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A comparative gene-expression analysis of CD34+ hematopoietic stem and progenitor cells grown in static and stirred culture systems
2006
Cellular & Molecular Biology Letters
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The results revealed that 103 and 99 genes were significantly expressed in CD34+ cells from static and stirred systems, respectively. ...
To understand the genetic changes provoked by culture microenvironments, the gene expression profiling of CD34+ HSPCs grown in static and stirred culture systems was compared using SMART-PCR and cDNA arrays ...
We are grateful to Yan Zhou, Xu Zhang, Minglong Zhu and Ping Hua for their help in the laboratory, and Lin Wei and Dongning Pan for their work on the cDNA array analysis. ...
doi:10.2478/s11658-006-0039-x
pmid:16983455
fatcat:zmuidldcuzcapcr2lt52yatpwm
A comparative gene-expression analysis of CD34+ hematopoietic stem and progenitor cells grown in static and stirred culture systems
2006
Cellular & Molecular Biology Letters
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Static and stirred culture systems are widely used to expand hematopoietic cells, but differential culture performances are observed between these systems. ...
The results revealed that 103 and 99 genes were significantly expressed in CD34 + cells from static and stirred systems, respectively. ...
We are grateful to Yan Zhou, Xu Zhang, Minglong Zhu and Ping Hua for their help in the laboratory, and Lin Wei and Dongning Pan for their work on the cDNA array analysis. ...
doi:10.2478/s11658-006-0051-1
fatcat:vdwuoumjanhwfiztca6m2dnbxe
Biology of biomechanics: Finite element analysis of a statically determinate system to rotate the occlusal plane for correction of a skeletal Class III open-bite malocclusion
2015
American Journal of Orthodontics and Dentofacial Orthopedics
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Finite element analysis (FEA) is emerging as a clinical technology to assist in diagnosis, treatment planning and retrospective analysis. ...
Methods: Seventeen published case reports were selected for patients treated with statically determinate mechanics, utilizing posterior mandible (PM) or infrazygomatic crest (IZC) bone screw anchorage, ...
For 3D statically determinate systems, there can be 3 force components and 3 moment components. ...
doi:10.1016/j.ajodo.2015.10.002
pmid:26672700
fatcat:io6kuff3pzaf7o5bmgfdjrhwga
Korean Systems Biology and Biotechnology Research
2006
Asia-Pacific Biotech News
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Acknowledgements This study was supported by Korean Systems Biology Research grant from Korean Ministry of Science and Technology, and the Brain Korea 21 Project. ...
We also like to thank the support received from the LG Chemicals Chair Professorship, Microsoft and IBM SUR program. ...
The static model includes constraints-based fl ux analysis, topology analysis and stoichiometric analysis. ...
doi:10.1142/s0219030306001509
fatcat:nayftmu2ivd27exnntkqlgcibe
Preface
2009
Theoretical Computer Science
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In order to better meet the modelling, simulation and analysis requirements of systems biology, molecular and cellular processes have begun inspiring the creation and evolution of novel formalisms and ...
We propose to use the term "concurrent systems biology" for this recent research frontier of systems biology (which indeed was originally based on differential equations) stemming from the community of ...
The analysis offers a basis for establishing static checks of biological dynamic properties. ...
doi:10.1016/j.tcs.2009.04.001
fatcat:koifdbhh6jhojmdo6k7brcvfc4
Static Analysis for Biological Systems (BioAmbients)
[article]
2015
arXiv
pre-print
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In this paper, I present a summary on some works that utilized static analysis techniques for understanding biological systems. ...
Control flow analysis, context dependent analysis, and other techniques were employed to investigate the properties of BioAmbients. ...
Nielson [2] is currently investigating a methodology to code biological systems in BioAmbients. ...
arXiv:1501.00349v1
fatcat:njnagdmzlfebfe3x2uvn5bzrna
279 CYCLICAL HYPEROSMOLAR LOADING OF HUMAN ARTICULAR CHONDROCYTES INCREASES SOX9 GENE EXPRESSION AND P38 SIGNALLING IS REQUIRED
2010
Osteoarthritis and Cartilage
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Cyp1A1 mRNA expression was synergistically stimulated by TCDD and IL-1B treatment,. ...
Conversely, AhR ligands synergized with IL1-B and clearly increased the amount of IL-1B mRNA, but only moderately that of IL1-RA mRNA. ...
Understanding the regulation of SOX9 could lead to novel strategies to improve techniques of cartilage repair
Systems Biology Approach and High-throughput Proteomic Analysis Identifies Toll-Like-Receptor ...
doi:10.1016/s1063-4584(10)60306-8
fatcat:c6duw5lwhjcgvfg6hbaoa24pnm
Validation of a multicellular tumor microenvironment system for modeling patient tumor biology and drug response
2021
Scientific Reports
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This work further validates the TMES for modeling patient tumor biology and drug response indicating utility of the TMES as a predictive tool for drug discovery and development and potential for use as ...
a system for patient avatars. ...
Gioeli, Jameson, Bouton, Dudley, Kashatus, Park, Rutkowski, Smith, and Zong for helpful discussions. We thank the team at HemoShear Therapeutics and Garnett Mingledorff for technical assistance. ...
doi:10.1038/s41598-021-84612-z
pmid:33692370
pmcid:PMC7946945
fatcat:drzsje25rzhhpdqljxypnxx5nu
Computational Modeling, Formal Analysis, and Tools for Systems Biology
2016
PLoS Computational Biology
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The growing interest in systems biology in executable models and their analysis has necessitated the borrowing of terms and methods from computer science, such as formal analysis, model checking, static ...
As the amount of biological data in the public domain grows, so does the range of modeling and analysis techniques employed in systems biology. ...
, abstraction, model checking, reachability analysis, formal verification, and static analysis) that is scarcely known in other scientific communities such as systems biology. ...
doi:10.1371/journal.pcbi.1004591
pmid:26795950
pmcid:PMC4721667
fatcat:6fb2c7qe4fdwzbawec5qf42qga
Differential network biology
2012
Molecular Systems Biology
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Protein and genetic interaction maps can reveal the overall physical and functional landscape of a biological system. ...
gene expression and protein phosphorylation studies are already pervasive in genomic and proteomic analysis. ...
This work was supported by grants from the NIH (GM085764 and GM084279 to TI and GM084448, GM084279, GM081879 and GM098101 to NJK). TI is a David and Lucille Packard Fellow. ...
doi:10.1038/msb.2011.99
pmid:22252388
pmcid:PMC3296360
fatcat:dt6vdp65fngupl6wmh5jldhjqy
Network systems biology for targeted cancer therapies
2012
Chinese Journal of Cancer
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From biological network modeling to structural/dynamic network analysis, network systems biology provides unique insight into the potential mechanisms underlying the growth and progression of cancer cells ...
However, due to the complexity of biological systems, the current progress is far from enough. ...
systems biology. ...
doi:10.5732/cjc.011.10282
pmid:22176777
pmcid:PMC3777487
fatcat:hidrfb3p4bcthlrq7x2h4knpxu
On the feasibility of dynamical analysis of network models of biochemical regulation
[article]
2021
arXiv
pre-print
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Unlike what is suggested in the article, graph-based analysis of static features is not the only analytical avenue for large systems biology models of regulation and signaling dynamics because there are ...
However, the authors claim that dynamical analysis of large automata network models is "not even feasible." ...
Acknowledgements The author is indebted to the anonymous reviewers for their most valuable comments and references which have considerably strengthened this letter. ...
arXiv:2110.10821v1
fatcat:u6oiqyt7sbguhji62vulmxwftu
Does animation enhance learning? A meta-analysis
2016
Computers & Education
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This meta-analysis investigated whether animation is beneficial overall for learning compared to static graphics, while also identifying moderator factors affecting the global effect. ...
A total of 50 papers were considered, and consecutively 61 primary studies (N ¼ 7036), yielding 140 pair-wise comparisons of animated vs. static graphic visualizations in multimedia instructional material ...
An important but surprising finding of this meta-analysis is that the positive effect of animation over static graphics was found only for system-paced instructional material, or in other words when learners ...
doi:10.1016/j.compedu.2016.06.005
fatcat:sygwbtjdbffwjiufy7sm4ibdcm
Reverse engineering biomolecular systems using -omic data: challenges, progress and opportunities
2012
Briefings in Bioinformatics
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validate and analyze theoretical system models directly through experimental synthesis, i.e. analysis-by-synthesis. ...
The ultimate goal is to address the present and future challenges in reverse engineering biomolecular systems (REBMS) using integrated workflow of data mining, systems modeling and synthetic biology. ...
; Georgia Cancer Coalition Distinguished Cancer Scholar Award to MD Wang, and grants 5R21DA025168-02, 1R01HG004836-01 and 4R00LM009826-03 to G. ...
doi:10.1093/bib/bbs026
pmid:22833495
pmcid:PMC3404400
fatcat:rctmpuedxbcbxh6ipuloiy4kji
280 Systems Biology Approach and High-throughput Proteomic Analysis Identifies Toll-Like-Receptor Activators as Major Players of Cartilage Degeneration
2010
Osteoarthritis and Cartilage
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Statistical analysis was performed using mixed effects regression models. ...
Osmotic load was either static or cyclical, where loads were applied by incubating cells for 5 hours in 380 and 550mOsm medium alternating every 30 or 60 minutes, containing either DMSO, or 20μM p38 MAP ...
Association between evolution of non-EOA to EOA and baseline characteristics OR (95% CI)* OR (95% CI)**
282 Figure 2 2 Figure 2
280 Systems 280 Biology Approach and High-throughput Proteomic Analysis ...
doi:10.1016/s1063-4584(10)60307-x
fatcat:w6a7b7lxsrakfg7qlp3lxjs5sa
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