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Central neurogenetic signatures of the visuomotor integration system
2020
Proceedings of the National Academy of Sciences of the United States of America
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In this study, we used neuroimaging connectomic approaches to map the visuomotor integration (VMI) system in the human brain and investigated the topology approximation of the VMI network to the Allen ...
Human Brain Atlas, a whole-brain transcriptome-wide atlas of cortical genetic expression. ...
Human Brain Atlas, a whole-brain transcriptome-wide atlas of cortical genetic expression. ...
doi:10.1073/pnas.1912429117
pmid:32144139
fatcat:i7kmer7uffcgfdfi5oketza5du
Untapped Neuroimaging Tools for Neuro-Oncology: Connectomics and Spatial Transcriptomics
2022
Cancers
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Magnetic resonance imaging (MRI) is instrumental for the diagnosis and treatment monitoring of patients with brain tumors. ...
These normative analyses are uncommonly used in neuro-oncology research. Once the data have been normalized, voxel-wise analyses and spatial mapping can be performed. ...
The resulting spatial maps of those analyses can then be used as input for the spatial transcriptomics analysis outlined on the right side of the figure. ...
doi:10.3390/cancers14030464
pmid:35158732
pmcid:PMC8833690
fatcat:ly35atvdzvf7jft2dgzighnfti
Regional expression profiles of risk genes for depression are associated with brain activation patterns in emotion and reward tasks
[article]
2020
bioRxiv
pre-print
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Here, we estimated the spatial association between genome-wide transcriptome maps and brain activation patterns from functional magnetic resonance imaging (fMRI) with two established paradigms of great ...
The identification of multiple subordinate genes correlated with fMRI maps and their corresponding regulators presumably will reshape the prospects for neuroimaging genetics. ...
Acknowledgements We thank the students of the Laboratory of Systems Neuroscience and Imaging in Psychiatry ...
doi:10.1101/2020.06.27.175257
fatcat:itzsynemejbdjdnnth7rhfree4
From online resources to collaborative global neuroscience research: where are we heading?
2020
Neuroscience Research Notes
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The most visible contributions from neuroinformatics include the myriad reference atlases of brain anatomy (human and other mammals such as rodents, primates and pig), gene and protein sequences and the ...
Neuroinformatics is an emerging sub-field of neuroscience which focuses on addressing the unique technological and computational challenges to integrate and analyze the increasingly high-volume, multi-dimensional ...
The BigBrain is an ultrahighresolution three-dimensional (3D) reconstruction of the whole human brain, from cell-body stained histology, with 20 micrometres isotropic resolution. ...
doi:10.31117/neuroscirn.v3i3.51
fatcat:ffjk3qexf5evhj73a43thh7ubi
Cortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human Brain
2021
Frontiers in Human Neuroscience
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This connectomic-transcriptome approach thus identifies gene expression profiles associated with high creative ability, linking cognitive flexibility to neural plasticity in the human brain. ...
Our findings reveal strong spatial correlations between connectivity maps and sets of genes devoted to synaptic assembly and signaling. ...
The AHBA provides whole-brain expression distributions for six human subjects (Hawrylycz et al., 2012) . ...
doi:10.3389/fnhum.2021.694274
pmid:34381343
pmcid:PMC8350487
fatcat:3qsp6w7c2jbjzipiw5b3p2tf6q
Distinct genetic signatures of cortical and subcortical regions associated with human memory
2019
eNeuro
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Here, we devised an unsupervised framework that relies on spatial correlations between human transcriptome data and functional neuroimaging maps to uncover the genetic signatures of memory in functionally-defined ...
Despite the discovery of gene variants linked to memory performance, understanding the genetic basis of adult human memory remains a challenge. ...
Data were provided by the Allen Institute for Brain Science and the Neurosynth repository. ...
doi:10.1523/eneuro.0283-19.2019
pmid:31818829
pmcid:PMC6917897
fatcat:qltfeg6mejf2pdteif4psqxr2e
The ENIGMA Toolbox: Cross-disorder integration and multiscale neural contextualization of multisite neuroimaging datasets
[article]
2020
bioRxiv
pre-print
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yielded some of the largest studies of the healthy and diseased brain. ...
Here, we introduce the ENIGMA Toolbox, a Python/Matlab ecosystem for (i) accessing ENIGMA datasets, allowing for cross-disorder analysis, (ii) visualizing data on brain surfaces, and (iii) contextualizing ...
P.M.T. received partial grant support from Biogen, Inc., and consulting payments from Kairos Venture Capital, Inc., for work unrelated to ENIGMA and this manuscript. ...
doi:10.1101/2020.12.21.423838
fatcat:attlmrhftzhtbp4csnq4pthgni
Brain transcriptome atlases: a computational perspective
2016
Brain Structure and Function
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The immense complexity of the mammalian brain is largely reflected in the underlying molecular signatures of its billions of cells. ...
Brain transcriptome atlases provide valuable insights into gene expression patterns across different brain areas throughout the course of development. ...
, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. ...
doi:10.1007/s00429-016-1338-2
pmid:27909802
pmcid:PMC5406417
fatcat:zflsrogrsze53jro2ayrcdffs4
Recent Technical Advances in Accelerating the Clinical Translation of Small Animal Brain Imaging: Hybrid Imaging, Deep Learning, and Transcriptomics
2022
Frontiers in Medicine
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Advances in structural, functional, and molecular imaging using MRI, PET, fluorescence imaging, and optoacoustic imaging have enabled the interrogation of the rodent brain across a large temporal and spatial ...
Small animal models play a fundamental role in brain research by deepening the understanding of the physiological functions and mechanisms underlying brain disorders and are thus essential in the development ...
The development of 7 T human MRI allows imaging of the living human brain at the mesoscopic level with a high spatial and temporal signal-to-noise ratio (SNR) (7, 8) . ...
doi:10.3389/fmed.2022.771982
pmid:35402436
pmcid:PMC8987112
fatcat:63egkkymnfcixj6piv4tnkl73m
Whole-Cortex Mapping of Common Genetic Influences on Depression and Social Deficits
[article]
2018
bioRxiv
pre-print
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a toolbox that maps genetic and environmental associations between brain and behavior at high resolution. ...
However, heritability varies within brain regions, so a high-resolution genetic perspective is needed.Method In a sample of 258 same-sex twin pairs from the Colorado Longitudinal Twin Study (LTS), we developed ...
Finally, using high-resolution analysis and MNI coordinates allows for integration with functional and transcriptomics literature more broadly. imaging data passed quality control were included. ...
doi:10.1101/500827
fatcat:bijafpghwvgehgj3xfbdpfzx4q
Connectivity adaptations in dopaminergic systems define the brain maturity of investors
2021
Scientific Reports
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As experience is capable of molding both the structure and function of the human brain, we have used a novel neuroimaging connectomic-genetic approach to investigate the influence of investment work experience ...
AbstractInvestment decisions rely on perceptions from external stimuli along with the integration of inner brain-body signals, all of which are shaped by experience. ...
The AHBA provides high-resolution genome-wide expression values for six human subjects, quantifying more than 20,000 genes in 3702 samples spatially distributed throughout the brain 56 . ...
doi:10.1038/s41598-021-91227-x
pmid:34083626
fatcat:yx2jn47jpvanxek4mvidcpf6eu
Autism excitation-inhibition imbalance linked to brain hyperconnectivity: An analysis based on 657 autistic subjects
[article]
2022
bioRxiv
pre-print
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The large heterogeneity in autism spectrum disorder (ASD) is a major drawback for the development of therapies. ...
The two subtypes did not differ in structural imaging metrics in any of the regions analyzed (64 cortical and 14 subcortical), nor in any of the behavioral scores (including Intelligence Quotient, ADI ...
Acknowledgments The authors are really pleased to thank Amaia Iribar Zabala for her fantastic work at the initial stage of this ...
doi:10.1101/2022.07.14.500131
fatcat:dwkp26gq4jhwpfvyctfigjfhmi
Neuroscience in the era of functional genomics and systems biology
2009
Nature
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Methods for network analysis and systems biology offer the promise of integrating these multiple levels of data, connecting molecular pathways to nervous system function. ...
One of the most exciting and challenging frontiers in neuroscience involves harnessing the power of large-scale genetic, genomic and phenotypic data sets, and the development of tools for data integration ...
Coppola, who helped with several figures and provided critical comments on the manuscript; M. Oldham, for his pioneering use of WGCNA in the brain; and D. ...
doi:10.1038/nature08537
pmid:19829370
pmcid:PMC3645852
fatcat:em76lkwtljeennjp34u6gpl7hi
Integrated transcriptomic and neuroimaging brain model decodes biological mechanisms in aging and Alzheimer's disease
2021
eLife
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However, generative brain models of aging and AD are limited in incorporating the measures of these biological factors at different spatial resolutions. ...
Here, we propose a personalized bottom-up spatiotemporal brain model that accounts for the direct interplay between hundreds of RNA transcripts and multiple macroscopic neuroimaging modalities (PET, MRI ...
Acknowledgements This research was undertaken by funding from the Canada First Research Excellence Fund, awarded to McGill University for the Healthy Brains for Healthy Lives Initiative, the Fonds de la ...
doi:10.7554/elife.62589
fatcat:xsjoim5fdjevdf4qfcdhhbxpgy
Whole-cortex mapping of common genetic influences on depression and a social deficits dimension
2019
Translational Psychiatry
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We developed a toolbox that maps genetic and environmental associations between brain and behavior at high resolution. ...
We then overlapped the two maps to generate coordinates that allow for tests of downstream effects of genes influencing our clusters. ...
Acknowledgements This research was supported by NIH grants MH063207, AG046938, and MH016880. Cold Spring Harbor Laboratory hosted the preprint for this manuscript on Bioarchive. ...
doi:10.1038/s41398-019-0611-6
pmid:31727881
pmcid:PMC6856353
fatcat:6e5emmu2nve3foxhotl5x5ps6a
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