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A Neuron–Glial Perspective for Computational Neuroscience [chapter]

Maurizio De Pittà, Hugues Berry
2019 Springer Series in Computational Neuroscience  
In this perspective, we present a selection of arguments inspired by available experimental and modeling studies with the aim to provide a biophysical and conceptual platform to computational neuroscience  ...  There is growing excitement around glial cells, as compelling evidence point to new, previously unimaginable roles for these cells in information processing of the brain, with the potential to affect behavior  ...  glutamate (Oliet and Mothet, 2009) , or by slow depolarizing and hyperpolarizing currents (De Pittà and Brunel, 2016) , respectively mediated by extrasynaptic NMDA and GABA receptors (Kozlov et al.  ... 
doi:10.1007/978-3-030-00817-8_1 fatcat:c2iffskzs5h2fdtrnnapd4nvb4

Poster Sessions Monday/Tuesday

2017 Journal of Neurochemistry  
kinase inhibitor of TrkB-FL receptors.  ...  CuO-NPs were synthesized by a wet-chemical method and were coated with dimercaptosuccinic acid and bovine serum albumin to improve colloidal stability in physiological media.  ...  Using the patch-clamp recording of currents mediated by ionic channels expressed in CHO cells we have analyzed its action on GABA receptors (GABARs) and 5 subtypes of homomeric glycine receptors (GlyRs  ... 
doi:10.1111/jnc.14093 fatcat:2ms572hs7jfj7apydnl2urupsq

Lee_columbia_0054D_11147.pdf [article]

2017
Since astrocyte-mediated "gliotransmission" has been found to have multiple neuromodulatory roles, Aβ peptides may have a normal physiological function in regulating this type of neuron-glia signaling.  ...  Astrocytes, as crucial glial support cells with roles in modulating synaptic transmission, are likely cellular candidates for participating in this type of physiological Aβ signaling.  ...  The Aβ peptides generated in the recycling compartments can then be secreted into the extracellular space.  ... 
doi:10.7916/d8zw1t6p fatcat:sdijbfiuhzfctppiktscfexg6m