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Psychophysiological correlates of generalized anxiety disorder with or without comorbid depression

Stefan G. Hofmann, Stefan M. Schulz, Sanna Heering, Frederick Muench, Lynn F. Bufka
2010 International Journal of Psychophysiology  
It remains uncertain whether generalized anxiety disorder (GAD) and major depressive disorder (MDD) represent two separate diagnostic entities. The goal of this study was to examine whether comorbid MDD distinguishes individuals with GAD on a psychophysiological level during an experimentally-induced worrying procedure. Participants included 39 individuals with GAD, 14 of whom met criteria for MDD. During the experimental procedure, participants were asked to worry or relax after an initial
more » ... line phase while measuring their heart rate, high frequency heart rate variability (HF-HRV), skin conductance level, and subjective level of anxiety. The two groups did not differ in their subjective anxiety, heart rate response, and skin conductance levels. However, participants with comorbid MDD had greater HF-HRV values throughout the experiment than did those without MDD. At baseline, HF-HRV was significantly correlated with a self-report measure of depression. These results suggest that individuals with comorbid GAD and MDD can be distinguished based on HF-HRV from individuals with GAD but without MDD. These results support the distinction between GAD and MDD.
doi:10.1016/j.ijpsycho.2009.12.016 pmid:20093149 pmcid:PMC2888902 fatcat:m7p65jrfrzcynks4ek2dk3suha

Pharmacological Treatments for Disordered Gambling: A Meta-analysis

Martina Goslar, Max Leibetseder, Hannah M. Muench, Stefan G. Hofmann, Anton-Rupert Laireiter
2018 Journal of Gambling Studies  
Disordered gambling is a public health concern associated with detrimental consequences for affected individuals and social costs. Currently, opioid antagonists are considered the first-line treatments to reduce symptoms of uncontrolled gambling. Only recently, glutamatergic agents and combined pharmacological and psychological treatments have been examined appearing promising options for the management of gambling disorder. A multilevel literature search yielded 34 studies including open-label
more » ... and placebo-controlled trials totaling 1340 participants to provide a comprehensive evaluation of the short- and long-term efficacies of pharmacological and combined treatments. Pharmacological treatments were associated with large and medium pre-post reductions in global severity, frequency, and financial loss (Hedges's g: 1.35, 1.22, 0.80, respectively). The controlled effect sizes for the outcome variables were significantly smaller (Hedges's g: 0.41, 0.11, 0.22), but robust for the reduction of global severity at short-term. In general, medication classes yielded comparable effect sizes independent of predictors of treatment outcome. Of the placebo controlled studies, results showed that opioid antagonists and mood stabilizers, particularly the glutamatergic agent topiramate combined with a cognitive intervention and lithium for gamblers with bipolar disorders demonstrated promising results. However, more rigorously designed, large-scale randomized controlled trials with extended placebo lead-in periods are necessary. Moreover, future studies need to monitor concurrent psychosocial treatments, the type of comorbidity, use equivalent measurement tools, include outcome variables according to the Banff, Alberta Consensus, and provide follow-up data in order to broaden the knowledge about the efficacy of pharmacological treatments for this disabling condition.
doi:10.1007/s10899-018-09815-y pmid:30570700 pmcid:PMC6517351 fatcat:ckaxlumtcng2dpbqhqxluq5fsi

Characterization of ceramics based on laser speckle photometry

Lili Chen, Ulana Cikalova, Beatrice Bendjus, Stefan Muench, Mike Roellig
2020 Journal of Sensors and Sensor Systems  
The details of the correlation were presented in our previous work (Muench et al., 2017) .  ...  After the establishment of the model, mechanical stress can also be calculated directly from the LSP signal, provided it is the same material and has a similar surface condition (Muench et al., 2017)  ... 
doi:10.5194/jsss-9-345-2020 fatcat:l5vctx72x5d3zfzzgzdcv77ge4

Impact of Specifically Adsorbing Anions on the Electroless Growth of Gold Nanotubes

Falk Muench, Cornelia Neetzel, Stefan Lauterbach, Hans-Joachim Kleebe, Wolfgang Ensinger
2012 Journal of Nanomaterials  
Electroless metal deposition on nanochannel-containing templates is a versatile route towards metal nanotubes and nanowires if the plating reaction can be sufficiently controlled. In this study, disulfitoaurate-formaldehyde-based gold plating baths were modified by the addition of halides, pseudohalides, and EDTA. The introduction of specifically adsorbing anions strongly affected the heterogeneously autocatalyzed plating reaction and allowed the regulation of the reaction rate and the product
more » ... orphology. The new plating baths showed enhanced stability and allowed the synthesis of homogeneous nanotubes of high aspect ratios (>150) in 30 μm thick ion track-etched polymer templates. Depending on the reaction conditions, solid and porous structures consisting of gold nanoparticles of differing size and shape were accessible. The presented strategy offers adapted gold thin films, nanotubes, and nanowires for applications in catalysis or sensing.
doi:10.1155/2012/104748 fatcat:jzaatcl3jng5jfrjacih3vhhn4

Deposition of Nanofilms inside a Polymer Template:Formation of Metal Nanotubes

Falk Muench, Stefan Lauterbach, Hans-Joachim Kleebe, Wolfgang Ensinger
2012 e-Journal of Surface Science and Nanotechnology  
Given sufficient synthetic control, electroless plating is a suitable method for the fabrication of precisely defined nanomaterials. This study focuses on requirements which have to be met for the homogeneous and conformal electroless metal deposition within ion track etched polymer templates, allowing the fabrication of high aspect ratio metal nanotubes. Namely, the effects of (i) the seed density of the substrate, (ii) the surface-selectivity of the plating reaction and (iii) the deposition
more » ... eed and the grain size of the resulting deposit are examined, and strategies to modify these characteristics in order to improve nanotube formation are illustrated. With optimized procedures, Ag, Au and Pt nanotubes were obtained. As an application example, metal nanotube membranes were utilized as flow-through microreactors, catalyzing the reduction of 4-nitrophenol with sodium borohydride. By partial exchange of Ag precursor structures with Pt, roughened Ag-Pt nanotubes with significantly improved activity were obtained.
doi:10.1380/ejssnt.2012.578 fatcat:yczkhmyg2rfrzhj5gmmqin24dm

A new Method for the in vivo identification of material properties of the human eye. Feasibility analysis based on synthetic data [article]

Stefan Muench, Mike Roellig, Daniel Balzani
2021 arXiv   pre-print
This paper proposes a new method for in vivo and almost real-time identification of biomechanical properties of the human cornea based on non-contact tonometer data. Further goal is to demonstrate the method's functionality based on synthetic data serving as reference. For this purpose, a finite element model of the human eye is constructed to synthetically generate displacement full-fields from different datasets with keratoconus-like degradations. Then, a new approach based on the equilibrium
more » ... gap method (EGM) combined with a mechanical morphing approach is proposed and used to identify the material parameters from virtual test data sets. In a further step, random absolute noise is added to the virtual test data to investigate the sensitivity of the new approach to noise. As a result, the proposed method shows a relevant accuracy in identifying material parameters based on displacement full fields. At the same time, the method turns out to work almost in real-time (order of a few minutes on a regular work station) and is thus much faster than inverse problems solved by typical forward approaches. On the other hand, the method shows a noticeable sensitivity to rather small noise amplitudes. However, analysis show that the accuracy is sufficient for the identification of diseased tissue properties.
arXiv:2107.08208v1 fatcat:tef2o6v2vrc7bgfftplyrkgzlu

Performance Assessment of different Machine Learning Algorithm for Life-Time Prediction of Solder Joints based on Synthetic Data [article]

Stefan Muench, Darshankumar Bhat, Leonhard Heindel, Peter Hantschke, Mike Roellig, Markus Kaestner
2022 arXiv   pre-print
This paper proposes a computationally efficient methodology to predict the damage progression in solder contacts of electronic components using temperature-time curves. For this purpose, two machine learning algorithms, a Multilayer Perceptron and a Long Short-Term Memory network, are trained and compared with respect to their prediction accuracy and the required amount of training data. The training is performed using synthetic, normally distributed data that is realistic for automotive
more » ... tions. A finite element model of a simple bipolar chip resistor in surface mount technology configuration is used to numerically compute the synthetic data. As a result, both machine learning algorithms show a relevant accuracy for the prediction of accumulated creep strains. With a training data length of 350 hours (12.5 training data), both models show a constantly good fitting performance of R^2 of 0.72 for the Multilayer Perceptron and R^2 of 0.87 for the Long Short-Term Memory network. The prediction errors of the accumulated creep strains are less than 10 lifetime prediction directly on the electronic device.
arXiv:2204.06627v1 fatcat:tthqyjorgjflrorlao4dussa2e

Treatments for internet addiction, sex addiction and compulsive buying: A meta-analysis

Martina Goslar, Max Leibetseder, Hannah M. Muench, Stefan G. Hofmann, Anton-Rupert Laireiter
2020 Journal of Behavioral Addictions  
Muench, Anton-Rupert Laireiter, and Stefan G. Hofmann. All authors contributed to and approved the final manuscript.  ...  Muench declares that she has no conflict of interest. Dr.  ... 
doi:10.1556/2006.2020.00005 pmid:32359229 pmcid:PMC8935188 fatcat:up3dxz2y2bglppcmmbx3t35aay

Nanoparticles as a Metal Source in Plasma Processes

Stefan Flege, Ruriko Hatada, Gennadi Jantsen, Torsten Walbert, Wolfgang Ensinger, Koumei Baba, Takao Morimura, Falk Muench
2017 Transactions of the Materials Research Society of Japan  
When a metal is added to a layer of diamond-like carbon (DLC), the resulting particle size of the metal within the film usually depends on the metal content. To be more flexible in influencing the size of the particles that result when using a plasma based preparation process two different approaches were tested: on the one hand the combination of a gaseous precursor with magnetron sputtering, where a nanostructured coating is applied on top of the sputter target in advance; on the other hand,
more » ... he addition of preformed metallic nanoparticles to a liquid. In both cases, the nanoparticles or -structures were prepared by a wet chemical process, whereas the DLC layer was prepared by a plasma process. The produced metal-containing DLC films were characterized regarding their metal content and distribution as well as regarding possible contaminations from the chemical preparation process.
doi:10.14723/tmrsj.42.31 fatcat:idajzmcl7vdi5ff74zj4jspkc4

A novel yeast hybrid modeling framework integrating Boolean and enzyme-constrained networks enables exploration of the interplay between signaling and metabolism [article]

Linnea Osterberg, Ivan Domenzain, Julia Muench, Jens Nielsen, Stefan Hohmann, Marija Cvijovic
2020 bioRxiv   pre-print
The interplay between nutrient-induced signaling and metabolism plays an important role in maintaining homeostasis and its malfunction has been implicated in many different human diseases such as obesity, type 2 diabetes, cancer and neurological disorders. Therefore, unravelling the role of nutrients as signaling molecules and metabolites as well as their interconnectivity may provide a deeper understanding of how these conditions occur. Both signalling and metabolism have been extensively
more » ... ed using various systems biology approaches. However, they are mainly studied individually and in addition current models lack both the complexity of the dynamics and the effects of the crosstalk in the signaling system. To gain a better understanding of the interconnectivity between nutrient signaling and metabolism, we developed a hybrid model, combining Boolean model, describing the signalling layer and the enzyme constraint model accounting for metabolism using a regulatory network as a link. The model was capable of reproducing the regulatory effects that are associated with the Crabtree effect and glucose repression. We show that using this methodology one can investigat intrinsically different systems, such as signaling and metabolism, in the same model and gain insight into how the interplay between them can have non-trivial effects by showing a connection between Snf1 signaling and chronological lifespan by the regulation of NDE and NDI usage in respiring conditions. In addition, the model showed that during fermentation, enzyme utilization is the more important factor governing the protein allocation, while in low glucose conditions robustness and control is prioritized.
doi:10.1101/2020.09.11.290817 fatcat:7hvdnsx7bbeb3ngvj5j7w5by4m

Nano- and microstructured silver films synthesised by halide-assisted electroless plating

Falk Muench, Benjamin Juretzka, Suman Narayan, Aldin Radetinac, Stefan Flege, Sandra Schaefer, Robert W. Stark, Wolfgang Ensinger
2015 New Journal of Chemistry  
Halide-directed particle growth is introduced as a new structuring tool for Ag plating and used to create biomimetic, superhydrophobic coatings.
doi:10.1039/c5nj00952a fatcat:z5ftslao3jecvbseupicwhmkbu

Efficacy of face-to-face versus self-guided treatments for disordered gambling: A meta-analysis

Martina Goslar, Max Leibetseder, Hannah M. Muench, Stefan G. Hofmann, Anton-Rupert Laireiter
2017 Journal of Behavioral Addictions  
and aims: In the light of growing traditional and novel forms of gambling, the treatment of disordered gambling is gaining increasing importance and practical relevance. Most studies have examined face-to-face treatments. Although trials implementing self-guided treatments have recently been conducted, these options have not yet been systematically examined. The primary objective of this meta-analysis, therefore, was to analyze the efficacy of all types of psychological face-to-face and
more » ... ded treatments. Methods: A multilevel literature search yielded 27 randomized controlled studies totaling 3,879 participants to provide a comprehensive comparative evaluation of the short-and long-term efficacies of face-to-face and self-guided treatments for disordered gambling. Results: As expected, the results revealed significantly higher effect sizes for face-to-face treatments (16 studies with Hedges's g ranging from 0.67 to 1.15) as compared with self-guided treatments (11 studies with Hedges's g ranging from 0.12 to 0.30) regarding the reduction of problematic gambling behavior. The intensity of treatment moderated the therapy effect, particularly for self-guided treatments. Discussion and Conclusions: The results of this metaanalysis favor face-to-face treatments over self-guided treatments for the reduction of disordered gambling. Although the findings broaden the scope of knowledge about psychological treatment modalities for disordered gambling, further research is needed to identify the reasons for these differences with the goal to optimize the treatment for this disabling condition.
doi:10.1556/2006.6.2017.034 pmid:28662618 pmcid:PMC5520130 fatcat:64w2vwdahrflpm6ptftmpikcoq

Heterologous ChAdOx1 nCoV-19 and BNT162b2 prime-boost vaccination elicits potent neutralizing antibody responses and T cell reactivity [article]

Ruediger Gross, Michelle Zanoni, Alina Seidel, Carina Conzelmann, Andrea Gilg, Daniela Krnavek, Suemeyye Erdemci-evin, Benjamin Mayer, Markus Hoffmann, Stefan Poehlmann, Alexandra Beil, Joris Kroschel (+5 others)
2021 medRxiv   pre-print
Heterologous prime-boost schedules with vector- and mRNA-based COVID-19 vaccines are already administered, but immunological responses and elicited protection have not been reported. Methods We here analyzed a cohort of 26 individuals aged 25-46 (median 30.5) years that received a ChAdOx1 nCoV-2019 prime followed by a BNT162b2 boost after an 8-week interval for reactogenicity, antibody responses and T cell reactivity. Results Self-reported solicited symptoms after ChAdOx1 nCoV-2019 prime were
more » ... line with previous reports and less severe after the BNT162b2 boost. Antibody titers increased significantly over time resulting in strong neutralization titers 2 weeks after the BNT162b2 boost. Neutralizing activity against the prevalent strain B.1.1.7 was 3.9-fold higher than in individuals receiving homologous BNT162b2 vaccination, only 2-fold reduced for variant of concern B.1.351, and similar for variant B.1.617. In addition, CD4+ and CD8+ T cells reacted to SARS-CoV-2 spike peptide stimulus 2 weeks after the full vaccination. Conclusions The heterologous ChAdOx1 nCoV-2019 / BNT162b2 prime-boost vaccination regimen is not associated with serious adverse events and results in a potent humoral immune response and elicits T cell reactivity. Variants of concern B.1.1.7, B.1.351 and B.1.617 are potently neutralized by sera of all participants. These results suggest that this heterologous vaccination regimen is at least as immunogenic and protective as homologous vaccinations.
doi:10.1101/2021.05.30.21257971 fatcat:44ftg3dfvjc7vjyfnmcgnclfwi

Structured health care for subjects with diabetic foot ulcers results in a reduction of major amputation rates

Matthias Weck, Torsten Slesaczeck, Hartmut Paetzold, Dirk Muench, Thomas Nanning, Georg von Gagern, Andrej Brechow, Ulf Dietrich, Mandy Holfert, Stefan Bornstein, Andreas Barthel, Antje Thomas (+2 others)
2013 Cardiovascular Diabetology  
Objective We tested the effects of structured health care for the diabetic foot in one region in Germany aiming to reduce the number of major amputations. Research design and methods In a prospective study we investigated patients with diabetic foot in a structured system of outpatient, in-patient and rehabilitative treatment. Subjects were recruited between January 1 st , 2000 and December 31, 2007. All participants underwent a two-year follow-up. The modified University of Texas Wound
more » ... cation System (UT) was the basis for documentation and data analysis. We evaluated numbers of major amputations, rates of ulcer healing and mortality. In order to compare the effect of the structured health care program with usual care in patients with diabetic foot we evaluated the same parameters at another regional hospital without interdisciplinary care of diabetic foot (controls). Results 684 patients with diabetic foot and 508 controls were investigated. At discharge from hospital 28.3% (structured health care program, SHC) vs. 23.0% (controls) of all ulcers had healed completely. 51.5% (SHC) vs. 49.8% (controls) were in UT grade 1. Major amputations were performed in 32 subjects of the structured health care program group (4.7%) vs. 110 (21.7%) in controls (p<0.0001). Mortality during hospitalization was 2.5% (SHC) vs. 9.4% in controls (p<0.001). Conclusions With the structured health care program we achieved a significant reduction of major amputation rates by more than 75% as compared to standard care.
doi:10.1186/1475-2840-12-45 pmid:23497152 pmcid:PMC3627905 fatcat:2wkk44zcezdkxd3rphos7r27fm

Natural Cystatin C fragments inhibit GPR15-mediated HIV and SIV infection without interfering with GPR15L signaling [article]

Manuel Hayn, Andrea Bloetz, Armando Rodriguez-Alfonso, Solange Vidal, Nico Preising, Ludger Staendker, Sebastian Wiese, Christina M Stuerzel, Mirja Harms, Ruediger Gross, Christoph Jung, Miriam Kiene (+8 others)
2020 bioRxiv   pre-print
Hahn, Timo Jacob, Stefan Pöhlmann, Wolf-Georg Forssmann, Jan Münch, Konstantin M. J. Sparrer, Klaus Seuwen, Figure S1 ( S1 related to Figure 2).  ... 
doi:10.1101/2020.10.26.355172 fatcat:fda32jriwragnlwub3fpoosvgq
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