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Sparse Dose Painting Based on a Dual-Pass Kinetic-Oxygen Mapping of Dynamic PET Images [chapter]

Kuangyu Shi, Sabrina T. Astner, Liang Sun, Nassir Navab, Fridtjof Nüsslin, Peter Vaupel, Jan J. Wilkens
2011 Lecture Notes in Computer Science  
This paper proposes a novel framework to optimize the dose prescription based on dual-pass modeling of dynamic [ 18 F]FMISO PET images.  ...  Dose efficiency is defined using the linear-quadratic model. The radiosensitivity given by the oxygen tension is estimated using a dual-pass kinetic-oxygen mapping strategy.  ...  Supported by BMBF MobiTUM project (01EZ0826) and DFG Cluster of Excellence: Munich-Centre for Advanced Photonics.  ... 
doi:10.1007/978-3-642-23623-5_61 fatcat:m3hspp3vx5aspct2daei6npbay

Imaging Tumor Hypoxia to Advance Radiation Oncology

Chen-Ting Lee, Mary-Keara Boss, Mark W. Dewhirst
2014 Antioxidants and Redox Signaling  
Future Directions: A better understanding of the mechanisms of tumor hypoxia with non-invasive imaging will provide a basis for improved radiation therapeutic practices. Antioxid.  ...  Significance: Most solid tumors contain regions of low oxygenation or hypoxia. Tumor hypoxia has been associated with a poor clinical outcome and plays a critical role in tumor radioresistance.  ...  It is important to consider the dynamic properties of tumor oxygenation with cycling hypoxia when planning IMRT hypoxia imaged-guided dose painting treatment plans.  ... 
doi:10.1089/ars.2013.5759 pmid:24329000 pmcid:PMC4060775 fatcat:sfymwzq4unce3nehgzbz7zl6qe

An introduction to molecular imaging in radiation oncology: A report by the AAPM Working Group on Molecular Imaging in Radiation Oncology (WGMIR)

Michael T. Munley, George C. Kagadis, Kiaran P. McGee, Assen S. Kirov, Sunyoung Jang, Sasa Mutic, Robert Jeraj, Lei Xing, J. Daniel Bourland
2013 Medical Physics (Lancaster)  
For the radiation oncology physicist in particular, these methods and their roles in molecular imaging of oncologic processes are reviewed with respect to their physical bases and imaging characteristics  ...  Molecular imaging is the direct or indirect noninvasive monitoring and recording of the spatial and temporal distribution of in vivo molecular, genetic, and/or cellular processes for biochemical, biological  ...  on PET image quality and accuracy  ... 
doi:10.1118/1.4819818 pmid:24089890 fatcat:ec24iaifgvfork4uvfb3vmpnli

Proceedings of the World Molecular Imaging Congress 2021, October 5-8, 2021: General Abstracts

2022 Molecular Imaging and Biology  
Conclusions: An efficient, iterative deconvolution algorithm with a novel resolution subsets-based approach that operates on patient DICOM images has been used for quantitative improvement in MRI clinical  ...  An efficient rapidly converging deconvolution algorithm with a novel resolution subsets-based approach RSEMD for improving the quantitative accuracy of previously reconstructed clinical MRI images by commercial  ...  Using serial image-based ROI data from 4-48h p.i., prospective Lu-177 dosimetry was estimated assuming complete local absorption of β particles only.  ... 
doi:10.1007/s11307-021-01693-y pmid:34982365 pmcid:PMC8725635 fatcat:4sfb3isoyfdhfbiwxfr55gvqym

A combined local and global motion estimation and compensation method for cardiac CT

Qiulin Tang, Beshan Chiang, Akinola Akinyemi, Alexander Zamyatin, Bibo Shi, Satoru Nakanishi, Bruce R. Whiting, Christoph Hoeschen
2014 Medical Imaging 2014: Physics of Medical Imaging  
(United States) Conference 9033: Physics of Medical Imaging Graphical analysis is employed in the research setting to provide quantitative estimation of PET tracer kinetics from dynamic images at a single  ...  A set of published kinetic parameters and the XCAT phantom were employed for the simulation of dynamic multi-bed acquisitions.  ...  2 cm) in tens of minutes yielding images containing millions of spectra. Spectra are then automatically classified as one of seven cell-types in prostate tissue in a matter of seconds.  ... 
doi:10.1117/12.2043492 fatcat:fyzpc5m6jbh7fjohqpdmtzkhte

Proceedings of the World Molecular Imaging Congress 2020, October 7-9, 2020: General Abstracts

2022 Molecular Imaging and Biology  
Conclusion: Tumor specific uptake of pan800 provided remarkable contrast and a flexible imaging window for fluorescence-guided identification of HGGs despite modest EGFR expression.  ...  Targeted imaging and therapeutic attempts could benefit a significant HGG population.  ...  become more correlated (D7-D9), and finally show a decrease of MC due to formation of abnormal blood vessels (D10-D15).  ... 
doi:10.1007/s11307-021-01691-0 pmid:34982363 pmcid:PMC8725637 fatcat:ipn7hwekzzh6nbsk6dr2mzuhhm

Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment

Dominika Skwierawska, José Antonio López-Valverde, Marcin Balcerzyk, Antonio Leal
2022 Cancers  
The success of BNCT depends mainly on the sufficient spatial biodistribution of 10B located around or within neoplastic cells to produce a high-dose gradient between the tumor and healthy tissue.  ...  Regardless, not only imaging methods but also proteomics and gene expression methods will facilitate BNCT becoming a modality of personalized medicine.  ...  PET using [ 18 F]FBPA is a useful treatment strategy for BNCT and the technique of determination of the boron concentration in tumor and normal tissues based on [ 18 F]FBPA molecular imaging has developed  ... 
doi:10.3390/cancers14122865 pmid:35740531 pmcid:PMC9221296 fatcat:6l44xp73hvbqvd5nurw5fzgwgi

A proton range telescope for quality assurance in hadrontherapy

D.A. Watts, U. Amaldi, A. Go, Y.-H. Chang, W. Hajdas, S. Iliescu, N. Malakhov, J. Samarati, F. Sauli
2009 2009 IEEE Nuclear Science Symposium Conference Record (NSS/MIC)  
The design for a unit PET detector based on crystal follows the trends in current PET research allowing for the depth-of-interaction (DOI) to be measured as well as the time-of-flight (TOF) between the  ...  The first is based on inorganic scintillators (crystals) coupled to a photodetector, having many similarities to conventional PET hardware for nuclear medicine.  ...  dual-head planar scanner geometry based on MRPC technologies.  ... 
doi:10.1109/nssmic.2009.5402303 fatcat:7mzoyadpe5b65ob6ddphwxrc54

Power pulsing of the CALICE tile hadron calorimeter

Mathias Reinecke
2016 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop (NSS/MIC/RTSD)  
Much of what we know about neutrinos comes from studying neutrino flavour oscillations, whereby one type of neutrino transforms into a different type as it propagates over a large distance.  ...  Nevertheless, as a result of a series of innovative large experiments in the last 20 years, we have learnt a great deal about neutrinos.  ...  M13A-9: A Direct Image Reconstruction Algorithm for PET Scanners Based on Monolithic Crystals Acknowledgments: This work was done as part of the INSERT collaboration, which is supported by the EC: FP7-  ... 
doi:10.1109/nssmic.2016.8069748 fatcat:zjgd7dmfdbhntb4kfwdtrlejhi

ECR 2015 Book of Abstracts - A - Postgraduate Educational Programme

2015 Insights into Imaging  
These are dynamic contrast-enhanced perfusion MRI, T1-mapping in combination with inhalative oxygen as a contrast media, and non-contrast Fourier-decomposition MRI, which allow for a regional analysis  ...  This presentation reviews existing material decomposition methods and patient dose minimisation algorithms with a focus on image-based approaches.  ...  of dose painting, enabled by new technology, is a hot topic for actual research developments.  ... 
doi:10.1007/s13244-015-0386-0 pmid:25708993 pmcid:PMC4349897 fatcat:m7eyvqcwojfpvf3lr5hy6dwjb4

ECR 2016 Book of Abstracts - A - Postgraduate Educational Programme

2016 Insights into Imaging  
These are dynamic contrast-enhanced perfusion MRI, T1-mapping in combination with inhalative oxygen as a contrast media, and non-contrast Fourier-decomposition MRI, which allow for a regional analysis  ...  This presentation reviews existing material decomposition methods and patient dose minimisation algorithms with a focus on image-based approaches.  ...  of dose painting, enabled by new technology, is a hot topic for actual research developments.  ... 
doi:10.1007/s13244-016-0474-9 pmid:26873353 pmcid:PMC4762839 fatcat:itxslbcacjhh3kixfkcwmdbt44

ECR 2013 Book of Abstracts - A - Postgraduate Educational Programme

2013 Insights into Imaging  
These are dynamic contrast-enhanced perfusion MRI, T1-mapping in combination with inhalative oxygen as a contrast media, and non-contrast Fourier-decomposition MRI, which allow for a regional analysis  ...  This presentation reviews existing material decomposition methods and patient dose minimisation algorithms with a focus on image-based approaches.  ...  of dose painting, enabled by new technology, is a hot topic for actual research developments.  ... 
doi:10.1007/s13244-013-0227-y pmid:23468009 pmcid:PMC3666656 fatcat:yitsk227mba2pl7wcypouf6tz4

ECR 2011 Book of Abstracts - A - Postgraduate Educational Programme

2011 Insights into Imaging  
These are dynamic contrast-enhanced perfusion MRI, T1-mapping in combination with inhalative oxygen as a contrast media, and non-contrast Fourier-decomposition MRI, which allow for a regional analysis  ...  This presentation reviews existing material decomposition methods and patient dose minimisation algorithms with a focus on image-based approaches.  ...  of dose painting, enabled by new technology, is a hot topic for actual research developments.  ... 
doi:10.1007/s13244-011-0078-3 pmid:23100070 pmcid:PMC3533621 fatcat:qa3ln4hhvve2hhumgwwnmykgoe

Effect of MR contrast agents on quantitative accuracy of PET in combined whole-body PET/MR imaging

Cristina Lois, Ilja Bezrukov, Holger Schmidt, Nina Schwenzer, Matthias K. Werner, Jürgen Kupferschläger, Thomas Beyer
2012 European Journal of Nuclear Medicine and Molecular Imaging  
Sponsoring Institutes and Companies The 2011 Nuclear Science Symposium and Medical Imaging Conference is  ...  Technique for Kinetic Parameter Estimation from Dynamic PET Data J.  ...  Kim Pusan National University, Republic of Korea MIC9.S-274 Cluster-Based Priors for MAP PET Image Reconstruction L. Lu 1 , J. Tang 2 , N. Karakatsanis 3 , W. Chen 1 , A.  ... 
doi:10.1007/s00259-012-2190-0 pmid:22890801 fatcat:gaikvxa6hrc2xobeyxp7gyu3ha

Magnetic Resonance Biomarkers in Radiation Oncology

Kiaran P McGee, Ken Hwang, Daniel C Sullivan, John Kurhanewicz, Yanle Hu, Jihong Wang, Wen Li, Josef Debbins, Eric Paulson, Jeffrey R Olsen, Chia-Ho Hua, Lizette Warner (+4 others)
2021 Medical Physics (Lancaster)  
Their appropriate use, however, must be based on knowledge of the physical origin of the biomarker signal, the relationship to the underlying biological processes, and their strengths and limitations.  ...  derived from the MR imaging process.  ...  CONFLICTS OF INTEREST The members of TG294 listed below attest that they have no potential Conflicts of Interest related to the subject matter or materials presented in this document.  ... 
doi:10.1002/mp.14884 pmid:33864283 pmcid:PMC8361924 fatcat:ovov3g4weze43op2jixcftuepq
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