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Spatiotemporal modeling of distribution-valued data applied to DTI tract evolution in infant neurodevelopment
2013
2013 IEEE 10th International Symposium on Biomedical Imaging
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This paper proposes a novel method that extends spatiotemporal growth modeling to distribution-valued data. ...
Concept is demonstrated in the context of our driving application which is modeling of age-related changes along white matter tracts in early neurodevelopment. ...
Our driving application is the characterization of DTI-derived diffusivity changes along white matter tracts in infant neurodevelopment. ...
doi:10.1109/isbi.2013.6556567
pmid:24443688
pmcid:PMC3892706
dblp:conf/isbi/SharmaFGEVGSG13
fatcat:f6dga4ex5fhrvbvupyqf3nzygy
Longitudinal growth modeling of discrete-time functions with application to DTI tract evolution in early neurodevelopment
2012
2012 9th IEEE International Symposium on Biomedical Imaging (ISBI)
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The new framework is validated with synthetic data and applied to longitudinal DTI from 15 infants. ...
Interpretation of estimated model growth parameters is facilitated by visualization in the original coordinate space of fiber tracts. ...
Application to pediatric data We apply our method to pediatric longitudinal DTI data (FA curves for the genu tract) from 15 infants, scanned at approximately 2 weeks, 1 year and 2 year (scan times are ...
doi:10.1109/isbi.2012.6235829
pmid:24443681
pmcid:PMC3892762
dblp:conf/isbi/SharmaDGG12
fatcat:tjtw54q2iretpgv4o4hnyln27q
Parametric regression scheme for distributions: Analysis of DTI fiber tract diffusion changes in early brain development
2014
2014 IEEE 11th International Symposium on Biomedical Imaging (ISBI)
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Our driving application is the modeling of age-related changes along DTI white matter tracts. ...
Results are shown for the spatiotemporal population trajectory of genu tract estimated from 45 healthy infants and compared with a Krabbe's patient. ...
Application to pediatric DTI data We apply our method to pediatric DTI data (FA values for the genu tract (Fig.2) from 45 healthy infants registered to a common atlas space. ...
doi:10.1109/isbi.2014.6867932
pmid:25356194
pmcid:PMC4209698
fatcat:55jenoyahbgenlamwzxfcedr4m
Longitudinal modeling of appearance and shape and its potential for clinical use
2016
Medical Image Analysis
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Availability of such data spawned progress in the development of advanced 4D image analysis methodologies that carry the notion of linear and nonlinear regression, now applied to complex, high-dimensional ...
These include spatiotemporal shape modeling and growth trajectories of white matter fiber tracts demonstrated with examples from ongoing longitudinal clinical neuroimaging studies such as analysis of early ...
From observations distributed sparsely in time, we must infer the continuous evolution in an attempt to capture the dynamics of anatomical change. ...
doi:10.1016/j.media.2016.06.014
pmid:27344938
pmcid:PMC5381523
fatcat:ts6v44b6lnedpo6yqwfmxwtmwa
FRATS: Functional Regression Analysis of DTI Tract Statistics
2010
IEEE Transactions on Medical Imaging
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the splenium of the corpus callosum tract and the right internal capsule tract in a clinical study of neurodevelopment. ...
the p-value of the global test statistic. ...
This work was supported in part by NSF grant BCS-08-26844 and NIH grants UL1-RR025747-01, MH086633, and AG033387 to Dr. Zhu, NIH grants MH064065, HD053000, and MH070890 to Dr. ...
doi:10.1109/tmi.2010.2040625
pmid:20335089
pmcid:PMC2896997
fatcat:3s2qsd2lrfgizfn24nwzi3u3ra
Mapping the critical gestational age at birth that alters brain development in preterm-born infants using multi-modal MRI
2017
NeuroImage
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T2 mapping data in 43 term-born and 43 preterm-born infants. ...
A novel multivariate linear model-the change point model, was applied to detect change points in fractional anisotropy, mean diffusivity, and T2 relaxation time. ...
The authors are grateful to the families of our research participants, the pediatricians/neonatologists who referred the participants (Dr. Lillian Fujimoto, Dr. Lois Chiu, and Dr. ...
doi:10.1016/j.neuroimage.2017.01.046
pmid:28111189
pmcid:PMC5367973
fatcat:gubbsuffhjeqjepmw7wbkktdkm
FADTTS: Functional analysis of diffusion tensor tract statistics
2011
NeuroImage
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We apply FADTTS to investigate the development of white matter diffusivities along the splenium of the corpus callosum tract and the right internal capsule tract in a clinical study of neurodevelopment ...
Simulated data are used to evaluate the finite sample performance of FADTTS. ...
As an illustration, in model (3) , we are interested in comparing the evolution speeds of the three eigenvalues of the DTs along selected fiber tracts in 128 healthy pediatric subjects in our clinical ...
doi:10.1016/j.neuroimage.2011.01.075
pmid:21335092
pmcid:PMC3085665
fatcat:p3epyuzshzc6fnxy7olfpwxgyu
Clinical neuroimaging in the preterm infant: Diagnosis and prognosis
2017
NeuroImage: Clinical
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Specifically, we focus our discussions on the use of neuroimaging to aid diagnosis, measure morphometric brain damage, and track longterm neurodevelopmental outcomes. ...
Due to increased neonatal survival and the intrinsic characteristics of diffuse WMA, there is a growing need to study the brain of the premature infant using non-invasive neuroimaging techniques sensitive ...
Tractography enables one to observe the morphology, location, distribution, and connectivity of white matter and its subsequent correlation with neurodevelopment (Anderson et al., 2015; Harmony et al. ...
doi:10.1016/j.nicl.2017.08.015
pmid:28861337
pmcid:PMC5568883
fatcat:des3tlkuqzbqjg7ro2jdvhnbp4
Annual Research Review: Growth connectomics - the organization and reorganization of brain networks during normal and abnormal development
2014
Journal of Child Psychology and Psychiatry and Allied Disciplines
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to a more mechanistic understanding of neurodevelopmental disorders in future. ...
Finally, we note that many brain and mind disorders are thought to be neurodevelopmental in origin and that charting the trajectory of brain network changes associated with healthy development also sets ...
The authors have declared that they have no competing or potential conflicts of interest in relation to this article. ...
doi:10.1111/jcpp.12365
pmid:25441756
pmcid:PMC4359009
fatcat:u5iizt6wunat5ptmbswkk4dypu
Quantitative mapping of the brain's structural connectivity using diffusion MRI tractography: a review
[article]
2021
arXiv
pre-print
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In this paper, we provide a high-level overview of how tractography is used to enable quantitative analysis of the brain's structural connectivity in health and disease. ...
We then review studies that have used quantitative tractography approaches to study the brain's white matter, focusing on applications in neurodevelopment, aging, neurological disorders, mental disorders ...
CHY is grateful to the Ministry of Science and Technology of Taiwan (MOST 109-2222-E-182-001-MY3) for the support. ...
arXiv:2104.11644v1
fatcat:l3ixpcwu7jb7zcqo2sm5pswmja
Multidirectional and Topography-based Dynamic-scale Varifold Representations with Application to Matching Developing Cortical Surfaces
2016
NeuroImage
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Both variants improved the matching accuracy in terms of closeness to the target surface and the goodness of alignment with regional anatomical boundaries, when compared with three state-of-the-art methods ...
Methods that geodesically shoot surfaces into one another as currents (a distribution of oriented normals) and varifolds (a distribution of non-oriented normals) provide an elegant Riemannian framework ...
This work was supported in part by National Institutes of Health (MH108914, MH100217, EB006733, EB008374, EB009634, MH088520, NS055754, HD053000, AG041721, and MH070890). Dr. ...
doi:10.1016/j.neuroimage.2016.04.037
pmid:27138207
pmcid:PMC4916020
fatcat:6mbchcxskbabnfqlnkbf3udmhy
FADTTS: Functional analysis of diffusion tensor tract statistics
2011
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We also apply FADTTS to investigate the development of white matter diffusivities along the splenium of the corpus callosum tract and the right internal capsule tract in a clinical study of neurodevelopment ...
Simulated data are used to evaluate the finite sample performance of FADTTS. ...
As an illustration, in model (3) , we are interested in comparing the evolution speeds of the three eigenvalues of the diffusion tenors along selected fiber tracts in 128 healthy pediatric subjects in ...
doi:10.17615/2cdy-xq61
fatcat:mj4ytrnrljfrzlmykqqcp5b22a
ESNR 2016
2016
Neuroradiology
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We used analysis of variance to assess differences in SRT among groups and analysis of covariance (ANCOVA) including variables associated with cognitive scores (p<0.01) to analyze relations between DTI-metrics ...
Purpose: We studied differences in diffusion tensor imaging metrics (DTI-metrics) of white matter structural integrity among cohorts of subjects with multiple sclerosis (MS) classified according to progression ...
Recognizing such fibers in utero and measuring their microstructural properties with DTI with high angular resolution can be an important marker of neurodevelopment in the future. ...
doi:10.1007/s00234-016-1734-6
pmid:27578442
fatcat:ia2lasp4prfqxf7u2sh7hsyvem
In-depth analysis reveals complex molecular etiology of idiopathic cerebral palsy
[article]
2020
bioRxiv
pre-print
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In a CP patient with normal intelligence, we identified a mitochondrial enzyme GPAM, the hypomorphic form of which led to hypomyelination of corticospinal tract. ...
By a compilation of 117 CP-related genes, we recognized the characteristic features in terms of inheritance and function, and proposed a dichotomous classification system according to the expression patterns ...
infant brains 1 . ...
doi:10.1101/2020.08.17.255158
fatcat:vbnhdbwabbf4vnjqdiwwqlr7gm
ACNP 58th Annual Meeting: Panels, Mini-Panels and Study Groups
2019
Neuropsychopharmacology
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Conclusions: The combination of photoactivatable neuropeptides and genetically-encoded optical neuropeptide sensors enable experiments into the spatiotemporal dynamics of neuropeptidergic signaling in ...
The Influence of Periphery-To-Brain Communication in Alzheimer's Disease Abstract not included. Abstract not included. ...
Data were analyzed with software packages: for DTI, FMRIB Software Library (FSL) to perform Tract-Based Spatial Statistics (TBSS), and the ENIGMA-DTI protocol to study 43 tract-wise regions of interest ...
doi:10.1038/s41386-019-0544-z
pmid:31801977
pmcid:PMC6957922
fatcat:hjyvf7fcpbf2fhxit6rlhsvg2y
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