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Stephen T. Asma, Stuffed Animals and Pickled Heads: The Culture and Evolution of Natural History Museums
2016
Nordisk Museologi
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Bokens titel Stuffed Animals and Pickled Heads är ägnad att väcka nyfikenhet. Och jag är därför skyldig att inte här avslöja, vilka inlagda huvuden som åsyftas. ...
En filosof och collegeprofessor i Chicago, Stephen T. Asma, har med öppna sinnen vandrat genom salarna i vår tids stora naturhisto-riska museer. ...
doi:10.5617/nm.3499
fatcat:wfvbumd2uraudjzlcj4csfamqi
Block algorithms for quark propagator calculation
1998
Nuclear Physics B - Proceedings Supplements
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Computing quark propagators in lattice QCD is equivalent to solving large, sparse linear systems with multiple right-hand sides. Block algorithms attempt to accelerate the convergence of iterative Krylov-subspace methods by solving the multiple systems simultaneously. This paper compares a block generalisation of the quasi-minimal residual method (QMR), Block Conjugate Gradient on the normal equation, Block Lanczos and (γ_5-symmetric) Block BiConjugate Gradient.
doi:10.1016/s0920-5632(97)00955-9
fatcat:wmfh3spvzfg6zmz3tnikpcktme
Staphylococcus aureus Myocarditis with Associated Left Ventricular Apical Thrombus
2018
Case Reports in Cardiology
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Staphylococcus aureus myocarditis is a rare diagnosis with a high mortality rate, usually seen in people who are immunocompromised. Here, we report a case of a 44-year-old man on methotrexate for rheumatoid arthritis who presented in septic shock and was diagnosed with staphylococcus aureus myocarditis. The myocarditis was associated with a left ventricular apical thrombus, with normal systolic function. The myocarditis and associated thrombus were characterised on transthoracic echocardiogram
doi:10.1155/2018/7017286
pmid:29951322
pmcid:PMC5989289
fatcat:t4wqjq4tufcitdp427igpggile
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... nd subsequently on cardiac magnetic resonance imaging. Cardiac magnetic resonance (CMR) imaging showed oedema in the endomyocardium, consistent with acute myocarditis, associated with an apical mural thrombus. Repeat CMR 3 weeks following discharge from hospital showed marked improvement in endomyocardial oedema and complete resolution of the apical mural thrombus. He was treated with a 12-week course of antibiotics and anticoagulated with apixaban. The patient was successfully managed with intravenous antibiotics and anticoagulation with complete recovery.
The economic impact of epilepsy: a systematic review
2015
BMC Neurology
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In this review we aimed to determine the economic impact of epilepsy and factors associated with costs to individuals and health systems. Methods: A narrative systematic review of incidence and case series studies with prospective consecutive patient recruitment and economic outcomes published before July 2014 were retrieved from Medline, Embase and PsycInfo. Results: Of 322 studies reviewed, 22 studies met the inclusion criteria and 14 were from high income country settings. The total costs
doi:10.1186/s12883-015-0494-y
pmid:26607561
pmcid:PMC4660784
fatcat:vgwoeodjrrdrxitcr4ol62hvym
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... ociated with epilepsy varied significantly in relation to the duration and severity of the condition, response to treatment, and health care setting. Where assessed, 'out of pocket' costs and productivity losses were found to create substantial burden on households which may be offset by health insurance. However, populations covered ostensibly for the upfront costs of care can still bear a significant economic burden. Conclusions: Epilepsy poses a substantial economic burden for health systems and individuals and their families. There is uncertainty over the degree to which private health insurance or social health insurance coverage provides adequate protection from the costs of epilepsy. Future research is required to examine the role of different models of care and insurance programs in protecting against economic hardship for this condition, particularly in low and middle income settings.
Access to mammography screening in a large urban population: a multi-level analysis
2009
Cancer Causes and Control
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Objective To understand area-based sociodemographics,
doi:10.1007/s10552-009-9373-4
pmid:19543987
pmcid:PMC2746895
fatcat:eianjmyehfbihi5hwdua5pt5vm
Q fever vertebral osteomyelitis in the absence of cardiovascular involvement: Two cases and a literature review
2020
Clinical Infection in Practice
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Pickles, et al., Q fever vertebral osteomyelitis in the absence of cardiovascular involvement: Two cases and a litera..., Clinical Infection in Practice, https://doi.org/10.1016/j.clinpr.2020.100019 ...
statement 205 Sarah Browning:Conceptualization, Methodology, Writing -origi-206 nal draft.Katy Lai:Conceptualization, Methodology, Writing -.Robert Pickles:Conceptualization, Writing -review & editing. 208 Stephen ...
doi:10.1016/j.clinpr.2020.100019
fatcat:ere6w4qlrvh55iwgqhreckrjxu
Laminin Modulates Morphogenic Properties of the Collagen XVIII Endostatin Domain
2002
Journal of Biological Chemistry
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We have shown previously that the oligomeric endostatin domain of collagen XVIII (NC1) functioned as a motility-inducing factor regulating the extracellular matrix-dependent morphogenesis of endothelial cells. This motogenic activity gave rise to structures resembling filipodia and lamellipodia and was dependent on Rac, Cdc42, and mitogen-activated protein kinase. Here, we demonstrate that these properties of endostatin are primarily mediated by laminin in the basement membrane and heparan
doi:10.1074/jbc.m206358200
pmid:12237301
fatcat:ves3nu6cb5cqxdr7ls7zc4rcmy
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... tes on the cell surface. The sites of interaction between laminin and oligomeric endostain include the N-terminal regions of all three laminin chains (amino acids 204 -1243 of the ␣ chain, 932-1161 of the  chain, and 150 -965 of the ␥ chain). A monoclonal antibody that blocks the interactions between endostatin and laminin was utilized to inhibit the motogenic activity of endostatin. In parallel, we have engineered selective point mutations and produced recombinant forms that lack binding to heparan sulfates on the cell surface. Our data are consistent with a model of endostatin with two binding sites: one mainly to laminin in the basement membrane and the other to heparan sulfates on the cell surface. The two binding domains on endostatin appear to be separate with the possibility of some overlap between the two sites. vated protein kinase; PDM, peptide-directed monoclonal; ES, endostatin.
Using Bonferroni, BIC and AIC to assess evidence for alternative biological pathways: covariate selection for the multilevel Embryo-Uterus model
2013
BMC Medical Research Methodology
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IVF treatments for infertility involve the transfer of multiple embryos in any one treatment cycle. When data is available on individual embryos the outcomes of each embryo are only partially observed, as treatment outcome (live birth) is assessed at the patient level. Two-level Embryo-Uterus (EU) models have been developed which assume a biologically plausible mechanism and assume that effects are mediated directly through the embryo (E) and also through the uterine environment (U),
doi:10.1186/1471-2288-13-73
pmid:23738824
pmcid:PMC3680067
fatcat:c2tb3oktpfhbrkjjl76bczqbuq
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... by two sub-models. This approach potentially allows inference as to the association of patient variables with outcome. However, when the variable is measured at the patient level either additional decisions have to be made in the modelling process as to in which sub-model the variable should be included or some model selection algorithm has to be invoked. These uncertainties have limited the practical application of these models. Methods: We have conducted simulation studies based around realistic parameter values of situations where a putative patient-level variable is being considered for inclusion in an EU model and/or the mechanistic interpretation from the sub-model assignment is of interest. Firstly we explore various strategies for inference for a variable of interest where the sub-model is either pre-specified or considered unknown. Secondly we explore the use of information criteria to select the appropriate sub-model and the strength of evidence for that assignment. These are demonstrated in a reanalysis of a previously published dataset. Results: In the absence of prior evidence for potential prognostic factors measured at the patient level, two single degree-of-freedom likelihood ratio tests with a Bonferroni correction including the variable of interest in first the E then the U sub-model performs well as a statistical test for association with outcome. For model building the information criteria can be used, but large differences are required (≳6) to provide reasonable evidence of submodel assignment. Previous interpretations have been over-optimistic. Conclusions: These results suggest simple strategies and should enable these models to be used more confidently in practical applications.
Understanding usual care in randomised controlled trials of complex interventions: A multi-method approach
2020
Palliative Medicine
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Evaluations of complex interventions compared to usual care provided in palliative care are increasing. Not describing usual care may affect the interpretation of an intervention's effectiveness, yet how it can be described remains unclear. Aim: To demonstrate the feasibility of using multi-methods to describe usual care provided in randomised controlled trials (RCTs) of complex interventions, shown within a feasibility cluster RCT. Design: Multi-method approach comprising usual care
doi:10.1177/0269216320905064
pmid:32081088
fatcat:6mccooqycfgrnoeytv3vg7tdwy
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... res, baseline case note review and focus groups with ward staff completed at study end. Thematic analysis of qualitative data, descriptive statistics of quantitative data, followed by methodological triangulation to appraise approach in relation to study aim. Setting/participants: Four general medical wards chosen from UK hospitals. Purposive sampling of healthcare professionals for usual care questionnaires, and focus groups. Review of 20 patients' notes from each ward who died during admission or within 100 days of discharge. Results: Twenty-three usual care questionnaires at baseline, two focus groups comprising 20 healthcare professionals and 80 case note reviews. Triangulation of findings resulted in understanding the usual care provided to the targeted population in terms of context, structures, processes and outcomes for patients, families and healthcare professionals. Usual care was described, highlighting (1) similarities and embedded practices, (2) heterogeneity and (3) subtle changes in care during the trial within and across sites. Conclusions: We provide a feasible approach to defining usual care that can be practically adopted in different settings. Understanding usual care enhances the reliability of tested complex interventions, and informs research and policy priorities.
Instability in the molecular dynamics step of a hybrid Monte Carlo algorithm in dynamical fermion lattice QCD simulations
2000
Physical Review D, Particles and fields
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2000 pre-print arXiv:hep-lat/0005023v1 fatcat:nn3b4oje2ve3dlcu6rrsq2oiey
We investigate instability and reversibility within Hybrid Monte Carlo simulations using a non-perturbatively improved Wilson action. We demonstrate the onset of instability as tolerance parameters and molecular dynamics step sizes are varied. We compare these findings with theoretical expectations and present limits on simulation parameters within which a stable and reversible algorithm is obtained for physically relevant simulations. Results of optimisation experiments with respect to tolerance prarameters are also presented.
doi:10.1103/physrevd.62.114501
fatcat:mpw2deg6pnh5vdmmbcno4eaksi
Parent, Teacher and Observational Reports of Emotional and Behavioral Problems in Young Autistic Children
2022
Journal of Autism and Developmental Disorders
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AbstractEmotional and behavioral problems (EBPs) frequently occur in young autistic children. Discrepancies between parents and other informants are common but can lead to uncertainty in formulation, diagnosis and care planning. This study aimed to explore child and informant characteristics are associated with reported child EBPs across settings. Participants were 83 4–8-year-old autistic children and their parents and teachers in the Autism Spectrum Treatment and Resilience (ASTAR) study.
doi:10.1007/s10803-021-05421-x
pmid:35028809
fatcat:j56fjnt42fe7ffiohjhoa4rqfq
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... tionnaires of child EBPs were completed by parents and teachers, and self-reported parenting stress and wellbeing measures were obtained. An observation of parent–child/researcher-child interaction was also completed. Parents reported more EBPs than teachers and parent-teacher agreement was low, particularly for emotional problems. Greater parenting stress and being verbal was associated with more parent- but not teacher-reported EBPs. More observed behaviors that challenge were displayed by minimally verbal children. More parenting stress could be associated with the presence of more EBPs in the home; alternatively, parenting stress may confound reports. It is essential for assessments of EBPs in autistic children to take a multi-informant approach. Better understanding of the associations between informant characteristics and informant discrepancies of EBPs is needed.
A Complex Endomembrane System in the Archaeon Ignicoccus hospitalis Tapped by Nanoarchaeum equitans
2017
Frontiers in Microbiology
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Based on serial sectioning, focused ion beam scanning electron microscopy (FIB/SEM), and electron tomography, we depict in detail the highly unusual anatomy of the marine hyperthermophilic crenarchaeon, Ignicoccus hospitalis. Our data support a complex and dynamic endomembrane system consisting of cytoplasmic protrusions, and with secretory function. Moreover, we reveal that the cytoplasm of the putative archaeal ectoparasite Nanoarchaeum equitans can get in direct contact with this
doi:10.3389/fmicb.2017.01072
pmid:28659892
pmcid:PMC5468417
fatcat:pcnmovetkbagbiwigngleldwni
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... system, complementing and explaining recent proteomic, transcriptomic and metabolomic data on this inter-archaeal relationship. In addition, we identified a matrix of filamentous structures and/or tethers in the voluminous inter-membrane compartment (IMC) of I. hospitalis, which might be responsible for membrane dynamics. Overall, this unusual cellular compartmentalization, ultrastructure and dynamics in an archaeon that belongs to the recently proposed TACK superphylum prompts speculation that the eukaryotic endomembrane system might originate from Archaea.
Tuning actions and observables in lattice QCD
1998
Physical Review D, Particles and fields
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We propose a strategy for conducting lattice QCD simulations at fixed volume but variable quark mass so as to investigate the physical effects of dynamical fermions. We present details of techniques which enable this to be carried out effectively, namely the tuning in bare parameter space and efficient stochastic estimation of the fermion determinant. Preliminary results and tests of the method are presented. We discuss further possible applications of these techniques.
doi:10.1103/physrevd.58.114504
fatcat:d6zq7fnndjdjrig6q25z2bu3rm
Validation of the Modes of Transmission Model as a Tool to Prioritize HIV Prevention Targets: A Comparative Modelling Analysis
2014
PLoS ONE
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Citation: Mishra S, Pickles M, Blanchard JF, Moses S, Shubber Z, et al. (2014) Validation of the Modes of Transmission Model as a Tool to Prioritize HIV Prevention Targets: A Comparative Modelling Analysis ...
doi:10.1371/journal.pone.0101690
pmid:25014543
pmcid:PMC4090151
fatcat:fqkgmrw2frasbnavupi4lfheay
Parallel tempering in lattice QCD withO(a)-improved Wilson fermions
1999
Physical Review D, Particles and fields
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1998 pre-print arXiv:hep-lat/9810032v1 fatcat:wfb7xfkkwjddfe3w2dc5ekq23i
We also wish to thank Tony Kennedy and Stephen Booth for helpful discussions. ...
doi:10.1103/physrevd.59.114501
fatcat:fvblzjkp5nbhrkt5z7rn3hr37m
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