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Magnetowetting of Ferrofluidic Thin Liquid Films

Srinivas Tenneti, Sri Ganesh Subramanian, Monojit Chakraborty, Gaurav Soni, Sunando DasGupta
2017 Scientific Reports  
An extended meniscus of a ferrofluid solution on a silicon surface is subjected to axisymmetric, non-uniform magnetic field resulting in significant forward movement of the thin liquid film. Image analyzing interferometry is used for accurate measurement of the film thickness profile, which in turn, is used to determine the instantaneous slope and the curvature of the moving film. The recorded video, depicting the motion of the film in the Lagrangian frame of reference, is analyzed frame by
more » ... e, eliciting accurate information about the velocity and acceleration of the film at any instant of time. The application of the magnetic field has resulted in unique changes of the film profile in terms of significant non-uniform increase in the local film curvature. This was further analyzed by developing a model, taking into account the effect of changes in the magnetic and shape-dependent interfacial force fields. Process intensification in the micro-scale domain has been garnering attention due to their inherent abilities and advantages to control the transport phenomena with a minimal expense of resources 1,2 . Micro-Electro-Mechanical-Systems (MEMS) and nanotechnology have been paving way for newer and more advanced discoveries 3 such as Polymerase Chain Reaction (PCR) 4 , microsystems for DNA amplification and identification 5 , enzyme linked immunosorbent assay (ELISA) 6 , capillary electrophoresis 7 , electroporation 8 , biochips for the detection of hazardous chemical and biological agents 9 and microsystems for high throughput drug screening and selection 10,11 . Another well defined and established application of microfluidics and microfabrication is in the domain of device fabrications, utilizing photolithography 12,13 . Integrated circuits (IC's), the basic building blocks of any electronic device are becoming more complex, efficient and affordable due to the advancements in photolithography. However, the performance of IC's is limited by their significant heat generation, creating a need for the rapid development in alternate cooling strategies, such as micro-heat pipes 14 , thin film micro-refrigerators, etc 15,16 . Droplet based micro fluidics 17 that operate on electrowetting is also becoming a popular alternative for micro-chip cooling. The theory of electrowetting 18,19 along with its applications have been reviewed and reported by various researchers. The phenomenon of droplet electrowetting has been exploited on various surfaces and processes, such as paper 20 , carbon nanotubes 21 , liquid infused films 22 and more recently for energy harvesting and storage 23 and hot spot cooling enhancement 24,25 . Droplet motions with specific applications in lab on a chip devices have been extensively analyzed and reported by various researchers [26] [27] [28] [29] . Dynamics of droplets subjected to various modes of perturbation such as acoustic 30 , thermal 31 , optical 32 and magnetic 33 have been studied extensively, whereas droplet manipulation through magnetic actuation, with advancements in point of care medical diagnostics has been reported by Shin et al. 34 . The related concepts have been further extended to thin liquid films as well. Subjecting a thin liquid film to external perturbations resulting in the actuation of liquid motion is used to probe and manipulate the transport phenomena near the contact line region. The analysis of the dynamics of partially wetting thin liquid films, experiencing an external perturbation, is a complex process [35] [36] [37] . Evaporating thin liquid films may provide very high heat transfer coefficients across the liquid-vapour interface 38,39 . The physics associated with the dynamics of thin liquid films undergoing cycles of evaporation and condensation was first studied and quantified by Potash and Wayner 39 . The hydrodynamic flows associated with thin liquid films when subjected to continuous evaporative-condensing cycles in micro heat pipes has been studied and reported by Swanson et al. 40 . Since then, the response of thin liquid films subjected to various modes of perturbation such as thermal 38,41 and electrical 35 have been investigated and reported. Extensive reviews on intermolecular forces and interactions present in a thin liquid-solid-vapour system have been presented by Derjaguin et al. 42 . The contact angle hysteresis and
doi:10.1038/srep44738 pmid:28303971 pmcid:PMC5356190 fatcat:kvi4i5kabrfqngocnvdl4xumlq

Design and Development of Vancomycin Liposomes

Srinivas Lankalapalli, Venkata Satya Vinai Kumar Tenneti, Sunil Kumar Nimmali
2015 Indian Journal of Pharmaceutical Education and Research  
Vancomycin hydrochloride is water soluble and poorly absorbable glycopeptide antibiotic act by inhibition of the synthesis of peptidoglycan a major component of bacteria cell wall. It is highly effective against the Staphylococcus aureus and other Staphylococcus species microorganisms. Structurally vancomycin hydrochloride has six peptide bonds with a molecular weight of approximately 1500 Da. Liposomes, the colloidal vesicular structures due to their biphasic environment can act as carriers
more » ... both lipophilic & hydrophilic drugs. The encapsulation of antimicrobials in liposomes potentially offers enhanced pharmacokinetics and pharmacodynamics and decreased toxicity. This delivery system has the advantages of targeted, long circulation, low toxicity, sustained-release, no immunogenicity and protecting the encapsulated drugs from the destructive action of the external media. The present research work is planned to develop liposomal formulation of Vancomycin hydrochloride and to study the possibility of permeability enhancement. Liposomes are prepared by using various permeation enhancers like propylene glycol, poly ethylene glycol 400, poly ethylene glycol 600, Tween 80 and Span 60. The prepared liposomes are characterized by optical microscopy, scanning electron microscopy, particle size determination, encapsulation efficiency, FTIR spectroscopy studies and in vitro diffusion studies using dialysis membrane. Among six different liposomes F2 formulation (containing propylene glycol) has showed promising results with respect to drug entrapment and percentage drug release.
doi:10.5530/ijper.49.3.6 fatcat:2o4ff6wfuvb2xby6ekvszwqbcq

MFCC for Voiced Part Using VAD and GMM Based Gender Recognition

Hema Pentapati, Srinivas Vasamsetti, Madhu Tenneti
2017 Advances in Modelling and Analysis B  
For many applications, identifying the gender information of a speaker is important. In this paper, we implemented the system which identifies the speaker and also gender of the speaker by using MFCC and GMM in an uncontrolled environment. In this text independent system, we aim on the classification using GMM for the extracted features using MFCC and also the speech signal is processed with Voice Activity Detector (VAD). In the experiments using locally recorded database, the system without
more » ... ce activity detector (VAD) does not provide accurate results. So, the main aim of this paper is to develop a text independent speaker identification and also gender identification using MFCC along with VAD and GMM which improves the performance further relatively when compared with the system without VAD. The performance of the proposed system tested for 70 speakers with 100 percent recognition rate is achieved based on the log likelihood scores. Key words Mel frequency cepstral coefficients (MFCC), Vector quantization, Gaussian mixture model (GMM), Voice Activity Detector (VAD).
doi:10.18280/ama_b.600305 fatcat:2xblr6nn3bddzfh4yjxt6xuydi

NANOPARTICULATE DRUG DELIVERY SYSTEMS: PROMISING APPROACHES FOR DRUG DELIVERY

Srinivas Lankalapalli, Krishna Chaitanya Routhu, Shruthi Ojha, VS Vinai Kumar Tenneti
2014 Journal of Drug Delivery and Therapeutics  
Properties of Nanoparticles In pharmaceutics, ~90% of all medicines, the active ingredient is in the form of solid particles. The evolution of nanotechnology made it possible to produce drug ABSTRACT Advanced drug delivery technologies can increase safety and efficacy, extend patent lives and provide competitive differentiation for biopharmaceuticals by helping drug manufacturers in differentiating new therapeutics from existing products that enable novel treatments. It provides improved
more » ... through increased efficacy and duration of drug activity, decreased dosing frequency, convenient routes of administration and improved targeting of drug to specific sites reducing unwanted side effects. The role of advanced drug delivery based on Nanoparticles is discussed herein. The growing range of nanoparticle based drug delivery methods is assured of changing the formulation characteristics of new compounds and extending the lifecycle of existing compounds. In order to achieve this, article deals with the fundamental understanding of their properties, types, manufacturing, characterization, challenges and emerging trends in the field of drug delivery.
doi:10.22270/jddt.v0i0.883 fatcat:sh66brztffegldw4uvcthkkwiy

DESIGN OF DOMESTIC SCALE BIO-DIGESTER ASSEMBLY, EXPERIMENTATION FOR BIOGAS PRODUCTION AND COMPARISON OF RESULTS WITH CONVENTIONAL DIGESTER

Susmita Mishra, Srinivas Tenneti, Suman Mishra
2015 Jurnal Teknologi  
Graphical abstract Abstract The work explored various digesters that are currently under implementation, explored their pros and cons and designed a digestion gas collection mechanism suitable for small scale applications. Internal mixing being uneconomical in the domestic and individual scale, it is not being practiced which has to be compensated with large hydraulic retention time to prevent sludge accumulation and scum formation. This in turn reduces the plant capacity for gas production.
more » ... design configuration incorporates automatic and controlled pressure swing mechanisms incorporated by the gas production which acts as the driving force for slurry circulation in the digester and promotes gas recovery as well as improve digestion efficiency. The configuration was run in 20 l and 50 L scales and observed for the physical constraints encountered during operation, recorded for change in digestion parameters with changes in substrate and organic loading rates and also recorded the gas production which was compared with the results in the literature as well as conventionally operated domestic scale digesters. Abstrak Kerja-kerja ini diterokai pelbagai pencerna yang sedang dalam pelaksanaan, diterokai kebaikan dan keburukan mereka dan mereka bentuk satu penghadaman mekanisme pengumpulan gas yang sesuai untuk aplikasi kecil. Pencampuran dalaman yang tidak ekonomi dalam skala tempatan dan individu, ia tidak diamalkan yang perlu diberi pampasan dengan besar masa tahanan hidraulik untuk mencegah pengumpulan enapcemar dan pembentukan buih. Ini seterusnya mengurangkan kapasiti kilang untuk pengeluaran gas. Konfigurasi reka bentuk kami menggabungkan mekanisme ayunan tekanan automatik dan dikawal diperbadankan oleh pengeluaran gas yang bertindak sebagai kuasa memandu untuk edaran buburan dalam pencerna dan menggalakkan pemulihan gas serta meningkatkan kecekapan penghadaman. Konfigurasi telah dijalankan di 20 l dan 50 L skala dan diperhatikan untuk kekangan fizikal yang dihadapi semasa operasi, mencatatkan perubahan dalam parameter penghadaman dengan perubahan dalam substrat dan kadar muatan organik dan juga mencatatkan pengeluaran gas yang telah dibandingkan dengan keputusan dalam kesusasteraan dan juga konvensional beroperasi pencerna skala domestik.
doi:10.11113/jt.v75.5332 fatcat:ltzamplrlnhq3dchnlsxmd45o4

Transient Dynamics of Epidemic Spreading and Its Mitigation on Large Networks [article]

Chul-Ho Lee, Srinivas Tenneti, Do Young Eun
2019 arXiv   pre-print
In this paper, we aim to understand the transient dynamics of a susceptible-infected (SI) epidemic spreading process on a large network. The SI model has been largely overlooked in the literature, while it is naturally a better fit for modeling the malware propagation in early times when patches/vaccines are not available, or over a wider range of timescales when massive patching is practically infeasible. Nonetheless, its analysis is simply non-trivial, as its important dynamics are all
more » ... nt and the usual stability/steady-state analysis no longer applies. To this end, we develop a theoretical framework that allows us to obtain an accurate closed-form approximate solution to the original SI dynamics on any arbitrary network, which captures the temporal dynamics over all time and is tighter than the existing approximation, and also to provide a new interpretation via reliability theory. As its applications, we further develop vaccination policies with or without knowledge of already-infected nodes, to mitigate the future epidemic spreading to the extent possible, and demonstrate their effectiveness through numerical simulations.
arXiv:1903.00167v3 fatcat:babgpzdbnzagxkw4scpgvyqu3q

Architectures for intelligent robots in the age of exploitation

E. L. Hall, S. M. Alhaj Ali, M. Ghaffari, X. Liao, Saurabh Sarkar, Kovid Mathur, Srinivas Tennety, David P. Casasent, Ernest L. Hall, Juha Röning
2009 Intelligent Robots and Computer Vision XXVI: Algorithms and Techniques  
In this article, an explanation is offered for the confusion-invention-exploitation cycle and how robotics is now entering the exploitation stage of that cycle.
doi:10.1117/12.806232 fatcat:6mb2u4yqabcfzl24ejso7abt6u

Genome wide analysis of hnRNP binding to HIV-1 RNA reveals a key role for hnRNP H1 in alternative viral mRNA splicing

Sebla B. Kutluay, Ann Emery, Srinivas Penumutchu, Dana Townsend, Kasyap Tenneti, Michaela K. Madison, Amanda M. Stukenbroeker, Chelsea Powell, David Jannain, Blanton S. Tolbert, Ronald I. Swanstrom, Paul D. Bieniasz
2019 Journal of Virology  
Alternative splicing of HIV-1 mRNAs increases viral coding potential and controls the levels and timing of gene expression. HIV-1 splicing is regulated in part by heterogeneous nuclear ribonucleoproteins (hnRNPs) and their viral target sequences, that typically repress splicing when studied outside their native viral context. Here, we determined the location and extent of hnRNP binding to HIV-1 mRNAs and their impact on splicing in a native viral context. Notably, hnRNPA1, hnRNPA2 and hnRNPB1
more » ... und to many dispersed sites across viral mRNAs. Conversely, hnRNPH1 bound to a few discrete purine-rich sequences, a finding that was mirrored in vitro. HnRNPH1 depletion and mutation of a prominent viral RNA hnRNPH1 binding site decreased use of splice acceptor A1, causing a deficit in Vif expression and replicative fitness. This quantitative framework for determining the regulatory inputs governing alternative HIV-1 splicing revealed an unexpected splicing enhancer role for hnRNPH1 through binding to its target element. IMPORTANCE Alternative splicing of HIV-1 mRNAs is an essential, yet quite poorly understood step of virus replication that enhances the coding potential of the viral genome and allows temporal regulation of viral gene expression. Although HIV-1 constitutes an important model system for general studies of the regulation of alternative splicing, the inputs that determine the efficiency with which splice sites are utilized remain poorly defined. Our studies provide an experimental framework to study an essential step of HIV-1 replication more comprehensively and in much greater detail than was previously possible and reveal novel cis acting elements regulating HIV-1 splicing.
doi:10.1128/jvi.01048-19 pmid:31413137 pmcid:PMC6803249 fatcat:gj4sgesxqvgsbjl635plwmzhiu

Support Vector Machines Based Mobile Robot Path Planning in an Unknown Environment

Srinivas Tennety, Saurabh Sarkar, Ernest L. Hall, Manish Kumar
2009 ASME 2009 Dynamic Systems and Control Conference, Volume 1   unpublished
In this paper the use of support vector machines (SVM) for path planning has been investigated through a Player/Stage simulation for various case studies. SVMs are maximum margin classifiers that obtain a non-linear class boundary between the data sets. In order to apply SVM to the path planning problem, the entire obstacle course is divided in to two classes of data sets and a separating class boundary is obtained using SVM. This non-linear class boundary line determines the heading of the
more » ... t for a collision-free path. Complex obstacles and maps have been created in the simulation environment of Player/Stage. The effectiveness of SVM for path planning on unknown tracks has been studied and the results have been presented. For the classification of newly detected data points in the unknown environment, the k-nearest neighbors algorithm has been studied and implemented.
doi:10.1115/dscc2009-2703 fatcat:qhkoooljbffozflwvne7sdyw2a

Effect of Operational Parameters on Biogas Production using Tomato Waste as Substrate and Cow Dung as Inoculating Medium

Susmita Mishra, Srinivas Tenneti
2013 International Journal of Science and Research (IJSR)   unpublished
A balanced and self-inoculated system that could maintain the optimal acidogenic-methanogenic microbial ratio for the consistent production of biogas was developed using cow dung as mixed microbial culture. This was attained by maintaining the system in mesophilic phase (28-34 0 C) and neutral pH in a 50 L scale digester for 10 days during which the reactor was treated as the batch digester and analyzed for biogas production. A cumulative gas production of 27.5 L was observed and the gas
more » ... d flammability form the 4 th day of experiment. Thedigester was next fed with tomato wastes in a semi continuous manner and observed for gas production. Parameters influencing the gas production such as OLR (organic loading rate), pH, and hydraulic retention time (HRT) were optimized during the process. The average gas production was optimum for HRT of 24 days and moderate for 20 days but the digester turned acidic at HRT of 16 days with volatile solid (VS) concentration 8 % W/V and OLR of 5 Kg VS/m 3 day.
fatcat:qtzjbh25ujfrbaag3yjkpfcxi4

Purinergic Signaling in Gut Inflammation: The Role of Connexins and Pannexins

Erica F. Diezmos, Paul P. Bertrand, Lu Liu
2016 Frontiers in Neuroscience  
., 1996; Tenneti et al., 1998) .  ...  For connexins, both gap junction and hemichannel activity needs to be considered (Verselis and Srinivas, 2013) .  ... 
doi:10.3389/fnins.2016.00311 pmid:27445679 pmcid:PMC4925662 fatcat:u63hgtad4fag7eiz75nekighwa

Effect of PVDF characteristics on extruded film morphology and porous membranes feasibility by stretching

F. Sadeghi, S. H. Tabatabaei, A. Ajji, P. J. Carreau
2009 Journal of Polymer Science Part B: Polymer Physics  
H.; Srinivas, S.; Tsou, A. H.; Balta-Calleja, F. J.; Ezquerra, T. A. Polymer 2001, 42, 5247-5256. 28. Sadeghi, F.; Carreau, P. J. Can J Chem Eng 2008, 86, 1103-1110.  ...  .; Tenneti, K. K.; Li, C. Y.; Ko, F. K.; Sics, I.; Hsiao, B. S. Polymer 2006, 47, 1678— 1688. . Sajkiewicz, P.; Wasiak, A.; Goclowski, Z. Eur Polym J 1999, 35, 423-429. PVDF FILM AND MEMBRANE 1229 3.  ... 
doi:10.1002/polb.21725 fatcat:m4zmwqwc5bhczdd2wfwlyxqmau

Cellular Distribution and Functions of P2 Receptor Subtypes in Different Systems [chapter]

Geoffrey Burnstock, Gillian E. Knight
2004 International Review of Cytology  
Release of ATP from the cornea was also induced by shear stress (Srinivas et al., 2002) .  ...  is involved in the regulation of ionic balance Jørgensen et al., 1995 b P2X 7 (B) P2X 7 (GI) Fukushi et al., 1997 b ATP increases [Ca 2þ ] i Tojyo et al., 1997 b Mizuno-Kamiya et al., 1998 c Tenneti  ... 
doi:10.1016/s0074-7696(04)40002-3 pmid:15548415 fatcat:vn6qemqve5d4pb4mvegsw7hr7q