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Diagnostics and Treatment of Hepatocellular Carcinoma in 2016: Standards and Developments
<span title="">2016</span>
<i title="S. Karger AG">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zn6kjlzzarf7vfwylh3cdemzxq" style="color: black;">Visceral Medicine</a>
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Interstitial photodynamic laser therapy in interventional oncology
<span title="2004-06-01">2004</span>
<i title="Springer Nature">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/y352pep6tjcphcqt3p6tv3d7se" style="color: black;">European Radiology</a>
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Photodynamic therapy (PDT) is a well-investigated locoregional cancer treatment in which a systemically administered photosensitizer is activated locally by illuminating the diseased tissue with light of a suitable wavelength. PDT offers various treatment strategies in oncology, especially palliative ones. This article focuses on the development and evaluation of interstitial PDT for the treatment of solid tumors, particularly liver tumors. The PDT is mostly used for superficial and endoluminal
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<a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00330-004-2290-8">doi:10.1007/s00330-004-2290-8</a>
<a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/15045520">pmid:15045520</a>
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... lesions like skin or bladder malignancies and also more frequently applied for the treatment of lung, esophageal, and head and neck cancer. With the help of specially designed application systems, PDT is now becoming a practicable option for solid lesions, including those in parenchymal organs such as the liver. After intravenous treatment with the photosensitizer followed by interstitial light activation, contrastenhanced computed tomography shows the development of therapyinduced necrosis around the lightguiding device. With the use of multiple devices, ablation of liver tumors seems to be possible, and no severe side effects or toxicities related to the treatment are reported. PDT can become a clinically relevant adjunct in the locoregional therapy strategies.
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Colorectal liver metastases: regional chemotherapy via transarterial chemoembolization (TACE) and hepatic chemoperfusion: an update
<span title="2006-08-30">2006</span>
<i title="Springer Nature">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/y352pep6tjcphcqt3p6tv3d7se" style="color: black;">European Radiology</a>
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Colorectal liver metastases: regional chemotherapy via transarterial chemoembolization (TACE) and hepatic chemoperfusion: an update Abstract Liver metastasis is one of the main problems encountered in colorectal cancer management as the liver is the most common metastatic site. Several treatment options are available, among which transarterial chemotherapy has proved effective in achieving some local tumour control, improving the quality of life through symptomatic control as well as survival
<span class="external-identifiers">
<a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00330-006-0372-5">doi:10.1007/s00330-006-0372-5</a>
<a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/16944163">pmid:16944163</a>
<a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/cwp2lsntvjcrrbn47itjqkzuby">fatcat:cwp2lsntvjcrrbn47itjqkzuby</a>
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... me. The present paper is intended to provide an overview of the techniques, indications and results of regional chemotherapy, which comprises transarterial chemoembolization (TACE) and chemoperfusion. This treatment approach has symptomatic, palliative, adjuvant and potentially curative objectives. We reviewed the studies involving TACE and chemoperfusion of colorectal liver metastases during the last few years to update the previous reviews published on this subject. The results achieved were so variable, due to the variations in patient selection criteria and regimens used between the different studies. The median survival ranged from 9 to 62 months and the morphological response ranged from 14 to 76%. Technical aspects, results, and complications of this modality will be demonstrated with a detailed analysis and comments.
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Current strategies in interventional oncology of colorectal liver metastases
<span title="">2016</span>
<i title="British Institute of Radiology">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/vngwqxkavfdxxnv7qnd3n2eoli" style="color: black;">British Journal of Radiology</a>
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The adequate treatment of non-resectable liver metastases from colorectal cancer which are resistant to systemic chemotherapy currently provides a great challenge. The aim is to identify and review key strategies in the treatment of colorectal liver metastases. A search for current literature on the topic of interventional strategies for colorectal metastases was performed in Medline in order to achieve this goal. Studies before 2005 and with ,20 patients treated for colorectal metastases were
<span class="external-identifiers">
<a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1259/bjr.20151060">doi:10.1259/bjr.20151060</a>
<a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27164030">pmid:27164030</a>
<a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5124876/">pmcid:PMC5124876</a>
<a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gpzq75nfkngbpntzv6j73ysjmm">fatcat:gpzq75nfkngbpntzv6j73ysjmm</a>
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... xcluded. Transarterial chemoembolization (TACE), transarterial embolization and selective internal radiation therapy (SIRT) were identified as examples of regional strategies for colorectal liver metastases, utilizing the unique blood supply of the liver. Radiofrequency ablation (RFA), microwave ablation (MWA) and cryoablation were selected as examples for currently available ablative techniques. Median survival in the key studies reviewed ranged from 7.7 to 28.6 for TACE, 8.3-12.6 for SIRT, 8.2-53.2 for RFA and 29-43 months for MWA. After review of the literature, it can be concluded that interventional oncologic therapies are a safe and effective method for treating colorectal liver metastases. The use of new chemotherapeutic agents for local therapy and new ablation technologies and techniques may increase patient survival and allows a neoadjuvant therapy setting. In addition, a combination of local therapies may be used to increase effectiveness in the future, which is subject to further research.
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Repetitive transarterial chemoembolization (TACE) of liver metastases from renal cell carcinoma: Local control and survival results
<span title="2008-02-29">2008</span>
<i title="Springer Nature">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/y352pep6tjcphcqt3p6tv3d7se" style="color: black;">European Radiology</a>
</i>
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Repetitive transarterial chemoembolization (TACE) of liver metastases from renal cell carcinoma: Local control and survival results Abstract The purpose was to evaluate the effectiveness of transarterial chemoembolization (TACE) in local tumor control and survival in patients with hepatic metastases from renal cell carcinoma (RCC). Prospective evaluation of TACE treatment outcome in 22 patients recruited from 1999 and 2005 was performed. The chemotherapeutic agent used was mitomycin only in 45%
<span class="external-identifiers">
<a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00330-008-0887-z">doi:10.1007/s00330-008-0887-z</a>
<a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/18309493">pmid:18309493</a>
<a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ct2tojebszawrcp3t5banbm7lm">fatcat:ct2tojebszawrcp3t5banbm7lm</a>
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... of the patients and mitomycin together with gemcitabine in the other 55%. The embolizing materials used in all of the patients were iodized oil (lipiodol) and degradable starch microspheres. Local response was evaluated by MRI and judged according to Response Eval-uation Criteria in Solid Tumors (RECIST). Mean and median survival and survival probability after diagnosis and treatment were both calculated by Kaplan-Meier method. Partial response was achieved in 13.7%, stable disease in 59% and progressive disease in 27.3% of patients. Survival time from the diagnosis of metastases ranged from 18 to 307 months and from 2.2 to 35 months from the start of TACE treatment. The median and mean survival times from the date of diagnosis were 68.6 and 102.9 months, respectively. The median and mean survival times from the start of TACE were 8.2 and 11.7 months, respectively. Survival probability from the start of treatment was 31% after 1 year and 6% after 2 years. TACE can result in a favorable local tumor response in patients with hepatic metastases from RCC, but survival results are still limited.
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Computed Tomography Guided Percutaneous Liver Biopsy Using a Robotic Assistance Device—A Corpse Study
<span title="">2015</span>
<i title="Scientific Research Publishing, Inc,">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/lylgrpbgavd3fi7flsw43nabvy" style="color: black;">Open Journal of Radiology</a>
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Purpose: To investigate a robot assistance device for CT-guided percutan liver biopsy. Materials and Methods: The liver of a corpse was equipped with target dummies. Four radiologists used a 16 G needle to perform biopsy of the target region in standard free hand technique and then used a robot system which allowed planning and aligning the trajectory path. Accuracy in terms of needle tip deviation, and time efficiency and radiation exposure in terms of effective dose for the radiologists were
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<a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.4236/ojrad.2015.52014">doi:10.4236/ojrad.2015.52014</a>
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... easured. Results: For in plane procedures, there was no significant benefit in accuracy when using the robot versus standard technique (4 mm vs. 5.6 mm, p = 0.11); timely effort was worse (443 sec vs. 405 sec, p = 0.64). For angulated punctures, a needle tip of 3.7 mm was measured by using the robotic device (vs. 10.8 mm, p < 0.01); mean biopsy duration was 490 sec (vs. 900 sec, p < 0.01). Mean radiation exposures in freehand technique were 2.4 µSv (in plane procedures) and 10.8 µSv (oblique procedures); the robotic assisted procedures were performed without additional image guidance. Conclusion: The proposed robotic assistance device may be superior for angulated interventions regarding accuracy and timely effort. Furthermore, the zero radiation exposure is a significant benefit for the interventional radiologist.
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Accuracy and speed of robotic assisted needle interventions using a modern cone beam computed tomography intervention suite: a phantom study
<span title="2012-07-21">2012</span>
<i title="Springer Nature">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/y352pep6tjcphcqt3p6tv3d7se" style="color: black;">European Radiology</a>
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Objective To analyse the feasibility and accuracy of robotic aided interventions on a phantom when using a modern Carm-mounted cone beam computed tomography (CBCT) device in combination with needle guidance software. Methods A small robotic device capable of holding and guiding needles was attached to the intervention table. After acquiring a 3D data set the access path was planned on the CBCT workstation and shown on the intervention monitor. Then the robot was aligned to the live fluorosopic
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<a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00330-012-2585-0">doi:10.1007/s00330-012-2585-0</a>
<a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22821395">pmid:22821395</a>
<a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/t3mevmd5wncrvaftyzmirjyj6a">fatcat:t3mevmd5wncrvaftyzmirjyj6a</a>
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... mage. A total of 40 punctures were randomly conducted on a phantom armed with several targets (diameter 2 mm) in single and double oblique trajectory (n020 each). Target distance, needle deviation and time for the procedures were analysed.
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Intervention Planning Using a Laser Navigation System for CT-Guided Interventions: A Phantom and Patient Study
<span title="">2015</span>
<i title="The Korean Society of Radiology (KAMJE)">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/c6pm5ttsdzfx3eaeb2ndqzlyje" style="color: black;">Korean Journal of Radiology</a>
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Objective: To investigate the accuracy, efficiency and radiation dose of a novel laser navigation system (LNS) compared to those of free-handed punctures on computed tomography (CT). Materials and Methods: Sixty punctures were performed using a phantom body to compare accuracy, timely effort, and radiation dose of the conventional free-handed procedure to those of the LNS-guided method. An additional 20 LNS-guided interventions were performed on another phantom to confirm accuracy. Ten patients
<span class="external-identifiers">
<a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3348/kjr.2015.16.4.729">doi:10.3348/kjr.2015.16.4.729</a>
<a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26175571">pmid:26175571</a>
<a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4499536/">pmcid:PMC4499536</a>
<a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7cnzqrs4w5a4pnbrmfp2zuo3yy">fatcat:7cnzqrs4w5a4pnbrmfp2zuo3yy</a>
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... subsequently underwent LNS-guided punctures. Results: The phantom 1-LNS group showed a target point accuracy of 4.0 ± 2.7 mm (freehand, 6.3 ± 3.6 mm; p = 0.008), entrance point accuracy of 0.8 ± 0.6 mm (freehand, 6.1 ± 4.7 mm), needle angulation accuracy of 1.3 ± 0.9° (freehand, 3.4 ± 3.1°; p < 0.001), intervention time of 7.03 ± 5.18 minutes (freehand, 8.38 ± 4.09 minutes; p = 0.006), and 4.2 ± 3.6 CT images (freehand, 7.9 ± 5.1; p < 0.001). These results show significant improvement in 60 punctures compared to freehand. The phantom 2-LNS group showed a target point accuracy of 3.6 ± 2.5 mm, entrance point accuracy of 1.4 ± 2.0 mm, needle angulation accuracy of 1.0 ± 1.2°, intervention time of 1.44 ± 0.22 minutes, and 3.4 ± 1.7 CT images. The LNS group achieved target point accuracy of 5.0 ± 1.2 mm, entrance point accuracy of 2.0 ± 1.5 mm, needle angulation accuracy of 1.5 ± 0.3°, intervention time of 12.08 ± 3.07 minutes, and used 5.7 ± 1.6 CT-images for the first experience with patients. Conclusion: Laser navigation system improved accuracy, duration of intervention, and radiation dose of CT-guided interventions.
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Preliminary experience with transarterial chemoembolization (TACE) in liver metastases of uveal malignant melanoma: local tumor control and survival
<span title="2006-10-05">2006</span>
<i title="Springer Nature">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/gi2y7vfdfne4pk7opbq3poadz4" style="color: black;">Journal of Cancer Research and Clinical Oncology</a>
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Purpose To evaluate results in the palliative treatment of patients with liver metastases of uveal malignant melanoma using transarterial chemoembolization (TACE). Materials and methods Superselective TACE was repeatedly performed in 12 patients with liver metastases of uveal malignant melanoma. Six patients presented with solitary liver metastases (6-12 cm in size) and six patients with oligonodular metastases (n · 6). The embolization suspension consisted of a maximum of 10 mg/m 2 Mitomycin
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<a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00432-006-0155-z">doi:10.1007/s00432-006-0155-z</a>
<a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17021903">pmid:17021903</a>
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... 10 ml Lipiodol, and an injection of 200-450 mg resorbable microspheres for vascular occlusion. In the follow-up, magnetic resonance imaging was performed in 3-month intervals. Results The TACE procedure was well tolerated in all patients without any relevant side eVects. Three patients responded to TACE with a size reduction of more than 50% (partial response), Wve patients with stable disease, and four patients with progressive disease with an increase in volume of more than 25%. Mean survival following primary tumor treatment was 32.9 months, and after Wrst embolization 19.5 months. Lower survival rates were recorded for the progressive group (16.5 months). Conclusion Repeated TACE oVers a palliative treatment option in patients with oligonodular liver metastases of uveal malignant melanoma.
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TRANS-FUSIMO -- clinical translation of patient specific planning and conduction of FUS treatment in moving organs
<span title="">2015</span>
<i title="Springer Nature">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/caorm5h62ncl5odul6ri5chohu" style="color: black;">Journal of Therapeutic Ultrasound</a>
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Background/introduction The movement of the target challenges the application of high intensive focused ultrasound (HiFU/MRgFUS) for the treatment of malignancies in moving abdominal organs such as liver and kidney. Moreover, the anatomical location of the lesion is often behind the rib cage. The physiology of the organs, the dynamic and complex blood perfusion impairs the energy disposition in the tissue due to the heat transfer within the organ. To explore the full potential of extracorporeal
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<a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/2050-5736-3-s1-o85">doi:10.1186/2050-5736-3-s1-o85</a>
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... FUS to safely and precisely destroy tissue in the depth of a moving organ requires sophisticated software and advanced hardware. In the EU project FUSIMO (www.fusimo.eu) a software demonstrator for the patient specific planning of FUS in the liver has been developed in order to empower the physician to perform safe, effective and efficient ablation of tumours and to facilitate prediction of the outcome. The new EU project TRANS-FUSIMO (www.trans-fusimo.eu) aims at the translation of this software demonstrator into a fully integrated system for the FUS treatment of the liver. Methods The FUSIMO software demonstrator based on MeVisLab incorporates a set of dynamic organ models for the physical and biophysical processes involved in MR guided FUS treatment: (i) an organ motion model simulates the patient specific deformation of the relevant anatomical structures during breathing; (ii) a patient specific tissue model represents the ultrasound propagation, the energy distribution as well as the tissue heating and cooling; (iii) an organ/ tumour model captures the patient specific tissue's response to the therapy. These model components are integrated into a software demonstrator, which orchestrates the interplay between the models and feeds them with model parameters that are extracted from patient specific MR and/or US imaging data. The system and the model components are being validated in phantom and ex vivo experiments and in Thiel soft embalmed human cadavers. In TRANS-FUSIMO the safety, efficacy and efficiency of the software assistant will be evaluated in an in vivo animal study. Moreover, a two-arm study (neoadjuvant TRANS-FUSIMO MRgFUS + resection, TRANS-FUSIMO MRgFUS only) for human patients with metastases or HCC will show the feasibility of the TRANS-FUSIMO system for the clinical setting. Results and conclusions The FUSIMO/TRANS-FUSIMO software demonstrator comprises specific models for the simulation of FUS application in moving organs based on imaging data derived from volunteers. It supports the assessment of the feasibility of the intervention, predicting and optimizing the outcome, detecting potential risks and avoiding them, as well as monitoring the progress and tracking deviations from the planned procedure. Our ex vivo experiments show that the FUSIMO system is capable of compensating organ motion through real-time motion detection, motion modelling and real-time beam steering. In TRANS-FUSIMO a fully integrated system will be developed for which in vivo animal studies and first patient study shall show that MRgFUS in moving organs can be performed safely, efficaciously and effectively.
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Evaluation of Multiparametric MRI of the Prostate: Impact of Standardized Examination Protocols and the Endorectal Coil
<span title="">2020</span>
<i title="Scientific Research Publishing, Inc.">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/lcnhr2kxdndp7fysgg73b7nv6q" style="color: black;">Open Journal of Medical Imaging</a>
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Purpose: The aim of the present study was to evaluate the patient population, different MRI examination protocols and the patient's acceptance of the endorectal coil in the diagnosis of prostate cancer regarding the current discussion in PI-RADS v2.1. Material and Methods: In our institute, 256 patients were examined with different protocols and separated into six groups. The value of the different MRI protocols was identified by analyzing sensitivity, specificity, negative predictive value and
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<a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.4236/ojmi.2020.101003">doi:10.4236/ojmi.2020.101003</a>
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... positive predictive value. The patient population was tested for statistically significant differences in their characteristics to detect a distortion of the results. The patients' acceptance of endorectal coil was evaluated by a query. Results: In total 4.7% of the patients would not recommend a MRI examination because of subjective physical strain and 65.6% of all patients subjectively saw a benefit in the examination in regard to an optimal diagnostic process. The protocol groups reached a sensitivity from 66.7% -100%, a specificity from 40% -75%, a positive predictive value from 33.3% -80% and a negative predictive value from 66.7% -100%. Conclusion: MRI of the prostate is a safe and comfortable tool with high sensitivity and negative predictive value and the potential of ruling out a clinically significant prostate cancer. However, a general recommendation for the use of biparametric MRI could not be given, considering a higher sensitivity could be performed when using dynamic contrast-enhanced MRI or spectroscopy.
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Go-Smart: Open-Ended, Web-Based Modelling of Minimally Invasive Cancer Treatments via a Clinical Domain Approach
[article]
<span title="2018-03-24">2018</span>
<i >
arXiv
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<span class="release-stage" >pre-print</span>
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Clinicians benefit from online treatment planning systems, through off-site accessibility, data sharing and professional interaction. As well as enhancing clinical value, incorporation of simulation tools affords innovative avenues for open-ended, multi-disciplinary research collaboration. An extensible system for clinicians, technicians, manufacturers and researchers to build on a simulation framework is presented. This is achieved using a domain model that relates entities from theoretical,
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<a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1803.09166v1">arXiv:1803.09166v1</a>
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... gineering and clinical domains, allowing algorithmic generation of simulation configuration for several open source solvers. The platform is applied to Minimally Invasive Cancer Treatments (MICTs), allowing interventional radiologists to upload patient data, segment patient images and validate simulated treatments of radiofrequency ablation, cryoablation, microwave ablation and irreversible electroporation. A traditional radiology software layout is provided in-browser for clinical use, with simple, guided simulation, primarily for training and research. Developers and manufacturers access a web-based system to manage their own simulation components (equipment, numerical models and clinical protocols) and related parameters. This system is tested by interventional radiologists at four centres, using pseudonymized patient data, as part of the Go-Smart Project (http://gosmart-project.eu). The simulation technology is released as a set of open source components http://github.com/go-smart.
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Performances de reproduction du poisson chat endogène du Cameroun Clarias jaensis (Boulenger, 1909) en milieu contrôlé
<span title="2016-09-12">2016</span>
<i title="African Journals Online (AJOL)">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/acb4z6fzrjcdbdpxbk3plun25e" style="color: black;">International Journal of Biological and Chemical Sciences</a>
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Par ailleurs, les valeurs de diamètre des ovocytes (1.65 ± 0.07 à 1.73 ± 0.15 mm) ont été comparables à 1.56 ± 0.13 à 2.5 ± 0.17 mm obtenues par Zango et al. (2015) chez la même espèce prête à pondre et ...
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Trans-arterial chemoperfusion for the treatment of liver metastases of breast cancer and colorectal cancer: Clinical results in palliative care patients
<span title="">2017</span>
<i title="Baishideng Publishing Group Inc.">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/apjzekmfazfnxhpufo6fafmvsy" style="color: black;">World Journal of Clinical Oncology</a>
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Gruber-Rouh T, Langenbach M, Naguib NNN, Nour-Eldin NEM, Vogl TJ, Zangos S, Beeres M. ...
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Combination of Sorafenib and Transarterial Chemoembolization in Selected Patients with Advanced-Stage Hepatocellular Carcinoma: A Retrospective Cohort Study at Three German Liver Centers
<span title="2021-04-28">2021</span>
<i title="MDPI AG">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2zwku6u6nfdcri773tpisi6ldi" style="color: black;">Cancers</a>
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(Stephan Zangos), S.Z. ...
(Stephan Zangos), S.Z. ...
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