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Gating of the Pore of the Human Ryanodine Receptor Type 2 does not require Glycine Hinges

Joanne Euden, Sammy A. Mason, Cedric Viero, N. Lowri Thomas, Matthew V. Davies, Alan J. Williams
2013 Biophysical Journal  
Ryanodine receptors (RyRs) form a class of intracellular calcium release channels in various excitable tissues and cells such as muscles and neurons.  ...  Here, we compare and relate two distinct approaches of analysing STED microscopy images of RyR2 clusters (cardiac ryanodine receptor type 2).  ...  Ryanodine receptors (RyRs) form a class of intracellular calcium release channels in various excitable tissues and cells such as muscles and neurons.  ... 
doi:10.1016/j.bpj.2012.11.2465 fatcat:6uwxm362gvhsvg4uxfabuhawyi

Structural Insight into the Phosphorylation Domain in Ryanodine Receptors

Zhiguang Yuchi, Kelvin Lau, Filip Van Petegem
2013 Biophysical Journal  
Ryanodine receptors (RyRs) form a class of intracellular calcium release channels in various excitable tissues and cells such as muscles and neurons.  ...  Here, we compare and relate two distinct approaches of analysing STED microscopy images of RyR2 clusters (cardiac ryanodine receptor type 2).  ...  Ryanodine receptors (RyRs) form a class of intracellular calcium release channels in various excitable tissues and cells such as muscles and neurons.  ... 
doi:10.1016/j.bpj.2012.11.2463 fatcat:gujk5hposrasfbvz2lzrpqmqhi

Modeling a Ryanodine Receptor Amino-Terminal Domain Connecting the Central Vestibule and the Corner Clamp Region

Li Zhu, Xiaowei Zhong, S.R. Wayne Chen, Nilesh Banavali, Zheng Liu
2013 Biophysical Journal  
Ryanodine receptors (RyRs) form a class of intracellular calcium release channels in various excitable tissues and cells such as muscles and neurons.  ...  Here, we compare and relate two distinct approaches of analysing STED microscopy images of RyR2 clusters (cardiac ryanodine receptor type 2).  ...  Ryanodine receptors (RyRs) form a class of intracellular calcium release channels in various excitable tissues and cells such as muscles and neurons.  ... 
doi:10.1016/j.bpj.2012.11.2462 fatcat:jvvtcfabwbbbvol7oslhml7woa

Analysis of Fluorescence Microscopy Super-Resolution Data of Protein Assemblies

Tobias Kohl, Ulrich Parlitz, Stefan W. Hell, Stefan Luther, Stephan E. Lehnart
2013 Biophysical Journal  
Ryanodine receptors (RyRs) form a class of intracellular calcium release channels in various excitable tissues and cells such as muscles and neurons.  ...  Here, we compare and relate two distinct approaches of analysing STED microscopy images of RyR2 clusters (cardiac ryanodine receptor type 2).  ...  Ryanodine receptors (RyRs) form a class of intracellular calcium release channels in various excitable tissues and cells such as muscles and neurons.  ... 
doi:10.1016/j.bpj.2012.11.2464 fatcat:xv477wmlfja5vafqfcur3ncyny

Obscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integrity

Davide Randazzo, Emiliana Giacomello, Stefania Lorenzini, Daniela Rossi, Enrico Pierantozzi, Bert Blaauw, Carlo Reggiani, Stephan Lange, Angela K. Peter, Ju Chen, Vincenzo Sorrentino
2013 The Journal of General Physiology  
Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers. J Cell Biol. 1999 Aug 9;146(3):621-30.  ...  Deletion of the ryanodine receptor type 3 (RyR3) impairs forms of synaptic plasticity and spatial learning. EMBO J. 1999 Oct 1;18(19):5264-73.  ... 
doi:10.1085/jgp1414oia9 fatcat:745hbiz3lzhwfeew4qvnkcrq6q

Co-Expression of TRIC-A and Cardiac Ryanodine Receptor affects Store-Overload Induced Calcium Release in HEK293 Cells

Xinyu Zhou, Ki Ho Park, Pei-hui Lin, Daiju Yamazaki, Zui Pan, S.R. Wayne Chen, Hiroshi Takeshima, Jianjie Ma
2013 Biophysical Journal  
This provides insight into some of the essential properties of the cytoplasmic Ca 2þ regulatory machinery in the posterior pituitary.  ...  of 1850 5 485 nM and concentration of 243 5 46 mM for the endogenous Ca 2þ buffer (n = 16).  ...  We can conclude that miR-208 affects Ca 2þ handling by regulating the expression of proteins involved in phosphorylationdephosphorylation of ryanodine receptors and phospholamban.  ... 
doi:10.1016/j.bpj.2012.11.3359 fatcat:yzmt63k53jawfo32qniprdqrtq

Iron (II) Modulation of the Cardiac Ryanodine Receptor (RyR2)

Daniel T. Baptista-Hon, Austin C. Elliott, Mary E. Diaz
2009 Biophysical Journal  
Early studies showed that protamine (>20mg/ml) inhibits skeletal RyR1 regardless of the cytosolic Ca 2þ levels (Koulen et al., Mol. Biol. Cell. 11:2213-9, 2000.  ...  We extended these studies to cardiac RyR2 reconstituted into planar lipid bilayers. We found that protamine (0.2mg/ml) added to the cytosolic surface of 587-Pos Board B466  ...  Stabilisation of cardiac ryanodine receptors (RyR2) has emerged as an important approach for normalising Ca 2þ cycling dysfunction in cardiac disease.  ... 
doi:10.1016/j.bpj.2008.12.497 fatcat:5xkbsgayznf63frpb5db3dbfo4

Physiological Role(S) of RyR1 in Smooth Muscle Cells

Ruben Lopez, Mirko Vukcevic, Francesco Zorzato, Susan Treves
2013 Biophysical Journal  
FKBP12 in the Conformational Dynamics of RyR1 The ryanodine receptor (RyR) is an intracellular ion channel with an important role in depolarization-induced Ca 2þ release in excitable cells.  ...  Skeletal Muscle Ryanodine Receptor Ion Channel-FKBP12 Complex by the 1,4-Benzothiazepine Derivative S107  ...  Ryanodine receptors (RyRs) form a class of intracellular calcium release channels in various excitable tissues and cells such as muscles and neurons.  ... 
doi:10.1016/j.bpj.2012.11.2461 fatcat:aashgm73q5buzjkrmwpq3mei7e

Calcium polymorphic ventricular tachycardia: a new name for CPVT?

F. Brette
2010 Cardiovascular Research  
dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation.  ...  The rise of intracellular [Ca 2+ ] that activates the contractile proteins -the systolic Ca 2+ transient -is the spatial and temporal sum of such local releases.  ...  Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia, Circulation 2001;103:196-200. 4 George CH, Higgs GV, and Lai FA.  ... 
doi:10.1093/cvr/cvq128 pmid:20472567 pmcid:PMC2883901 fatcat:e7lw7ekzpncp3jurpxytz3a33u

Ros in Cardiac Calcium Signaling

Moradeke A. Bamgboye, W.J. Lederer
2013 Biophysical Journal  
This provides insight into some of the essential properties of the cytoplasmic Ca 2þ regulatory machinery in the posterior pituitary.  ...  of 1850 5 485 nM and concentration of 243 5 46 mM for the endogenous Ca 2þ buffer (n = 16).  ...  We can conclude that miR-208 affects Ca 2þ handling by regulating the expression of proteins involved in phosphorylationdephosphorylation of ryanodine receptors and phospholamban.  ... 
doi:10.1016/j.bpj.2012.11.3362 fatcat:36lithap5ngkbgxsb37sihy5l4

Temperature Dependence of Ip3-Mediated Signals

George D. Dickinson, Ian Parker
2013 Biophysical Journal  
This provides insight into some of the essential properties of the cytoplasmic Ca 2þ regulatory machinery in the posterior pituitary.  ...  of 1850 5 485 nM and concentration of 243 5 46 mM for the endogenous Ca 2þ buffer (n = 16).  ...  We can conclude that miR-208 affects Ca 2þ handling by regulating the expression of proteins involved in phosphorylationdephosphorylation of ryanodine receptors and phospholamban.  ... 
doi:10.1016/j.bpj.2012.11.3360 fatcat:fwlj4nrxmvg3rltaflbaxikvc4

Serca Located in the Junctional SR Shapes Calcium Release in Cardiac Myocytes

Terje R. Kolstad, Mathis K. Stokke, Espen Stang, Sverre H. Brorson, Louch E. William, Ole M. Sejersted
2015 Biophysical Journal  
Rotation of the NBD and SBD around the interdomain linker may play an important role in the allosteric mechanism.  ...  We used pulsed dipolar ESR and ion mobility mass spectroscopy technologies to characterize the conformational ensembles of DnaK in its allosteric states to better understand how the nucleotide and substrates  ...  This local control is possible because of the spatial arrangement of L-type Ca 2þ channels and clusters of ryanodine receptors at the sites of Ca 2þ release (dyads) (Stern 1992) .  ... 
doi:10.1016/j.bpj.2014.11.2756 fatcat:bkv76pv4orfhnlzigsugvmm2tm

Page 4794 of The Journal of Neuroscience Vol. 14, Issue 8 [page]

1994 The Journal of Neuroscience  
The spatial dynamics of Ca?* signaling are crucially affected by the heterogeneous spatial distribution of a variety of plasmalemmal and organellar channel types within the cell. This local [Ca?  ...  +], are affected by the spatial distributions of various Ca?+-increasing molecules (channels and receptors). The ryanodine receptor (RyR) is an intracellular channel through which Ca?  ... 

Models of cardiac excitation–contraction coupling in ventricular myocytes

George S.B. Williams, Gregory D. Smith, Eric A. Sobie, M. Saleet Jafri
2010 Mathematical Biosciences  
With the increase in biophysical and physiological data available, the modeling has become more sophisticated with investigations spanning in scale from molecular components to whole cells.  ...  Mathematical and computational modeling of cardiac excitation-contraction coupling has produced considerable insights into how the heart muscle contracts.  ...  but minimal representation of a whole cell model of CICR incorporating local control.  ... 
doi:10.1016/j.mbs.2010.03.005 pmid:20346962 pmcid:PMC5499386 fatcat:iicxx73mmjdjrlk7pcmkx46s4m

The Latest Waves in Calcium Signaling

Craig Montell
2005 Cell  
Ca 2+ is a universal second messenger that is a key Spatially and temporally controlled changes in Ca 2+ component of myriad processes in all cell types.  ...  of the VOCC in *Correspondence: cmontell@jhmi.edu Cell 158  ...  Such strategies include mutations in PLN with cardiac failure in humans.  ... 
doi:10.1016/j.cell.2005.07.009 pmid:16094745 fatcat:do3gbsfgijfbblbxgqebfofaaq
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