leading to a silo. This article presents an approach to combining multi-user modelling with any external version control system, with no merging and no lock-outs.
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