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Large-scale, high-resolution electrophysiological imaging of field potentials in brain slices with microelectronic multielectrode arrays

E. Ferrea, A. Maccione, L. Medrihan, T. Nieus, D. Ghezzi, P. Baldelli, F. Benfenati, L. Berdondini
2012 Frontiers in Neural Circuits  
Here, we present a large-scale array recording simultaneously from 4096 electrodes used to study propagating spontaneous and evoked network activity in acute murine cortico-hippocampal brain slices at  ...  We demonstrate that multiple chemically induced epileptiform episodes in the mouse cortex and hippocampus can be classified according to their spatio-temporal dynamics.  ...  ACKNOWLEDGMENTS The authors acknowledge support from the Istituto Italiano di Tecnologia (IIT) and the parallel cluster CASPUR (Consorzio Interuniversitario per le Applicazioni di Supercalcolo per Universitàe  ... 
doi:10.3389/fncir.2012.00080 pmid:23162432 pmcid:PMC3496908 fatcat:e55bmfhbrrewxeckauggp3vbei

Depolarization Block of Neurons During Maintenance of Electrographic Seizures

Marom Bikson, Philip J. Hahn, John E. Fox, John G.R. Jefferys
2003 Journal of Neurophysiology  
Reflections of low calcium epileptiform activity from area CA1 into dentate gyrus in the rat hippocampal slice. Brain Res 480: 393-396, 1989. Alkadhi KA and Tian LM.  ...  Suppression of epileptiform activity by high frequency sinusoidal fields in rat hippocampal slices. J Physiol 531: 181-191, 2001. Blume WT, Young GB, and Lemieux JF.  ...  If depolarization block occurs during human epileptic seizures, its most extreme manifestation would be the suppression of rhythmic EEG activity.  ... 
doi:10.1152/jn.00467.2003 pmid:12801897 fatcat:auf2q5ew5ncbpkdx6zqujz2eqe

Characterizing concentration-dependent neural dynamics of 4-aminopyridine-induced epileptiform activity [article]

Timothy L Myers, Oscar C Gonzalez, Jacob B Stein, Maxim Bazhenov
2018 bioRxiv   pre-print
The frequency component and the spatio-temporal patterns of the epileptiform activity revealed a dose-dependent response.  ...  Typically, inter-ictal events or large bouts of population level activity can be measured between seizures and are generally asymptomatic.  ...  Indeed, in rat brain slices treated with 4AP, reduction of KCC2 activity prevents seizure-like discharges while inter-ictal activity remained relatively intact (18).  ... 
doi:10.1101/252726 fatcat:6crbt2x4tbauxd4bmhkjxuv5pa

Synaptic transmission modulates while non-synaptic processes govern the transition from pre-ictal to seizure activity in vitro [article]

Marom Bikson, Ana Ruiz-Nuño, Dolores Miranda, Greg Kronberg, Premysl Jiruska, John E. Fox, John G.R. Jefferys
2018 bioRxiv   pre-print
We investigated the interaction of intact synaptic activity with non-synaptic mechanisms in the isolated CA1 region of rat hippocampal slices using the 'elevated-K+' model of epilepsy.  ...  When population spikes are disrupted for up to several seconds, intracellular recording demonstrated that the prolonged suppression of population spikes during ictal activity was due to depolarization  ...  Studies in human epilepsy and animal models have suggested a sub-class of inter-ictal events: "pre-ictal" discharges which are more correlated temporally and spatially with seizure initiation and present  ... 
doi:10.1101/280321 fatcat:pc6uhsfbpnhyjadxrjhtpgbpua

An investigation of EEG dynamics in an animal model of temporal lobe epilepsy using the maximum Lyapunov exponent

Sandeep P. Nair, Deng-Shan Shiau, Jose C. Principe, Leonidas D. Iasemidis, Panos M. Pardalos, Wendy M. Norman, Paul R. Carney, Kevin M. Kelly, J. Chris Sackellares
2009 Experimental Neurology  
Analysis of intracranial electroencephalographic (iEEG) recordings in patients with temporal lobe epilepsy (TLE) has revealed characteristic dynamical features that distinguish the interictal, ictal, and  ...  to ictal state is associated with a convergence in STL max values among cortical sites. iEEGs were recorded from bilateral frontal cortices and hippocampi.  ...  More detailed inspection on the T-index comparisons further revealed that the spatio-temporal order increases from the interictal to preictal period, and continue to increase from the preictal to ictal  ... 
doi:10.1016/j.expneurol.2008.11.009 pmid:19100262 pmcid:PMC2643305 fatcat:a5bfywyab5h4xgr22r27grpcme

Spatiotemporal neuronal correlates of seizure generation in focal epilepsy

Mark R. Bower, Matt Stead, Fredric B. Meyer, W. Richard Marsh, Gregory A. Worrell
2012 Epilepsia  
Methods-Microelectrode arrays recorded action potentials from neurons in mesial temporal structures (often including contralateral mesial temporal structures) in seven patients with mesial temporal lobe  ...  These early changes varied from seizure to seizure, demonstrating the heterogeneity of ensemble activity underlying the generation of focal seizures.  ...  limited spatio-temporal sampling that simply misses seizure-related activation of a fixed population of "epileptic neurons".  ... 
doi:10.1111/j.1528-1167.2012.03417.x pmid:22352423 pmcid:PMC3339564 fatcat:c4q5bvjkr5bwhm3shevfw2rs6m

High and low frequency electrical stimulation in non-lesional temporal lobe epilepsy

Colette Boëx, Serge Vulliémoz, Laurent Spinelli, Claudio Pollo, Margitta Seeck
2007 Seizure  
On the other hand, a single human study reported a beneficial effect of LFS on temporal lobe mesiobasal epileptic foci. 6 Since there are very few data on LFS in human, and given that the effect of HFS  ...  Introduction About 20% of epileptic patients suffer from a pharmacologically intractable epilepsy. 1 A surgical intervention is not possible in many cases because seizures arise from several brain regions  ... 
doi:10.1016/j.seizure.2007.05.009 pmid:17582791 fatcat:jmclzpb7lzbp7edcoso4cozo6y

Role of Multiple-Scale Modeling of Epilepsy in Seizure Forecasting

Levin Kuhlmann, David B. Grayden, Fabrice Wendling, Steven J. Schiff
2015 Journal of clinical neurophysiology  
Here we review the literature on the multiple-scale neural modelling of epilepsy and the use of such models to infer physiological changes underlying epilepsy and epileptic seizures.  ...  EEG electroencephalography iEEG intracranial electroencephalography K + potassium ion Na+ sodium ion GABA gamma-aminobutyric acid CA1 hippocampus, Cornu Ammonis area 1 PSP post-synaptic potential TLE temporal  ...  Acknowledgements The Bionics Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program.  ... 
doi:10.1097/wnp.0000000000000149 pmid:26035674 pmcid:PMC4455036 fatcat:oiime3h2ejdslajqib45ggqaoa

The spatio-temporal mapping of epileptic networks: Combination of EEG–fMRI and EEG source imaging

S. Vulliemoz, R. Thornton, R. Rodionov, D.W. Carmichael, M. Guye, S. Lhatoo, A.W. McEvoy, L. Spinelli, C.M. Michel, J.S. Duncan, L. Lemieux
2009 NeuroImage  
separate recordings.  ...  This combination provides new opportunities for investigating epileptic networks.  ...  This work was undertaken at UCLH/UCL who received a proportion of funding from the Department of Health's NIHR Biomedical Research Centres funding scheme.  ... 
doi:10.1016/j.neuroimage.2009.01.070 pmid:19408351 pmcid:PMC2977852 fatcat:7etpeo5npnhivbv7y4b26bubsy

Abstracts

2015 Epilepsia  
Purpose: Temporal lobe epilepsy (TLE) is the most frequent type of localization-related focal epilepsy seen in humans.  ...  Purpose: We review our experience with SEEG recording in patients with medically intractable epilepsy and suspected insular involvement in the initiation and organization of the epileptic activity.  ...  Method: 34 IGEs (26 females) who underwent an EEG-functional MRI (EEG-fMRI) study with the recording of GSWDs were selected.  ... 
doi:10.1111/epi.13241 fatcat:jnz7opo6tnccjcljtelg53ux6u

Probing the polarity of GABAergic transmission in vivo [article]

Olivier Dubanet, Arnaldo Ferreira, Andreas Frick, Hajime Hirase, Anna Beyeler, Xavier Leinekugel
2019 bioRxiv   pre-print
postsynaptic field-potentials (fIPSPs) and silicon probe recording of the firing activity of multiple individually identified neurons.  ...  Here, we show that the polarity of GABAergic transmission can be probed across the CA3 hippocampal circuit in vivo with single cell resolution, by combining extracellular detection of unitary inhibitory  ...  Electrophysiological recordings displayed both interictal activity and hippocampal ictal seizures, recognized as complex events lasting 30 to 40 seconds (37.4 ±9.3s, n=14 seizures from 7 mice), even though  ... 
doi:10.1101/630608 fatcat:l2eq2ikeivbbph6utrgk5rpryu

Saturday, December 5, 2009�Poster Session 1�1:00 p.m.-8:00 p.m

2009 Epilepsia  
from incoming calls.  ...  Electronic records may contribute to improving efficiencies in these services however, standardised procedures and a commitment to resource these services from hospital management is imperative.  ...  Rationale: The epileptic activity emanating from an epileptogenic lesion causes widespread changes in the grey and white matter in the human brain.  ... 
doi:10.1111/j.1528-1167.2009.02377_1.x pmid:19817824 fatcat:75g2b4qnwrbrnpmcvebgz24dvq

Seizures initiate in zones of relative hyperexcitation in a zebrafish epilepsy model [article]

James E Niemeyer, Poornima Gadamsetty, Chanwoo Chun, Sherika Sylvester, Jacob P Lucas, Hongtao Ma, Theodore H Schwartz, Emre Aksay
2021 bioRxiv   pre-print
Seizures are thought to arise from an imbalance of excitatory and inhibitory neuronal activity.  ...  While most classical studies suggest excessive excitatory neural activity plays a generative role, some recent findings challenge this view and instead argue that excessive activity in inhibitory neurons  ...  PTZ is known to induce seizures in humans (31, 32) and lower seizure threshold in 277 epileptic patients (33).  ... 
doi:10.1101/2021.03.30.437750 fatcat:2pintbgzazhyhjti42lbfiubky

Augmenting interictal mapping with neurovascular coupling biomarkers by structured factorization of epileptic EEG and fMRI data [article]

Simon Van Eyndhoven, Patrick Dupont, Simon Tousseyn, Nico Vervliet, Wim Van Paesschen, Sabine Van Huffel, Borbála Hunyadi
2020 arXiv   pre-print
We show that the extracted source signatures provide a sensitive localization of the ictal onset zone, and, moreover, that complementary localizing information can be derived from the spatial variation  ...  for localizing the ictal onset zone.  ...  human brain activity (Shirer et al., 2012) .  ... 
arXiv:2004.14185v1 fatcat:cqg4jzfhavhdhalxl2ugadaqim

Third International Workshop of UOEFH on Emotion and Higher Nervous Function
第3回国際ワークショップ:情動と高次神経機能

1990 Journal of UOEH  
Thc relationship between spatio-temporal analysis of EEG activity and productivity of VDT work was investigated. ). SErvice, LCvogo Brain and Ifkart Center.  ...  In a series of experiments, we recorded single neuron activities from these two rcgions dur- ing frec copulatory behavior ofmale rats.  ... 
doi:10.7888/juoeh.12.283 fatcat:ofscskh2g5ehxigum4nxa6di2i
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