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Statistical Methods for Processing Neuroimaging Data from Two Different Sites with a Down Syndrome Population Application
[chapter]
2020
Communications in Computer and Information Science
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We applied the Removal of Artificial Voxel Effect by Linear regression (RAVEL) method to normalize T1-MRI intensities collected on two different scanners across two different sites as part of the Neurodegeneration ...
in Aging Down syndrome (NiAD) study. ...
Methods
Study Participants Forty subjects with Down syndrome were selected from two sites participating in the Neurodegeneration in Aging Down Syndrome (NiAD) study, 20 subjects from the University of ...
doi:10.1007/978-3-030-50153-2_28
fatcat:qk2lsb4x55dw5oeauixpu7vdhy
Patient Registries in Cognitive Neuroscience Research: Advantages, Challenges, and Practical Advice
2008
Journal of Cognitive Neuroscience
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Shared, centrally managed research registries provide a framework for facilitating access to this method for nonclinicians, addressing ethical concerns, streamlining recruitment and screening procedures ...
Recent advances in neuroimaging, statistics and information management provide powerful tools to support neuropsychological research. ...
Typically, for example, explicit consent is needed for so-called secondary use of data that were originally collected for a different purpose. ...
doi:10.1162/jocn.2008.20065
pmid:18211249
fatcat:r6rzem3qmbabpgvkaphko2mtwy
Protocols to establish genotype-phenotype correlations in Down syndrome
1991
American Journal of Human Genetics
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Acknowledgments The Workshop of Genotype-Phenotype Correlations in Down Syndrome was organized and supported by the Mental Retardation and Developmental Disabilities Branch, National Institute of Child ...
We thank Scot Gerwehr for expert assistance in the preparation of figure ...
Neuroimaging The neuroimaging protocols follow in part from the neuropathological data concerning brains of persons with Down syndrome (see below) and from quantitative computed tomography (CT) studies ...
pmid:1829580
pmcid:PMC1683195
fatcat:fhjaud5umjgzdm2fufekj4jh2q
Structural magnetic resonance imaging demonstrates abnormal cortical thickness in Down syndrome: Newborns to young adults
2019
NeuroImage: Clinical
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Down syndrome (DS) is a genetic disorder caused by an extra copy of all or part of chromosome 21 and is characterized by intellectual disability. ...
neurotypical participants (aged 5 to 32 years) with the objective of assessing the clinical presentation of Down syndrome, towards better understanding the neurological development associated with the ...
histogram of age distributions for our Down Syndrome and neurotypical populations. ...
doi:10.1016/j.nicl.2019.101874
pmid:31176294
pmcid:PMC6551568
fatcat:smwkeojimjdm3hqbk66oty5hei
Offering to Share: How to Put Heads Together in Autism Neuroimaging
2007
Journal of Autism and Developmental Disorders
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We outline the desiderata for a data-sharing scheme that combines imaging with other measures of phenotype and with genetics, defines requirements for comparability of derived data and recommendations ...
Data sharing in autism neuroimaging presents scientific, technical, and social obstacles. ...
We are grateful for financial support from Christopher and Jill Escher, without whose generosity this meeting could not have taken place and these collaborations would not have begun to be explored. ...
doi:10.1007/s10803-006-0352-2
pmid:17347882
pmcid:PMC3076291
fatcat:4rhdtfb3fnegnfmb5xvzith4ve
Neuroimaging of Central Sensitivity Syndromes: Key Insights from the Scientific Literature
2016
Current Rheumatology Reviews
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A defining neuroimaging "signature" cannot be discerned for any of the particular syndromes or for an over-arching central sensitization mechanism common to all of the syndromes. ...
A coherent picture of a "central sensitization" mechanism that bridges across all of these syndromes does not emerge from the existing scientific evidence. ...
ICA is a data-driven method that does not require any a priori seed. ...
doi:10.2174/1573397112666151231111104
pmid:26717948
pmcid:PMC4785050
fatcat:r6um2icd4fhwphd2fjdew5mwwe
ENIGMA and Global Neuroscience: A Decade of Large-Scale Studies of the Brain in Health and Disease Across More Than 40 Countries
2020
Biological Psychiatry
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This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying ...
We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in ...
Core funding for ENIGMA was provided by the NIH Big Data to Knowledge (BD2K) program under consortium grant U54 EB020403, by the ENIGMA World Aging Center (R56 AG058854), and by the ENIGMA Sex Differences ...
doi:10.1016/j.biopsych.2020.02.167
fatcat:rcamgpjlcvfgzikfleqbunef3u
Loss of dopamine-D2 receptor binding sites in Parkinsonian plus syndromes
1998
Journal of Nuclear Medicine
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This study analyzed temporal changes of striatal dopamine-D2 receptor binding during the course of different extrapyramidal movement disorders using 123I-iodobenzamide (IBZM) SPECT. ...
Methods Eighteen patients (9 with Parkinson's disease, 9 with parFdnsonianplus syndrome) were followed for 11-53 mo. ...
Statistical analysis revealed a significant difference between the two populations (j' 0.001, Mann Whitney test), however, a significant overlap between both study groups was found (Fig. 1) . ...
pmid:9627325
fatcat:5z4kf7lz5beixcieoeexkkxkwq
Annual Research Review: Understudied populations within the autism spectrum - current trends and future directions in neuroimaging research
2017
Journal of Child Psychology and Psychiatry and Allied Disciplines
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However, neuroimaging methods are a potentially powerful tool for understanding the etiology of these ASD subtypes. ...
, theoretical, and practical considerations for future research involving neuroimaging assessment of these populations. ...
This review was invited by the Editors of JCPP (for which the first author has been offered a small honorarium towards expenses) and has been subject to full external peer review. ...
doi:10.1111/jcpp.12687
pmid:28102566
pmcid:PMC5367938
fatcat:yzx5tttotbdv7kogjn3okkpgrm
Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014
2015
Alzheimer's & Dementia
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Methods-We searched for ADNI publications using established methods. ...
as a data-sharing model; (6) generated data used in over 600 publications, leading to the identification of novel AD risk alleles, and an understanding of the relationship between biomarkers and AD progression ...
Table 1 Major findings using ADNI data Area of research Major findings using ADNI data References
Conflicts of Interest ...
doi:10.1016/j.jalz.2015.04.005
pmid:26194320
pmcid:PMC4659407
fatcat:ba7v6zu5pvhqjf6ovuvwa7acl4
Advances in neuroimaging to support translational medicine in dementia
2021
Journal of Neurology, Neurosurgery and Psychiatry
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In combination with large datasets, open data and artificial intelligence analysis methods, new informatics-based approaches are set to enable accurate single-subject inferences for diagnosis, prediction ...
Advances in neuroimaging are ideally placed to facilitate the translation from progress made in cellular genetics and molecular biology of neurodegeneration into improved diagnosis, prevention and treatment ...
data is the application of a standardised univariate method at large scale. ...
doi:10.1136/jnnp-2019-322402
pmid:33568448
pmcid:PMC8862738
fatcat:kfzojf7vpncq7pgln7xiaue324
Alzheimer's disease in Down syndrome: An overlooked population for prevention trials
2018
Alzheimer s & Dementia Translational Research & Clinical Interventions
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The discovery that adults with Down syndrome (DS) have neuropathological features identical to individuals with sporadic Alzheimer's disease (AD) played a key role in the identification of the amyloid ...
Individuals with DS have a lifetime risk for dementia in excess of 90%, and DS is now acknowledged to be a genetic form of AD similar to rare autosomal-dominant causes. ...
Data from the Rotterdam group, as yet unpublished. Abbreviation: DS, Down syndrome.
Fig. 3 . 3 Fig. 3. Flow diagram showing existing DS trial-ready cohorts. Abbreviation: DS, Down syndrome. ...
doi:10.1016/j.trci.2018.10.006
pmid:30581976
pmcid:PMC6296162
fatcat:4gl4fmibnbdeve3xfyfnsbfszy
On the Use and Misuse of Genomic and Neuroimaging Science in Forensic Psychiatry: Current Roles and Future Directions
2011
Child and Adolescent Psychiatric Clinics of North America
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Acknowledgments This manuscript work was produced with the support of the National Institute of Mental Health (F31MH087015) to M.T.T. and (T32MH018921) to J.W.B. ...
Neuroimaging for the Assessment of Brain Abnormalities In considering the application of neuroimaging data to forensic assessment, a distinction must be drawn between whether the neuroimaging data are ...
A statistically significant difference in the occurrence of that trait, behavior, or disorder between the two genotype groups is taken as an evidence of a positive genetic association. ...
doi:10.1016/j.chc.2011.03.012
pmid:21683918
pmcid:PMC5530871
fatcat:v4musqpydrey3kczirmkugubpe
ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
2020
Translational Psychiatry
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This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying ...
We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in ...
Core funding for ENIGMA was provided by the NIH Big Data to Knowledge (BD2K) program under consortium grant U54 EB020403, by the ENIGMA World Aging Center (R56 AG058854), and by the ENIGMA Sex Differences ...
doi:10.1038/s41398-020-0705-1
pmid:32198361
pmcid:PMC7083923
fatcat:b4oftx6e3rg7vhwcuhnjcab7pa
FDG PET and cognitive symptoms of dementia
2013
Clinical and translational imaging
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FDG PET imaging in subjects with underlying neurodegenerative pathology has emerged as a crucial tool available to the fields of cognitive neurology and neuroscience for both diagnosis and evaluation of ...
The existing methods for semiquantitative assessment of brain functional changes provide topographical maps of molecular alterations both for group and single-subject comparisons. ...
In a multicenter study, FDG PET images from population of patients with FTD were compared with images from controls of a similar age. ...
doi:10.1007/s40336-013-0029-8
fatcat:arpp2yjms5f7nprzu2lak23rwa
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