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EXPANSION LOAD [chapter]

Stephan Peischl, Laurent Excoffier
2016 Invasion Genetics  
The long-term dynamics of expansion load have been studied elsewhere (Peischl et al. 2013; Peischl et al. 2014) .  ...  Gene surfing can also affect the spread of selected variants (Travis et al. 2007; Burton and Travis 2008; Lehe et al. 2012; Peischl et al. 2013; Peischl et al. 2014) .  ... 
doi:10.1002/9781119072799.ch13 fatcat:vwgq666iavaxrf5f4kzs3ehzqi

When does gene flow facilitate evolutionary rescue? [article]

Matteo Tomasini, Stephan Peischl
2019 bioRxiv   pre-print
Stephan Peischl is one of the PCI Evol Biol recommenders.  ...  [2012] and Tomasini and Peischl [2018] .  ...  The critical threshold at which swamping occurs remains unaffected, as it depends on the ratio between z and m only [Tomasini and Peischl, 2018] .  ... 
doi:10.1101/622142 fatcat:hjnil2ebfzdyfdypvhmwoaefuu

Fragmentation helps evolutionary rescue in highly connected habitats [article]

Matteo Tomasini, Stephan Peischl
2020 bioRxiv   pre-print
Peischl. Evolutionary rescue by beneficial mutations in environments that change 341 in space and time.  ...  The conditions for150 when intermediate migration rates increase the probability of rescue in a two-deme model can be found 151 in Tomasini and Peischl [2020].  ... 
doi:10.1101/2020.10.29.360842 fatcat:3q2fml2idbh2tfsk3wpmzs6o4i

Establishment of locally adapted mutations under divergent selection [article]

Matteo Tomasini, Stephan Peischl
2018 bioRxiv   pre-print
evolution of dispersal traits deterministically, which would yield a time-dependent multi-406 type branching process that could be studied with a perturbation approach similar to the one 407 derived in [Peischl  ... 
doi:10.1101/248013 fatcat:yxmkjka64fhw5hqpvjpxg4yzmi

Evolution of dispersal can rescue populations from expansion load [article]

Stephan Peischl, Kimberly J. Gilbert
2018 bioRxiv   pre-print
If mutations affect only fitness but not dispersal probabilities, Peischl et al.  ...  If s m = 0, we recover the fixation probability 175 on the expansion front derived in Peischl et al. (2013).  ... 
doi:10.1101/483883 fatcat:dhnycc26cbhwzewekxurh3xsqm

Genetic surfing in human populations: from genes to genomes [article]

Stephan Peischl, Isabelle Dupanloup, Lars Bosshard, Laurent Excoffier
2016 bioRxiv   pre-print
Peischl S, Kirkpatrick M, Excoffier L: Expansion load and the evolutionary dynamics of a species range.  ...  Peischl S, Dupanloup I, Kirkpatrick M, Excoffier L: On the accumulation of deleterious mutations during range expansions.  ... 
doi:10.1101/055145 fatcat:rc5dqymurjhp5imkerf52cgf2i

Establishment of New Mutations in Changing Environments

Stephan Peischl, Mark Kirkpatrick
2012 Genetics  
Understanding adaptation in changing environments is an important topic in evolutionary genetics, especially in the light of climatic and environmental change. In this work, we study one of the most fundamental aspects of the genetics of adaptation in changing environments: the establishment of new beneficial mutations. We use the framework of time-dependent branching processes to derive simple approximations for the establishment probability of new mutations assuming that temporal changes in
more » ... e offspring distribution are small. This approach allows us to generalize Haldane's classic result for the fixation probability in a constant environment to arbitrary patterns of temporal change in selection coefficients. Under weak selection, the only aspect of temporal variation that enters the probability of establishment is a weighted average of selection coefficients. These weights quantify how much earlier generations contribute to determining the establishment probability compared to later generations. We apply our results to several biologically interesting cases such as selection coefficients that change in consistent, periodic, and random ways and to changing population sizes. Comparison with exact results shows that the approximation is very accurate.
doi:10.1534/genetics.112.140756 pmid:22542964 pmcid:PMC3389982 fatcat:r7sw4ctrmva6baf24eodrfal3y

Mutation load dynamics during environmentally-driven range shifts [article]

Kimberly Julie Gilbert, Stephan Peischl, Laurent Excoffier
2018 bioRxiv   pre-print
To compare our (0) = 1 424 results to simulations we assume that F = K m/2 (Peischl et al. 2015). Acknowledgements 426 We would like to thank_____.  ...  F is the number of founders of a new deme during the 0 419 379 fitness effects and 10% have beneficial effects to match previous simulations(Peischl et al.  ... 
doi:10.1101/333252 fatcat:yvoe5u6vkjfypiyko6qvygmyca

On the accumulation of deleterious mutations during range expansions [article]

Stephan Peischl, Isabelle Dupanloup, Mark Kirkpatrick, Laurent Excoffier
2013 arXiv   pre-print
We investigate the effect of spatial range expansions on the evolution of fitness when beneficial and deleterious mutations co-segregate. We perform individual-based simulations of a uniform linear habitat and complement them with analytical approximations for the evolution of mean fitness at the edge of the expansion. We find that deleterious mutations accumulate steadily on the wave front during range expansions, thus creating an expansion load. Reduced fitness due to the expansion load is
more » ... restricted to the wave front but occurs over a large proportion of newly colonized habitats. The expansion load can persist and represent a major fraction of the total mutation load thousands of generations after the expansion. Our results extend qualitatively and quantitatively to two-dimensional expansions. The phenomenon of expansion load may explain growing evidence that populations that have recently expanded, including humans, show an excess of deleterious mutations. To test the predictions of our model, we analyze patterns of neutral and non-neutral genetic diversity in humans and find an excellent fit between theory and data.
arXiv:1306.1652v1 fatcat:gyxa7cmb5ndcbd2nixc4ktc2d4

Expansion load: recessive mutations and the role of standing genetic variation [article]

Stephan Peischl, Laurent Excoffier
2014 bioRxiv   pre-print
Gene surfing can also affect the spread of 57 selected variants (Travis et al. 2007; Burton and Travis 2008; Lehe et al. 2012; Peischl et al. 2013; 58 Peischl et al. 2014).  ...  populations incur a mutation burden -the "expansion load" (Peischl et al. 2013) .  ... 
doi:10.1101/011593 fatcat:e6ou3cryhjbnja63us3klb4dwy

Gene surfing of underdominant alleles promotes formation of hybrid zones [article]

Kimberly J Gilbert, Antoine F Moinet, Stephan Peischl
2021 bioRxiv   pre-print
tions in (Peischl et al., 2013, 2015) and simply replace s with sT and N with F.  ...  Unlike deleterious mutations that can lead to 320 a transient increase in mutation load in recently colonized areas (Peischl et al., 2013), 321 underdominant mutations will be maintained in the form of  ... 
doi:10.1101/2021.05.30.446372 fatcat:sud7vyfle5fnfien4q4nn4qule

Establishment of Locally Adapted Mutations Under Divergent Selection

Matteo Tomasini, Stephan Peischl
2018 Genetics  
Kirkpatrick and Peischl (2013) used a similar approach to study the contribution of new mutations to evolutionary rescue in environments that change in space and time.  ...  the evolution of dispersal traits deterministically, which would yield a time-dependent multi-type branching process that could be studied with a perturbation approach similar to the one derived in Peischl  ... 
doi:10.1534/genetics.118.301104 pmid:29773560 pmcid:PMC6028263 fatcat:6xsl3psqgbbytj4zipyied4qiu

Accumulation of deleterious mutations during bacterial range expansions [article]

Lars Bosshard, Isabelle Dupanloup, Olivier Tenaillon, Remy Bruggmann, Martin Ackermann, Stephan Peischl, Laurent Excoffier
2016 bioRxiv   pre-print
However, whereas the process and consequences of expansion load during range expansions have been well described (PEISCHL et al. 2016; PEISCHL et al. 2013; PEISCHL AND EXCOFFIER 2015; PEISCHL et al. 2015  ...  et al. 2013; PEISCHL et al. 2015) .  ... 
doi:10.1101/093658 fatcat:j7hfwebm7baozgh2xgqtqnzhqu

Genomic analysis of fast expanding bacteria reveals new molecular adaptive mechanisms [article]

Lars Bosshard, Stephan Peischl, Martin Ackermann, Laurent Excoffier
2018 bioRxiv   pre-print
Bacterial populations have been shown to accumulate deleterious mutations during spatial expansions that overall decrease their fitness and ability to grow. However, it is unclear if and how they can respond to selection in face of this mutation load. We examine here if artificial selection can counteract the negative effects of range expansions. We investigated the molecular evolution of 20 lines (SEL) selected for fast expansions and compared them to 20 lines without artificial selection
more » ... ROL). We find that all 20 SEL lines have been able to increase their expansion speed relative to the ancestral line, unlike CONTROL lines, showing that enough beneficial mutations are produced during spatial expansions to counteract the negative effect of expansion load. Importantly, SEL and CONTROL lines have similar numbers of mutations indicating that they evolved for the same number of generations and that increased fitness is not due to a purging of deleterious mutations. We find that loss of function (LOF) mutations are better at explaining the increased expansion speed of SEL lines than non-synonymous mutations or a combination of the two. Interestingly, most LOF mutations are found in simple sequence repeats located in genes involved in gene regulation and gene expression. We postulate that such potentially reversible mutations could play a major role in the rapid adaptation of bacteria to changing environmental conditions by shutting down expensive genes and adjusting gene expression.
doi:10.1101/355404 fatcat:4eirhlgpsjh4rnqsvxxq6p2ree

Evolution of dominance under frequency-dependent intraspecific competition

Stephan Peischl, Reinhard Bürger
2008 Journal of Theoretical Biology  
Examples are given and proved in Peischl (2006) . A.3. The equilibriump ðmÞ A.3.1. The case a ¼ 0 This case is much simpler than aa0 because the equilibrium can be calculated explicitly if a ¼ 0.  ...  , Otto and Bourguet do not mention it, it can be shown that in their model, in which modifiers have no direct fitness effects, an internal equilibrium can exist, which may be stable or unstable; see Peischl  ... 
doi:10.1016/j.jtbi.2007.11.014 pmid:18177673 fatcat:wv5zngug2bcwjldtppjce6jgnu
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