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Folds induced by multiple parallel or antiparallel double-helices: (pseudo)knotting of single-stranded RNA
[article]
2021
bioRxiv
pre-print
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Those circular folds lead to pseudoknotted folds for linear ssRNA strands. ...
The fold topology is captured by a 'contracted fold' which merges helices separated by bulges and removes hairpin loops. Contracted folds are either trivial or pseudoknotted. ...
Table 14 identified the fold {1 e 2 e 123 e 4 e 34} with t 1 , t 2 , t 3 , t 4 = 0, 2, 2, 4 as knotted, forming the 5 2 knot. • {1 o 2 o 3 o 123} L ⌦ ⇧ t 1 t 2 t 3 t 4 pseudoknot knot knot ID {1 e 2 e ...
doi:10.1101/2021.03.12.435210
fatcat:esleaxuj3jgtdbkmpjv3fqw77i
Amino acid torsion angles enable prediction of protein fold classification
2020
Scientific Reports
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B 1 ) stands for the Hausdorff distance between A 1 and B 1 after shifting A 1 by t. ...
Our results demonstrate that this new approach is efficient and reliable on protein structure prediction, and can obtain multiple different structures for the same sequence, improve protein-folding recognition ...
doi:10.1038/s41598-020-78465-1
pmid:33303802
fatcat:twnsd5xov5gbrkwwps76qgvzny
Assembly of a M4L4 "folded-cube" using a T-shaped, right-angled ligand
2015
Dalton Transactions
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A new bipyridine ligand based on a T-shaped 2,4,7-trisubstituted benzimidazole framework was synthesised. ...
When combined with [Pt(dppp)]2+ corners, eight right angles (four metal and four ligand) combine to form a M4L4 cluster with an unusual folded-cube structure. ...
The T-shaped, bipyridine ligand with a benzimidazole core was prepared as outlined in Scheme 1. ...
doi:10.1039/c4dt03198a
pmid:25462831
fatcat:tvrhtery3ndmtbdwspfam6ep7y
MEG-based neurofeedback for hand rehabilitation
2015
Journal of NeuroEngineering and Rehabilitation
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Success rate was also significant for each subject when considering grasp-only and restonly trials (p < 0.001, t-test). ...
Success rate was significantly better than chance for each participant (p < 0.001, t-test) with chance levels ranging from 12 to 31 %. ...
doi:10.1186/s12984-015-0076-7
pmid:26392353
pmcid:PMC4578759
fatcat:p4oqzhyik5arnhuy2sflalse5e
Altered modulation of sensorimotor rhythms with chronic paralysis
2017
Journal of Neurophysiology
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Foldes ST, Weber DJ, Collinger JL. Altered modulation of sensorimotor rhythms with chronic paralysis. ...
Time-frequency representations span the grasp/release cycle with the cue to grasp at t ϭ 0. ...
A new approach to MI therapy is to supplement MI practice with real-time neurofeedback of the patient's brain activity (Foldes et al. 2015; Ramos-Murguialday et al. 2013 ). ...
doi:10.1152/jn.00878.2016
pmid:28768745
fatcat:ihglvmvk2bf7ll5bqsh57rdoz4
POEMS neuropathy: optimising diagnosis and management
2018
Practical Neurology
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Ethics: All patients signed consent forms to allow for their case histories and clinical images to be published. Abstract POEMS syndrome is a rare and disabling autoinflammatory condition, typified by a typical peripheral neuropathy and the presence of a monoclonal plasma cell disorder. The acronym 'POEMS' represents the complex and multi-system features of the disease, including polyneuropathy, organomegaly, endocrinopathy, a monoclonal plasma cell disorder, and skin disease. The diagnosis of
doi:10.1136/practneurol-2017-001792
pmid:29511110
fatcat:6viylhnrpjg4plulzdytffzrze
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... OEMS is a significant challenge because of the heterogeneity of clinical presentations and variation of POEMS features. Patients are often misdiagnosed with another cause of inflammatory neuropathy and receive one or more ineffective immunomodulatory medications resulting in delayed diagnosis and further clinical deterioration before a diagnosis is made. University College London Hospital sees one of the largest reported POEMS cohorts in Europe, and runs a multi-specialist clinic to assist with diagnosis, treatment and ongoing support. This review draws upon our experience to present the typical features of POEMS syndrome, and highlight diagnostic conundrums commonly experienced supplemented with clinical cases. We will provide an investigative guide for clinicians when considering POEMS as the diagnosis, and propose a treatment algorithm which centres on the site and degree of monoclonal cell proliferation.
Approaches to Multimodality Monitoring in Pediatric Traumatic Brain Injury
2019
Frontiers in Neurology
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Copyright © 2019 Appavu, Burrows, Foldes and Adelson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). ...
doi:10.3389/fneur.2019.01261
pmid:32038449
pmcid:PMC6988791
fatcat:scdhwdnjzjfwvpdftlm2sqmbku
High surface area and Z′ in a thermally stable 8-fold polycatenated hydrogen-bonded framework
2015
Chemical Communications
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Permanent porosity, a large surface area, and unprecedented Z′ was exhibited in an 8-fold polycatenated hydrogen-bonded organic framework. ...
polycatenation; (e) extended view of the 8-fold polycatenation of hexagonal layers. ...
The polycatenating hexagonal sheets are created through the two-fold rotation axis (Fig. 4a) . ...
doi:10.1039/c5cc04219d
pmid:26099041
fatcat:6qfbo2kmvzfdrkllbhyybt7euu
Carboxyl pKa Values, Ion Pairs, Hydrogen Bonding, and the pH-dependence of Folding the Hyperthermophile Proteins Sac7d and Sso7d
2007
Journal of Molecular Biology
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The linkage of the ionization of two or more side chains to protein folding leads to apparent cooperativity in the pH dependence of folding, although each group titrates independently with a Hill coefficient ...
The small number (3) of significantly altered pK a values was in good agreement with a linkage analysis of the temperature, pH, and salt dependence of folding. ...
The stabilities of Sac7d and Sso7d are some of the best characterized of any protein. 63, 64 This is the result of the fact that not only are these thermophile proteins with T m values that approach ...
doi:10.1016/j.jmb.2007.06.089
pmid:17692336
pmcid:PMC2083566
fatcat:g7yjusznpfay3lat6mspj7mwdm
Contribution of Residue B5 to the Folding and Function of Insulin and IGF-I
2009
Journal of Biological Chemistry
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denaturation studies indicate that His B5 does not significantly enhance thermodynamic stability (ΔΔG u 0.2 ± 0.2 kcal/mole), implying that the substitution favors canonical pairing by destabilizing competing folds ...
Paired Student's t tests were used for all statistical analyses. Significance was accepted at P < 0.05. ...
(B) Ribbon model of human insulin (T-state protomer; PDB accession code 4INS). The coloring scheme is as in panel A. His B5 is shown in green. ...
doi:10.1074/jbc.m109.062992
pmid:19959476
pmcid:PMC2836107
fatcat:xtuu4tncivbblp5beltubesg5q
Transdermal Electrical Neuromodulation for Anxiety and Sleep Problems in High-Functioning Autism Spectrum Disorder: Feasibility and Preliminary Findings
2021
Journal of Personalized Medicine
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Autism spectrum disorder (ASD) is associated with anxiety and sleep problems. We investigated transdermal electrical neuromodulation (TEN) of the cervical nerves in the neck as a safe, effective, comfortable and non-pharmacological therapy for decreasing anxiety and enhancing sleep quality in ASD. Methods: In this blinded, sham-controlled study, seven adolescents and young adults with high-functioning ASD underwent five consecutive treatment days, one day of the sham followed by four days of
doi:10.3390/jpm11121307
pmid:34945779
pmcid:PMC8704341
fatcat:lq4shzzakbbgjevmp7zokrlq4u
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... threshold TEN for 20 min. Anxiety-provoking cognitive tasks were performed after the sham/TEN. Measures of autonomic nervous system activity, including saliva α-amylase and cortisol, electrodermal activity, and heart rate variability, were collected from six participants. Results: Self-rated and caretaker-rated measures of anxiety were significantly improved with TEN treatment as compared to the sham, with effect sizes ranging from medium to large depending on the rating scale. Sleep scores from caretaker questionnaires also improved, but not significantly. Performance on two of the three anxiety-provoking cognitive tasks and heart rate variability significantly improved with TEN stimulation as compared to the sham. Four of the seven (57%) participants were responders, defined as a ≥ 30% improvement in self-reported anxiety. Salivary α-amylase decreased with more TEN sessions and decreased from the beginning to the end of the session on TEN days for responders. TEN was well-tolerated without significant adverse events. Conclusions: This study provides preliminary evidence that TEN is well-tolerated in individuals with ASD and can improve anxiety.
Speaking and cognitive distractions during EEG-based brain control of a virtual neuroprosthesis-arm
2013
Journal of NeuroEngineering and Rehabilitation
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On average, all metrics showed a decline in control performance with increased cognitive load, although this decline was not significant in the more variable movement-time metric (paired t-test). ...
doi:10.1186/1743-0003-10-116
pmid:24359452
pmcid:PMC3878059
fatcat:6ieex4afd5cdvmsjgtuszawepi
Smoothing a rugged protein folding landscape by sequence-based redesign
2016
Scientific Reports
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Characterization of its structure, folding and dynamics suggest that consensus design has remodeled the folding landscape to reconcile competing requirements for stability and function. ...
To investigate how serpins balance function and folding, we used consensus design to create conserpin, a synthetic serpin that folds reversibly, is functional, thermostable, and polymerization resistant ...
Variable-temperature far-UV CD melting curves in 2 M GuHCl gave a T m of 60.7 °C (conserpin T m = 72.5 °C; (Fig. S7F) ). ...
doi:10.1038/srep33958
pmid:27667094
pmcid:PMC5036219
fatcat:ykgt5exnovbnjgn7vfgfs5hf54
Decoding Brain States Based on Magnetoencephalography From Prespecified Cortical Regions
2016
IEEE Transactions on Biomedical Engineering
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Hence, we evaluate the decoding accuracy by using six-fold cross-validation [19] and assess the ROI selectivity by using the discriminant pattern source localization (DPSL) method [29] . ...
The power of y Φ and yΦ can be calculated as p Φ = y Φ y T Φ = w T · m ∈Φ n ∈Φ A m · q m · q T n · A T n · w (10) pΦ = yΦ y T Φ = w T · m / ∈Φ n / ∈Φ A m · q m · q T n · A T n · w. (11) We use the ratio ...
Based on this observation, we define w = w 1 w 2 · · · w M −1 1 T = v T 1 T , (28) where v = [w 1 w 2 ... w M −1 ] T . ...
doi:10.1109/tbme.2015.2439216
pmid:26699648
fatcat:ksjfgxb5z5fijcijpytsrayxbi
Hereditary transthyretin amyloidosis: baseline characteristics of patients in the NEURO-TTR trial
2018
Amyloid: Journal of Protein Folding Disorders
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Statistical significance was determined by analysis of variance (ANOVA) and two-sample t-test with two-sided significance level of 0.05. ...
doi:10.1080/13506129.2018.1503593
pmid:30169969
fatcat:dsy5sibheja4zjvi65ikqttkve
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