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Spatiotemporal Independent Component Analysis for the Detection of Functional Responses in Cat Retinal Images

E.S. Barriga, M.. Pattichis, D.. Ts'o, M.. Abramoff, R.. Kardon, Young Kwon, P.. Soliz
2007 IEEE Transactions on Medical Imaging  
In this paper, we quantify the limits of independent component analysis (ICA) for detecting the low intensity functional signal and apply ICA to 60 video sequences from experiments using an anesthetized  ...  Measured changes in reflectance in response to the visual stimulus are on the order of 0.1%-1% of the total reflected intensity level, which makes the functional signal difficult to detect by standard  ...  The analysis was repeated for different number of independent components, but results were similar.  ... 
doi:10.1109/tmi.2007.897366 pmid:17695124 fatcat:kebrigdkbff4hhc7hcxrghvena

Independent component analysis for the detection of in-vivo intrinsic signals from an optical imager of retinal function

Eduardo S. Barriga, Marios Pattichis, Michael Abramoff, Dan T'so, Young Kwon, Randy Kardon, Peter Soliz, Fabrice Manns, Per G. Soederberg, Arthur Ho, Bruce E. Stuck, Michael Belkin
2007 Ophthalmic Technologies XVII  
To overcome the difficulty in detection of loss of retinal activity, a functional-Retinal Imaging Device (f-RID) was developed.  ...  In this paper, we present a new Independent Component Analysis (ICA) algorithm used to analyze the video sequences from a set of experiments with different patterned stimuli from cats and humans.  ...  X A S = (1) Then independent component analysis consists of estimating both A and S using only the observations in X and the assumption that the source signals are statistically independent [24] .  ... 
doi:10.1117/12.701360 fatcat:ys5gr2zy4vgzvkiu7k7yzlonbi

Extreme synergy: Spatiotemporal correlations enable rapid image reconstruction from computer-generated spike trains

Garrett T. Kenyon
2010 Journal of Vision  
Over the brief time intervals available for processing retinal output, the number of spikes generated by individual ganglion cells can be quite variable.  ...  Here, two examples of extreme synergy are used to illustrate how realistic long-range spatiotemporal correlations can greatly improve the quality of retinal images reconstructed from computer-generated  ...  of the manuscript.  ... 
doi:10.1167/10.3.21 pmid:20377298 fatcat:eaj6yuggurgwhnqthommbwqazu

Retinal Intrinsic Optical Signals in a Cat Model of Primary Congenital Glaucoma

Jesse B. Schallek, Gillian J. McLellan, Suresh Viswanathan, Daniel Y. Ts'o
2012 Investigative Ophthalmology and Visual Science  
To examine the impact of reduced inner retinal function and breed on intrinsic optical signals in cats. METHODS.  ...  Stimulus-evoked, NIR retinal reflectance signals were observed in PCG cats despite severe degeneration of the nerve fiber layer and inner retinal function.  ...  Matthew Ellinwood, Iowa State University, and Arthur Weber, Michigan State University, for their contributions and expertise regarding the Siamese glaucoma and optic nerve crush cat models, respectively  ... 
doi:10.1167/iovs.11-8299 pmid:22395886 pmcid:PMC3996824 fatcat:v3k6koaw3fcctfmmqowmpgjfqu

A theory of the influence of eye movements on the refinement of direction selectivity in the cat's primary visual cortex

Antonino Casile, Michele Rucci
2009 Network  
Acknowledgments This work was supported by the DFG grant SFB550-C10, NIH grant 5R01EY18363, NSF grants BCS-0719849 and CCF-0726901 and the Hermann and Lilly Schilling Foundation.  ...  However, in order to model the retinal stimulus experienced by cats chronically exposed to stroboscopic illumination, the input image was flashed every 125 ms for one time step of the simulation (1 ms)  ...  The retinal image motion caused by eye movements might contribute to shaping the responses of neurons in the visual system.  ... 
doi:10.3109/09548980903314204 pmid:19919281 pmcid:PMC2951336 fatcat:5on5rpikpfepzcloifkjwuruvy

Spatial Frequency Analysis in the Visual System

R Shapley, P Lennie
1985 Annual Review of Neuroscience  
Within the last 15 years, a method called "spatial frequency analysis" has been applied widely to the study of receptive fields of neurons in the visual pathway.  ...  The aim of this paper is to explain why "spatial frequency analysis" is useful, and to review the insights into visual function that have resulted from its application.  ...  Visual detection of aperiodic spatial stimuli by probability summa-www.annualreviews.org/aronline Annual Reviews  ... 
doi:10.1146/annurev.ne.08.030185.002555 pmid:3920946 fatcat:efyvr7ncfzhjtcpjuxzt7eifim

Spatiotemporally Asymmetric Excitation Supports Mammalian Retinal Motion Sensitivity

Akihiro Matsumoto, Kevin L. Briggman, Keisuke Yonehara
2019 Current Biology  
The detection of visual motion is a fundamental function of the visual system. How motion speed and direction are computed together at the cellular level, however, remains largely unknown.  ...  Our results highlight the role of an excitatory mechanism in retinal motion computation by which feature selectivity emerges from non-selective inputs.  ...  After the calculation, responsive pixels were detected based on a threshold, mean + 3 SD. The glutamate signals for each responsive pixel detected were resampled using the MATLAB interp function.  ... 
doi:10.1016/j.cub.2019.08.048 pmid:31564498 pmcid:PMC6865067 fatcat:udn3uoeedbg5plie2gbg5odjyu

Analysis of Direction Selectivity Arising from Recurrent Cortical Interactions

Paul Mineiro, David Zipser
1998 Neural Computation  
The relative c o n tributions of feedforward and recurrent connectivity t o t h e direction selective responses of cells in layer IVB of primary visual cortex is currently the subject of debate in the  ...  The approach also allows analysis of the recurrently propagated signal, revealing the predictive nature of the implementation.  ...  independent of absolute retinal position.  ... 
doi:10.1162/089976698300017791 pmid:9472486 fatcat:ujnrp2oszndbrmrpqmrr3q2kv4

Stimulus-Evoked Intrinsic Optical Signals in the Retina: Pharmacologic Dissection Reveals Outer Retinal Origins

Jesse Schallek, Randy Kardon, Young Kwon, Michael Abramoff, Peter Soliz, Daniel Ts'o
2009 Investigative Ophthalmology and Visual Science  
vecuronium bromide for imaging stability.  ...  Variants of the electroretinogram (pattern ERG and long-pulse ERG) were also recorded as additional measures of retinal function.  ...  METHODS Animals and Preparation We imaged the retinas of four adult healthy cats between the ages of 1 and 2.4 years.  ... 
doi:10.1167/iovs.08-3291 pmid:19420331 pmcid:PMC5201214 fatcat:zkhdd4jjsvb6lnvotnxpej6vdq

Subject index

1998 Vision Research  
quality of the retinal vasculature 38:2685 Retinal image quality in the human eye as a function of the accommodation 38:2897 IMMUNOCHEMISTRY Diversity of glutamate receptors in the mammalian retina 38  ...  pools in the human visual cortex 38:3735 Temporal analysis of the chromatic flash VEP-separate colour and luminance contrast components 38:3979 EYE-MOVEMENTS Extra-retinal and perspective cues cause the  ... 
doi:10.1016/s0042-6989(99)80004-2 fatcat:4sorb7gyobempbham6yzgklsza

Macaque retinal ganglion cell responses to visual patterns: harmonic composition, noise, and psychophysical detectability

Bonnie Cooper, Barry B. Lee, Dingcai Cao
2016 Journal of Neurophysiology  
Response variance (noise) was also quantified as a function of harmonic component. Noise increased to some degree for the higher harmonics.  ...  The data are relevant for psychophysical detection or discrimination of visual patterns, and we discuss the results in this context.  ...  ACKNOWLEDGMENTS We thank Jan Kremers and Joel Pokorny for comments on the manuscript. We also thank Rob Ennis for help with the physiological recordings.  ... 
doi:10.1152/jn.00411.2015 pmid:26936977 pmcid:PMC4922617 fatcat:ruj2drxasrby3d2ia6izddx7xi

A natural approach to studying vision

Gidon Felsen, Yang Dan
2005 Nature Neuroscience  
Achieving this goal requires knowledge of both the characteristics of natural stimuli and the response properties of sensory neurons under natural stimulation.  ...  Here, focusing on the early visual pathway, we argue that the use of natural stimuli is vital for advancing our understanding of sensory processing.  ...  Vinje for helpful comments. This work was supported by a grant from the National Eye Institute (R01 EY12561).  ... 
doi:10.1038/nn1608 pmid:16306891 fatcat:75xvswiblveetn3jto5gzq33c4

Functional characterization of retinal ganglion cells using tailored nonlinear modeling [article]

Qing Shi, Pranjal Gupta, Alexandra Boukhvalova, Joshua H Singer, Daniel A Butts
2018 bioRxiv   pre-print
It identified multiple receptive fields (RFs) reflecting the main excitatory and suppressive components of the response of each neuron.  ...  We recorded ganglion cell responses to a correlated noise ("cloud") stimulus designed to accentuate the important features of retinal processing in an in vitro preparation of mouse retina and found that  ...  The robust identification of multiple spatiotemporal RFs contributing to a given ganglion cell response allows for detailed analysis of their spatial integration properties, as well as detecting the presence  ... 
doi:10.1101/421396 fatcat:bifa6kzn6zc3rbunibjbvtlisu

Spatiotemporal receptive fields of cells in V1 are optimally shaped for stimulus velocity estimation

Giacomo Cocci, Davide Barbieri, Alessandro Sarti
2011 Optical Society of America. Journal A: Optics, Image Science, and Vision  
Analysis of the model parameters' cortical distribution suggests that V1 is spatiotemporally organized to maximize the resolution on the stimulus velocity measure.  ...  In recent literature, particularly interesting stimulus velocity-selective behaviors were found in the response properties of neurons belonging to the primary visual cortex (V1).  ...  In Subsection 2.A we briefly describe the reconstruction of the dataset used for the analysis.  ... 
doi:10.1364/josaa.29.000130 pmid:22218360 fatcat:bzcvytepn5dfpp3xg64psptdca

Coherence of early motion signals

Joseph S Lappin, Michael P Donnelly, Haruyuki Kojima
2001 Vision Research  
Three horizontally aligned Gaussian blobs oscillated horizontally, with the center in-phase or out-of-phase with the two flankers.  ...  Motion phase relations must be coherent among spatially separate retinal signals, carrying information about intrinsic image structure.  ...  Spike trains in cat retinal ganglion cells were recorded in response to nearthreshold oscillations of a vertical bar.  ... 
doi:10.1016/s0042-6989(01)00035-9 pmid:11348646 fatcat:bwu4xz5ao5hwblxkfwegqwrbmm
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