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Statistical Methods for Processing Neuroimaging Data from Two Different Sites with a Down Syndrome Population Application [chapter]

Davneet S. Minhas, Zixi Yang, John Muschelli, Charles M. Laymon, Joseph M. Mettenburg, Matthew D. Zammit, Sterling Johnson, Chester A. Mathis, Ann D. Cohen, Benjamin L. Handen, William E. Klunk, Ciprian M. Crainiceanu (+2 others)
2020 Communications in Computer and Information Science  
We applied the Removal of Artificial Voxel Effect by Linear regression (RAVEL) method to normalize T1-MRI intensities collected on two different scanners across two different sites as part of the Neurodegeneration  ...  in Aging Down syndrome (NiAD) study.  ...  Methods Study Participants Forty subjects with Down syndrome were selected from two sites participating in the Neurodegeneration in Aging Down Syndrome (NiAD) study, 20 subjects from the University of  ... 
doi:10.1007/978-3-030-50153-2_28 fatcat:qk2lsb4x55dw5oeauixpu7vdhy

Patient Registries in Cognitive Neuroscience Research: Advantages, Challenges, and Practical Advice

Lesley K. Fellows, Marianna Stark, Arlene Berg, Anjan Chatterjee
2008 Journal of Cognitive Neuroscience  
Shared, centrally managed research registries provide a framework for facilitating access to this method for nonclinicians, addressing ethical concerns, streamlining recruitment and screening procedures  ...  Recent advances in neuroimaging, statistics and information management provide powerful tools to support neuropsychological research.  ...  Typically, for example, explicit consent is needed for so-called secondary use of data that were originally collected for a different purpose.  ... 
doi:10.1162/jocn.2008.20065 pmid:18211249 fatcat:r6rzem3qmbabpgvkaphko2mtwy

Protocols to establish genotype-phenotype correlations in Down syndrome

C J Epstein, J R Korenberg, G Annerén, S E Antonarakis, S Aymé, E Courchesne, L B Epstein, A Fowler, Y Groner, J L Huret, et al.
1991 American Journal of Human Genetics  
Acknowledgments The Workshop of Genotype-Phenotype Correlations in Down Syndrome was organized and supported by the Mental Retardation and Developmental Disabilities Branch, National Institute of Child  ...  We thank Scot Gerwehr for expert assistance in the preparation of figure  ...  Neuroimaging The neuroimaging protocols follow in part from the neuropathological data concerning brains of persons with Down syndrome (see below) and from quantitative computed tomography (CT) studies  ... 
pmid:1829580 pmcid:PMC1683195 fatcat:fhjaud5umjgzdm2fufekj4jh2q

Structural magnetic resonance imaging demonstrates abnormal cortical thickness in Down syndrome: Newborns to young adults

Jacob Levman, Allissa MacDonald, Nicole Baumer, Patrick MacDonald, Natalie Stewart, Ashley Lim, Liam Cogger, Tadashi Shiohama, Emi Takahashi
2019 NeuroImage: Clinical  
Down syndrome (DS) is a genetic disorder caused by an extra copy of all or part of chromosome 21 and is characterized by intellectual disability.  ...  neurotypical participants (aged 5 to 32 years) with the objective of assessing the clinical presentation of Down syndrome, towards better understanding the neurological development associated with the  ...  histogram of age distributions for our Down Syndrome and neurotypical populations.  ... 
doi:10.1016/j.nicl.2019.101874 pmid:31176294 pmcid:PMC6551568 fatcat:smwkeojimjdm3hqbk66oty5hei

Offering to Share: How to Put Heads Together in Autism Neuroimaging

Matthew K. Belmonte, John C. Mazziotta, Nancy J. Minshew, Alan C. Evans, Eric Courchesne, Stephen R. Dager, Susan Y. Bookheimer, Elizabeth H. Aylward, David G. Amaral, Rita M. Cantor, Diane C. Chugani, Anders M. Dale (+12 others)
2007 Journal of Autism and Developmental Disorders  
We outline the desiderata for a data-sharing scheme that combines imaging with other measures of phenotype and with genetics, defines requirements for comparability of derived data and recommendations  ...  Data sharing in autism neuroimaging presents scientific, technical, and social obstacles.  ...  We are grateful for financial support from Christopher and Jill Escher, without whose generosity this meeting could not have taken place and these collaborations would not have begun to be explored.  ... 
doi:10.1007/s10803-006-0352-2 pmid:17347882 pmcid:PMC3076291 fatcat:4rhdtfb3fnegnfmb5xvzith4ve

Neuroimaging of Central Sensitivity Syndromes: Key Insights from the Scientific Literature

Brian Walitt, Marta Ceko, John L. Gracely, Richard H. Gracely
2016 Current Rheumatology Reviews  
A defining neuroimaging "signature" cannot be discerned for any of the particular syndromes or for an over-arching central sensitization mechanism common to all of the syndromes.  ...  A coherent picture of a "central sensitization" mechanism that bridges across all of these syndromes does not emerge from the existing scientific evidence.  ...  ICA is a data-driven method that does not require any a priori seed.  ... 
doi:10.2174/1573397112666151231111104 pmid:26717948 pmcid:PMC4785050 fatcat:r6um2icd4fhwphd2fjdew5mwwe

ENIGMA and Global Neuroscience: A Decade of Large-Scale Studies of the Brain in Health and Disease Across More Than 40 Countries

Paul Thompson
2020 Biological Psychiatry  
This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying  ...  We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in  ...  Core funding for ENIGMA was provided by the NIH Big Data to Knowledge (BD2K) program under consortium grant U54 EB020403, by the ENIGMA World Aging Center (R56 AG058854), and by the ENIGMA Sex Differences  ... 
doi:10.1016/j.biopsych.2020.02.167 fatcat:rcamgpjlcvfgzikfleqbunef3u

Loss of dopamine-D2 receptor binding sites in Parkinsonian plus syndromes

J Hierholzer, M Cordes, S Venz, L Schelosky, C Harisch, W Richter, U Keske, N Hosten, J Mäurer, W Poewe, R Felix
1998 Journal of Nuclear Medicine  
This study analyzed temporal changes of striatal dopamine-D2 receptor binding during the course of different extrapyramidal movement disorders using 123I-iodobenzamide (IBZM) SPECT.  ...  Methods Eighteen patients (9 with Parkinson's disease, 9 with parFdnsonianplus syndrome) were followed for 11-53 mo.  ...  Statistical analysis revealed a significant difference between the two populations (j' 0.001, Mann Whitney test), however, a significant overlap between both study groups was found (Fig. 1) .  ... 
pmid:9627325 fatcat:5z4kf7lz5beixcieoeexkkxkwq

Annual Research Review: Understudied populations within the autism spectrum - current trends and future directions in neuroimaging research

Allison Jack, Kevin A. Pelphrey
2017 Journal of Child Psychology and Psychiatry and Allied Disciplines  
However, neuroimaging methods are a potentially powerful tool for understanding the etiology of these ASD subtypes.  ...  , theoretical, and practical considerations for future research involving neuroimaging assessment of these populations.  ...  This review was invited by the Editors of JCPP (for which the first author has been offered a small honorarium towards expenses) and has been subject to full external peer review.  ... 
doi:10.1111/jcpp.12687 pmid:28102566 pmcid:PMC5367938 fatcat:yzx5tttotbdv7kogjn3okkpgrm

Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014

Michael W. Weiner, Dallas P. Veitch, Paul S. Aisen, Laurel A. Beckett, Nigel J. Cairns, Jesse Cedarbaum, Michael C. Donohue, Robert C. Green, Danielle Harvey, Clifford R. Jack, William Jagust, John C. Morris (+6 others)
2015 Alzheimer's & Dementia  
Methods-We searched for ADNI publications using established methods.  ...  as a data-sharing model; (6) generated data used in over 600 publications, leading to the identification of novel AD risk alleles, and an understanding of the relationship between biomarkers and AD progression  ...  Table 1 Major findings using ADNI data Area of research Major findings using ADNI data References Conflicts of Interest  ... 
doi:10.1016/j.jalz.2015.04.005 pmid:26194320 pmcid:PMC4659407 fatcat:ba7v6zu5pvhqjf6ovuvwa7acl4

Advances in neuroimaging to support translational medicine in dementia

Thomas Edmund Cope, Rimona Sharon Weil, Emrah Düzel, Bradford C Dickerson, James Benedict Rowe
2021 Journal of Neurology, Neurosurgery and Psychiatry  
In combination with large datasets, open data and artificial intelligence analysis methods, new informatics-based approaches are set to enable accurate single-subject inferences for diagnosis, prediction  ...  Advances in neuroimaging are ideally placed to facilitate the translation from progress made in cellular genetics and molecular biology of neurodegeneration into improved diagnosis, prevention and treatment  ...  data is the application of a standardised univariate method at large scale.  ... 
doi:10.1136/jnnp-2019-322402 pmid:33568448 pmcid:PMC8862738 fatcat:kfzojf7vpncq7pgln7xiaue324

Alzheimer's disease in Down syndrome: An overlooked population for prevention trials

André Strydom, Antonia Coppus, Rafael Blesa, Adrian Danek, Juan Fortea, John Hardy, Johannes Levin, Georg Nuebling, Anne-Sophie Rebillat, Craig Ritchie, Cornelia van Duijn, Shahid Zaman (+1 others)
2018 Alzheimer s & Dementia Translational Research & Clinical Interventions  
The discovery that adults with Down syndrome (DS) have neuropathological features identical to individuals with sporadic Alzheimer's disease (AD) played a key role in the identification of the amyloid  ...  Individuals with DS have a lifetime risk for dementia in excess of 90%, and DS is now acknowledged to be a genetic form of AD similar to rare autosomal-dominant causes.  ...  Data from the Rotterdam group, as yet unpublished. Abbreviation: DS, Down syndrome. Fig. 3 . 3 Fig. 3. Flow diagram showing existing DS trial-ready cohorts. Abbreviation: DS, Down syndrome.  ... 
doi:10.1016/j.trci.2018.10.006 pmid:30581976 pmcid:PMC6296162 fatcat:4gl4fmibnbdeve3xfyfnsbfszy

On the Use and Misuse of Genomic and Neuroimaging Science in Forensic Psychiatry: Current Roles and Future Directions

Michael T. Treadway, Joshua W. Buckholtz
2011 Child and Adolescent Psychiatric Clinics of North America  
Acknowledgments This manuscript work was produced with the support of the National Institute of Mental Health (F31MH087015) to M.T.T. and (T32MH018921) to J.W.B.  ...  Neuroimaging for the Assessment of Brain Abnormalities In considering the application of neuroimaging data to forensic assessment, a distinction must be drawn between whether the neuroimaging data are  ...  A statistically significant difference in the occurrence of that trait, behavior, or disorder between the two genotype groups is taken as an evidence of a positive genetic association.  ... 
doi:10.1016/j.chc.2011.03.012 pmid:21683918 pmcid:PMC5530871 fatcat:v4musqpydrey3kczirmkugubpe

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Paul M. Thompson, for the ENIGMA Consortium, Neda Jahanshad, Christopher R. K. Ching, Lauren E. Salminen, Sophia I. Thomopoulos, Joanna Bright, Bernhard T. Baune, Sara Bertolín, Janita Bralten, Willem B. Bruin, Robin Bülow (+159 others)
2020 Translational Psychiatry  
This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying  ...  We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in  ...  Core funding for ENIGMA was provided by the NIH Big Data to Knowledge (BD2K) program under consortium grant U54 EB020403, by the ENIGMA World Aging Center (R56 AG058854), and by the ENIGMA Sex Differences  ... 
doi:10.1038/s41398-020-0705-1 pmid:32198361 pmcid:PMC7083923 fatcat:b4oftx6e3rg7vhwcuhnjcab7pa

FDG PET and cognitive symptoms of dementia

Daniela Perani
2013 Clinical and translational imaging  
FDG PET imaging in subjects with underlying neurodegenerative pathology has emerged as a crucial tool available to the fields of cognitive neurology and neuroscience for both diagnosis and evaluation of  ...  The existing methods for semiquantitative assessment of brain functional changes provide topographical maps of molecular alterations both for group and single-subject comparisons.  ...  In a multicenter study, FDG PET images from population of patients with FTD were compared with images from controls of a similar age.  ... 
doi:10.1007/s40336-013-0029-8 fatcat:arpp2yjms5f7nprzu2lak23rwa
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