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Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer's disease
2016
Brain
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By using linear mixed-effects models, fibrillar amyloid-b plaque deposition was first observed in the striatum of presymptomatic autosomal dominant Alzheimer's disease carriers from 17 years before expected ...
In this study, longitudinal multitracer positron emission tomography imaging of individuals with autosomal dominant or sporadic Alzheimer's disease was used to quantify the changes in regional distribution ...
Dr Anne Kinhult Sta ˚hlbom is acknowledged for clinical professional help, Mr Johan Lilja for support related to imaging software (VOIager), and Dr Rita Almeida for advice and support related to statistical ...
doi:10.1093/brain/awv404
pmid:26813969
pmcid:PMC4766380
fatcat:fte46t3l4rfjrbzrs4othhsxmq
Longitudinal Patterns of β-Amyloid Deposition in Nondemented Older Adults
2011
Archives of Neurology
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Participants: Twenty-four nondemented participants (4 with a baseline Clinical Dementia Rating Scale score of 0.5; mean [SD] age, 79.2 [8.1] years) in the Baltimore Longitudinal Study of Aging underwent ...
serial carbon 11labeled Pittsburgh Compound B-positron emission tomography ([ 11 C]PiB-PET) (follow-up at a mean [SD] of 1.5 [0.5] years), with 5 participants undergoing a third [ 11 C]PiB-PET examination ...
These differential rates of [ 11 C]PiB retention are consistent with models of longitudinal change proposing variable rates of A deposition in nondemented older adults. 13, 23 Understanding factors ...
doi:10.1001/archneurol.2011.77
pmid:21555640
pmcid:PMC3136195
fatcat:bfvrup2iqreqrpbiguhgxhddfy
Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB
2010
Neurology
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To measure [ 11 C]PiB retention, distribution volume ratios (DVR) for 15 regions of interest were estimated by fitting a simplified reference tissue model to the measured time activity curves. ...
Method: [ 11 C]PiB images were obtained to measure fibrillar A burden in 57 participants without dementia from the Baltimore Longitudinal Study of Aging. ...
ACKNOWLEDGMENT The authors thank the staff of the PET facility at Johns Hopkins University and the neuroimaging staff of the NIA for their assistance.
DISCLOSURE ...
doi:10.1212/wnl.0b013e3181d3e3e9
pmid:20147655
pmcid:PMC2839197
fatcat:a4qvjrfhvbewrc3xxsnuy3d6de
Effects of amyloid and vascular markers on cognitive decline in subcortical vascular dementia
2015
Neurology
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Effects of PiB positivity and SVD markers (white matter hyperintensities [WMH], lacunes, and microbleeds) on longitudinal cognitive decline were evaluated using generalized estimation equation after controlling ...
Methods: A longitudinal cohort study was conducted involving patients from outpatient clinics of 2 tertiary referral centers. ...
Jae-Hong Lee had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. ...
doi:10.1212/wnl.0000000000002097
pmid:26468407
pmcid:PMC4653105
fatcat:4dsahjvo5jcerj6h2esmpixegy
PET Imaging of Tau Deposition in the Aging Human Brain
2016
Neuron
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Age and β-amyloid (measured using PiB PET) were differentially associated with tau tracer retention in healthy aging. ...
Furthermore, patterns of tracer retention corresponded well with Braak staging of neurofibrillary tau pathology. ...
ACKNOWLEDGEMENTS We thank Philip Insel for statistical analyses support, and Dr. ...
doi:10.1016/j.neuron.2016.01.028
pmid:26938442
pmcid:PMC4779187
fatcat:sll6cwyq3jczrac3wpvp3rgxj4
Amyloid-β associated cortical thinning in clinically normal elderly
2011
Annals of Neurology
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Regression models were used to relate PiB retention to cortical thickness and hippocampal volume. ...
Results: We found that PiB retention in CN subjects was (1) age-related and (2) associated with cortical thickness reductions, particularly in parietal and posterior cingulate regions extending into the ...
FIGURE 3 : 3 Modeling of PCC thickness as a function of PiB retention in CN and AD groups. ...
doi:10.1002/ana.22333
pmid:21437929
pmcid:PMC3117980
fatcat:nxrzxrosyfcrzmtom5euarap24
Relative 11C-PiB Delivery as a Proxy of Relative CBF: Quantitative Evaluation Using Single-Session 15O-Water and 11C-PiB PET
2015
Journal of Nuclear Medicine
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Multiple analysis approaches provided regional 15 O-water and 11 C-PiB measures of delivery and 11 C-PiB retention that included compartmental modeling distribution volume ratio (DVR), arterial-and reference-based ...
cerebral blood flow (CBF), with a secondary goal of directly examining the extent to which simplified uptake measures of 11 C-PiB retention (amyloid-b load) may be influenced by CBF, in a cohort of controls ...
sensitivity of longitudinal changes in 11 C-PiB SUVR to changes in flow (20) . ...
doi:10.2967/jnumed.114.152405
pmid:26045309
pmcid:PMC4730871
fatcat:z2yong35bvh3rauuik2pzxozii
The effect of amyloid β on cognitive decline is modulated by neural integrity in cognitively normal elderly
2013
Alzheimer's & Dementia
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PiB retention was dichotomized into a positive (n = 13) and negative (n = 25) PiB status. ...
The objective of this study was to relate AD-sensitive biomarkers of A and neurodegeneration and their interaction to longitudinal cognitive change in cognitively normal elderly. ...
Higher PiB retention was associated with longitudinal cognitive decline but did not affect baseline performance. ...
doi:10.1016/j.jalz.2012.10.012
pmid:23474040
pmcid:PMC3823816
fatcat:tlnr7es3zjcx5nw6pgentmu7gm
Changes in Aβ biomarkers and associations with APOE genotype in 2 longitudinal cohorts
2015
Neurobiology of Aging
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PET-PiB retention increased and CSF Aβ 1-42 declined longitudinally. ...
APOE ε4 was significantly associated with higher PET-PiB retention and lower CSF Aβ 1-42, independent of age and sex, but APOE genotype did not significantly affect Aβ change over time. ...
Acknowledgments The BLSA study was supported in part by the Intramural Research Program of the NIH, National ...
doi:10.1016/j.neurobiolaging.2015.04.001
pmid:26004017
pmcid:PMC5084914
fatcat:hcgv7x5kjjea3pclvxulgqg4ym
Longitudinal Cerebral Blood Flow and Amyloid Deposition: An Emerging Pattern?
2008
Journal of Nuclear Medicine
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On the basis of mean cortical distribution volume ratios, participants were divided into groups with high or low 11 C-PIB retention. ...
reference-tissue model to the measured time-activity curves. ...
Klunk and Mathis are co-inventors of PIB and, as such, have a financial interest in this license agreement. ...
doi:10.2967/jnumed.108.051946
pmid:18703614
pmcid:PMC2570023
fatcat:7u7gvnhesnarrouxha2sb2rgqy
11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment
2008
Brain
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Pair-wise inter-group diagnostic separation was significant for all group-wise pairs for both PiB and hippocampal volume with the exception of CN vs. aMCI which was not significant for PiB. ...
Both global cortical PiB retention and hippocampal volumes demonstrated significant correlation in the expected direction with cognitive testing performance; however, correlations were stronger with MRI ...
We fit and report on four POLR models: a model with global cortical PiB retention only, a model with hippocampal W score only, an additive model with both these terms, and a model with both terms and an ...
doi:10.1093/brain/awm336
pmid:18263627
pmcid:PMC2730157
fatcat:gew27dn47nbqblzlpb7ycnxn3e
Regional amyloid burden and intrinsic connectivity networks in cognitively normal elderly subjects
2014
Brain
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in the default mode network and central executive network in the Pittsburgh compound B positive group might reflect a detrimental effect of amyloid retention on functional changes in the course of Alzheimer's ...
Anterior cingulate cortex Pittsburgh compound B retention was negatively correlated with the functional connectivities of the posterior default mode network, and positively correlated with fronto-parietal ...
Hence, exploring the interaction between the APOE gene, functional connectivities and PiB retention would be needed for an integrative model of neurobiological mechanisms of the normal ageing process. ...
doi:10.1093/brain/awu271
pmid:25266592
pmcid:PMC4240287
fatcat:hdre7q57krbd3juvr4bxtffhiq
Lack of association between 11C-PiB and longitudinal brain atrophy in non-demented older individuals
2011
Neurobiology of Aging
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Participants were prospectively followed through the Baltimore Longitudinal Study of Aging, with up to 10 consecutive MRI scans (M = 8.1) and an 11 C-PiB scan approximately 10 years after the initial MRI ...
Linear mixed effects models were used to determine whether mean cortical 11 C-PiB distribution volume ratios, estimated by fitting a reference tissue model to the measured time activity curves, were associated ...
Driscoll had full access to the data in the study and takes responsibility for the integrity of the data and the accuracy of the analysis. ...
doi:10.1016/j.neurobiolaging.2009.12.008
pmid:20176414
pmcid:PMC2908199
fatcat:w564legac5dj3f6fcbq745l3fe
Predicting sites of new hemorrhage with amyloid imaging in cerebral amyloid angiopathy
2012
Neurology
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PiB retention decreased with increasing distance from sites of observed bleeds (p Ͻ 0.0001). ...
Mean distribution volume ratio (DVR) of PiB was determined at the sites of new micro/ macrobleeds identified on follow-up MRI and compared with PiB retention at "simulated" hemorrhages, randomly placed ...
This longitudinal analysis of PiB retention and hemorrhage location suffers from several methodologic limitations. ...
doi:10.1212/wnl.0b013e31826043a9
pmid:22786597
pmcid:PMC3400097
fatcat:ktptbjfgd5dl7jiaojsouogggi
Lower Late-Life Body-Mass Index is Associated with Higher Cortical Amyloid Burden in Clinically Normal Elderly
2016
Journal of Alzheimer's Disease
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For the primary analysis, a general linear regression model was used to evaluate the association of BMI with PiB retention. Covariates included age, sex, years of education, and APOE4 carrier status. ...
Results-In the primary analysis, greater PiB retention was associated with lower BMI (β= −0.14, p=0.02). ...
The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. ...
doi:10.3233/jad-150987
pmid:27340843
pmcid:PMC4976009
fatcat:tncw4pdorzdclos7tfkzrye2hi
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