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A revised limbic system model for memory, emotion and behaviour

Marco Catani, Flavio Dell'Acqua, Michel Thiebaut de Schotten
2013 Neuroscience and Biobehavioral Reviews  
This revised network model of the limbic system reconciles recent functional imaging findings with anatomical accounts of clinical disorders commonly associated with limbic pathology.  ...  ; (ii) The temporo-amygdala-orbitofrontal network for the integration of visceral sensation and emotion with semantic memory and behaviour; (iii) the default-mode network involved in autobiographical memories  ...  Acknowledgment We thank the Natbrainlab (, Emilio Verche, Guy's and St. Thomas' Charity and the French Agence Nationale de la Recherche (project CAFORPFC, no.  ... 
doi:10.1016/j.neubiorev.2013.07.001 pmid:23850593 fatcat:5yqsfutri5bgphef3mnzaakoym

Issues surrounding the cognitive neuroscience of obsessive-compulsive disorder

Kevin D. Wilson
1998 Psychonomic Bulletin & Review  
Obsessive-compulsive disorder (OCD) has been studied extensively in recent years, with increased emphasis on understanding OCD's biological substrates.  ...  Obsessive-compulsive disorder (OCD) is a relatively common form of psychopathology with a lifetime prevalence of2%-3% (Robins et al., 1984) .  ...  Hoen-Saric, found decreased activity in the medial-frontal cortex following a 12-to 16-week trial of fluoxetine.  ... 
doi:10.3758/bf03212942 fatcat:nnaifa3mmneilf3ypdcrg6kgqm

Functional Neuroimaging in Obsessive-Compulsive Disorder

A. Del Casale, G.D. Kotzalidis, C. Rapinesi, D. Serata, E. Ambrosi, A. Simonetti, M. Pompili, S. Ferracuti, R. Tatarelli, P. Girardi
2011 Neuropsychobiology  
Improvements in spatial resolution of neuroimaging techniques may contribute to a better understanding of the neurocircuitry of OCD and other anxiety disorders.  ...  eral studies have targeted brain regions hypothesised to be involved in the pathogenesis of OCD, showing the existence of dysfunctional connectivity in the corticostriatothalamocortical circuitry.  ...  Disclosure Statement M.P. has served as a consultant to, or was engaged in research collaborations with Eli Lilly and Organon Corporations in Italy.  ... 
doi:10.1159/000325223 pmid:21701225 fatcat:h7xr2ixhcjh43kdpcf6srntiue

Inhibitory dysfunction contributes to some of the motor and non-motor symptoms of movement disorders and psychiatric disorders

Marjan Jahanshahi, John C. Rothwell
2017 Philosophical Transactions of the Royal Society of London. Biological Sciences  
Within this framework, some of the clinical manifestations of Parkinson's disease, dystonia, Tourette syndrome, and obsessive compulsive disorder can be considered to represent an imbalance between goal-directed  ...  It is possible that surgical interventions targeting the basal ganglia nuclei, such as deep brain stimulation of the subthalamic nucleus or the internal segment of the globus pallidus improve these disorders  ...  Obsessive compulsive disorder People with obsessive compulsive disorder (OCD) experience intrusive unwanted thoughts and images (obsessions) and repetitive behaviours (compulsions), which are driven by  ... 
doi:10.1098/rstb.2016.0198 pmid:28242732 pmcid:PMC5332857 fatcat:wn4s7qsdabeizb4gg3y5j2a4bm

Morphologic and Functional Connectivity Alterations of Corticostriatal and Default Mode Network in Treatment-Naïve Patients with Obsessive-Compulsive Disorder

Jingming Hou, Lingheng Song, Wei Zhang, Wenjing Wu, Jian Wang, Daiquan Zhou, Wei Qu, Junwei Guo, Shanshan Gu, Mei He, Bing Xie, Haitao Li (+1 others)
2013 PLoS ONE  
Previous studies have demonstrated that structural deficits and functional connectivity imbalances might underlie the pathophysiology of obsessive-compulsive disorder (OCD).  ...  matter volume in the bilateral medial orbitofrontal cortex, left anterior cingulate cortex, and left inferior frontal gyrus.  ...  We are indebted to technicians Chuan Li, Xin Wang and Bing Ji for MRI scanning. Author Contributions  ... 
doi:10.1371/journal.pone.0083931 pmid:24358320 pmcid:PMC3865285 fatcat:gvz2azdtzffa3py6oouhuwluzq

Role of Glutamatergic System in Obsessive-Compulsive Disorder with Possible Therapeutic Implications

Přemysl Vlček, Jakub Polák, Martin Brunovský, Jiří Horáček
2017 Pharmacopsychiatry  
AbstractObsessive-compulsive disorder (OCD) is a chronic psychiatric illness and 1 of the most common anxiety disorders with the prevalence of 3%.  ...  This effect should be even more pronounced in certain subtypes of patients with specific cognitive deficits and maladaptive compensatory memory processes (e.g., checkers).  ...  Conflict of Interest No conflict of interest has been declared by the author(s).  ... 
doi:10.1055/s-0043-118665 pmid:28950396 fatcat:trt3x6j7rzgadom5gnlarhw6ze

Neurobiology of addiction: a neurocircuitry analysis

George F Koob, Nora D Volkow
2016 Lancet psychiatry  
The craving and deficits in executive function in the so-called preoccupation/anticipation stage involve the dysregulation of key afferent projections from the prefrontal cortex and insula, including glutamate  ...  , maintenance, and relapse associated with addiction.  ...  Acknowledgments We thank Michael Arends for assistance with manuscript preparation.  ... 
doi:10.1016/s2215-0366(16)00104-8 pmid:27475769 pmcid:PMC6135092 fatcat:5avvepmv4barnjdvvpglpubzoe

Neuropsychological and neurophysiological insights into hoarding disorder

Jessica Grisham, Peter Baldwin
2015 Neuropsychiatric Disease and Treatment  
Research and theory suggest that hoarding may be associated with specific deficits in information processing, particularly in the areas of attention, memory, and executive functioning.  ...  Thus, the primary aim of this review is to summarize the current state of evidence regarding neuropsychological deficits associated with hoarding and review research on its neurophysiological underpinnings  ...  Acknowledgment The first author was supported in part by the June Griffith Fellowship from the Faculty of Science of the University of New South Wales.  ... 
doi:10.2147/ndt.s62084 pmid:25897231 pmcid:PMC4396642 fatcat:2c4vubjzkbhabjocowhxso2nnm

Neural Correlates of Moral Sensitivity in Obsessive-Compulsive Disorder

Ben J. Harrison, Jesus Pujol, Carles Soriano-Mas, Rosa Hernández-Ribas, Marina López-Solà, Hector Ortiz, Pino Alonso, Joan Deus, José M. Menchon, Eva Real, Cinto Segalàs, Oren Contreras-Rodríguez (+2 others)
2012 Archives of General Psychiatry  
Context: Heightened moral sensitivity seems to characterize patients with obsessive-compulsive disorder (OCD).  ...  Objective: To test the hypothesis that patients with OCD demonstrate an increased response of relevant ventromedial prefrontal and orbitofrontal cortex regions in a functional magnetic resonance imaging  ...  with obsessive-compulsive disorder.  ... 
doi:10.1001/archgenpsychiatry.2011.2165 pmid:22752238 fatcat:zo7tjwotbbcb7pq5au47xijxo4

Toward a Neurobiology of Obsessive-Compulsive Disorder

Ann M Graybiel, Scott L Rauch
2000 Neuron  
orbitofrontal cortex, the anterior (2) The obsessions and compulsions usually are not cingulate/caudal medial prefrontal cortex, and the caubizarre.  ...  This high cooccurrence, together with the to a particular obsession, as if to neutralize the anxiety phenomenologic similarities between OCD and TS, has and negative affect associated with that obsession  ...  Coordination of human brain imaging of this sort with Neurophysiol., in press. laboratory-based experiments holds great promise for  ... 
doi:10.1016/s0896-6273(00)00113-6 pmid:11144344 fatcat:3ksn4rf5obfmfpnddawb2rsssy

A debate on working memory and cognitive control: can we learn about the treatment of substance use disorders from the neural correlates of anorexia nervosa?

Samantha J. Brooks
2016 BMC Psychiatry  
Additionally, excessive employment of working memory (WM), alongside more prominent cognitive deficits may be utilised to cope with the experience of negative emotions and may account for aberrant brain  ...  Intriguingly, people with AN are less likely to engage in substance use, whereas those who suffer from an ED with a bingeing component are more vulnerable to substance use disorder (SUD).  ...  ; HC: healthy control; OCD: obsessive-compulsive disorder; OCPD: Obsessive-Compulsive Personality Disorder; OFC: orbitofrontal cortex; SN: salience network; SUD: substance use disorder; WM: working memory  ... 
doi:10.1186/s12888-016-0714-z pmid:26772802 pmcid:PMC4715338 fatcat:kucg2gfeu5bvxjuqpbymim7oxm

Executive functions in obsessive?compulsive disorder: state or trait deficits?

Shelley Bannon, Craig J. Gonsalvez, Rodney J. Croft, Philip M. Boyce
2006 Australian and New Zealand journal of psychiatry (Print)  
Task Self-Ordered Pointing Task C A N T A B : Spatial Working Memory Task C A N T A B : Spatial Working Memory Task Self-Ordered Search Task Dual Task Digit Span Deficit in O C D subjects  ...  areas t r C B F orbitofrontal, superior frontal and dorsolateral prefrontal cortex, right anterior cingulate, anterior, medial, lateral temporal cortex t fronto-striatal in area associated with urge to  ... 
doi:10.1111/j.1440-1614.2006.01928.x pmid:17054573 fatcat:x4qibymobrhp3mix7smxfpiz2e

Abnormal Spontaneous Neural Activity in Obsessive-Compulsive Disorder: A Resting-State Functional Magnetic Resonance Imaging Study

Li Ping, Li Su-Fang, Han Hai-Ying, Dong Zhang-Ye, Luo Jia, Guo Zhi-Hua, Xiong Hong-Fang, Zang Yu-Feng, Li Zhan-Jiang, Krish Sathian
2013 PLoS ONE  
Moreover, ReHo in the orbitofrontal cortex was correlated with the duration of obsessive-compulsive disorder.  ...  These findings suggest that increased intra-and inter-regional synchronized activity in the orbitofrontal cortex may have a key role in the pathology of obsessive-compulsive disorder.  ...  Acknowledgments The authors thank Dr. TANG Yi-Lang for his helpful comments on the earlier version of this paper.  ... 
doi:10.1371/journal.pone.0067262 pmid:23826251 pmcid:PMC3695040 fatcat:dhfscuk3crezjisj7v64siwnvq

Neuroimaging of cognitive brain function in paediatric obsessive compulsive disorder: a review of literature and preliminary meta-analysis

Silvia Brem, Tobias U. Hauser, Reto Iannaccone, Daniel Brandeis, Renate Drechsler, Susanne Walitza
2012 Journal of neural transmission  
Obsessive compulsive disorder (OCD) is a frequent psychiatric disorder with a prevalence of 1-3 %, and it places an enormous burden on patients and their relatives.  ...  Abstract Obsessive compulsive disorder (OCD) is a frequent psychiatric disorder with a prevalence of 1-3 %, and it places an enormous burden on patients and their relatives.  ...  Conflict of interest S. Walitza received speakers honoraria from Eli Lilly, Janssen-Cilag and AstraZeneca in the last five years. The other authors declare no competing financial interests.  ... 
doi:10.1007/s00702-012-0813-z pmid:22678698 fatcat:t5s522ezarh6zonidh6eil66hy

Brain activation during cognitive planning in twins discordant or concordant for obsessive-compulsive symptoms

A. den Braber, D. van 't Ent, D. C. Cath, J. Wagner, D. I. Boomsma, E. J. C. de Geus
2010 Brain  
These inconsistencies may reflect the differential impact of environmental and genetic risk factors for obsessive-compulsive disorder on different parts of the brain.  ...  Neuroimaging studies have indicated abnormalities in cortico-striatal-thalamo-cortical circuits in patients with obsessivecompulsive disorder compared with controls.  ...  Acknowledgements We thank Gabrië lla Blokland, Myrle Kemperman and Mira Geirnaert for help with MRI data collection.  ... 
doi:10.1093/brain/awq229 pmid:20823085 pmcid:PMC2947427 fatcat:6krm7g5vxzam5n7oafqisss7le
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