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Stephen T. Asma, Stuffed Animals and Pickled Heads: The Culture and Evolution of Natural History Museums

Erik Hedqvist
2016 Nordisk Museologi  
Bokens titel Stuffed Animals and Pickled Heads är ägnad att väcka nyfikenhet. Och jag är därför skyldig att inte här avslöja, vilka inlagda huvuden som åsyftas.  ...  En filosof och collegeprofessor i Chicago, Stephen T. Asma, har med öppna sinnen vandrat genom salarna i vår tids stora naturhisto-riska museer.  ... 
doi:10.5617/nm.3499 fatcat:wfvbumd2uraudjzlcj4csfamqi

Block algorithms for quark propagator calculation

Stephen M. Pickles
1998 Nuclear Physics B - Proceedings Supplements  
Computing quark propagators in lattice QCD is equivalent to solving large, sparse linear systems with multiple right-hand sides. Block algorithms attempt to accelerate the convergence of iterative Krylov-subspace methods by solving the multiple systems simultaneously. This paper compares a block generalisation of the quasi-minimal residual method (QMR), Block Conjugate Gradient on the normal equation, Block Lanczos and (γ_5-symmetric) Block BiConjugate Gradient.
doi:10.1016/s0920-5632(97)00955-9 fatcat:wmfh3spvzfg6zmz3tnikpcktme

Staphylococcus aureus Myocarditis with Associated Left Ventricular Apical Thrombus

Michael McGee, Emily Shiel, Stephen Brienesse, Stuart Murch, Robert Pickles, James Leitch
2018 Case Reports in Cardiology  
Staphylococcus aureus myocarditis is a rare diagnosis with a high mortality rate, usually seen in people who are immunocompromised. Here, we report a case of a 44-year-old man on methotrexate for rheumatoid arthritis who presented in septic shock and was diagnosed with staphylococcus aureus myocarditis. The myocarditis was associated with a left ventricular apical thrombus, with normal systolic function. The myocarditis and associated thrombus were characterised on transthoracic echocardiogram
more » ... nd subsequently on cardiac magnetic resonance imaging. Cardiac magnetic resonance (CMR) imaging showed oedema in the endomyocardium, consistent with acute myocarditis, associated with an apical mural thrombus. Repeat CMR 3 weeks following discharge from hospital showed marked improvement in endomyocardial oedema and complete resolution of the apical mural thrombus. He was treated with a 12-week course of antibiotics and anticoagulated with apixaban. The patient was successfully managed with intravenous antibiotics and anticoagulation with complete recovery.
doi:10.1155/2018/7017286 pmid:29951322 pmcid:PMC5989289 fatcat:t4wqjq4tufcitdp427igpggile

The economic impact of epilepsy: a systematic review

Katharina Allers, Beverley M. Essue, Maree L. Hackett, Janani Muhunthan, Craig S. Anderson, Kristen Pickles, Franziska Scheibe, Stephen Jan
2015 BMC Neurology  
In this review we aimed to determine the economic impact of epilepsy and factors associated with costs to individuals and health systems. Methods: A narrative systematic review of incidence and case series studies with prospective consecutive patient recruitment and economic outcomes published before July 2014 were retrieved from Medline, Embase and PsycInfo. Results: Of 322 studies reviewed, 22 studies met the inclusion criteria and 14 were from high income country settings. The total costs
more » ... ociated with epilepsy varied significantly in relation to the duration and severity of the condition, response to treatment, and health care setting. Where assessed, 'out of pocket' costs and productivity losses were found to create substantial burden on households which may be offset by health insurance. However, populations covered ostensibly for the upfront costs of care can still bear a significant economic burden. Conclusions: Epilepsy poses a substantial economic burden for health systems and individuals and their families. There is uncertainty over the degree to which private health insurance or social health insurance coverage provides adequate protection from the costs of epilepsy. Future research is required to examine the role of different models of care and insurance programs in protecting against economic hardship for this condition, particularly in low and middle income settings.
doi:10.1186/s12883-015-0494-y pmid:26607561 pmcid:PMC4660784 fatcat:vgwoeodjrrdrxitcr4ol62hvym

Access to mammography screening in a large urban population: a multi-level analysis

Stephen C. Meersman, Nancy Breen, Linda W. Pickle, Helen I. Meissner, Paul Simon
2009 Cancer Causes and Control  
Objective To understand area-based sociodemographics,
doi:10.1007/s10552-009-9373-4 pmid:19543987 pmcid:PMC2746895 fatcat:eianjmyehfbihi5hwdua5pt5vm

Q fever vertebral osteomyelitis in the absence of cardiovascular involvement: Two cases and a literature review

Sarah Browning, Katy Lai, Robert Pickles, Stephen R. Graves
2020 Clinical Infection in Practice  
Pickles, et al., Q fever vertebral osteomyelitis in the absence of cardiovascular involvement: Two cases and a litera..., Clinical Infection in Practice,  ...  statement 205 Sarah Browning:Conceptualization, Methodology, Writing -origi-206 nal draft.Katy Lai:Conceptualization, Methodology, Writing -.Robert Pickles:Conceptualization, Writing -review & editing. 208 Stephen  ... 
doi:10.1016/j.clinpr.2020.100019 fatcat:ere6w4qlrvh55iwgqhreckrjxu

Laminin Modulates Morphogenic Properties of the Collagen XVIII Endostatin Domain

Kashi Javaherian, Susan Y. Park, Winfried F. Pickl, Kenneth R. LaMontagne, Robert Tjin Tham Sjin, Stephen Gillies, Kin-Ming Lo
2002 Journal of Biological Chemistry  
We have shown previously that the oligomeric endostatin domain of collagen XVIII (NC1) functioned as a motility-inducing factor regulating the extracellular matrix-dependent morphogenesis of endothelial cells. This motogenic activity gave rise to structures resembling filipodia and lamellipodia and was dependent on Rac, Cdc42, and mitogen-activated protein kinase. Here, we demonstrate that these properties of endostatin are primarily mediated by laminin in the basement membrane and heparan
more » ... tes on the cell surface. The sites of interaction between laminin and oligomeric endostain include the N-terminal regions of all three laminin chains (amino acids 204 -1243 of the ␣ chain, 932-1161 of the ␤ chain, and 150 -965 of the ␥ chain). A monoclonal antibody that blocks the interactions between endostatin and laminin was utilized to inhibit the motogenic activity of endostatin. In parallel, we have engineered selective point mutations and produced recombinant forms that lack binding to heparan sulfates on the cell surface. Our data are consistent with a model of endostatin with two binding sites: one mainly to laminin in the basement membrane and the other to heparan sulfates on the cell surface. The two binding domains on endostatin appear to be separate with the possibility of some overlap between the two sites. vated protein kinase; PDM, peptide-directed monoclonal; ES, endostatin.
doi:10.1074/jbc.m206358200 pmid:12237301 fatcat:ves3nu6cb5cqxdr7ls7zc4rcmy

Using Bonferroni, BIC and AIC to assess evidence for alternative biological pathways: covariate selection for the multilevel Embryo-Uterus model

Christos Stylianou, Andrew Pickles, Stephen A Roberts
2013 BMC Medical Research Methodology  
IVF treatments for infertility involve the transfer of multiple embryos in any one treatment cycle. When data is available on individual embryos the outcomes of each embryo are only partially observed, as treatment outcome (live birth) is assessed at the patient level. Two-level Embryo-Uterus (EU) models have been developed which assume a biologically plausible mechanism and assume that effects are mediated directly through the embryo (E) and also through the uterine environment (U),
more » ... by two sub-models. This approach potentially allows inference as to the association of patient variables with outcome. However, when the variable is measured at the patient level either additional decisions have to be made in the modelling process as to in which sub-model the variable should be included or some model selection algorithm has to be invoked. These uncertainties have limited the practical application of these models. Methods: We have conducted simulation studies based around realistic parameter values of situations where a putative patient-level variable is being considered for inclusion in an EU model and/or the mechanistic interpretation from the sub-model assignment is of interest. Firstly we explore various strategies for inference for a variable of interest where the sub-model is either pre-specified or considered unknown. Secondly we explore the use of information criteria to select the appropriate sub-model and the strength of evidence for that assignment. These are demonstrated in a reanalysis of a previously published dataset. Results: In the absence of prior evidence for potential prognostic factors measured at the patient level, two single degree-of-freedom likelihood ratio tests with a Bonferroni correction including the variable of interest in first the E then the U sub-model performs well as a statistical test for association with outcome. For model building the information criteria can be used, but large differences are required (≳6) to provide reasonable evidence of submodel assignment. Previous interpretations have been over-optimistic. Conclusions: These results suggest simple strategies and should enable these models to be used more confidently in practical applications.
doi:10.1186/1471-2288-13-73 pmid:23738824 pmcid:PMC3680067 fatcat:c2tb3oktpfhbrkjjl76bczqbuq

Understanding usual care in randomised controlled trials of complex interventions: A multi-method approach

Emel Yorganci, Catherine J Evans, Halle Johnson, Stephen Barclay, Fliss EM Murtagh, Deokhee Yi, Wei Gao, Andrew Pickles, Jonathan Koffman
2020 Palliative Medicine  
Evaluations of complex interventions compared to usual care provided in palliative care are increasing. Not describing usual care may affect the interpretation of an intervention's effectiveness, yet how it can be described remains unclear. Aim: To demonstrate the feasibility of using multi-methods to describe usual care provided in randomised controlled trials (RCTs) of complex interventions, shown within a feasibility cluster RCT. Design: Multi-method approach comprising usual care
more » ... res, baseline case note review and focus groups with ward staff completed at study end. Thematic analysis of qualitative data, descriptive statistics of quantitative data, followed by methodological triangulation to appraise approach in relation to study aim. Setting/participants: Four general medical wards chosen from UK hospitals. Purposive sampling of healthcare professionals for usual care questionnaires, and focus groups. Review of 20 patients' notes from each ward who died during admission or within 100 days of discharge. Results: Twenty-three usual care questionnaires at baseline, two focus groups comprising 20 healthcare professionals and 80 case note reviews. Triangulation of findings resulted in understanding the usual care provided to the targeted population in terms of context, structures, processes and outcomes for patients, families and healthcare professionals. Usual care was described, highlighting (1) similarities and embedded practices, (2) heterogeneity and (3) subtle changes in care during the trial within and across sites. Conclusions: We provide a feasible approach to defining usual care that can be practically adopted in different settings. Understanding usual care enhances the reliability of tested complex interventions, and informs research and policy priorities.
doi:10.1177/0269216320905064 pmid:32081088 fatcat:6mccooqycfgrnoeytv3vg7tdwy

Instability in the molecular dynamics step of a hybrid Monte Carlo algorithm in dynamical fermion lattice QCD simulations

Bálint Joó, Brian Pendleton, Anthony D. Kennedy, Alan C. Irving, James C. Sexton, Stephen M. Pickles, Stephen P. Booth
2000 Physical Review D, Particles and fields  
We investigate instability and reversibility within Hybrid Monte Carlo simulations using a non-perturbatively improved Wilson action. We demonstrate the onset of instability as tolerance parameters and molecular dynamics step sizes are varied. We compare these findings with theoretical expectations and present limits on simulation parameters within which a stable and reversible algorithm is obtained for physically relevant simulations. Results of optimisation experiments with respect to tolerance prarameters are also presented.
doi:10.1103/physrevd.62.114501 fatcat:mpw2deg6pnh5vdmmbcno4eaksi

Parent, Teacher and Observational Reports of Emotional and Behavioral Problems in Young Autistic Children

Melanie Palmer, Joanne Tarver, Virginia Carter Leno, Juan Paris Perez, Margot Frayne, Vicky Slonims, Andrew Pickles, Stephen Scott, Tony Charman, Emily Simonoff
2022 Journal of Autism and Developmental Disorders  
AbstractEmotional and behavioral problems (EBPs) frequently occur in young autistic children. Discrepancies between parents and other informants are common but can lead to uncertainty in formulation, diagnosis and care planning. This study aimed to explore child and informant characteristics are associated with reported child EBPs across settings. Participants were 83 4–8-year-old autistic children and their parents and teachers in the Autism Spectrum Treatment and Resilience (ASTAR) study.
more » ... tionnaires of child EBPs were completed by parents and teachers, and self-reported parenting stress and wellbeing measures were obtained. An observation of parent–child/researcher-child interaction was also completed. Parents reported more EBPs than teachers and parent-teacher agreement was low, particularly for emotional problems. Greater parenting stress and being verbal was associated with more parent- but not teacher-reported EBPs. More observed behaviors that challenge were displayed by minimally verbal children. More parenting stress could be associated with the presence of more EBPs in the home; alternatively, parenting stress may confound reports. It is essential for assessments of EBPs in autistic children to take a multi-informant approach. Better understanding of the associations between informant characteristics and informant discrepancies of EBPs is needed.
doi:10.1007/s10803-021-05421-x pmid:35028809 fatcat:j56fjnt42fe7ffiohjhoa4rqfq

A Complex Endomembrane System in the Archaeon Ignicoccus hospitalis Tapped by Nanoarchaeum equitans

Thomas Heimerl, Jennifer Flechsler, Carolin Pickl, Veronika Heinz, Benjamin Salecker, Josef Zweck, Gerhard Wanner, Stefan Geimer, Rachel Y. Samson, Stephen D. Bell, Harald Huber, Reinhard Wirth (+3 others)
2017 Frontiers in Microbiology  
Based on serial sectioning, focused ion beam scanning electron microscopy (FIB/SEM), and electron tomography, we depict in detail the highly unusual anatomy of the marine hyperthermophilic crenarchaeon, Ignicoccus hospitalis. Our data support a complex and dynamic endomembrane system consisting of cytoplasmic protrusions, and with secretory function. Moreover, we reveal that the cytoplasm of the putative archaeal ectoparasite Nanoarchaeum equitans can get in direct contact with this
more » ... system, complementing and explaining recent proteomic, transcriptomic and metabolomic data on this inter-archaeal relationship. In addition, we identified a matrix of filamentous structures and/or tethers in the voluminous inter-membrane compartment (IMC) of I. hospitalis, which might be responsible for membrane dynamics. Overall, this unusual cellular compartmentalization, ultrastructure and dynamics in an archaeon that belongs to the recently proposed TACK superphylum prompts speculation that the eukaryotic endomembrane system might originate from Archaea.
doi:10.3389/fmicb.2017.01072 pmid:28659892 pmcid:PMC5468417 fatcat:pcnmovetkbagbiwigngleldwni

Tuning actions and observables in lattice QCD

Alan C. Irving, James C. Sexton, Eamonn Cahill, Joyce Garden, Bálint Joó, Stephen M. Pickles, Zbigniew Sroczynski
1998 Physical Review D, Particles and fields  
We propose a strategy for conducting lattice QCD simulations at fixed volume but variable quark mass so as to investigate the physical effects of dynamical fermions. We present details of techniques which enable this to be carried out effectively, namely the tuning in bare parameter space and efficient stochastic estimation of the fermion determinant. Preliminary results and tests of the method are presented. We discuss further possible applications of these techniques.
doi:10.1103/physrevd.58.114504 fatcat:d6zq7fnndjdjrig6q25z2bu3rm

Validation of the Modes of Transmission Model as a Tool to Prioritize HIV Prevention Targets: A Comparative Modelling Analysis

Sharmistha Mishra, Michael Pickles, James F. Blanchard, Stephen Moses, Zara Shubber, Marie-Claude Boily, Julian W. Tang
2014 PLoS ONE  
Citation: Mishra S, Pickles M, Blanchard JF, Moses S, Shubber Z, et al. (2014) Validation of the Modes of Transmission Model as a Tool to Prioritize HIV Prevention Targets: A Comparative Modelling Analysis  ... 
doi:10.1371/journal.pone.0101690 pmid:25014543 pmcid:PMC4090151 fatcat:fqkgmrw2frasbnavupi4lfheay

Parallel tempering in lattice QCD withO(a)-improved Wilson fermions

Bálint Joó, Brian Pendleton, Stephen M. Pickles, Zbigniew Sroczynski, Alan C. Irving, James C. Sexton
1999 Physical Review D, Particles and fields  
We also wish to thank Tony Kennedy and Stephen Booth for helpful discussions.  ... 
doi:10.1103/physrevd.59.114501 fatcat:fvblzjkp5nbhrkt5z7rn3hr37m
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