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Transfer Function Models for the Localization of Seizure Onset Zone From Cortico-Cortical Evoked Potentials

Golnoosh Kamali, Rachel June Smith, Mark Hays, Christopher Coogan, Nathan E Crone, Joon Y Kang, Sridevi V Sarma
2020 Frontiers in Neurology  
Surgical resection of the seizure onset zone (SOZ) could potentially lead to seizure-freedom in medically refractory epilepsy patients.  ...  We hypothesized that evoked responses from single pulse electrical stimulation (SPES) can also be used to localize the SOZ as they may express the natural frequencies and connectivity of the iEEG network  ...  ACKNOWLEDGMENTS The authors would like to thank the members of the Neuromedical Control Systems Lab (NCSL) and the Crone Lab for their helpful discussions regarding this work.  ... 
doi:10.3389/fneur.2020.579961 pmid:33362689 pmcid:PMC7758451 fatcat:f7jfx3vzmzc67lit7ejeqqmlgq

Decoding Epileptogenesis in a Reduced State Space [article]

François G. Meyer, Alexander M. Benison, Zachariah Smith, and Daniel S. Barth
2017 arXiv   pre-print
We use a hidden Markov model to learn the dynamics of the evoked potential, as it evolves along these smooth low-dimensional subsets.  ...  Using an animal model of acquired epilepsy, wechronically record hippocampal evoked potentials elicited by an auditory stimulus.  ...  What is the local dimension of the state-space?  ... 
arXiv:1701.07243v1 fatcat:qect3pfd3nddfgvsne3hwvukkm

Decoding Epileptogenesis in a Reduced State Space

Francois G. Meyer, Alexander M. Benison, Zachariah Smith, Daniel S. Barth
2016 2016 15th IEEE International Conference on Machine Learning and Applications (ICMLA)  
We use a hidden Markov model to learn the dynamics of the evoked potential, as it evolves along these smooth low-dimensional subsets.  ...  Using an animal model of acquired epilepsy, we chronically record hippocampal evoked potentials elicited by an auditory stimulus.  ...  What is the local dimension of the state-space?  ... 
doi:10.1109/icmla.2016.0033 dblp:conf/icmla/MeyerBSB16 fatcat:efgnwdaz6jb27auy7tcwcxtmba

Brain–Computer Interface (BCI) Applications in Mapping of Epileptic Brain Networks Based on Intracranial-EEG: An Update

Rafeed Alkawadri
2019 Frontiers in Neuroscience  
Recording of seizures and localization of the Seizure Onset Zone (SOZ) in the subgroup of "surgical" patients, who require intracranial-EEG (icEEG) evaluations, remain to date the best available surrogate  ...  The clinical care remains inspired by the original practices of recording the seizures and expert visual analysis of rhythms at onset.  ...  ACKNOWLEDGMENTS The author wishes to thank Rebecca Khozein DOM, MS, REEG/EPT, RPSGT, RNCST, and Tamara Wing REEGT for assistance in EEG data acquisition.  ... 
doi:10.3389/fnins.2019.00191 pmid:30971871 pmcid:PMC6446441 fatcat:eqjc4sxsavcehca62dymnim5rm

High-frequency oscillations and other electrophysiological biomarkers of epilepsy: underlying mechanisms

Richard J Staba, Anatol Bragin
2011 Biomarkers in Medicine  
In the normal mammalian brain, neuronal synchrony occurs on a spatial scale of submillimeters to centimeters and temporal scale of submilliseconds to seconds that is reflected in the occurrence of high-frequency  ...  frequency and state-dependent characteristics similar to those in rats [4][5][6][7].  ...  Interictal pHFOs as a biomarker of epilepsy • The association between pHFOs and epileptogenicity suggest pHFOs could help localize the seizure onset zone and might identify the epileptogenic zone more  ... 
doi:10.2217/bmm.11.72 pmid:22003903 pmcid:PMC3233380 fatcat:ritipiohrbgido4rwg7a4qd5sy

Graph theoretical analysis of evoked potentials shows network influence of epileptogenic mesial temporal region

Mark A. Hays, Christopher Coogan, Nathan E. Crone, Joon Y. Kang
2021 Human Brain Mapping  
Effective connectivity within the MTR had significantly greater magnitude (evoked potential amplitude) and network density, regardless of epileptogenicity.  ...  It is now widely accepted that seizures arise from the coordinated activity of epileptic networks, and as a result, traditional methods of analyzing seizures have been augmented by techniques like single-pulse  ...  ACKNOWLEDGMENTS The authors would like to thank Anna Korzeniewska and Yujing Wang for helpful discussions and experimental coordination involving this work, and Raphael Bechtold for help in electrode localization  ... 
doi:10.1002/hbm.25418 pmid:34165233 pmcid:PMC8356982 fatcat:uiuksgswfzbshnerexaubkbneu

Single pulse electrical stimulation to probe functional and pathological connectivity in epilepsy

Riki Matsumoto, Takeharu Kunieda, Dileep Nair
2017 Seizure  
These evoked potentials that emanate from adjacent and remote cortices have been termed cortico-cortical evoked potentials (CCEPs).  ...  With regard to epilepsy, SPES has been used for the two major purposes, one to probe cortical excitability of the focus, namely, epileptogenicity, and the other to probe seizure networks.  ...  Acknowledgments The authors would like to thank Professors Hiroshi Shibasaki, Hans Lüders, and Akio Ikeda for their long-standing supports and advices for establishment of CCEP methodology.  ... 
doi:10.1016/j.seizure.2016.11.003 pmid:27939100 pmcid:PMC5291825 fatcat:s5sbgnkckvddhnkp7tiqgzc7qa

Beta oscillations in the sensorimotor cortex correlate with disease and remission in benign epilepsy with centrotemporal spikes

Dan Y. Song, Sally M. Stoyell, Erin E. Ross, Lauren M. Ostrowski, Emily L. Thorn, Steven M. Stufflebeam, Amy K. Morgan, Britt C. Emerton, Mark A. Kramer, Catherine J. Chu
2019 Brain and Behavior  
Seizures arise from the lower half of the sensorimotor cortex of the brain (e.g. seizure onset zone) and the abnormal epileptiform discharges observed increase during NREM sleep.  ...  Oscillations in this frequency band are modulated by state of consciousness and thought to reflect intrinsic inhibitory mechanisms.  ...  After the resting EEG session was completed, somatosensory evoked potentials (SEP) from the median nerve from each arm were recorded to localize the sensorimotor cortex and confirm EEG-MRI co-registration  ... 
doi:10.1002/brb3.1237 pmid:30790472 pmcid:PMC6422718 fatcat:fdvmznt2azh3dmtcogscs2qcfe

Dynamics of large-scale brain activity in normal arousal states and epileptic seizures

P. A. Robinson, C. J. Rennie, D. L. Rowe
2002 Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics  
precursor arousal states in the reduced space.  ...  Nonlinear stimulus-induced entrainment and seizures are also seen, EEG spectra and potentials evoked by stimuli are reproduced, and numerous other points of experimental agreement are found.  ...  ACKNOWLEDGMENTS The authors thank J.J. Wright, S.C. O'Connor, M. Breakspear, and E. Gordon for stimulating discussions.  ... 
doi:10.1103/physreve.65.041924 pmid:12005890 fatcat:6l4tdp64lvd2hfujjvn4yhddk4

A Rat Model Of Somatosensory-Evoked Reflex Seizures Induced By Peripheral Stimulation [article]

Aleksandra Bortel, Ze Shan Yao, Amir Shmuel
2018 bioRxiv   pre-print
Optical imaging of the cerebral blood volume response showed that they propagated from the onset zone to adjacent cortical areas, beyond the S1FL representation of the stimulated digit or forepaw.  ...  Objective: We introduce a novel animal model of somatosensory stimulation-induced reflex seizures which generates focal seizures without causing damage to the brain.  ...  A reliable method to detect the seizure state and to localize the discrete epileptogenic zone could enhance the therapeutic possibilities.  ... 
doi:10.1101/506352 fatcat:5566bimksjgurmf4ifb5n3pstm

Corticocortical Evoked Potentials Reveal Projectors and Integrators in Human Brain Networks

C. J. Keller, C. J. Honey, L. Entz, S. Bickel, D. M. Groppe, E. Toth, I. Ulbert, F. A. Lado, A. D. Mehta
2014 Journal of Neuroscience  
Here we combined direct electrical stimulation with recordings from the cortical surface to provide a novel insight into directed, inter-regional influence within the cerebral cortex of awake humans.  ...  However, higher-level network topology analysis revealed differences between electrical stimulation and ECoG that were partially related to the reciprocity of connections.  ...  Figure 4 . 4 Relationship of seizure onset zone to CCEP networks measures.  ... 
doi:10.1523/jneurosci.4289-13.2014 pmid:24990935 pmcid:PMC4078089 fatcat:6yiednfwhzgw7nhpesl2wbhxfm

Physiological consequences of abnormal connectivity in a developmental epilepsy

Mouhsin M. Shafi, Marine Vernet, Debby Klooster, Catherine J. Chu, Katica Boric, Mollie E. Barnard, Kelsey Romatoski, M. Brandon Westover, Joanna A. Christodoulou, John D. E. Gabrieli, Susan Whitfield-Gabrieli, Alvaro Pascual-Leone (+1 others)
2015 Annals of Neurology  
abnormal TMS-evoked activity overlapped with the spike and seizure onset zone.  ...  Objective: Many forms of epilepsy are associated with aberrant neuronal connections, but the relationship between such pathological connectivity and the underlying physiological predisposition to seizures  ...  Potential Conflicts of Interest A.P.  ... 
doi:10.1002/ana.24343 pmid:25858773 pmcid:PMC4394240 fatcat:5fhmxjhiffajdkj4p4xgctgeay

Studying Network Mechanisms Using Intracranial Stimulation in Epileptic Patients

Olivier David, Julien Bastin, Stéphan Chabardès, Lorella Minotti, Philippe Kahane
2010 Frontiers in Systems Neuroscience  
be used for the characterization of functional networks, the identification of the seizure onset zone, the study of brain plasticity mechanisms, and the anticipation of epileptic seizures.  ...  After a brief summary of mechanisms of action of brain electrical stimulation, we recall the conceptual framework for interpreting DES results in the context of brain connectivity and review how DES can  ...  These authors in localizing the seizure onset zone in patients suffering from various forms of focal epilepsy.  ... 
doi:10.3389/fnsys.2010.00148 pmid:21060722 pmcid:PMC2972750 fatcat:kasa4nwhqjhf7aja6domctuuvq

Mapping Epileptic Activity: Sources or Networks for the Clinicians?

Francesca Pittau, Pierre Mégevand, Laurent Sheybani, Eugenio Abela, Frédéric Grouiller, Laurent Spinelli, Christoph M. Michel, Margitta Seeck, Serge Vulliemoz
2014 Frontiers in Neurology  
Epileptic seizures of focal origin are classically considered to arise from a focal epileptogenic zone and then spread to other brain regions.  ...  In this paper, we review the potential clinical contribution of these functional mapping techniques as well as invasive electrophysiology in human beings and animal models for characterizing network connectivity  ...  to consider more than the sole seizure-onset zone for estimating the epileptogenic zone.  ... 
doi:10.3389/fneur.2014.00218 pmid:25414692 pmcid:PMC4220689 fatcat:onsc67xnxnd6vhuvh6lmcjgsha

The Effects of Focal Epileptic Activity on Regional Sensory-Evoked Neurovascular Coupling and Postictal Modulation of Bilateral Sensory Processing

Sam Harris, Michael Bruyns-Haylett, Aneurin Kennerley, Luke Boorman, Paul G Overton, Hongtao Ma, Mingrui Zhao, Theodore H Schwartz, Jason Berwick
2013 Journal of Cerebral Blood Flow and Metabolism  
Our results provide insights into sensory-evoked neurovascular dynamics and coupling in epilepsy, and may have implications for the localization of epileptogenic foci and neighboring eloquent cortex.  ...  Stimulation consisted of electrical pulse trains (16 seconds, 5 Hz, 1.2 mA) presented to the mystacial pad.  ...  information on the seizure onset zone (SOZ).  ... 
doi:10.1038/jcbfm.2013.115 pmid:23860375 pmcid:PMC3790930 fatcat:t4q66ovpcvdexm5op5fk3fa6si
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