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Transfer Function Models for the Localization of Seizure Onset Zone From Cortico-Cortical Evoked Potentials
2020
Frontiers in Neurology
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Surgical resection of the seizure onset zone (SOZ) could potentially lead to seizure-freedom in medically refractory epilepsy patients. ...
We hypothesized that evoked responses from single pulse electrical stimulation (SPES) can also be used to localize the SOZ as they may express the natural frequencies and connectivity of the iEEG network ...
ACKNOWLEDGMENTS The authors would like to thank the members of the Neuromedical Control Systems Lab (NCSL) and the Crone Lab for their helpful discussions regarding this work. ...
doi:10.3389/fneur.2020.579961
pmid:33362689
pmcid:PMC7758451
fatcat:f7jfx3vzmzc67lit7ejeqqmlgq
Decoding Epileptogenesis in a Reduced State Space
[article]
2017
arXiv
pre-print
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We use a hidden Markov model to learn the dynamics of the evoked potential, as it evolves along these smooth low-dimensional subsets. ...
Using an animal model of acquired epilepsy, wechronically record hippocampal evoked potentials elicited by an auditory stimulus. ...
What is the local dimension of the state-space? ...
arXiv:1701.07243v1
fatcat:qect3pfd3nddfgvsne3hwvukkm
Decoding Epileptogenesis in a Reduced State Space
2016
2016 15th IEEE International Conference on Machine Learning and Applications (ICMLA)
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We use a hidden Markov model to learn the dynamics of the evoked potential, as it evolves along these smooth low-dimensional subsets. ...
Using an animal model of acquired epilepsy, we chronically record hippocampal evoked potentials elicited by an auditory stimulus. ...
What is the local dimension of the state-space? ...
doi:10.1109/icmla.2016.0033
dblp:conf/icmla/MeyerBSB16
fatcat:efgnwdaz6jb27auy7tcwcxtmba
Brain–Computer Interface (BCI) Applications in Mapping of Epileptic Brain Networks Based on Intracranial-EEG: An Update
2019
Frontiers in Neuroscience
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Recording of seizures and localization of the Seizure Onset Zone (SOZ) in the subgroup of "surgical" patients, who require intracranial-EEG (icEEG) evaluations, remain to date the best available surrogate ...
The clinical care remains inspired by the original practices of recording the seizures and expert visual analysis of rhythms at onset. ...
ACKNOWLEDGMENTS The author wishes to thank Rebecca Khozein DOM, MS, REEG/EPT, RPSGT, RNCST, and Tamara Wing REEGT for assistance in EEG data acquisition. ...
doi:10.3389/fnins.2019.00191
pmid:30971871
pmcid:PMC6446441
fatcat:eqjc4sxsavcehca62dymnim5rm
High-frequency oscillations and other electrophysiological biomarkers of epilepsy: underlying mechanisms
2011
Biomarkers in Medicine
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In the normal mammalian brain, neuronal synchrony occurs on a spatial scale of submillimeters to centimeters and temporal scale of submilliseconds to seconds that is reflected in the occurrence of high-frequency ...
frequency and state-dependent characteristics similar to those in rats [4][5][6][7]. ...
Interictal pHFOs as a biomarker of epilepsy • The association between pHFOs and epileptogenicity suggest pHFOs could help localize the seizure onset zone and might identify the epileptogenic zone more ...
doi:10.2217/bmm.11.72
pmid:22003903
pmcid:PMC3233380
fatcat:ritipiohrbgido4rwg7a4qd5sy
Graph theoretical analysis of evoked potentials shows network influence of epileptogenic mesial temporal region
2021
Human Brain Mapping
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Effective connectivity within the MTR had significantly greater magnitude (evoked potential amplitude) and network density, regardless of epileptogenicity. ...
It is now widely accepted that seizures arise from the coordinated activity of epileptic networks, and as a result, traditional methods of analyzing seizures have been augmented by techniques like single-pulse ...
ACKNOWLEDGMENTS The authors would like to thank Anna Korzeniewska and Yujing Wang for helpful discussions and experimental coordination involving this work, and Raphael Bechtold for help in electrode localization ...
doi:10.1002/hbm.25418
pmid:34165233
pmcid:PMC8356982
fatcat:uiuksgswfzbshnerexaubkbneu
Single pulse electrical stimulation to probe functional and pathological connectivity in epilepsy
2017
Seizure
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These evoked potentials that emanate from adjacent and remote cortices have been termed cortico-cortical evoked potentials (CCEPs). ...
With regard to epilepsy, SPES has been used for the two major purposes, one to probe cortical excitability of the focus, namely, epileptogenicity, and the other to probe seizure networks. ...
Acknowledgments The authors would like to thank Professors Hiroshi Shibasaki, Hans Lüders, and Akio Ikeda for their long-standing supports and advices for establishment of CCEP methodology. ...
doi:10.1016/j.seizure.2016.11.003
pmid:27939100
pmcid:PMC5291825
fatcat:s5sbgnkckvddhnkp7tiqgzc7qa
Beta oscillations in the sensorimotor cortex correlate with disease and remission in benign epilepsy with centrotemporal spikes
2019
Brain and Behavior
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Seizures arise from the lower half of the sensorimotor cortex of the brain (e.g. seizure onset zone) and the abnormal epileptiform discharges observed increase during NREM sleep. ...
Oscillations in this frequency band are modulated by state of consciousness and thought to reflect intrinsic inhibitory mechanisms. ...
After the resting EEG session was completed, somatosensory evoked potentials (SEP) from the median nerve from each arm were recorded to localize the sensorimotor cortex and confirm EEG-MRI co-registration ...
doi:10.1002/brb3.1237
pmid:30790472
pmcid:PMC6422718
fatcat:fdvmznt2azh3dmtcogscs2qcfe
Dynamics of large-scale brain activity in normal arousal states and epileptic seizures
2002
Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics
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precursor arousal states in the reduced space. ...
Nonlinear stimulus-induced entrainment and seizures are also seen, EEG spectra and potentials evoked by stimuli are reproduced, and numerous other points of experimental agreement are found. ...
ACKNOWLEDGMENTS The authors thank J.J. Wright, S.C. O'Connor, M. Breakspear, and E. Gordon for stimulating discussions. ...
doi:10.1103/physreve.65.041924
pmid:12005890
fatcat:6l4tdp64lvd2hfujjvn4yhddk4
A Rat Model Of Somatosensory-Evoked Reflex Seizures Induced By Peripheral Stimulation
[article]
2018
bioRxiv
pre-print
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Optical imaging of the cerebral blood volume response showed that they propagated from the onset zone to adjacent cortical areas, beyond the S1FL representation of the stimulated digit or forepaw. ...
Objective: We introduce a novel animal model of somatosensory stimulation-induced reflex seizures which generates focal seizures without causing damage to the brain. ...
A reliable method to detect the seizure state and to localize the discrete epileptogenic zone could enhance the therapeutic possibilities. ...
doi:10.1101/506352
fatcat:5566bimksjgurmf4ifb5n3pstm
Corticocortical Evoked Potentials Reveal Projectors and Integrators in Human Brain Networks
2014
Journal of Neuroscience
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Here we combined direct electrical stimulation with recordings from the cortical surface to provide a novel insight into directed, inter-regional influence within the cerebral cortex of awake humans. ...
However, higher-level network topology analysis revealed differences between electrical stimulation and ECoG that were partially related to the reciprocity of connections. ...
Figure 4 . 4 Relationship of seizure onset zone to CCEP networks measures. ...
doi:10.1523/jneurosci.4289-13.2014
pmid:24990935
pmcid:PMC4078089
fatcat:6yiednfwhzgw7nhpesl2wbhxfm
Physiological consequences of abnormal connectivity in a developmental epilepsy
2015
Annals of Neurology
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abnormal TMS-evoked activity overlapped with the spike and seizure onset zone. ...
Objective: Many forms of epilepsy are associated with aberrant neuronal connections, but the relationship between such pathological connectivity and the underlying physiological predisposition to seizures ...
Potential Conflicts of Interest A.P. ...
doi:10.1002/ana.24343
pmid:25858773
pmcid:PMC4394240
fatcat:5fhmxjhiffajdkj4p4xgctgeay
Studying Network Mechanisms Using Intracranial Stimulation in Epileptic Patients
2010
Frontiers in Systems Neuroscience
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be used for the characterization of functional networks, the identification of the seizure onset zone, the study of brain plasticity mechanisms, and the anticipation of epileptic seizures. ...
After a brief summary of mechanisms of action of brain electrical stimulation, we recall the conceptual framework for interpreting DES results in the context of brain connectivity and review how DES can ...
These authors in localizing the seizure onset zone in patients suffering from various forms of focal epilepsy. ...
doi:10.3389/fnsys.2010.00148
pmid:21060722
pmcid:PMC2972750
fatcat:kasa4nwhqjhf7aja6domctuuvq
Mapping Epileptic Activity: Sources or Networks for the Clinicians?
2014
Frontiers in Neurology
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Epileptic seizures of focal origin are classically considered to arise from a focal epileptogenic zone and then spread to other brain regions. ...
In this paper, we review the potential clinical contribution of these functional mapping techniques as well as invasive electrophysiology in human beings and animal models for characterizing network connectivity ...
to consider more than the sole seizure-onset zone for estimating the epileptogenic zone. ...
doi:10.3389/fneur.2014.00218
pmid:25414692
pmcid:PMC4220689
fatcat:onsc67xnxnd6vhuvh6lmcjgsha
The Effects of Focal Epileptic Activity on Regional Sensory-Evoked Neurovascular Coupling and Postictal Modulation of Bilateral Sensory Processing
2013
Journal of Cerebral Blood Flow and Metabolism
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Our results provide insights into sensory-evoked neurovascular dynamics and coupling in epilepsy, and may have implications for the localization of epileptogenic foci and neighboring eloquent cortex. ...
Stimulation consisted of electrical pulse trains (16 seconds, 5 Hz, 1.2 mA) presented to the mystacial pad. ...
information on the seizure onset zone (SOZ). ...
doi:10.1038/jcbfm.2013.115
pmid:23860375
pmcid:PMC3790930
fatcat:t4q66ovpcvdexm5op5fk3fa6si
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