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(FH) Stephan Klingner, M.Sc. wissenschaftlicher Mitarbeiter in der Abteilung Betriebliche Informationssysteme an der Universität Leipzig (klingner@informatik. uni-leipzig.de). Dipl.-Inf. ... Böttcher/Klingner, 2010). ...doi:10.15358/0935-0381-2011-10-509 fatcat:zkhc2twehng5dgnxvkn4tjstze
The task of this module Enterprise Modelling and Information Systems Architectures Vol. 10, No. 1, December 2015 42 Michael Becker and Stephan Klingner Figure 14 : Screenshot of the service modeller ... With Enterprise Modelling and Information Systems Architectures Vol. 10, No. 1, December 2015 32 Michael Becker and Stephan Klingner hierarchical and logical dependencies, it is possible to define validity ...doi:10.18417/emisa.10.1.2 dblp:journals/emisaij/BeckerK15 fatcat:yxyvn5ive5efnflvon4ez3iqvm
Moreover, functional requirements and enhancements were discusses in numerous workshops with project partners (Klingner, et al., 2011) . ... So far, service literature has shown the applicability of modularization and mass customization in the service domain (Sundbo, 1994; Heiskala, et al., 2005; Böttcher & Klingner, 2010) . ...doi:10.4018/jssmet.2013040105 fatcat:4ncopj4q3jdwnlzwg6xshybb5i
Stephan Klingner and Michael Becker has several cells that convert light energy into electrical energy. ... Enterprise Modelling and Information Systems Architectures Vol. 7, No. 1, November 2012 58 Stephan Klingner and Michael Becker The PV example has two requirements. ...doi:10.1007/bf03345922 fatcat:lrrpakgw3bbp7ds6wj3bhutoci
Precise quantification of molecular targets in a biological sample across a wide dynamic range is a key requirement in many diagnostic procedures, such as monitoring response to therapy or detection of measurable residual disease. State of the art digital PCR assays provide for a dynamic range of four orders of magnitude. However digital assays are complex and require sophisticated microfluidic tools. Here we present an assay format that enables ultra-precise quantification of RNA targets in adoi:10.1101/2020.11.05.369637 fatcat:i4nbbgvzbbhb3hp32r4banhcze
more »... ingle measurement across a dynamic range of more than seven orders of magnitude. The approach is based on hydrogel beads that provide for microfluidic free compartmentalization of the sample as they are used as digital nanoreactors for reverse transcription, PCR amplification and combined real time and digital detection of gene transcripts. We have applied these nanoreactors for establishing an assay for the detection and quantification of BCR-ABL1 fusion transcripts. The assay has been characterized for its accuracy and linear dynamic range. A comparison of the new method against the current clinical standard procedure with clinical samples from patients with chronic myeloid leukemia (CML) revealed good agreement between the results obtained with the respective method.
Klingner and Michael Becker Implementation of an Information Production System (IPS) for Precision Farming" (support code 01IS12013B) and EUMONIS (support code 01IS10033D). ... für Bildung und Forschung, BMBF) partially supported this work in the context of the DLR projects "Concept and Enterprise Modelling and Information Systems Architectures Vol. 0, No. 0, month 0000 20 Stephan ... Enterprise Modelling and Information Systems Architectures Vol. 0, No. 0, month 0000 4 Stephan Klingner and Michael Becker These units can be managed independently. ...doi:10.18417/emisa.7.1.3 dblp:journals/emisaij/KlingnerB12 fatcat:t4mqnxtsg5emndfi6mfcvuhiyi
AbstractIn the competitive, increasingly international music business, publishers are developing new ways to increase effectiveness and efficiency of the monetization of the copyrights they own or manage. Driven by various needs, publishers become entrepreneurs in new markets by choosing the path of direct memberships in foreign copyright collecting societies, rather than entrusting sub-publishers or taking the detour through their domestic copyright collecting society. Since with great powerdoi:10.1007/s10824-021-09412-9 fatcat:6jlbjxcc3veena7b7vwkk52jr4
more »... mes great responsibility, publishers as entrepreneurs are pursuing various economic opportunities, but at the same time are also facing great challenges. This paper aims at studying the motivation, obstacles and potentials and deriving possible solutions for this step and thus improving the understanding of as well as supporting publishers in this entrepreneurial activity.
Precise quantification of molecular targets in a biological sample across a wide dynamic range is a key requirement in many diagnostic procedures, such as monitoring response to therapy or detection of measurable residual disease. State of the art digital PCR assays provide for a dynamic range of four orders of magnitude. However digital assays are complex and require sophisticated microfluidic tools. Here we present an assay format that enables ultra-precise quantification of RNA targets in adoi:10.1371/journal.pone.0242529 pmid:33735175 fatcat:qf2h5nqkorhqjmzlqbjfl56gne
more »... ingle measurement across a dynamic range of more than six orders of magnitude. The approach is based on hydrogel beads that provide for microfluidic free compartmentalization of the sample as they are used as nanoreactors for reverse transcription, PCR amplification and combined real time and digital detection of gene transcripts. We have applied these nanoreactor beads for establishing an assay for the detection and quantification of BCR-ABL1 fusion transcripts. The assay has been characterized for its precision and linear dynamic range. A comparison of the new method against conventional real time RT-PCR analysis (reference method) with clinical samples from patients with chronic myeloid leukemia (CML) revealed excellent concordance with Pearsons correlation coefficient of 0.983 and slope of 1.08.
Neural Machine Translation (NMT) is an end-to-end learning approach for automated translation, with the potential to overcome many of the weaknesses of conventional phrase-based translation systems. Unfortunately, NMT systems are known to be computationally expensive both in training and in translation inference. Also, most NMT systems have difficulty with rare words. These issues have hindered NMT's use in practical deployments and services, where both accuracy and speed are essential. In thisarXiv:1609.08144v2 fatcat:jux5jscohne6zp6x6kiada7wr4
more »... work, we present GNMT, Google's Neural Machine Translation system, which attempts to address many of these issues. Our model consists of a deep LSTM network with 8 encoder and 8 decoder layers using attention and residual connections. To improve parallelism and therefore decrease training time, our attention mechanism connects the bottom layer of the decoder to the top layer of the encoder. To accelerate the final translation speed, we employ low-precision arithmetic during inference computations. To improve handling of rare words, we divide words into a limited set of common sub-word units ("wordpieces") for both input and output. This method provides a good balance between the flexibility of "character"-delimited models and the efficiency of "word"-delimited models, naturally handles translation of rare words, and ultimately improves the overall accuracy of the system. Our beam search technique employs a length-normalization procedure and uses a coverage penalty, which encourages generation of an output sentence that is most likely to cover all the words in the source sentence. On the WMT'14 English-to-French and English-to-German benchmarks, GNMT achieves competitive results to state-of-the-art. Using a human side-by-side evaluation on a set of isolated simple sentences, it reduces translation errors by an average of 60% compared to Google's phrase-based production system.
The first step conducted by the two project partners (Agricon GmbH and the University of Leipzig), was to model the current nutrient mapping process (see Klingner et al. 2013) . ...fatcat:xtf53duuvbarnhy2dmvdigudu4
Zu Beginn des nunmehr abgeschlossenen Projektes wurde von beiden Projektpartnern, der Agricon GmbH und der Universität Leipzig, nach der in Klingner (2013) Auf dieser Grundlage wurde anschließend die ...fatcat:5w3nr7pf4feghp3ffptpy6pejy
Proceedings of the 50th Hawaii International Conference on System Sciences (2017)
Knowledge management (KM) and Knowledge Management Systems (KMS) are not new. With the rise of the Internet, distributed and increasingly social technology, the management principles as well as the tools supporting KM also start to address small and mediumsized enterprises (SME). Todays SMEs are increasingly required to manage knowledge assets in order to sustain their position on the competitive forefront in agile markets. This paper investigates the current state of the art on computerbaseddoi:10.24251/hicss.2017.551 fatcat:pcgyoqby2nc4zjco4y6yztgmza
more »... S (or KM tools as we call them) and commercial KM tools in order to harmonize the picture, derive a joint feature and application system scope and finally inspire future designoriented research by unveiling gaps. It shows that recent SMErelated KM tools do not address KM in a holistic managerial way, fail to link operative data sources such as ERP and CRM, lack effective reward and enabling processes to more quickly establish a knowledge sharing culture amongst SME employees. The main objective of the paper is to inform future designoriented research.
Zur Berechnung der Produktivität komplexer Dienstleistungen zerlegen Böttcher/Klingner/Becker Dienstleistungen in einzelne Komponenten zur Berechnung von Teilproduktivitäten. ... (FH) Stephan Klingner, M.Sc., und Dipl.-Inf. ...doi:10.15358/0935-0381-2011-10-493 fatcat:dutmgjabzfhe3onlwk7e4sngcq
Einführung · Grundbegriffe · 14. bis 16. Jahrhundert
Sie entspricht ihrer Verortung im Gefüge der dreibändigen Sprachgeschichte (der dritte Band erschien 1998 und wird zurzeit von Stephan Elspaß überarbeitet, der zweite Band erschien in einer überarbeiteten ... zu neueren Entwicklungen in den allgemeinen einführenden Teilen (Kap. 1), bei der Darstellung der Sprachwandeltheorien und Grund-Den Band möchten wir unserem viel zu früh verstorbenen Kollegen Jacob Klingner ... Weiterschreiben an der Sprachgeschichte dieses Zeitraumes maßgeblich gefördert haben; stellvertretend und für hilfreiche Diskussionen und Zusendung von Forschungsliteratur danken wir insbesondere Rolf Bergmann, Stephan ...doi:10.1515/9783110496208-003 fatcat:pa5256ykw5hvtclkktxwkws7qa
Klingner und Christian Zinke die ideale Ergänzung zu den Themen in dieser Schwerpunktausgabe. ... Herausgeberteams Thomas Barton, Christian Müller und Christian Seel sowie ebenfalls der Herausgeberband "Service Engineering -Von Dienstleistungen zu digitalen Service-Systemen" von Kyrill Mey-K er, Stephan ...doi:10.1365/s40702-019-00537-2 fatcat:gm2jidmdvvgntew44nt6q3lnri
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