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Corticothalamic gating of population auditory thalamocortical transmission in mouse [article]

Baher A. Ibrahim, Caitlin Murphy, Guido Muscioni, Aynaz Taheri, Georgiy Yudintsev, Robert V. Kenyon, Tanya Berger-Wolf, Matthew I. Banks, Daniel A. Llano
2019 bioRxiv   pre-print
All-or-none population responses (here called "ON" and "OFF" responses) were observed in vivo and in vitro in the mouse auditory cortex at near-threshold acoustic or electrical stimulation.  ...  Opto- and chemogenetic silencing of NTSR-positive corticothalamic layer 6 (CTL6) neurons as well as the pharmacological blocking of the thalamic reticular nucleus (TRN) retrieved the missing cortical responses  ...  By observing the variation of the pixel value over time, we were able to capture the 300 dynamicity of the signal traveling in the brain slice.  ... 
doi:10.1101/625988 fatcat:g3yiiyra2ff63o4dq5iu5m4tw4

Page 1482 of The Journal of Neuroscience Vol. 22, Issue 4 [page]

2002 The Journal of Neuroscience  
Third, the cortical electrode had to show a clear response during electrical stimulation of its thalamic counterpart.  ...  of the cortical sites, and to compare the spatiotemporal properties of the SW Ds with the spatiotemporal properties of the SEPs.  ... 

Fast voltage-sensitive dye imaging of excitatory and inhibitory synaptic transmission in the rat granular retrosplenial cortex

Ken'ichi Nixima, Kazuo Okanoya, Noritaka Ichinohe, Tohru Kurotani
2017 Journal of Neurophysiology  
The aim of this study was to investigate spatiotemporal dynamics of signal transduction in the GRS induced by ATN afferent stimulation by using fast voltage-sensitive dye imaging in rat brain slices.  ...  Cortical inhibitory responses upon layer 1a stimulation in horizontal slices were weaker than those in the coronal slices.  ...  However, little is known about spatiotemporal dynamics of signal transduction in the GRS.  ... 
doi:10.1152/jn.00734.2016 pmid:28701546 fatcat:vtxxdy3lo5ac3edpcru43ofsiq

Intracortical Circuits in Rat Anterior Cingulate Cortex Are Activated by Nociceptive Inputs Mediated by Medial Thalamus

Jenq-Wei Yang, Hsi-Chien Shih, Bai-Chuang Shyu
2006 Journal of Neurophysiology  
Responses of neurons in the caudal intralaminar thalamic complex of the rat to stimulation of the uterus, vagina, cervix, colon and skin. Brain Res 695: 92-95, 1995.  ...  High-frequency stimulation (100 Hz, 11 pulses) enhanced evoked responses in the ACC and evoked medial thalamic (MT) unit activities. MT lesions blocked evoked responses in the ACC.  ...  increase responses to MD thalamic stimulation in the presence of morphine (Giacchino and Henriksen 1998).  ... 
doi:10.1152/jn.00623.2006 pmid:16956990 fatcat:4s6olmdmlzfmximwzvybbmu7pi

Voltage-Sensitive Dye Imaging of Neocortical Spatiotemporal Dynamics to Afferent Activation Frequency

Diego Contreras, Rodolfo Llinás
2001 Journal of Neuroscience  
To study the role of afferent input frequency on cortical activation dynamics, the electrical activity of in vitro neocortex slices was imaged during white-matter electrical stimulation.  ...  In contrast, repetitive stimulation in the ␥ frequency range (ϳ40 Hz) rapidly restrained the area of excitation to a small columnar site directly above the stimulating electrode.  ...  In such models, spatiotemporal patterns of cortical activation depend solely on input dynamics and on the linear integrative properties of the target neurons.  ... 
doi:10.1523/jneurosci.21-23-09403.2001 pmid:11717373 fatcat:og3mt2idzfhqrccgytib4u3viu

Combined Voltage and Calcium Epifluorescence Imaging In Vitro and In Vivo Reveals Subthreshold and Suprathreshold Dynamics of Mouse Barrel Cortex

Thomas Berger, Aren Borgdorff, Sylvain Crochet, Florian B. Neubauer, Sandrine Lefort, Bruno Fauvet, Isabelle Ferezou, Alan Carleton, Hans-Rudolf Lüscher, Carl C. H. Petersen
2007 Journal of Neurophysiology  
Functional independence of layer IV barrels. J determine the cortical response to thalamic stimulation. Neuron 48: 811-823, 2005. Moore CI, and Nelson SB.  ...  Spatiotemporal dynamics of sensory responses in layer 2/3 of rat barrel cortex measured in vivo by voltage-sensitive dye imaging combined with whole-cell voltage recordings and neuron reconstructions.  ...  GRANTS DISCLOSURES There are no conflicts of interest. Page 25 of 47  ... 
doi:10.1152/jn.01178.2006 pmid:17360827 fatcat:th2osg4l6rdpnbv7drbcyzfvaq

Widespread Decoding of Tactile Input Patterns Among Thalamic Neurons

Anders Wahlbom, Jonas M. D. Enander, Henrik Jörntell
2021 Frontiers in Systems Neuroscience  
We find that a majority of thalamic neurons, regardless of location, respond to single pulse tactile inputs and generate spike responses to such tactile stimulation patterns that can be used to identify  ...  Since cortical neurons project back to the thalamus, the latter observation would suggest that thalamic neurons could contain information about tactile inputs, in principle regardless of where in the thalamus  ...  (A) PSTHs and KDEs of the responses to one stimulation pattern in four sample cells.  ... 
doi:10.3389/fnsys.2021.640085 pmid:33664654 pmcid:PMC7921320 fatcat:pvrtll7sgff57enf5e4wazg3tm

Cingulate seizure-like activity reveals neuronal avalanche regulated by network excitability and thalamic inputs

José Wu, Wei-Pang Chang, Hsi-Chien Shih, Chen-Tung Yen, Bai Shyu
2014 BMC Neuroscience  
Cortical neurons display network-level dynamics with unique spatiotemporal patterns that construct the backbone of processing information signals and contribute to higher functions.  ...  In the present study, we induced seizure activity in the anterior cingulate cortex (ACC) with medial thalamic inputs and evaluated the impact of cortical excitability and thalamic inputs on networklevel  ...  Chen, Institute of Physics, Academia Sinica, for valuable suggestions and comments during the experiment.  ... 
doi:10.1186/1471-2202-15-3 pmid:25539640 pmcid:PMC4299297 fatcat:j4u72ik5zjdb3i62hulx2uxmei

Depth-dependent cerebral hemodynamic responses following Direct Cortical Electrical Stimulation (DCES) revealed by in vivo dual-optical imaging techniques

Seungduk Lee, Dalkwon Koh, Areum Jo, Hae Young Lim, Young-Jin Jung, Choong-Ki Kim, Youngwook Seo, Chang-Hwan Im, Beop-Min Kim, Minah Suh
2012 Optics Express  
We studied depth-dependent cerebral hemodynamic responses of rat brain following direct cortical electrical stimulation (DCES) in vivo with optical recording of intrinsic signal (ORIS) and near-infrared  ...  In addition, NIRS signals from two different sets of source-detector separation were compared and analyzed to investigate the causality of perfusion, which demonstrated downstream propagation, indicating  ...  Acknowledgments This work was supported by the National Research Foundation (NRF) grant funded by the Ministry of Education, Science and Technology (2011-0018042) and Brain Research Center (2011K000284  ... 
doi:10.1364/oe.20.006932 pmid:22453371 fatcat:v6rycvxmabanpotqouowsdb6vm

Optical imaging of the rat brain suggests a previously missing link between top-down and bottom-up nervous system function

Susan A. Greenfield, Antoine-Scott Badin, Giovanni Ferrati, Ian M. Devonshire
2017 Neurophotonics  
We demonstrate in ex vivo rat brain slices how varying spatiotemporal dynamics of assemblies reveal differences not previously appreciated between: different stages of development in cortical versus subcortical  ...  and, in vivo, depths of anesthesia.  ...  Science Foundation, the Arete Initiative at the University of Chicago, the James Martin 21st Century School, and the European Society of Anesthesiology.  ... 
doi:10.1117/1.nph.4.3.031213 pmid:28573153 pmcid:PMC5443969 fatcat:fr5jy2dlbnaxffutlmozgrpvwm

Spatiotemporal dynamics of optogenetically induced and spontaneous seizure transitions in primary generalized epilepsy

Fabien B. Wagner, Wilson Truccolo, Jing Wang, Arto V. Nurmikko
2015 Journal of Neurophysiology  
induction, demonstrating a modulatory effect of brain states and neural excitation levels. 3) Evoked responses during stimulation propagated as cortical waves, likely reaching the cortical focus, which  ...  In this study, we used a novel combination of intracortical optogenetic stimulation and microelectrode array recordings in freely moving WAG/Rij rats, a model of absence epilepsy with a cortical focus  ...  We are especially grateful to the Deisseroth laboratory at Stanford University for sharing the optogenetic constructs. Present  ... 
doi:10.1152/jn.01040.2014 pmid:25552645 pmcid:PMC4416582 fatcat:fqhxzlj34nhyjhnhedtot45qse

Short-term facilitation in the anterior cingulate cortex following stimulation of the medial thalamus in the rat

Jyh-Jang Sun, Jeng Chuang Kung, Chia-Chuan Wang, Shin-Lang Chen, Bai-Chuang Shyu
2006 Brain Research  
Electrical stimulation at 10 Hz in the MT induced more pronounced c-fos immunolabeling of neurons in the medial prefrontal cortex than did 1-Hz stimulation.  ...  The short-term facilitation occurred in the middle layers and expanded to the deeper layers of the ACC.  ...  The present study was supported by grants from the National Science Council and Academia Sinica of the Republic of China.  ... 
doi:10.1016/j.brainres.2006.04.065 pmid:16725116 fatcat:pfxhrhlfpjcebo7gojep3fsapa

Frequency-selective control of cortical and subcortical networks by central thalamus

Jia Liu, Hyun Joo Lee, Andrew J Weitz, Zhongnan Fang, Peter Lin, ManKin Choy, Robert Fisher, Vadim Pinskiy, Alexander Tolpygo, Partha Mitra, Nicholas Schiff, Jin Hyung Lee
2015 eLife  
stimulations of central thalamus caused widespread activation of forebrain, including frontal cortex, sensorimotor cortex, and striatum, and transitioned the brain to a state of arousal in asleep rats.  ...  To investigate possible mechanisms underlying the frequency-dependent cortical inhibition, we performed recordings in zona incerta, where 10, but not 40, Hz stimulation evoked spindle-like oscillations  ...  Acknowledgements JHL would like to acknowledge Karl Deisseroth for providing the DNA plasmids. The authors thank the Lee Lab members for their contribution to ofMRI experiments.  ... 
doi:10.7554/elife.09215 pmid:26652162 pmcid:PMC4721962 fatcat:ja4ztktgxncslegxwt7q2x2geu

In vivo voltage-sensitive dye imaging of mouse cortical activity with mesoscopic optical tomography

Qinggong Tang, Vassiliy Tsytsarev, Feng Yan, Chen Wang, Reha S. Erzurumlu, Yu Chen
2020 Neurophotonics  
VSDi is a powerful technique for interrogating membrane potential dynamics in assemblies of cortical neurons, but it is traditionally used for two-dimensional (2D) imaging.  ...  A key challenge in studying circuit function within the neocortex is to understand the spatial and temporal patterns of information flow between different columns and layers.  ...  The 3D spatiotemporal dynamics of cortical activities in both S1 and M1 can be imaged (Fig. 6) .  ... 
doi:10.1117/1.nph.7.4.041402 pmid:33274250 pmcid:PMC7708784 fatcat:6trjrs2vare3jpqy3fq7wekzhu

Developmental Regulation of Plasticity in the Forepaw Representation of Ferret Somatosensory Cortex

Debra F. McLaughlin, Sharon L. Juliano
2003 Journal of Neurophysiology  
We hypothesized that cortical responses to stimulation of intact superficial radial nerve in adults will vary systematically according to maturation of thalamocortical relationships at the time of an ulnar  ...  This study characterized the spatiotemporal responses in ferret somatosensory cortex after sensory deprivation at different phases of cortical development.  ...  Tavedi for excellence in manufacturing the recording electrodes, and Dr. Joszef Czege for assistance with Mathematica programming. Assistance with data analyses was given by T. Lawler and N.  ... 
doi:10.1152/jn.01053.2002 pmid:12686585 fatcat:xhmlpczwonaxlaibjckfznhqri
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