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Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer's disease

Elena Rodriguez-Vieitez, Laure Saint-Aubert, Stephen F. Carter, Ove Almkvist, Karim Farid, Michael Schöll, Konstantinos Chiotis, Steinunn Thordardottir, Caroline Graff, Anders Wall, Bengt Långström, Agneta Nordberg
2016 Brain  
By using linear mixed-effects models, fibrillar amyloid-b plaque deposition was first observed in the striatum of presymptomatic autosomal dominant Alzheimer's disease carriers from 17 years before expected  ...  In this study, longitudinal multitracer positron emission tomography imaging of individuals with autosomal dominant or sporadic Alzheimer's disease was used to quantify the changes in regional distribution  ...  Dr Anne Kinhult Sta ˚hlbom is acknowledged for clinical professional help, Mr Johan Lilja for support related to imaging software (VOIager), and Dr Rita Almeida for advice and support related to statistical  ... 
doi:10.1093/brain/awv404 pmid:26813969 pmcid:PMC4766380 fatcat:fte46t3l4rfjrbzrs4othhsxmq

Longitudinal Patterns of β-Amyloid Deposition in Nondemented Older Adults

Jitka Sojkova, Yun Zhou, Yang An, Michael A. Kraut, Luigi Ferrucci, Dean F. Wong, Susan M. Resnick
2011 Archives of Neurology  
Participants: Twenty-four nondemented participants (4 with a baseline Clinical Dementia Rating Scale score of 0.5; mean [SD] age, 79.2 [8.1] years) in the Baltimore Longitudinal Study of Aging underwent  ...  serial carbon 11labeled Pittsburgh Compound B-positron emission tomography ([ 11 C]PiB-PET) (follow-up at a mean [SD] of 1.5 [0.5] years), with 5 participants undergoing a third [ 11 C]PiB-PET examination  ...  These differential rates of [ 11 C]PiB retention are consistent with models of longitudinal change proposing variable rates of A␤ deposition in nondemented older adults. 13, 23 Understanding factors  ... 
doi:10.1001/archneurol.2011.77 pmid:21555640 pmcid:PMC3136195 fatcat:bfvrup2iqreqrpbiguhgxhddfy

Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB

S. M. Resnick, J. Sojkova, Y. Zhou, Y. An, W. Ye, D. P. Holt, R. F. Dannals, C. A. Mathis, W. E. Klunk, L. Ferrucci, M. A. Kraut, D. F. Wong
2010 Neurology  
To measure [ 11 C]PiB retention, distribution volume ratios (DVR) for 15 regions of interest were estimated by fitting a simplified reference tissue model to the measured time activity curves.  ...  Method: [ 11 C]PiB images were obtained to measure fibrillar A␤ burden in 57 participants without dementia from the Baltimore Longitudinal Study of Aging.  ...  ACKNOWLEDGMENT The authors thank the staff of the PET facility at Johns Hopkins University and the neuroimaging staff of the NIA for their assistance. DISCLOSURE  ... 
doi:10.1212/wnl.0b013e3181d3e3e9 pmid:20147655 pmcid:PMC2839197 fatcat:a4qvjrfhvbewrc3xxsnuy3d6de

Effects of amyloid and vascular markers on cognitive decline in subcortical vascular dementia

Byoung Seok Ye, Sang Won Seo, Jung-Hyun Kim, Geon Ha Kim, Hanna Cho, Young Noh, Hee Jin Kim, Cindy W. Yoon, Sook-young Woo, Sook Hui Kim, Hee Kyung Park, Sung Tae Kim (+8 others)
2015 Neurology  
Effects of PiB positivity and SVD markers (white matter hyperintensities [WMH], lacunes, and microbleeds) on longitudinal cognitive decline were evaluated using generalized estimation equation after controlling  ...  Methods: A longitudinal cohort study was conducted involving patients from outpatient clinics of 2 tertiary referral centers.  ...  Jae-Hong Lee had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.  ... 
doi:10.1212/wnl.0000000000002097 pmid:26468407 pmcid:PMC4653105 fatcat:4dsahjvo5jcerj6h2esmpixegy

PET Imaging of Tau Deposition in the Aging Human Brain

Michael Schöll, Samuel N. Lockhart, Daniel R. Schonhaut, James P. O'Neil, Mustafa Janabi, Rik Ossenkoppele, Suzanne L. Baker, Jacob W. Vogel, Jamie Faria, Henry D. Schwimmer, Gil D. Rabinovici, William J. Jagust
2016 Neuron  
Age and β-amyloid (measured using PiB PET) were differentially associated with tau tracer retention in healthy aging.  ...  Furthermore, patterns of tracer retention corresponded well with Braak staging of neurofibrillary tau pathology.  ...  ACKNOWLEDGEMENTS We thank Philip Insel for statistical analyses support, and Dr.  ... 
doi:10.1016/j.neuron.2016.01.028 pmid:26938442 pmcid:PMC4779187 fatcat:sll6cwyq3jczrac3wpvp3rgxj4

Amyloid-β associated cortical thinning in clinically normal elderly

J. Alex Becker, Trey Hedden, Jeremy Carmasin, Jacqueline Maye, Dorene M. Rentz, Deepti Putcha, Bruce Fischl, Douglas N. Greve, Gad A. Marshall, Stephen Salloway, Donald Marks, Randy L. Buckner (+2 others)
2011 Annals of Neurology  
Regression models were used to relate PiB retention to cortical thickness and hippocampal volume.  ...  Results: We found that PiB retention in CN subjects was (1) age-related and (2) associated with cortical thickness reductions, particularly in parietal and posterior cingulate regions extending into the  ...  FIGURE 3 : 3 Modeling of PCC thickness as a function of PiB retention in CN and AD groups.  ... 
doi:10.1002/ana.22333 pmid:21437929 pmcid:PMC3117980 fatcat:nxrzxrosyfcrzmtom5euarap24

Relative 11C-PiB Delivery as a Proxy of Relative CBF: Quantitative Evaluation Using Single-Session 15O-Water and 11C-PiB PET

Y. J. Chen, B. L. Rosario, W. Mowrey, C. M. Laymon, X. Lu, O. L. Lopez, W. E. Klunk, B. J. Lopresti, C. A. Mathis, J. C. Price
2015 Journal of Nuclear Medicine  
Multiple analysis approaches provided regional 15 O-water and 11 C-PiB measures of delivery and 11 C-PiB retention that included compartmental modeling distribution volume ratio (DVR), arterial-and reference-based  ...  cerebral blood flow (CBF), with a secondary goal of directly examining the extent to which simplified uptake measures of 11 C-PiB retention (amyloid-b load) may be influenced by CBF, in a cohort of controls  ...  sensitivity of longitudinal changes in 11 C-PiB SUVR to changes in flow (20) .  ... 
doi:10.2967/jnumed.114.152405 pmid:26045309 pmcid:PMC4730871 fatcat:z2yong35bvh3rauuik2pzxozii

The effect of amyloid β on cognitive decline is modulated by neural integrity in cognitively normal elderly

Miranka Wirth, Hwamee Oh, Elizabeth C. Mormino, Candace Markley, Susan M. Landau, William J. Jagust
2013 Alzheimer's & Dementia  
PiB retention was dichotomized into a positive (n = 13) and negative (n = 25) PiB status.  ...  The objective of this study was to relate AD-sensitive biomarkers of A and neurodegeneration and their interaction to longitudinal cognitive change in cognitively normal elderly.  ...  Higher PiB retention was associated with longitudinal cognitive decline but did not affect baseline performance.  ... 
doi:10.1016/j.jalz.2012.10.012 pmid:23474040 pmcid:PMC3823816 fatcat:tlnr7es3zjcx5nw6pgentmu7gm

Changes in Aβ biomarkers and associations with APOE genotype in 2 longitudinal cohorts

Susan M. Resnick, Murat Bilgel, Abhay Moghekar, Yang An, Qing Cai, Mei-Cheng Wang, Madhav Thambisetty, Jerry L. Prince, Yun Zhou, Anja Soldan, Dean F. Wong, Richard J. O'Brien (+2 others)
2015 Neurobiology of Aging  
PET-PiB retention increased and CSF Aβ 1-42 declined longitudinally.  ...  APOE ε4 was significantly associated with higher PET-PiB retention and lower CSF Aβ 1-42, independent of age and sex, but APOE genotype did not significantly affect Aβ change over time.  ...  Acknowledgments The BLSA study was supported in part by the Intramural Research Program of the NIH, National  ... 
doi:10.1016/j.neurobiolaging.2015.04.001 pmid:26004017 pmcid:PMC5084914 fatcat:hcgv7x5kjjea3pclvxulgqg4ym

Longitudinal Cerebral Blood Flow and Amyloid Deposition: An Emerging Pattern?

J. Sojkova, L. Beason-Held, Y. Zhou, Y. An, M. A. Kraut, W. Ye, L. Ferrucci, C. A. Mathis, W. E. Klunk, D. F. Wong, S. M. Resnick
2008 Journal of Nuclear Medicine  
On the basis of mean cortical distribution volume ratios, participants were divided into groups with high or low 11 C-PIB retention.  ...  reference-tissue model to the measured time-activity curves.  ...  Klunk and Mathis are co-inventors of PIB and, as such, have a financial interest in this license agreement.  ... 
doi:10.2967/jnumed.108.051946 pmid:18703614 pmcid:PMC2570023 fatcat:7u7gvnhesnarrouxha2sb2rgqy

11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment

Clifford R. Jack, Val J. Lowe, Matthew L. Senjem, Stephen D. Weigand, Bradley J. Kemp, Maria M. Shiung, David S. Knopman, Bradley F. Boeve, William E. Klunk, Chester A. Mathis, Ronald C. Petersen
2008 Brain  
Pair-wise inter-group diagnostic separation was significant for all group-wise pairs for both PiB and hippocampal volume with the exception of CN vs. aMCI which was not significant for PiB.  ...  Both global cortical PiB retention and hippocampal volumes demonstrated significant correlation in the expected direction with cognitive testing performance; however, correlations were stronger with MRI  ...  We fit and report on four POLR models: a model with global cortical PiB retention only, a model with hippocampal W score only, an additive model with both these terms, and a model with both terms and an  ... 
doi:10.1093/brain/awm336 pmid:18263627 pmcid:PMC2730157 fatcat:gew27dn47nbqblzlpb7ycnxn3e

Regional amyloid burden and intrinsic connectivity networks in cognitively normal elderly subjects

Hyun Kook Lim, Robert Nebes, Beth Snitz, Ann Cohen, Chester Mathis, Julie Price, Lisa Weissfeld, William Klunk, Howard J. Aizenstein
2014 Brain  
in the default mode network and central executive network in the Pittsburgh compound B positive group might reflect a detrimental effect of amyloid retention on functional changes in the course of Alzheimer's  ...  Anterior cingulate cortex Pittsburgh compound B retention was negatively correlated with the functional connectivities of the posterior default mode network, and positively correlated with fronto-parietal  ...  Hence, exploring the interaction between the APOE gene, functional connectivities and PiB retention would be needed for an integrative model of neurobiological mechanisms of the normal ageing process.  ... 
doi:10.1093/brain/awu271 pmid:25266592 pmcid:PMC4240287 fatcat:hdre7q57krbd3juvr4bxtffhiq

Lack of association between 11C-PiB and longitudinal brain atrophy in non-demented older individuals

Ira Driscoll, Yun Zhou, Yang An, Jitka Sojkova, Christos Davatzikos, Michael A. Kraut, Weiguo Ye, Luigi Ferrucci, Chester A. Mathis, William E. Klunk, Dean F. Wong, Susan M. Resnick
2011 Neurobiology of Aging  
Participants were prospectively followed through the Baltimore Longitudinal Study of Aging, with up to 10 consecutive MRI scans (M = 8.1) and an 11 C-PiB scan approximately 10 years after the initial MRI  ...  Linear mixed effects models were used to determine whether mean cortical 11 C-PiB distribution volume ratios, estimated by fitting a reference tissue model to the measured time activity curves, were associated  ...  Driscoll had full access to the data in the study and takes responsibility for the integrity of the data and the accuracy of the analysis.  ... 
doi:10.1016/j.neurobiolaging.2009.12.008 pmid:20176414 pmcid:PMC2908199 fatcat:w564legac5dj3f6fcbq745l3fe

Predicting sites of new hemorrhage with amyloid imaging in cerebral amyloid angiopathy

M. E. Gurol, G. Dierksen, R. Betensky, C. Gidicsin, A. Halpin, A. Becker, J. Carmasin, A. Ayres, K. Schwab, A. Viswanathan, D. Salat, J. Rosand (+2 others)
2012 Neurology  
PiB retention decreased with increasing distance from sites of observed bleeds (p Ͻ 0.0001).  ...  Mean distribution volume ratio (DVR) of PiB was determined at the sites of new micro/ macrobleeds identified on follow-up MRI and compared with PiB retention at "simulated" hemorrhages, randomly placed  ...  This longitudinal analysis of PiB retention and hemorrhage location suffers from several methodologic limitations.  ... 
doi:10.1212/wnl.0b013e31826043a9 pmid:22786597 pmcid:PMC3400097 fatcat:ktptbjfgd5dl7jiaojsouogggi

Lower Late-Life Body-Mass Index is Associated with Higher Cortical Amyloid Burden in Clinically Normal Elderly

David C. Hsu, Elizabeth C. Mormino, Aaron P. Schultz, Rebecca E. Amariglio, Nancy J. Donovan, Dorene M. Rentz, Keith A. Johnson, Reisa A. Sperling, Gad A. Marshall, Duygu Tosun-Turgut
2016 Journal of Alzheimer's Disease  
For the primary analysis, a general linear regression model was used to evaluate the association of BMI with PiB retention. Covariates included age, sex, years of education, and APOE4 carrier status.  ...  Results-In the primary analysis, greater PiB retention was associated with lower BMI (β= −0.14, p=0.02).  ...  The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.  ... 
doi:10.3233/jad-150987 pmid:27340843 pmcid:PMC4976009 fatcat:tncw4pdorzdclos7tfkzrye2hi
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