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Phosphoinositide conversion in endocytosis and the endolysosomal system

Alexander Wallroth, Volker Haucke
<span title="2017-12-27">2017</span> <i title="American Society for Biochemistry &amp; Molecular Biology (ASBMB)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mryncoafc5cxdicldzfm4vlsze" style="color: black;">Journal of Biological Chemistry</a> </i> &nbsp;
-bisphosphate; PI(4,5)P 2 , phosphatidylinositol 4,5-bisphosphate; PI(3,4,5)P 3 , phosphatidylinositol 3,4,5-trisphosphate; Figure 4.  ...  ; PI(4)P, phosphatidylinositol 4-phosphate; TGN, trans-Golgi network; PI(3)P, phosphatidylinositol 3-phosphate; PI(3,5)P 2 , phosphatidylinositol 3,5-bisphosphate; PI(3,4)P 2 , phosphatidylinositol 3,4  ...  Hence, cytoplasmic turnover via the autophagy/lysosomal pathway require spatiotemporally controlled formation and conversion of PI 3-phosphates, the mechanisms of which remain poorly understood.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1074/jbc.r117.000629">doi:10.1074/jbc.r117.000629</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29282290">pmid:29282290</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/fm5wazxawjdnvmg7oik6axnkku">fatcat:fm5wazxawjdnvmg7oik6axnkku</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190426070917/http://www.jbc.org/content/293/5/1526.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/0a/4d/0a4d5e8fb9b8cc4e39b4e36203d87708d95926a0.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1074/jbc.r117.000629"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

Phosphatidylinositol control of endocytosis

Katrin Legg
<span title="">2013</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/7hc2el7lt5eqpot2khyjdeuoua" style="color: black;">Nature Cell Biology</a> </i> &nbsp;
Blocking the release of these granules by using mice that lack the exocytosis-priming protein MUNC13-4 inhibited the transendothelial migration of the cancer cells from subcutaneous xenografts and after  ...  pulmonary metastases compared with controls after tail vein injection of tumour cells.  ...  During clathrin-mediated endocytosis (CME), the phosphoinositide phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P 2 ) recruits proteins involved in the formation of clathrin-coated pits (CCPs).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/ncb2846">doi:10.1038/ncb2846</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/tjvmu3aosbff7cclxjgiig6zxe">fatcat:tjvmu3aosbff7cclxjgiig6zxe</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210717212145/https://www.nature.com/articles/ncb2846.pdf?error=cookies_not_supported&amp;code=e585ec53-9eb9-4dd1-a4b9-0a21a827a9c2" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ac/4e/ac4e1657554a66b79cd338b87e6dd48e9709ccbe.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/ncb2846"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> nature.com </button> </a>

Precision targeting by phosphoinositides: how PIs direct endomembrane trafficking in plants

Lise C Noack, Yvon Jaillais
<span title="">2017</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/qc64jkjd3bbafjfrajfx4j6jle" style="color: black;">Current opinion in plant biology</a> </i> &nbsp;
However, membranes are in constant flux within this system, which raises the questions of how the spatiotemporal pattern of phosphoinositides is established and maintained within the cell.  ...  of membrane compartments.  ...  This work was supported by ERC no. 3363360-APPL under FP/2007-2013 to Y.J; and by a fellowship from ENS Lyon to L.C.N.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.pbi.2017.06.017">doi:10.1016/j.pbi.2017.06.017</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28734137">pmid:28734137</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/pzn4wkbskzharfx6324iqfto3a">fatcat:pzn4wkbskzharfx6324iqfto3a</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200318053259/https://hal.archives-ouvertes.fr/hal-02352100/document" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/5f/8c/5f8c38fc5445dbf9fb879074bc264ed0d4d40be7.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.pbi.2017.06.017"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Phosphoinositide-metabolizing enzymes at the interface between membrane traffic and cell signalling

Michael Krauß, Volker Haucke
<span title="">2007</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ad4yn77omvbz5mxraouyuuhroq" style="color: black;">EMBO Reports</a> </i> &nbsp;
Recent studies have provided important clues as to how regulated activation of PI-metabolizing enzymes and recruitment of their binding proteins might cooperate in targeting distinct pools of PIs to different  ...  During the past decade, it has become clear that these lipids also act as constitutive signals that aid in defining organelle identity, and are short-lived recruiters and regulators of cytoskeletal and  ...  ACKNOWLEDGEMENTS V.H. is a member of the European Molecular Biology Organization Young Investigator Programme (EMBO-YIP) and is supported by grants from the Deutsche Forschungsgemeinschaft (HA2686/ 2-1  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/sj.embor.7400919">doi:10.1038/sj.embor.7400919</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17330069">pmid:17330069</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC1808040/">pmcid:PMC1808040</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/x5osrdlwkbh2rdly4wrnymwxzm">fatcat:x5osrdlwkbh2rdly4wrnymwxzm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170814004251/http://embor.embopress.org/content/embor/8/3/241.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/43/60/436008a7123cf8740b4bd28b8218d31a6254f704.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/sj.embor.7400919"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808040" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Platelets assist in extravasation

Nicola McCarthy
<span title="">2013</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/7hc2el7lt5eqpot2khyjdeuoua" style="color: black;">Nature Cell Biology</a> </i> &nbsp;
Blocking the release of these granules by using mice that lack the exocytosis-priming protein MUNC13-4 inhibited the transendothelial migration of the cancer cells from subcutaneous xenografts and after  ...  pulmonary metastases compared with controls after tail vein injection of tumour cells.  ...  During clathrin-mediated endocytosis (CME), the phosphoinositide phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P 2 ) recruits proteins involved in the formation of clathrin-coated pits (CCPs).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/ncb2844">doi:10.1038/ncb2844</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/l7lzoyf7rjhljloklp47gfv4hm">fatcat:l7lzoyf7rjhljloklp47gfv4hm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210718121803/https://www.nature.com/articles/ncb2844.pdf?error=cookies_not_supported&amp;code=b27105d3-aea3-42cb-822b-18b9e2876cd2" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/75/1d/751de45248e09e1baf8997dd704234321c744bb1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/ncb2844"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> nature.com </button> </a>

Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells

Charlotte M Smith, Volker Haucke, Adam McCluskey, Phillip J Robinson, Megan Chircop
<span title="">2013</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/fgif277mw5b6xokdmmdusvygrq" style="color: black;">Molecular Cancer</a> </i> &nbsp;
., Haucke, V. (2013) Spatiotemporal Control of Endocytosis by Phosphatidylinositol 3,4-Bisphosphate. Nature, 499, 233-237 59.  ...  Cancer, 12:4 doi:10.1186/1476-4598-, J., Wieffer, M., Krause, E., Freund, C., Gerth, F., Krauss, M., Haucke, V. (2012) Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1476-4598-12-4">doi:10.1186/1476-4598-12-4</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23327284">pmid:23327284</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3567983/">pmcid:PMC3567983</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/i6w2x7dimja6jfyd2jlbi43hii">fatcat:i6w2x7dimja6jfyd2jlbi43hii</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170829022054/http://www.leibniz-fmp.de/fileadmin/Haucke/CV_Volker_Haucke_2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a0/9b/a09bc73525b47fbde095f1519aa2c2ea7904b8b0.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1476-4598-12-4"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567983" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Following the trail of lipids: Signals initiated by PI3K function at multiple cellular membranes

Adam Naguib
<span title="2016-05-17">2016</span> <i title="American Association for the Advancement of Science (AAAS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/6exof3jwwrc5zbt7thlulo6kd4" style="color: black;">Science Signaling</a> </i> &nbsp;
Class I PI3K enzymes produce PtdIns(3,4,5)P 3 (3) by catalyzing the addition of phosphate to the substrate PtdIns(4,5)P 2 (phosphatidylinositol 4,5-bisphosphate) (4).  ...  Formation of PtdIns(3,4,5)P 3 is dictated not only by PI3K activation but also by the localization and access of PI3K to its substrate PtdIns(4,5)P 2 (phosphatidylinositol 4,5-bisphosphate).  ...  Furthermore, these data outline the spatiotemporal layered control of PtdIns(3,4,5)P 3 hydrolysis.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1126/scisignal.aad7885">doi:10.1126/scisignal.aad7885</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27188443">pmid:27188443</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/67x3r2bf65fvzgqayoczzzucgi">fatcat:67x3r2bf65fvzgqayoczzzucgi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180721180700/http://stke.sciencemag.org/content/sigtrans/9/428/re4.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e4/85/e4854185dbf7a6e0ff04a0f568a7f2819b6afad5.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1126/scisignal.aad7885"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> sciencemag.org </button> </a>

Review of PIP2 in Cellular Signaling, Functions and Diseases

Kalpana Mandal
<span title="2020-11-06">2020</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3loumxx7kzamnlu4h6x3xoz6ay" style="color: black;">International Journal of Molecular Sciences</a> </i> &nbsp;
Central to this process is phosphatidylinositol bisphosphate (PIP2).  ...  The levels of PIP2 in the membrane are rapidly altered by the activity of phosphoinositide-directed kinases and phosphatases, and it binds to dozens of different intracellular proteins.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/ijms21218342">doi:10.3390/ijms21218342</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33172190">pmid:33172190</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/uv4r6as6krbxfjtg4m47srk5am">fatcat:uv4r6as6krbxfjtg4m47srk5am</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201209222521/https://res.mdpi.com/d_attachment/ijms/ijms-21-08342/article_deploy/ijms-21-08342-v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c1/f0/c1f02980e0c4ffe7c3f2a28fd89d41c1332cc45f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/ijms21218342"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a>

Early innate immune responses to bacterial LPS

Charles V Rosadini, Jonathan C Kagan
<span title="">2017</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/74hmad4slndnrgvigiuwv6rezq" style="color: black;">Current Opinion in Immunology</a> </i> &nbsp;
A mammalian receptor for bacterial lipopolysaccharide (LPS), Toll-like receptor 4 (TLR4), plays a beneficial role in controlling bacterial infections, but is also a main driver of aberrant inflammation  ...  In this review, we discuss the importance of these receptor proximal activities in the spatiotemporal regulation of TLR4 signaling, and suggest interesting areas for future research.  ...  Acknowledgments We would like to thank the members of the Kagan  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.coi.2016.10.005">doi:10.1016/j.coi.2016.10.005</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27842237">pmid:27842237</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5426986/">pmcid:PMC5426986</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7vl4gfktpffunka564ypygjxwq">fatcat:7vl4gfktpffunka564ypygjxwq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200208221413/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5426986&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e9/53/e953ae933ca2a707ed35212d57f3c15548ddeb7f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.coi.2016.10.005"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426986" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Rapid tip growth: Insights from pollen tubes

Yuan Qin, Zhenbiao Yang
<span title="">2011</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/yhtjmgq5onhrtluy7fb36y7chy" style="color: black;">Seminars in Cell and Developmental Biology</a> </i> &nbsp;
Pollen tubes extend rapidly in an oscillatory manner by the extreme form of polarized growth, tip growth, and provide an exciting system for studying the spatiotemporal control of polarized cell growth  ...  Recent advances in the study of the mechanistic interlinks between ROP-centered signaling and spatiotemporal dynamics of cell membrane and wall remodeling will be discussed.  ...  This work was supported by the Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, and NIH grant (GM081451) to ZY.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.semcdb.2011.06.004">doi:10.1016/j.semcdb.2011.06.004</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/21729760">pmid:21729760</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3210868/">pmcid:PMC3210868</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/nbh2h5syjraodjm2ln75vxtcli">fatcat:nbh2h5syjraodjm2ln75vxtcli</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200429091738/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3210868&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/2b/32/2b3265d87564d754f09cb34dbb09d0580fc68418.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.semcdb.2011.06.004"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210868" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Phosphatidylinositol 3‐monophosphate: A novel actor in thrombopoiesis and thrombosis

Colin Valet, Marie Levade, Marie Bellio, Manuella Caux, Bernard Payrastre, Sonia Severin
<span title="2020-03-17">2020</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/kma262hvcfddrgqlyynulkzgjy" style="color: black;">Research and Practice in Thrombosis and Haemostasis</a> </i> &nbsp;
One of these lipids, phosphatidylinositol 3 monophosphate (PtdIns3P), is present in small amounts in mammalian cells and is involved in the control of endocytic/endosomal trafficking and in autophagy.  ...  Its metabolism is finely regulated by specific kinases and phosphatases including class II phosphoinositide 3-kinases (PI3KC2s) and the class III PI3K, Vps34.  ...  (PtdIns4P) and phosphatidylinositol (4, 5) bisphosphate (PtdIns(4,5)P 2 ) to generate, respectively, PtdIns3P, phosphatidylinositol (3, 4) bisphosphate (PtdIns(3,4)P 2 ). and phosphatidylinositol  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/rth2.12321">doi:10.1002/rth2.12321</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32548550">pmid:32548550</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7292656/">pmcid:PMC7292656</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7zqgawhzl5gpnpvuhlppj4dhie">fatcat:7zqgawhzl5gpnpvuhlppj4dhie</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200318172934/https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/rth2.12321" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ac/35/ac35f54e097be28f236ddcca587d0ef5d7c3bcef.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/rth2.12321"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> wiley.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292656" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Phosphatidylinositol 4,5-bisphosphate: Targeted production and signaling

Yue Sun, Narendra Thapa, Andrew C. Hedman, Richard A. Anderson
<span title="2013-04-10">2013</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4b3nxjjiivaspl2bdv5q6xppru" style="color: black;">Bioessays</a> </i> &nbsp;
The enormous diversity of PI4,5P 2 effector proteins and the spatiotemporal control of PI4,5P 2 generation allow PI4,5P 2 signaling to control a broad spectrum of cellular functions.  ...  Phosphatidylinositol 4,5-bisphosphate (PI4,5P 2 ) is a key lipid signaling molecule that regulates a vast array of biological activities.  ...  This work is supported by NIH grant CA104708 to R.A.A. and American Heart Association (AHA) grants to Y.S. The authors have declared no conflict of interest.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/bies.201200171">doi:10.1002/bies.201200171</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23575577">pmid:23575577</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3882169/">pmcid:PMC3882169</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/a7n3inq5hnbbhj5ndni45p5c6u">fatcat:a7n3inq5hnbbhj5ndni45p5c6u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170810050440/https://anderson.research.labs.wisc.edu/pdf/Phosphatidylinositol%204,5-bisphosphate-%20targeted%20production.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/77/5a/775a9953af3451fae8f87182dd0c601663af878f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/bies.201200171"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> wiley.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882169" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

A positive feedback loop between Flower and PI(4,5)P2 at periactive zones controls bulk endocytosis in Drosophila

Chi-Kuang Yao, Tsai-Ning Li, Yu-Jung Chen, You-Tung Wang, Hsin-Chieh Lin, Ting-Yi Lu
<span title="2020-12-10">2020</span> <i title="eLife Sciences Publications, Ltd"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/en4qj5ijrbf5djxx7p5zzpjyoq" style="color: black;">eLife</a> </i> &nbsp;
Here, we show that Flower Ca2+ channel-dependent phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) compartmentalization governs control of these processes in Drosophila.  ...  Intense stimulation induces activity-dependent bulk endocytosis (ADBE) to recapture large quantities of SV constituents in large endosomes from which SVs reform.  ...  by fixation with a solution of 1% OsO 4 /0.1 M cacodylic acid at room temperature for 3 h.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.7554/elife.60125">doi:10.7554/elife.60125</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33300871">pmid:33300871</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7748424/">pmcid:PMC7748424</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/sr5mcodcqverhevwrvcpjucibm">fatcat:sr5mcodcqverhevwrvcpjucibm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201211050008/https://elifesciences.org/download/aHR0cHM6Ly9jZG4uZWxpZmVzY2llbmNlcy5vcmcvYXJ0aWNsZXMvNjAxMjUvZWxpZmUtNjAxMjUtdjEucGRmP2Nhbm9uaWNhbFVyaT1odHRwczovL2VsaWZlc2NpZW5jZXMub3JnL2FydGljbGVzLzYwMTI1/elife-60125-v1.pdf?_hash=uh%2BvU0PMFxjvtW39Dlg3RbEWX0JTo2INiVAsUb%2F2Wpg%3D" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/f0/40/f0408321b14f8241dec022fb51a3bbb533e7a566.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.7554/elife.60125"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elifesciences.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748424" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Endocytic pathways and endosomal trafficking: a primer

Sarah R. Elkin, Ashley M. Lakoduk, Sandra L. Schmid
<span title="2016-02-09">2016</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/yi7eyaau5rdtfitlpntwj32rby" style="color: black;">Wiener Medizinische Wochenschrift</a> </i> &nbsp;
This brief overview of endocytic trafficking is written in honor of Renate Fuchs, who retires this year.  ...  We describe other sorting machinery and mechanisms, as well as the rab proteins and phosphatidylinositol lipids that serve to dynamically define membrane compartments along the endocytic pathway.  ...  the 3, 4, and 5 positions of the inositol ring [55, 56] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s10354-016-0432-7">doi:10.1007/s10354-016-0432-7</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26861668">pmid:26861668</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4873410/">pmcid:PMC4873410</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/siujr3pdqvflfojz44hhzoxznu">fatcat:siujr3pdqvflfojz44hhzoxznu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200506090537/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4873410&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/da/f7/daf7079dac1490c6ea6e7554b0f5e808203b57d7.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s10354-016-0432-7"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873410" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Flower initiates a positive feedback loop upon PIP2 enrichment at periactive zones to control bulk endocytosis [article]

Chi-Kuang Yao, Tsai-Ning Li, Yu-Jung Chen, You-Tung Wang, Hsin-Chieh Lin
<span title="2020-06-22">2020</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Here, we show that the Flower Ca2+ channel-dependent phosphatidylinositol 4,5-bisphosphate (PIP2) compartmentalization governs such control.  ...  Intense stimulation induces activity-dependent bulk endocytosis (ADBE) to recapture large quantities of SV constituents in large endosomes from which SVs reform.  ...  How these consecutive processes are spatiotemporally coordinated remains unknown. 36 Here, we show that the Flower Ca 2+ channel-dependent phosphatidylinositol 4,5-bisphosphate 37 ( .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.06.22.164400">doi:10.1101/2020.06.22.164400</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3p4xswi7s5gmflra2kc2difnf4">fatcat:3p4xswi7s5gmflra2kc2difnf4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201108161640/https://www.biorxiv.org/content/biorxiv/early/2020/06/22/2020.06.22.164400.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/6f/7e/6f7e83d4eb99623b0dd4d83e7256946e805e6ae1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.06.22.164400"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>
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