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Spatiotemporal modeling of distribution-valued data applied to DTI tract evolution in infant neurodevelopment

Anuja Sharma, P. Thomas Fletcher, John H. Gilmore, Maria L. Escolar, Avantika Vardhan, Aditya Gupta, Martin Styner, Guido Gerig
2013 2013 IEEE 10th International Symposium on Biomedical Imaging  
This paper proposes a novel method that extends spatiotemporal growth modeling to distribution-valued data.  ...  Concept is demonstrated in the context of our driving application which is modeling of age-related changes along white matter tracts in early neurodevelopment.  ...  Our driving application is the characterization of DTI-derived diffusivity changes along white matter tracts in infant neurodevelopment.  ... 
doi:10.1109/isbi.2013.6556567 pmid:24443688 pmcid:PMC3892706 dblp:conf/isbi/SharmaFGEVGSG13 fatcat:f6dga4ex5fhrvbvupyqf3nzygy

Longitudinal growth modeling of discrete-time functions with application to DTI tract evolution in early neurodevelopment

Anuja Sharma, Stanley Durrleman, John H. Gilmore, Guido Gerig
2012 2012 9th IEEE International Symposium on Biomedical Imaging (ISBI)  
The new framework is validated with synthetic data and applied to longitudinal DTI from 15 infants.  ...  Interpretation of estimated model growth parameters is facilitated by visualization in the original coordinate space of fiber tracts.  ...  Application to pediatric data We apply our method to pediatric longitudinal DTI data (FA curves for the genu tract) from 15 infants, scanned at approximately 2 weeks, 1 year and 2 year (scan times are  ... 
doi:10.1109/isbi.2012.6235829 pmid:24443681 pmcid:PMC3892762 dblp:conf/isbi/SharmaDGG12 fatcat:tjtw54q2iretpgv4o4hnyln27q

Parametric regression scheme for distributions: Analysis of DTI fiber tract diffusion changes in early brain development

Anuja Sharma, P. Thomas Fletcher, John H. Gilmore, Maria L. Escolar, Aditya Gupta, Martin Styner, Guido Gerig
2014 2014 IEEE 11th International Symposium on Biomedical Imaging (ISBI)  
Our driving application is the modeling of age-related changes along DTI white matter tracts.  ...  Results are shown for the spatiotemporal population trajectory of genu tract estimated from 45 healthy infants and compared with a Krabbe's patient.  ...  Application to pediatric DTI data We apply our method to pediatric DTI data (FA values for the genu tract (Fig.2) from 45 healthy infants registered to a common atlas space.  ... 
doi:10.1109/isbi.2014.6867932 pmid:25356194 pmcid:PMC4209698 fatcat:55jenoyahbgenlamwzxfcedr4m

Longitudinal modeling of appearance and shape and its potential for clinical use

Guido Gerig, James Fishbaugh, Neda Sadeghi
2016 Medical Image Analysis  
Availability of such data spawned progress in the development of advanced 4D image analysis methodologies that carry the notion of linear and nonlinear regression, now applied to complex, high-dimensional  ...  These include spatiotemporal shape modeling and growth trajectories of white matter fiber tracts demonstrated with examples from ongoing longitudinal clinical neuroimaging studies such as analysis of early  ...  From observations distributed sparsely in time, we must infer the continuous evolution in an attempt to capture the dynamics of anatomical change.  ... 
doi:10.1016/j.media.2016.06.014 pmid:27344938 pmcid:PMC5381523 fatcat:ts6v44b6lnedpo6yqwfmxwtmwa

FRATS: Functional Regression Analysis of DTI Tract Statistics

Hongtu Zhu, M. Styner, Niansheng Tang, Zhexing Liu, Weili Lin, J.H. Gilmore
2010 IEEE Transactions on Medical Imaging  
the splenium of the corpus callosum tract and the right internal capsule tract in a clinical study of neurodevelopment.  ...  the p-value of the global test statistic.  ...  This work was supported in part by NSF grant BCS-08-26844 and NIH grants UL1-RR025747-01, MH086633, and AG033387 to Dr. Zhu, NIH grants MH064065, HD053000, and MH070890 to Dr.  ... 
doi:10.1109/tmi.2010.2040625 pmid:20335089 pmcid:PMC2896997 fatcat:3s2qsd2lrfgizfn24nwzi3u3ra

Mapping the critical gestational age at birth that alters brain development in preterm-born infants using multi-modal MRI

Dan Wu, Linda Chang, Kentaro Akazawa, Kumiko Oishi, Jon Skranes, Thomas Ernst, Kenichi Oishi
2017 NeuroImage  
T2 mapping data in 43 term-born and 43 preterm-born infants.  ...  A novel multivariate linear model-the change point model, was applied to detect change points in fractional anisotropy, mean diffusivity, and T2 relaxation time.  ...  The authors are grateful to the families of our research participants, the pediatricians/neonatologists who referred the participants (Dr. Lillian Fujimoto, Dr. Lois Chiu, and Dr.  ... 
doi:10.1016/j.neuroimage.2017.01.046 pmid:28111189 pmcid:PMC5367973 fatcat:gubbsuffhjeqjepmw7wbkktdkm

FADTTS: Functional analysis of diffusion tensor tract statistics

Hongtu Zhu, Linglong Kong, Runze Li, Martin Styner, Guido Gerig, Weili Lin, John H. Gilmore
2011 NeuroImage  
We apply FADTTS to investigate the development of white matter diffusivities along the splenium of the corpus callosum tract and the right internal capsule tract in a clinical study of neurodevelopment  ...  Simulated data are used to evaluate the finite sample performance of FADTTS.  ...  As an illustration, in model (3) , we are interested in comparing the evolution speeds of the three eigenvalues of the DTs along selected fiber tracts in 128 healthy pediatric subjects in our clinical  ... 
doi:10.1016/j.neuroimage.2011.01.075 pmid:21335092 pmcid:PMC3085665 fatcat:p3epyuzshzc6fnxy7olfpwxgyu

Clinical neuroimaging in the preterm infant: Diagnosis and prognosis

Manuel Hinojosa-Rodríguez, Thalía Harmony, Cristina Carrillo-Prado, John Darrell Van Horn, Andrei Irimia, Carinna Torgerson, Zachary Jacokes
2017 NeuroImage: Clinical  
Specifically, we focus our discussions on the use of neuroimaging to aid diagnosis, measure morphometric brain damage, and track longterm neurodevelopmental outcomes.  ...  Due to increased neonatal survival and the intrinsic characteristics of diffuse WMA, there is a growing need to study the brain of the premature infant using non-invasive neuroimaging techniques sensitive  ...  Tractography enables one to observe the morphology, location, distribution, and connectivity of white matter and its subsequent correlation with neurodevelopment (Anderson et al., 2015; Harmony et al.  ... 
doi:10.1016/j.nicl.2017.08.015 pmid:28861337 pmcid:PMC5568883 fatcat:des3tlkuqzbqjg7ro2jdvhnbp4

Annual Research Review: Growth connectomics - the organization and reorganization of brain networks during normal and abnormal development

Petra E. Vértes, Edward T. Bullmore
2014 Journal of Child Psychology and Psychiatry and Allied Disciplines  
to a more mechanistic understanding of neurodevelopmental disorders in future.  ...  Finally, we note that many brain and mind disorders are thought to be neurodevelopmental in origin and that charting the trajectory of brain network changes associated with healthy development also sets  ...  The authors have declared that they have no competing or potential conflicts of interest in relation to this article.  ... 
doi:10.1111/jcpp.12365 pmid:25441756 pmcid:PMC4359009 fatcat:u5iizt6wunat5ptmbswkk4dypu

Quantitative mapping of the brain's structural connectivity using diffusion MRI tractography: a review [article]

Fan Zhang, Alessandro Daducci, Yong He, Simona Schiavi, Caio Seguin, Robert Smith, Chun-Hung Yeh, Tengda Zhao, Lauren J. O'Donnell
2021 arXiv   pre-print
In this paper, we provide a high-level overview of how tractography is used to enable quantitative analysis of the brain's structural connectivity in health and disease.  ...  We then review studies that have used quantitative tractography approaches to study the brain's white matter, focusing on applications in neurodevelopment, aging, neurological disorders, mental disorders  ...  CHY is grateful to the Ministry of Science and Technology of Taiwan (MOST 109-2222-E-182-001-MY3) for the support.  ... 
arXiv:2104.11644v1 fatcat:l3ixpcwu7jb7zcqo2sm5pswmja

Multidirectional and Topography-based Dynamic-scale Varifold Representations with Application to Matching Developing Cortical Surfaces

Islem Rekik, Gang Li, Weili Lin, Dinggang Shen
2016 NeuroImage  
Both variants improved the matching accuracy in terms of closeness to the target surface and the goodness of alignment with regional anatomical boundaries, when compared with three state-of-the-art methods  ...  Methods that geodesically shoot surfaces into one another as currents (a distribution of oriented normals) and varifolds (a distribution of non-oriented normals) provide an elegant Riemannian framework  ...  This work was supported in part by National Institutes of Health (MH108914, MH100217, EB006733, EB008374, EB009634, MH088520, NS055754, HD053000, AG041721, and MH070890). Dr.  ... 
doi:10.1016/j.neuroimage.2016.04.037 pmid:27138207 pmcid:PMC4916020 fatcat:6mbchcxskbabnfqlnkbf3udmhy

FADTTS: Functional analysis of diffusion tensor tract statistics

Martin Styner, Runze Li, Weili Lin, Hongtu Zhu, John H. Gilmore, Guido Gerig, Linglong Kong
2011
We also apply FADTTS to investigate the development of white matter diffusivities along the splenium of the corpus callosum tract and the right internal capsule tract in a clinical study of neurodevelopment  ...  Simulated data are used to evaluate the finite sample performance of FADTTS.  ...  As an illustration, in model (3) , we are interested in comparing the evolution speeds of the three eigenvalues of the diffusion tenors along selected fiber tracts in 128 healthy pediatric subjects in  ... 
doi:10.17615/2cdy-xq61 fatcat:mj4ytrnrljfrzlmykqqcp5b22a

ESNR 2016

2016 Neuroradiology  
We used analysis of variance to assess differences in SRT among groups and analysis of covariance (ANCOVA) including variables associated with cognitive scores (p<0.01) to analyze relations between DTI-metrics  ...  Purpose: We studied differences in diffusion tensor imaging metrics (DTI-metrics) of white matter structural integrity among cohorts of subjects with multiple sclerosis (MS) classified according to progression  ...  Recognizing such fibers in utero and measuring their microstructural properties with DTI with high angular resolution can be an important marker of neurodevelopment in the future.  ... 
doi:10.1007/s00234-016-1734-6 pmid:27578442 fatcat:ia2lasp4prfqxf7u2sh7hsyvem

In-depth analysis reveals complex molecular etiology of idiopathic cerebral palsy [article]

Na Li, Pei Zhou, Hongmei Tang, Lu He, Xiang Fang, Jinxiang Zhao, Xin Wang, Yifei Qi, Chuanbo Sun, Yunting Lin, Fengying Qin, Miaomiao Yang (+15 others)
2020 bioRxiv   pre-print
In a CP patient with normal intelligence, we identified a mitochondrial enzyme GPAM, the hypomorphic form of which led to hypomyelination of corticospinal tract.  ...  By a compilation of 117 CP-related genes, we recognized the characteristic features in terms of inheritance and function, and proposed a dichotomous classification system according to the expression patterns  ...  infant brains 1 .  ... 
doi:10.1101/2020.08.17.255158 fatcat:vbnhdbwabbf4vnjqdiwwqlr7gm

ACNP 58th Annual Meeting: Panels, Mini-Panels and Study Groups

2019 Neuropsychopharmacology  
Conclusions: The combination of photoactivatable neuropeptides and genetically-encoded optical neuropeptide sensors enable experiments into the spatiotemporal dynamics of neuropeptidergic signaling in  ...  The Influence of Periphery-To-Brain Communication in Alzheimer's Disease Abstract not included. Abstract not included.  ...  Data were analyzed with software packages: for DTI, FMRIB Software Library (FSL) to perform Tract-Based Spatial Statistics (TBSS), and the ENIGMA-DTI protocol to study 43 tract-wise regions of interest  ... 
doi:10.1038/s41386-019-0544-z pmid:31801977 pmcid:PMC6957922 fatcat:hjyvf7fcpbf2fhxit6rlhsvg2y
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