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Secondly, we conducted photo elicitation interviews (PEIs) to assess and differentiate children's attachment figures (Becke and Bongard, 2018a) . ... Finally, these studies on middle childhood are methodologically dominated by adult researchers and their own reflections on attachment, limiting the children's own contribution (Becke and Bongard, 2018a ...doi:10.3389/fpsyg.2018.01201 pmid:30065683 pmcid:PMC6057239 fatcat:i7cy7orbojff5ih6uxrr5u2uqy
Kinetic models have a great potential for metabolic engineering applications. They can be used for testing which genetic and regulatory modifications can increase the production of metabolites of interest, while simultaneously monitoring other key functions of the host organism. This work presents a methodology for increasing productivity in biotechnological processes exploiting dynamic models. It uses multi-objective dynamic optimization to identify the combination of targets (enzymaticdoi:10.1016/j.jbiotec.2016.01.005 pmid:26826510 fatcat:2degkbr5znelpnvsqa5ap43lsi
more »... ations) and the degree of up-or down-regulation that must be performed in order to optimize a set of pre-defined performance metrics subject to process constraints. The capabilities of the approach are demonstrated on a realistic and computationally challenging application: a large-scale metabolic model of Chinese Hamster Ovary cells (CHO), which are used for antibody production in a fed-batch process. The proposed methodology manages to provide a sustained and robust growth in CHO cells, increasing productivity while simultaneously increasing biomass production, product titer, and keeping the concentrations of lactate and ammonia at low values. The approach presented here can be used for optimizing metabolic models by finding the best combination of targets and their optimal level of up/down-regulation. Furthermore, it can accommodate additional trade-offs and constraints with great flexibility.
Dinge als Herausforderung
DISKUSSION Quelle: Sophia Becke ... Sie steht auf und verlässt die Küche für eine Weile.« (08.12.15, teilnehmende Beobachtung im Compound von Saidas Familie) Abbildung 5: Ein Mädchen (2 Jahre) mit der Mutter in der KücheQuelle: Sophia ...doi:10.14361/9783839445136-005 fatcat:4k2rnfayyjgxbgbcf7hh3edqku
Our choice was based on their excluded position as a small clan surrounded by more powerful clans, with this situation preserving distinct concepts of care, family, and childhood (Becke & Bongard, 2018 ... Excluded from this aspect of the clan, women are responsible for the daily farm work and childcare, thus excluding the male clan members from close relationships to infants (Becke & Bongard, 2018) . ...doi:10.1177/1609406918797017 fatcat:cfrzmymmwzd7hbriy2umxecuza
Supplemental material, Supplementary_Material_-_Captions for Attachment as a Collective Resource: Attachment Networks During Middle Childhood in a Cameroonian Clan by Sophia Daphne Becke, Stephan Bongard ...doi:10.25384/sage.7436153 fatcat:wttl74gh4nbvracgsfvrwbeosm
Mathematical models that predict the complex dynamic behaviour of cellular networks are fundamental in systems biology, and provide an important basis for biomedical and biotechnological applications. However, obtaining reliable predictions from large-scale dynamic models is commonly a challenging task due to lack of identifiability. The present work addresses this challenge by presenting a methodology for obtaining high-confidence predictions from dynamic models using time-series data. First,doi:10.1016/j.cmpb.2015.02.001 pmid:25716416 fatcat:nirudps52rcjzhxaj366mcijni
more »... o preserve the complex behaviour of the network while reducing the number of estimated parameters, model parameters are combined in sets of meta-parameters, which are obtained from correlations between biochemical reaction rates and between concentrations of the chemical species. Next, an ensemble of models with different parameterizations is constructed and calibrated. Finally, the ensemble is used for assessing the reliability of model predictions by defining a measure of convergence of model outputs (consensus) that is used as an indicator of confidence. We report results of computational tests carried out on a metabolic model of Chinese Hamster Ovary (CHO) cells, which are used for recombinant protein production. Using noisy simulated data, we find that the aggregated ensemble predictions are on average more accurate than the predictions of individual ensemble models. Furthermore, ensemble predictions with high consensus are statistically more accurate than ensemble predictions with large variance. The procedure provides quantitative estimates of the confidence in model predictions and enables the analysis of sufficiently complex networks as required for practical applications.
BMC Systems Biology
DISKUSSION Quelle: Sophia Becke ... Sie steht auf und verlässt die Küche für eine Weile.« (08.12.15, teilnehmende Beobachtung im Compound von Saidas Familie) Abbildung 5: Ein Mädchen (2 Jahre) mit der Mutter in der KücheQuelle: Sophia ...doi:10.25969/mediarep/13388 fatcat:h4ejgskynvgtrky3gpqb4vanga
Dynamic modelling is one of the cornerstones of systems biology. Many research efforts are currently being invested in the development and exploitation of large-scale kinetic models. The associated problems of parameter estimation (model calibration) and optimal experimental design are particularly challenging. The community has already developed many methods and software packages which aim to facilitate these tasks. However, there is a lack of suitable benchmark problems which allow a fair anddoi:10.1186/s12918-015-0144- arXiv:1407.5856v1 fatcat:d5onob2t6rgmfbizqunlu2j3ea
more »... systematic evaluation and comparison of these contributions. Here we present BioPreDyn-bench, a set of challenging parameter estimation problems which aspire to serve as reference test cases in this area. This set comprises six problems including medium and large-scale kinetic models of the bacterium E. coli, baker's yeast S. cerevisiae, the vinegar fly D. melanogaster, Chinese Hamster Ovary cells, and a generic signal transduction network. The level of description includes metabolism, transcription, signal transduction, and development. For each problem we provide (i) a basic description and formulation, (ii) implementations ready-to-run in several formats, (iii) computational results obtained with specific solvers, (iv) a basic analysis and interpretation. This suite of benchmark problems can be readily used to evaluate and compare parameter estimation methods. Further, it can also be used to build test problems for sensitivity and identifiability analysis, model reduction and optimal experimental design methods. The suite, including codes and documentation, can be freely downloaded from http://www.iim.csic.es/%7egingproc/biopredynbench/.
The company that made the robot, Hanson Robotics, has touted Sophia as the future of artificial intelligence (AI). ... We argue that the media performances of the Sophia robot were choreographed to advance specific political interests. ... The phenomenological notion of 'embodied intelligence' has begun to resonate in the field of robotics research (e.g., Pfeifer and Bongard 2006) . ...doi:10.1007/s00146-020-01104-w fatcat:elabxcljerektdhuniuy34gudy
Dinge als Herausforderung
Bongard, S., Frankenberg, E. & Etzler, S. (im Druck). Die Frankfurter Akkulturationsskala (FRAKK). Göttingen: Hegrefe. ... Zusammen mit Sophia Thubauville (Hg.): Anthropology as Homage, Köln 2018. »The Triangle of Orality. On Language, Culture, and Fieldwork in South Omo«. In: Alexander Meckelburg et al. ...doi:10.14361/9783839445136-018 fatcat:deuyhlju6bhyfozopozqmhraym
National Union Catalog
Title. 1, Bongard, Solomon ‘fSvetnoe p trekh- slolnykh inykh TR520.C45 Chel'fSov, V. S., ed. see Fotograficheskie materialy i protSessy ikh obrabotki. 1957. ... Library see Fegan, Ethel Sophia, 1877- The Cheltenham classification. .. j2d ed., rev.; Cambridge ,Eng., W. Heffer, 1958. 48 Cheltenham Township, Pa. Planning Commission. ...
So befassen sich Sophia Becke und Stephan Bongard mit dem Gebrauch und der Bedeutung von Tüchern in der Kinderpflege und Erziehung in Kamerun (67-99). ...doi:10.5771/0257-9774-2021-1-225 fatcat:rlunbvvg25fm7iodh37myzsxwu
., 1992 Bonfanti, Andrea, 30960 Bong, Mimi, 11402 Bongar, Bruce, 17368 Bongard, Stephan, 24745 Bongers, Ilja L., 21864 Bongers, Raoul M., 15255 Bonicalzi, Vincenzo, 29465 Boniecki, Kurt A., 5723, 32901 ... Borsboom, Denny, 5682, Borsoi, Diane. 14503 Borst, Alexander, 9241 Borsutzky, M., 2428 Borsutzky, Mathias, 19396 Borszcz, George S., 24628 Bortfeld, Heather, 27913 Borthwick, Arlene C., 35845 Borthwick, Sophia ...
Bongard-Levin del mismo instituto; el profesor Dieter Schuh del Seminar für Sprach-und Kulturwissenschaft Zentralasiens de la Universidad de Bonn en Alemania Federal; el profesor A. H. ... University, el profesor Arcadio Schwade de Ruhr Uni-/ersitát-Bochum, el profesor Kwang-kyu Lee de Seoul Naional University, el profesor Bae Ho-hahn de Korea Univeríity, el profesor Tadashi Kawata de Sophia ...doaj:bb2bfaee413d4b3fbeb65dd739a79391 fatcat:2hbw5uiahjgktnxjlrholvms5u
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