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Gating of the Pore of the Human Ryanodine Receptor Type 2 does not require Glycine Hinges
2013
Biophysical Journal
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Ryanodine receptors (RyRs) form a class of intracellular calcium release channels in various excitable tissues and cells such as muscles and neurons. ...
Here, we compare and relate two distinct approaches of analysing STED microscopy images of RyR2 clusters (cardiac ryanodine receptor type 2). ...
Ryanodine receptors (RyRs) form a class of intracellular calcium release channels in various excitable tissues and cells such as muscles and neurons. ...
doi:10.1016/j.bpj.2012.11.2465
fatcat:6uwxm362gvhsvg4uxfabuhawyi
Structural Insight into the Phosphorylation Domain in Ryanodine Receptors
2013
Biophysical Journal
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Ryanodine receptors (RyRs) form a class of intracellular calcium release channels in various excitable tissues and cells such as muscles and neurons. ...
Here, we compare and relate two distinct approaches of analysing STED microscopy images of RyR2 clusters (cardiac ryanodine receptor type 2). ...
Ryanodine receptors (RyRs) form a class of intracellular calcium release channels in various excitable tissues and cells such as muscles and neurons. ...
doi:10.1016/j.bpj.2012.11.2463
fatcat:gujk5hposrasfbvz2lzrpqmqhi
Modeling a Ryanodine Receptor Amino-Terminal Domain Connecting the Central Vestibule and the Corner Clamp Region
2013
Biophysical Journal
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Ryanodine receptors (RyRs) form a class of intracellular calcium release channels in various excitable tissues and cells such as muscles and neurons. ...
Here, we compare and relate two distinct approaches of analysing STED microscopy images of RyR2 clusters (cardiac ryanodine receptor type 2). ...
Ryanodine receptors (RyRs) form a class of intracellular calcium release channels in various excitable tissues and cells such as muscles and neurons. ...
doi:10.1016/j.bpj.2012.11.2462
fatcat:jvvtcfabwbbbvol7oslhml7woa
Analysis of Fluorescence Microscopy Super-Resolution Data of Protein Assemblies
2013
Biophysical Journal
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Ryanodine receptors (RyRs) form a class of intracellular calcium release channels in various excitable tissues and cells such as muscles and neurons. ...
Here, we compare and relate two distinct approaches of analysing STED microscopy images of RyR2 clusters (cardiac ryanodine receptor type 2). ...
Ryanodine receptors (RyRs) form a class of intracellular calcium release channels in various excitable tissues and cells such as muscles and neurons. ...
doi:10.1016/j.bpj.2012.11.2464
fatcat:xv477wmlfja5vafqfcur3ncyny
Obscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integrity
2013
The Journal of General Physiology
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Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers. J Cell Biol. 1999 Aug 9;146(3):621-30. ...
Deletion of the ryanodine receptor type 3 (RyR3) impairs forms of synaptic plasticity and spatial learning. EMBO J. 1999 Oct 1;18(19):5264-73. ...
doi:10.1085/jgp1414oia9
fatcat:745hbiz3lzhwfeew4qvnkcrq6q
Co-Expression of TRIC-A and Cardiac Ryanodine Receptor affects Store-Overload Induced Calcium Release in HEK293 Cells
2013
Biophysical Journal
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This provides insight into some of the essential properties of the cytoplasmic Ca 2þ regulatory machinery in the posterior pituitary. ...
of 1850 5 485 nM and concentration of 243 5 46 mM for the endogenous Ca 2þ buffer (n = 16). ...
We can conclude that miR-208 affects Ca 2þ handling by regulating the expression of proteins involved in phosphorylationdephosphorylation of ryanodine receptors and phospholamban. ...
doi:10.1016/j.bpj.2012.11.3359
fatcat:yzmt63k53jawfo32qniprdqrtq
Iron (II) Modulation of the Cardiac Ryanodine Receptor (RyR2)
2009
Biophysical Journal
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Early studies showed that protamine (>20mg/ml) inhibits skeletal RyR1 regardless of the cytosolic Ca 2þ levels (Koulen et al., Mol. Biol. Cell. 11:2213-9, 2000. ...
We extended these studies to cardiac RyR2 reconstituted into planar lipid bilayers. We found that protamine (0.2mg/ml) added to the cytosolic surface of 587-Pos Board B466 ...
Stabilisation of cardiac ryanodine receptors (RyR2) has emerged as an important approach for normalising Ca 2þ cycling dysfunction in cardiac disease. ...
doi:10.1016/j.bpj.2008.12.497
fatcat:5xkbsgayznf63frpb5db3dbfo4
Physiological Role(S) of RyR1 in Smooth Muscle Cells
2013
Biophysical Journal
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FKBP12 in the Conformational Dynamics of RyR1 The ryanodine receptor (RyR) is an intracellular ion channel with an important role in depolarization-induced Ca 2þ release in excitable cells. ...
Skeletal Muscle Ryanodine Receptor Ion Channel-FKBP12 Complex by the 1,4-Benzothiazepine Derivative S107 ...
Ryanodine receptors (RyRs) form a class of intracellular calcium release channels in various excitable tissues and cells such as muscles and neurons. ...
doi:10.1016/j.bpj.2012.11.2461
fatcat:aashgm73q5buzjkrmwpq3mei7e
Calcium polymorphic ventricular tachycardia: a new name for CPVT?
2010
Cardiovascular Research
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dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation. ...
The rise of intracellular [Ca 2+ ] that activates the contractile proteins -the systolic Ca 2+ transient -is the spatial and temporal sum of such local releases. ...
Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia, Circulation 2001;103:196-200. 4 George CH, Higgs GV, and Lai FA. ...
doi:10.1093/cvr/cvq128
pmid:20472567
pmcid:PMC2883901
fatcat:e7lw7ekzpncp3jurpxytz3a33u
Ros in Cardiac Calcium Signaling
2013
Biophysical Journal
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This provides insight into some of the essential properties of the cytoplasmic Ca 2þ regulatory machinery in the posterior pituitary. ...
of 1850 5 485 nM and concentration of 243 5 46 mM for the endogenous Ca 2þ buffer (n = 16). ...
We can conclude that miR-208 affects Ca 2þ handling by regulating the expression of proteins involved in phosphorylationdephosphorylation of ryanodine receptors and phospholamban. ...
doi:10.1016/j.bpj.2012.11.3362
fatcat:36lithap5ngkbgxsb37sihy5l4
Temperature Dependence of Ip3-Mediated Signals
2013
Biophysical Journal
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This provides insight into some of the essential properties of the cytoplasmic Ca 2þ regulatory machinery in the posterior pituitary. ...
of 1850 5 485 nM and concentration of 243 5 46 mM for the endogenous Ca 2þ buffer (n = 16). ...
We can conclude that miR-208 affects Ca 2þ handling by regulating the expression of proteins involved in phosphorylationdephosphorylation of ryanodine receptors and phospholamban. ...
doi:10.1016/j.bpj.2012.11.3360
fatcat:fwlj4nrxmvg3rltaflbaxikvc4
Serca Located in the Junctional SR Shapes Calcium Release in Cardiac Myocytes
2015
Biophysical Journal
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Rotation of the NBD and SBD around the interdomain linker may play an important role in the allosteric mechanism. ...
We used pulsed dipolar ESR and ion mobility mass spectroscopy technologies to characterize the conformational ensembles of DnaK in its allosteric states to better understand how the nucleotide and substrates ...
This local control is possible because of the spatial arrangement of L-type Ca 2þ channels and clusters of ryanodine receptors at the sites of Ca 2þ release (dyads) (Stern 1992) . ...
doi:10.1016/j.bpj.2014.11.2756
fatcat:bkv76pv4orfhnlzigsugvmm2tm
Page 4794 of The Journal of Neuroscience Vol. 14, Issue 8
[page]
1994
The Journal of Neuroscience
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The spatial dynamics of Ca?* signaling are crucially affected by the heterogeneous spatial distribution of a variety of plasmalemmal and organellar channel types within the cell. This local [Ca? ...
+], are affected by the spatial distributions of various Ca?+-increasing molecules (channels and receptors). The ryanodine receptor (RyR) is an intracellular channel through which Ca? ...
Models of cardiac excitation–contraction coupling in ventricular myocytes
2010
Mathematical Biosciences
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With the increase in biophysical and physiological data available, the modeling has become more sophisticated with investigations spanning in scale from molecular components to whole cells. ...
Mathematical and computational modeling of cardiac excitation-contraction coupling has produced considerable insights into how the heart muscle contracts. ...
but minimal representation of a whole cell model of CICR incorporating local control. ...
doi:10.1016/j.mbs.2010.03.005
pmid:20346962
pmcid:PMC5499386
fatcat:iicxx73mmjdjrlk7pcmkx46s4m
The Latest Waves in Calcium Signaling
2005
Cell
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Ca 2+ is a universal second messenger that is a key Spatially and temporally controlled changes in Ca 2+ component of myriad processes in all cell types. ...
of the VOCC in *Correspondence: cmontell@jhmi.edu Cell 158 ...
Such strategies include mutations in PLN with cardiac failure in humans. ...
doi:10.1016/j.cell.2005.07.009
pmid:16094745
fatcat:do3gbsfgijfbblbxgqebfofaaq
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