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Nachrichten der BGPN

Felix Betzler, Stephan Köhler
2018 Nervenheilkunde  
Stephan Köhler, Charité -Universitätsmedizin Berlin, Klinik für Psychiatrie und Psychotherapie, Campus Charité Mitte Literatur auf Anfrage Prof. Dr. Tom Bschor Redaktion: Dr. Anja M.  ... 
doi:10.1055/s-0038-1675714 fatcat:jogr6l7klvhxbm5sbzry2dmdei

Effectiveness of Menthacarin on symptoms of irritable bowel syndrome

Ahmed Madisch, Stephan Miehlke, Joachim Labenz, Berenike Stracke, Stephan Köhler
2018 Wiener Medizinische Wochenschrift  
The findings of Freise and Köhler [13] that the enteric-coated formulation leads to fewer side effects is consistent with published literature according to which adverse reactions like heartburn and  ...  In the data reported by Freise and Köhler [13] and by Madisch and colleagues [15] , the differences in changes of intensity of pain between Menthacarin on the one hand and the enteric-soluble formulation  ... 
doi:10.1007/s10354-018-0635-1 pmid:29728848 fatcat:eyj3chqzirczrdjxhnrguxgbnm

Benefits of a New Annular Darkfield Method Using Köhler Illumination in a Energy Filtering TEM

Gerd Benner, Erhard Zellmann, Stephan Hiller
2003 Microscopy and Microanalysis  
This paper describes a new DF which can be performed by a Köhler Illumination system (KIS) and has numerous advantages over the standard methods provided by conventional illumination systems.  ...  This paper describes a new DF which can be performed by a Köhler Illumination system (KIS) and has numerous advantages over the standard methods provided by conventional illumination systems.  ... 
doi:10.1017/s1431927603444747 fatcat:ziymysck4jamxlsg7w2au64pba

Vom Mittelalter zum Hanseraum

Stephan Köhler, Carsten Jahnke
2021 Hansische Geschichtsblätter  
Stephan Köhler und Carsten Jahnke 2.2 85 Ferrer I Mallol 2001, S. 916. Stolz 1955, Nr. 6, S. 57-59.  ...  Denzel 2016, S. 98.Stephan Köhler und Carsten Jahnke Vom Mittelmeer zum Hanseraum: Der Handel mit Rosinen, Korinthen und Zibeben  ... 
doi:10.21248/hgbll.2018.171 fatcat:e6orjzhd65afjp4vchonmtsbza

Schulenübergreifende Psychotherapie der chronischen Depression

Eva-Lotta Brakemeier, Stephan Köhler, Philipp Sterzer
2013 PiD - Psychotherapie im Dialog  
Köhler • Philipp Sterzer Was kennzeichnet die chronische Depression?  ...  mehrere Wochen behandelt werden, wurde CBASP als multidisziplinäres stationäres Konzept modifi ziert und inzwischen in vielen Kliniken implementiert (Brakemeier & Normann 2012).Eva-Lotta Brakemeier • Stephan  ... 
doi:10.1055/s-0033-1353815 fatcat:4nfhs25q4rgtvlheuctva6ecy4

Lithium Treatment Over the Lifespan in Bipolar Disorders

Constantin Volkmann, Tom Bschor, Stephan Köhler
2020 Frontiers in Psychiatry  
Lithium has been the treatment of choice for patients with bipolar disorder (BD) for nearly 70 years. It is recommended by all relevant guidelines as a first-line treatment for maintenance therapy. In this review, we outline the current state of evidence for lithium in the treatment of BD over the lifespan. First, we summarize the evidence on efficacy in general, from relapse prevention to acute anti-manic treatment and its role in treating mood episodes with mixed features and bipolar
more » ... n. As patients are often treated for many years and different aspects have to be considered in different phases of life, we discuss the particularities of lithium in the treatment of paediatric BD, in older aged individuals and in pregnant women. Lastly, we discuss the evidence on lithium's proposed suicide-preventive effects, the dangers of rapid discontinuation and lithium's adverse effects, particularly with regard to long-term treatment.
doi:10.3389/fpsyt.2020.00377 pmid:32457664 pmcid:PMC7221175 fatcat:6snaqfybrjfk5kr5ejq26sd2ye

On Subfamilies of AT-Free Graphs [chapter]

Ekkehard Köhler, Derek G. Corneil, Stephan Olariu, Lorna Stewart
2001 Lecture Notes in Computer Science  
We introduce two subfamilies of AT-free graphs, namely, path orderable graphs and strong asteroid free graphs. Path orderable graphs are defined by a linear ordering of the vertices that is a natural generalization of the ordering that characterizes cocomparability graphs. On the other hand, motivation for the definition of strong asteroid free graphs comes from the fundamental work of Gallai on comparability graphs. We show that cocomparability graphs ⊂ path orderable graphs ⊂ strong asteroid
more » ... ree graphs ⊂ AT-free graphs. In addition, we settle the recognition question for the two new classes by proving that recognizing path orderable graphs is NP-complete whereas the recognition problem for strong asteroid free graphs can be solved in polynomial time.
doi:10.1007/3-540-45477-2_22 fatcat:aiqoawlnbfcxhmborulusxmcjy

The Social and the Sexual [chapter]

Hans-Peter Kohler, Stéphane Helleringer, Jere R. Behrman, Susan C. Watkins
2015 Population in the Human Sciences  
The analysis of networks has become an important theme in contemporary demographic research in both developed and developing countries, including investigations of the determinants of fertility behaviors, the interaction between social network and social structures and population policies, the role of intergenerational networks in aging societies, and the relevance for sexual networks for the spread of HIV AIDS. This paper reviews the current research on networks across several domains in
more » ... aphic research, and it discusses some of the specific challenges of network-based approaches with respect to data collection, analytic approaches and methodologies, interpretation of results, and micro-to-macro aggregation by drawing on research conducted as part of the Kenyan Diffusion and Ideational Change Project (KDICP), the Malawi Longitudinal Study of Families and Health (MLSFH) and the Likoma Network Study (LNS).
doi:10.1093/acprof:oso/9780199688203.003.0008 fatcat:r5qsaqykhja5pfkgxumekksp2a

Gerhard Köhler: Zenon von Elea. Studien zu den 'Argumenten gegen die Vielheit' und zum sogenannten 'Argument des Orts'

Stephan Eberle
2018 Gnomon. Kritische Zeitschrift für die gesamte klassische Altertumswissenschaft  
Braunschweig Stephan Nicolas Vinel (V.) hat, gestützt auf umfangreiche Vorarbeiten, mit Iamblichs Schrift 'Zu Nikomachos' Arithmetik' eine wenig beachtete, gleichwohl mathematikhistorisch interessante  ...  Das Hauptverdienst von Köhlers Dissertation besteht darin, die nicht ganz eindeutige und stellenweise verwirrende Überlieferungsgeschichte der Fragmente Zenons und der Zeugnisse zu seiner Lehre eingehend  ... 
doi:10.17104/0017-1417-2018-6-493 fatcat:5ux2ta3ptvbvlcwg7yjb3djoxe

Terahertz emission from a large-area GaInAsN emitter

Falk Peter, Stephan Winnerl, Harald Schneider, Manfred Helm, Klaus Köhler
2008 Applied Physics Letters  
A large-area interdigitated terahertz emitter based on molecular-beam epitaxy grown GaInAsN with an additional AlGaAs heterostructure is investigated as a terahertz source for excitation wavelengths between 1.1 and 1.5 m. The optical and electrical properties of the emitter material exhibit absorption up to a wavelength of 1.5 m and have a resistivity of 550 k⍀ cm. Terahertz waves were detected by electro-optical sampling with a bandwidth exceeding 2 THz. Best performance is found for
more » ... wavelengths below 1.35 m. Furthermore the emission properties for several excitation powers are investigated, showing a linear increase in terahertz emission.
doi:10.1063/1.2978398 fatcat:gs73jkvmvng3nijn6fwg5fpehu

Ecthyma Gangrenosum: Escherichia coli or Pseudomonas aeruginosa?

Mohamed Abbas, Stéphane Emonet, Thilo Köhler, Gesuele Renzi, Christian van Delden, Jacques Schrenzel, Bernard Hirschel
2017 Frontiers in Microbiology  
Ecthyma gangrenosum (EG) are necrotic lesions that develop in the context of Pseudomonas aeruginosa bacteremia. Isolated reports describe EG in the setting of non-Pseudomonal infections. In a patient with EG, initial blood cultures showed Escherichia coli, and almost occulted P. aeruginosa bacteremia. Based on the clinical picture we suspected preponderant P. aeruginosa bacteremia, outgrown by concomitant low-grade E. coli bacteremia in the blood culture vials. Methods: We performed
more » ... polymerase chain reaction (PCR) assays with specific primers for P. aeruginosa and E. coli on blood collected at the same time for blood cultures. We also performed quantitative cultures of the strains isolated from the patient's blood. Results: Quantitative PCR showed that there were 1.5 × 10 E 7 copies/milliliter (ml) of P. aeruginosa DNA, whereas the quantity of E. coli DNA was below the detection limit of 2 × 10 E 4 copies/ml. We estimated that there was at least 1000 times more P. aeruginosa than E. coli. Quantitative cultures showed that E. coli grew faster than P. aeruginosa. Conclusion: Our patient with EG had preponderant P. aeruginosa bacteremia, that was almost occulted by concomitant low-grade E. coli bacteremia. Quantitative PCR was complementary to blood cultures in the final microbiological diagnosis, and proved beneficial in establishing the etiology of EG. This may question the existence of non-Pseudomonal EG, and also shows that blood culture results do not always reflect an "exact picture" of what happens in the patient's blood at the time of sampling. This case illustrates the importance of communication between the clinician and the microbiology laboratory to ensure best possible results.
doi:10.3389/fmicb.2017.00953 pmid:28611752 pmcid:PMC5447691 fatcat:kyu6jkipmfgv7jlgpjzuh2mbsi

Business model innovation: coffee triumphs for Nespresso

Kurt Matzler, Franz Bailom, Stephan Friedrich von den Eichen, Thomas Kohler
2013 Journal of Business Strategy  
doi:10.1108/02756661311310431 fatcat:ey4dqolpx5exxhcf4f64duxsoy

Ground State Bleaching at Donor-Acceptor Interfaces

Christian Schwarz, Felix Milan, Tobias Hahn, Markus Reichenberger, Stephan Kümmel, Anna Köhler
2014 Advanced Functional Materials  
Kümmel , and Anna Köhler * Introduction The effi ciency of promising low cost organic bulk heterojunction donor-acceptor (D-A) solar cells is successively increasing over the past decade reaching now  ...  one may expect that the original absorption from the donor polymer and the Ground State Bleaching at Donor-Acceptor Interfaces Christian Schwarz , Felix Milan , Tobias Hahn , Markus Reichenberger , Stephan  ... 
doi:10.1002/adfm.201400297 fatcat:ipoa2pojyrgvlnnmthvl7qdqdm

Optimizing Hollow Fibre Nanofiltration for Organic Matter Rich Lake Water

Alexander Keucken, Yuan Wang, Keng Tng, Greg Leslie, Tom Spanjer, Stephan Köhler
2016 Water  
Over the years, various technologies have been utilized for Natural Organic Matter (NOM) removal with varying degrees of success. Conventional treatment methods comprising of coagulation, flocculation, sedimentation, or filtration are widely used to remove NOM. An alternative to these conventional methods is to use spiral wound membranes. These membranes tend to remove too much hardness whilst being ineffective in disinfection. They also have a low tolerance to chlorine and thus, have limited
more » ... emical cleaning options. In this study, we investigated how an alternative and new innovative filtration concept, based on capillary NF membranes from modified polyethersulfone (PES), may be used to treat soft but humus-rich surface waters. Comprehensive performance tests, with a fully automated membrane pilot equipped with a full-scale sized test module (40 m 2 membrane surface), were conducted at WTP Görvälnverket, which is operated by the water utility Norrvatten, providing drinking water from Mälaren (SUVA = 2.7-3.3, TOC = 7.0-10.0 mg·L −1 ) for about 500,000 people in the northern part of the Swedish capital of Stockholm. The removal of both UV and DOC was modeled using a solution diffusion approach. The optimized parameters allow deducing optimal operation conditions with respect to energy, water consumption, and permeate water quality. Optimal cross flow velocity was determined to be 0.75 m·s −1 at 80% recovery and a flux of 12-18 L·m −2 ·h −1 . Under these conditions, 80% of the UV, 75% of the Humic Substances (MW = 600) and 70% of TOC were removed (from 8 to below 2 mg·L −1 ). A higher cross flow velocity led to marginal improvement (+2%) while both higher and lower membrane fluxes degraded permeate water quality. Apparent optimized diffusion coefficients for UV and TOC were around 1.2-2.4 × 10 −10 ·m 2 ·s −1 and were similar to values found in the literature. Due to their higher diffusion coefficients and higher permeability coefficient, only 40% of the low molecular weight acids (MW = 300-400) were retained. Approximately 30%-40% of the low molecular weight acids in the permeate can be further removed using GAC post NF. The resulting energy consumption of a hypothetical four-stage design, at average operating temperature of 5.73 • C, was calculated to be around 0.6 kWh·m −3 produced water. 430 2 of 25 and aquatic plants. The interrelation between NOM and climate change and notably the rising concentrations of NOM has attracted a lot of attention recently [1] [2][3][4][5][6][7][8][9]. Several potential factors, including an increase in air and surface water temperature, rainfall intensity, and atmospheric CO 2 and/or a decrease in acid deposition, have been proposed to explain the increased amount of NOM [10], but there is yet no scientific consensus on the issue [11] . NOM has a significant impact on drinking water quality directly, by reacting with water treatment chemicals contributing to disinfection by-product (DBP) formation [12, 13] , and indirectly, by impacting water treatment processes (including fouling of membranes and reducing the effectiveness of activated carbon for contaminant removal). In the recent years, reports worldwide indicate a continuing increase in the color and NOM of the surface water, which in turn, causes an adverse effect on drinking water purification [14] . Changes in the properties of NOM also influence the treatment significantly [15] . Therefore, the water industry has been focusing on improving current treatment processes and developing new applications for enhanced removal of NOM. One of the latest innovations in nanofiltration (NF) for effective removal of NOM, is capillary NF membranes which combine the chemical resistance of hollow fiber membranes with the organic retention of spiral wound nanofiltration [16, 17] . This new type of membrane (HFW1000) is suitable for raw waters that have low hardness and contain organic matter that are difficult to flocculate such as lake water. Recent studies indicated that a combined coagulation and NF process removed more than 90% of the dissolved organic carbon (DOC), and 96% of the absorbance at 254 nm in lake water [18], while using direct NF resulted in NOM removal with 93% in UV-absorbance (UVA) retention and 88% TOC retention [19] . An advanced autopsy of the hollow fiber NF membranes was conducted after 12 months of operation with no substantial changes to the membranes detected [20] . These results encouraged us to evaluate dimensioning parameters for the use of these NF membranes for direct lake water filtration. The transport of NOM through NF membrane pores is influenced either by convection or diffusion, depending on the hydrodynamic conditions and electrostatic interactions between the membrane surface and NOM molecules. Different mechanisms influencing the removal of small organic compounds have been suggested. The polarity and differences in diffusion rates in a non-porous structure may influence the rejection of small organic compounds in NF [21, 22] . The solution-diffusion model is the most widely used model of permeation in non-porous polymer membranes [23] [24] [25] while the Donnan steric pore model and dielectric exclusion model have also been used to describe mass transfer of electrolytes and neutral solutes through nanofiltration membranes [26] as well as to predict rejections of trace organics by NF membranes [27, 28] . The ability of the model to describe all non-porous membrane separation processes has been the subject of several reviews even in the past [23, 29, 30] . Since the selected capillary NF membrane for this study has been deemed to be a non-porous membrane [31] , the solution-diffusion model is used to obtain a design tool for prediction of permeate quality for different settings regarding filtration flux, cross-flow velocity, recovery and for different staging configurations. This paper describes and evaluates a 6-month (from January 2014 to June 2014) pilot test of hollow fiber nanofiltration by direct filtration of surface water from Lake Mälaren, a drinking water source for more than 2 million citizens. The pilot trials were conducted at Görvälnverket WTP and operated by the water utility, Norrvatten, providing drinking water for about 500,000 people in the northern part of the Swedish capital of Stockholm. Twenty short-term (<2 h) experiments, at a fixed recovery of 50%, with sufficient variations in filtration flux (5-25 L·m −2 ·h −1 ) and cross-flow velocity (0.25-1.0 m·s −1 ) were performed with a fully automated pilot plant to determine the solute diffusion coefficient and solute permeability coefficient to predict NOM retention (i.e., DOC). These short term experiments were complemented with a long term performance test of direct filtration at fixed filtration flux of 20 L·m −2 h −1 and fixed cross flow (0.5 m·s −1 ) but at varying recoveries (50%-90%) using the above-mentioned pilot plant. For all experiments, conventional NOM analysis (TOC, DOC, UV absorbance) was combined with LC-OCD Water 2016, 8, 430 3 of 25 analysis for feed water, concentrate and permeate to elucidate the retention of specific NOM fractions as a function of varying operation conditions.
doi:10.3390/w8100430 fatcat:kghd4wdqana2noyyxe3cpnmmx4

Cohort Profile: The Likoma Network Study (LNS)

Stéphane Helleringer, James Mkandawire, Linda Kalilani-Phiri, Hans-Peter Kohler
2013 International Journal of Epidemiology  
The Likoma network study (LNS) investigates the sexual networks connecting the inhabitants of Likoma, a small island of Lake Malawi with high HIV prevalence. Whereas previous studies of sexual networks and HIV/AIDS in sub-Saharan countries have focused solely on the personal networks of a small number of respondents, the LNS attempts to document the sexual networks of the entire adult population of Likoma. To do so, it uses a unique sociocentric study design, in which all members of the local
more » ... pulation are contacted for a survey interview and are asked to nominate their five most recent sexual partners. Using these data, quasi-complete 'maps' of the sexual networks connecting inhabitants of the island can be constructed. These maps allow investigation of the impact of networks on HIV epidemiology and can inform mathematical models of HIV prevention. In addition to data on sexual networks, the LNS data include information on the social networks (e.g. friendship), socioeconomic characteristics and HIV status of Likoma's residents. Baseline data were collected in 2005-06. A first follow-up was conducted in 2007-08 and a second follow-up is planned for early 2013. Access to the LNS data is contingent upon review of a short concept paper and forming collaborations with LNS investigators.
doi:10.1093/ije/dyt001 pmid:23543589 pmcid:PMC3997370 fatcat:culz3cz4jvh2dgkeorsdr6bqiu
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