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Typen der Melodiebildung in den Tanzsammlungen von Michael Praetorius und Johann Hermann Schein. Am Beispiel ausgewählter Couranten

Sonja Stojak
<span title="">2021</span> <i title="Gesellschaft fur Musiktheorie (GMTH)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/whrr4bvkhje6lbsk63llcwjzbq" style="color: black;">GMTH Proceedings</a> </i> &nbsp;
Sonja Stojak Typen der Melodiebildung in den Tanzsammlungen von Michael Praetorius und Johann Hermann Schein Am Beispiel ausgewählter Couranten ABSTRACT: Im Vorwort zu Terpsichore (1612) schreibt Michael  ...  In contrast, Johann Hermann Schein in his collection Banchetto musicale (1617) composed the dance melodies himself.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.31751/p.48">doi:10.31751/p.48</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vzpurriorvbzbokzeef7mmgg6i">fatcat:vzpurriorvbzbokzeef7mmgg6i</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210119023116/https://storage.gmth.de/proceedings/articles/48/pdf/gmth-proceedings-artikel-48.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/97/c3/97c31c98ce8a2bd4923ff2286cb670c523f2d2cb.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.31751/p.48"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Statistical Machine Translation with Scarce Resources Using Morpho-syntactic Information

Sonja Nießen, Hermann Ney
<span title="">2004</span> <i title="MIT Press - Journals"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/e4yflo6sufcufjwloald7xudm4" style="color: black;">Computational Linguistics</a> </i> &nbsp;
RWTH Aachen RWTH Aachen In statistical machine translation, correspondences between the words in the source and the target language are learned from parallel corpora, and often little or no linguistic knowledge is used to structure the underlying models. In particular, existing statistical systems for machine translation often treat different inflected forms of the same lemma as if they were independent of one another. The bilingual training data can be better exploited by explicitly taking
more &raquo; ... account the interdependencies of related inflected forms. We propose the construction of hierarchical lexicon models on the basis of equivalence classes of words. In addition, we introduce sentence-level restructuring transformations which aim at the assimilation of word order in related sentences. We have systematically investigated the amount of bilingual training data required to maintain an acceptable quality of machine translation. The combination of the suggested methods for improving translation quality in frameworks with scarce resources has been successfully tested: We were able to reduce the amount of bilingual training data to less than 10% of the original corpus, while losing only 1.6% in translation quality. The improvement of the translation results is demonstrated on two German-English corpora taken from the Verbmobil task and the Nespole! task. * Computational Linguistics Volume 30, Number 2 in most statistical machine translation systems. Apart from the improved coverage, the proposed lexicon models enable the disambiguation of ambiguous word forms by means of annotation with morpho-syntactic tags. Overview The article is organized as follows. After briefly reviewing the basic concepts of the statistical approach to machine translation, we discuss the state of the art and related work as regards the incorporation of morphological and syntactic information into systems for natural language processing. Section 2 describes the information provided by morpho-syntactic analysis and introduces a suitable representation of the analyzed corpus. Section 3 suggests solutions for two specific aspects of structural difference, namely, question inversion and separated verb prefixes. Section 4 is dedicated to hierarchical lexicon models. These models are able to infer translations of word forms from the translations of other word forms of the same lemma. Furthermore, they use morpho-syntactic information to resolve categorial ambiguity. In Section 5, we describe how disambiguation between different readings and their corresponding translations can be performed when no context is available, as is typically the case for conventional electronic dictionaries. Section 6 provides an overview of our procedure for training model parameters for statistical machine translation with scarce resources. Experimental results are reported in Section 7. Section 8 concludes the presentation with a discussion of the achievements of this work.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1162/089120104323093285">doi:10.1162/089120104323093285</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/jc5yin2y5na2bgeev5y7v3u634">fatcat:jc5yin2y5na2bgeev5y7v3u634</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170814151239/http://www.aclweb.org/anthology/J04-2003.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/cf/4d/cf4d3a1efd35fd4cb202809720da24039561d60a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1162/089120104323093285"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mitpressjournals.org </button> </a>

Pathogenesis of pruritus

Sonja Ständer, Ulrike Raap, Elke Weisshaar, Martin Schmelz, Thomas Mettang, Hermann Handwerker, Thomas A. Luger
<span title="2011-01-05">2011</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/gkvwqooxznc3pbajl3s7pvuaxe" style="color: black;">Journal der Deutschen Dermatologischen Gesellschaft</a> </i> &nbsp;
Sonja Ständer Competence Center Chronic Pruritus (KCP) Department of Dermatology, University of Münster Von-Esmarch-Straße 58 D-48149 Münster, Germany Tel.: +49-251-83-56501 Fax: +49-251-83-52559  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/j.1610-0387.2011.07585.x">doi:10.1111/j.1610-0387.2011.07585.x</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/21208378">pmid:21208378</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gpx5f2khbjdv3jy2t275tdxbbm">fatcat:gpx5f2khbjdv3jy2t275tdxbbm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200323054350/https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1610-0387.2011.07585.x" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/03/a9/03a9ed1f9f13035511d8b36e1c29f5e90e0980dc.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/j.1610-0387.2011.07585.x"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Supercritical Fluid Chromatography in Natural Product Analysis – An Update

Nora Gibitz Eisath, Sonja Sturm, Hermann Stuppner
<span title="2017-09-22">2017</span> <i title="Georg Thieme Verlag KG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/hhw2xy5d3rcdzffj3ritvlv5ze" style="color: black;">Planta Medica</a> </i> &nbsp;
AbstractThe wide chemical diversity of natural products has challenged analysts all over the world and has been a driving force for the development of innovative technologies since decades. In the last years, supercritical fluid chromatography (SFC) has finally emerged from the shadow of liquid chromatography (LC) and gas chromatography (GC) and has become a powerful tool in modern natural product analysis. Whereas in the past the technique had mainly been restricted to a small group of
more &raquo; ... compounds, it has largely expanded its suitability in the last years and has demonstrated possibilities without boundaries. This mini-review, focused on the latest applications, provides a brief update on the current status of SFC in natural product analysis with the aim to demonstrate its applicability for both polar and nonpolar plant constituents. The approaches cover the whole range of polarity, including carotenoids, flavonoids, water-unstable ginkgolides, and even highly polar triterpene saponins with several sugar residues.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1055/s-0037-1599461">doi:10.1055/s-0037-1599461</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28938494">pmid:28938494</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/mlye7d5a5bftpgovn5mx7xbzue">fatcat:mlye7d5a5bftpgovn5mx7xbzue</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200710085451/https://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1599461.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/3f/ca/3fca69f4d8314e1515b89cacc623fae6495ed9af.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1055/s-0037-1599461"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Spinal Cord Pathology in Alpha-Synuclein Transgenic Mice

Sonja Mendritzki, Saskia Schmidt, Teresa Sczepan, Xin-Ran Zhu, Daniel Segelcke, Hermann Lübbert
<span title="">2010</span> <i title="Hindawi Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ho44hu6idnfvhmsg63sv7jwk2i" style="color: black;">Parkinson&#39;s Disease</a> </i> &nbsp;
Accumulation ofα-synuclein is observed in neurodegenerative diseases like Parkinson's disease and Multiple System Atrophy. In previous studies with transgenic C57BL/6 mice overexpressingα-synuclein carrying the mutations A53T and A30P found in Parkinson's disease or with a parkin-null background, we reported severe mitochondrial impairments in neurons and to a larger extent in glial cells of the mesencephalon. Neuron death was not observed in the brain. Here we show that the mice show severe
more &raquo; ... or impairments in behavioral tests. In addition, these mice exhibit astrocytic cell death in the spinal cord, accompanied by extensive gliosis and microglial activation. This is shown by cell death staining and immunohistochemistry. Ultrastructural analyses revealed severe mitochondrial impairments not only in astrocytes, but also in oligodendrocytes and, to a small extent, in neurons. Thus, the transgenic mice show a profound pathology in glial cells of the spinal cord.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.4061/2010/375462">doi:10.4061/2010/375462</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20976083">pmid:20976083</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2957200/">pmcid:PMC2957200</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/fjasfxquabhxld3w7lockyesd4">fatcat:fjasfxquabhxld3w7lockyesd4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190220221721/http://pdfs.semanticscholar.org/2f77/c976c2602d3b948af6cff9823155b77fb750.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/2f/77/2f77c976c2602d3b948af6cff9823155b77fb750.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.4061/2010/375462"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957200" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Isobutanol Production by Autotrophic Acetogenic Bacteria

Sandra Weitz, Maria Hermann, Sonja Linder, Frank R. Bengelsdorf, Ralf Takors, Peter Dürre
<span title="2021-04-12">2021</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/tkuhrcyiufdxtkdmjqvay6f2ua" style="color: black;">Frontiers in Bioengineering and Biotechnology</a> </i> &nbsp;
In fact, a C. ljungdahlii:ilvE strain carrying pKAIA showed under such conditions an increased isobutanol production by factor 6.5 (Hermann et al., 2021) .  ...  Copyright © 2021 Weitz, Hermann, Linder, Bengelsdorf, Takors and Dürre. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fbioe.2021.657253">doi:10.3389/fbioe.2021.657253</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33912549">pmid:33912549</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8072342/">pmcid:PMC8072342</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/yimkmpuarzfefjp6ggr2xqbyfq">fatcat:yimkmpuarzfefjp6ggr2xqbyfq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210430192735/https://fjfsdata01prod.blob.core.windows.net/articles/files/657253/pubmed-zip/.versions/1/.package-entries/fbioe-09-657253/fbioe-09-657253.pdf?sv=2018-03-28&amp;sr=b&amp;sig=HXKL5uIZv5lcu%2FPcJUqOT%2B2pRxJowobxOfYk3PqRD70%3D&amp;se=2021-04-30T19%3A28%3A04Z&amp;sp=r&amp;rscd=attachment%3B%20filename%2A%3DUTF-8%27%27fbioe-09-657253.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/93/c4/93c4901285d1ae2a54e61822385dfe835cf21a94.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fbioe.2021.657253"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072342" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Necrotizing fasciitis due to Vibrio cholerae non-O1/non-O139 after exposure to Austrian bathing sites

Sonja Hirk, Steliana Huhulescu, Franz Allerberger, Sarah Lepuschitz, Sonja Rehak, Sandra Weil, Elisabeth Gschwandtner, Michael Hermann, Stephanie Neuhold, Alexander Zoufaly, Alexander Indra
<span title="2016-01-29">2016</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/iguqholv45dfvomlihn73uvimm" style="color: black;">Wiener Klinische Wochenschrift</a> </i> &nbsp;
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00508-015-0944-y">doi:10.1007/s00508-015-0944-y</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26825075">pmid:26825075</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4771811/">pmcid:PMC4771811</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3mzetgjcnvax5hd636l7ekd54a">fatcat:3mzetgjcnvax5hd636l7ekd54a</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171009011812/http://publisher-connector.core.ac.uk/resourcesync/data/Springer-OA/pdf/10d/aHR0cDovL2xpbmsuc3ByaW5nZXIuY29tLzEwLjEwMDcvczAwNTA4LTAxNS0wOTQ0LXkucGRm.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b3/bf/b3bffca3d9dd2f68e55538a61f9f14a6e60c79f2.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00508-015-0944-y"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771811" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The response of periodontal cells to kaolinite

Anna Sonja Müller, Klara Janjić, Hassan Shokoohi-Tabrizi, Gunpreet Oberoi, Andreas Moritz, Hermann Agis
<span title="2019-08-16">2019</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/cxemodliwvd3vpqvdcoal6mtdy" style="color: black;">Clinical Oral Investigations</a> </i> &nbsp;
The impact of kaolinite on human periodontal cells is yet unknown. The aim of the study was to assess the response of human periodontal cells to kaolinite. Human periodontal cells were treated with kaolinite at reducing concentrations from 30 to 0.0015 mg/mL and with conditioned medium, which was depleted of kaolinite. Cell viability was evaluated with a resazurin-based toxicity assay, Live-Dead staining, and MTT assay and staining. The pro-angiogenic factors vascular endothelial growth factor
more &raquo; ... VEGF) and interleukin (IL)-6 and IL-8 were quantified via ELISA in periodontal fibroblasts. L-929, a standard cell-line used for cytotoxicity studies, served as control cell line. Composition of kaolinite was verified using energy-dispersive X-ray spectroscopy. Kaolinite in suspension but not in conditioned medium impaired cell viability dose-dependently. VEGF, IL-6, and IL-8 production was not substantially modulated by kaolinite or the conditioned medium in periodontal cells. Overall, kaolinite can decrease cell viability dose-dependently while conditioned medium showed no toxic effect. No pronounced impact of kaolinite on VEGF, IL-6, and IL-8 production was observed. This study provided first insights into the impact of kaolinite on human periodontal cells thereby inferring to the basis for the evaluation of kaolinite as a carrier in regenerative dentistry. Kaolinite, a clay mineral, is successfully used in medicine due to its favorable properties. Also, applications in conservative dentistry are described. However, the response of oral cells to kaolinite is still unclear. Here, we assessed the impact of kaolinite on human periodontal cells.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00784-019-02984-z">doi:10.1007/s00784-019-02984-z</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31420747">pmid:31420747</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/jm5zg63fevdsbkvm55zso56kim">fatcat:jm5zg63fevdsbkvm55zso56kim</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200307065404/https://link.springer.com/content/pdf/10.1007%2Fs00784-019-02984-z.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/8f/1d/8f1d6dea1321cbe3cf4cf9c424f0a503241b99d7.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00784-019-02984-z"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a>

3D Printing—Encompassing the Facets of Dentistry

Gunpreet Oberoi, Sophie Nitsch, Michael Edelmayer, Klara Janjić, Anna Sonja Müller, Hermann Agis
<span title="2018-11-22">2018</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/tkuhrcyiufdxtkdmjqvay6f2ua" style="color: black;">Frontiers in Bioengineering and Biotechnology</a> </i> &nbsp;
This narrative review presents an overview on the currently available 3D printing technologies and their utilization in experimental, clinical and educational facets, from the perspective of different specialties of dentistry, including oral and maxillofacial surgery, orthodontics, endodontics, prosthodontics, and periodontics. It covers research and innovation, treatment modalities, education and training, employing the rapidly developing 3D printing process. Research-oriented advancement in
more &raquo; ... printing in dentistry is witnessed by the rising number of publications on this topic. Visualization of treatment outcomes makes it a promising clinical tool. Educational programs utilizing 3D-printed models stimulate training of dental skills in students and trainees. 3D printing has enormous potential to ameliorate oral health care in research, clinical treatment, and education in dentistry.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fbioe.2018.00172">doi:10.3389/fbioe.2018.00172</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30525032">pmid:30525032</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6262086/">pmcid:PMC6262086</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/e33n7fzqe5h4vdnwb2p6fa5tby">fatcat:e33n7fzqe5h4vdnwb2p6fa5tby</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190222233801/http://pdfs.semanticscholar.org/3e70/a8299d74f7d7b903825a23f5c411d5bedcab.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/3e/70/3e70a8299d74f7d7b903825a23f5c411d5bedcab.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fbioe.2018.00172"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262086" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Contraction dynamics of dental pulp cell rod microtissues

Gunpreet Oberoi, Klara Janjić, Anna Sonja Müller, Barbara Schädl, Andreas Moritz, Hermann Agis
<span title="2019-05-21">2019</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/cxemodliwvd3vpqvdcoal6mtdy" style="color: black;">Clinical Oral Investigations</a> </i> &nbsp;
The factors that contribute to the morphological changes of dental pulp cell-derived microtissues are unknown. Here, we investigated the contraction dynamics of rod-shaped microtissues derived from dental pulp cells and examined the underlying cell signaling pathways. Human dental pulp cells were seeded into agarose molds to assemble into rod-shaped microtissues. Resazurin- and tetrazolium-based cytotoxicity assays, Live/Dead staining, and hematoxylin and eosin staining for histological
more &raquo; ... on of rods were performed. Rod contraction was evaluated and measured for a period of 10 days. The role of TGF-β, phosphoinositide 3-kinase (PI3K)/AKT, and mitogen-activated protein kinase (MAPK) signaling pathway was analyzed. Dental pulp cells readily assembled into rods, maintaining the geometric shape for 48 h. Following this period, they condensed to form stable spheroidal structures that remained vital for 10 days from seeding. Inhibition of phosphoinositide 3-kinase signaling pathway by LY294002 significantly prolonged the diminution in the length of rods formed by dental pulp cells. TGF-β and pharmacological inhibition of TGF-β signaling did not show pronounced effects. Overall, dental pulp cells readily formed rod-shaped patterns of microtissues which, over a period of time, condensed into more stable spheroidal structures. Hence, technologies like bioprinting, using direct fabrication of microtissues need to consider the contraction dynamics. The field of regenerative endodontology will benefit from our findings as it can be applied as a novel platform to test the impact of pharmacological agents, biomaterials, and regenerative approaches including bioprinting.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00784-019-02917-w">doi:10.1007/s00784-019-02917-w</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31115693">pmid:31115693</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/6fid6bh4kzfu5ey3wsmil2wlnu">fatcat:6fid6bh4kzfu5ey3wsmil2wlnu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200509061025/https://link.springer.com/content/pdf/10.1007/s00784-019-02917-w.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c0/82/c0823156e8103a7d75348c016c3f110a1ca8914f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00784-019-02917-w"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a>

IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression

Alexander Thiem, Sonja Hesbacher, Hermann Kneitz, Teresa di Primio, Markus V. Heppt, Heike M. Hermanns, Matthias Goebeler, Svenja Meierjohann, Roland Houben, David Schrama
<span title="2019-09-11">2019</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ylpmmneaw5g43f4f6ghypj6lii" style="color: black;">Journal of Experimental &amp; Clinical Cancer Research</a> </i> &nbsp;
Immune checkpoint inhibition and in particular anti-PD-1 immunotherapy have revolutionized the treatment of advanced melanoma. In this regard, higher tumoral PD-L1 protein (gene name: CD274) expression is associated with better clinical response and increased survival to anti-PD-1 therapy. Moreover, there is increasing evidence that tumor suppressor proteins are involved in immune regulation and are capable of modulating the expression of immune checkpoint proteins. Here, we determined the role
more &raquo; ... of p53 protein (gene name: TP53) in the regulation of PD-L1 expression in melanoma. We analyzed publicly available mRNA and protein expression data from the cancer genome/proteome atlas and performed immunohistochemistry on tumors with known TP53 status. Constitutive and IFN-ɣ-induced PD-L1 expression upon p53 knockdown in wildtype, TP53-mutated or JAK2-overexpressing melanoma cells or in cells, in which p53 was rendered transcriptionally inactive by CRISPR/Cas9, was determined by immunoblot or flow cytometry. Similarly, PD-L1 expression was investigated after overexpression of a transcriptionally-impaired p53 (L22Q, W23S) in TP53-wt or a TP53-knockout melanoma cell line. Immunoblot was applied to analyze the IFN-ɣ signaling pathway. For TP53-mutated tumors, an increased CD274 mRNA expression and a higher frequency of PD-L1 positivity was observed. Interestingly, positive correlations of IFNG mRNA and PD-L1 protein in both TP53-wt and -mutated samples and of p53 and PD-L1 protein suggest a non-transcriptional mode of action of p53. Indeed, cell line experiments revealed a diminished IFN-ɣ-induced PD-L1 expression upon p53 knockdown in both wildtype and TP53-mutated melanoma cells, which was not the case when p53 wildtype protein was rendered transcriptionally inactive or by ectopic expression of p53L22Q,W23S, a transcriptionally-impaired variant, in TP53-wt cells. Accordingly, expression of p53L22Q,W23S in a TP53-knockout melanoma cell line boosted IFN-ɣ-induced PD-L1 expression. The impaired PD-L1-inducibility after p53 knockdown was associated with a reduced JAK2 expression in the cells and was almost abrogated by JAK2 overexpression. While having only a small impact on basal PD-L1 expression, both wildtype and mutated p53 play an important positive role for IFN-ɣ-induced PD-L1 expression in melanoma cells by supporting JAK2 expression. Future studies should address, whether p53 expression levels might influence response to anti-PD-1 immunotherapy.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s13046-019-1403-9">doi:10.1186/s13046-019-1403-9</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31506076">pmid:31506076</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6737652/">pmcid:PMC6737652</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/fyyy7ks2fvajjo7r3hvyxutt5m">fatcat:fyyy7ks2fvajjo7r3hvyxutt5m</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200216201950/https://jeccr.biomedcentral.com/track/pdf/10.1186/s13046-019-1403-9" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/22/83/2283e4fbf207d3a66f9d17ceb12cdb7ef32b5062.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s13046-019-1403-9"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737652" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Cytokine induction by Gram-positive bacteria

Christian Draing, Stefanie Sigel, Susanne Deininger, Stephanie Traub, Rebekka Munke, Christoph Mayer, Lars Hareng, Thomas Hartung, Sonja von Aulock, Corinna Hermann
<span title="">2008</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/doyhwbvmozan5mzji6xml5iipq" style="color: black;">Immunobiology</a> </i> &nbsp;
., 2003) and almost no IL-12 and IFNy induction (Hermann et aI., 2002) , which might be explained by the use of different TLR (Hermann et aI., 2002) .  ...  The increase in TNF release can be explained by a positive feedback of IFNy to the monocyte (Hermann et aI., 2003) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.imbio.2007.12.001">doi:10.1016/j.imbio.2007.12.001</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/18406374">pmid:18406374</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/eft7srankra4len3tzkmveaayy">fatcat:eft7srankra4len3tzkmveaayy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170815230858/https://kops.uni-konstanz.de/bitstream/handle/123456789/8653/Draing_Immunobiol_2008.pdf?sequence=1" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/5d/d9/5dd9fa2546ec59a44f02a1bdcd0aff57d7c05e12.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.imbio.2007.12.001"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Balloon-based Injury to Induce Myointimal Hyperplasia in the Mouse Abdominal Aorta

Grigol Tediashvili, Dong Wang, Hermann Reichenspurner, Tobias Deuse, Sonja Schrepfer
<span title="2018-02-07">2018</span> <i title="MyJove Corporation"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/fun2ww7r2rhm5k7oxcmmrgntwi" style="color: black;">Journal of Visualized Experiments</a> </i> &nbsp;
The use of animal models is essential for a better understanding of MH, one major cause for arterial stenosis.In this article, we demonstrate a murine balloon denudation model, which is comparable with established vessel injury models in large animals. The aorta denudation model with balloon catheters mimics the clinical setting and leads to comparable pathobiological and physiological changes. Briefly, after performing a horizontal incision in the aorta abdominalis, a balloon catheter will be
more &raquo; ... nserted into the vessel, inflated, and introduced retrogradely. Inflation of the balloon will lead to intima injury and overdistension of the vessel. After removing the catheter, the aortic incision will be closed with single stiches. The model shown in this article is reproducible, easy to perform, and can be established quickly and reliably. It is especially suitable for evaluating expensive experimental therapeutic agents, which can be applied in an economical fashion. By using different knockout-mouse strains, the impact of different genes on MH development can be assessed.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3791/56477">doi:10.3791/56477</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29443065">pmid:29443065</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5912362/">pmcid:PMC5912362</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/keqn5e4s6redvlc7rg47uuijqa">fatcat:keqn5e4s6redvlc7rg47uuijqa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190226181000/http://pdfs.semanticscholar.org/756a/d6b78a07bba3b5ddd8d99f58b96b216ca10d.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/75/6a/756ad6b78a07bba3b5ddd8d99f58b96b216ca10d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3791/56477"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912362" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency

Dong Wang, Grigol Tediashvili, Simon Pecha, Hermann Reichenspurner, Tobias Deuse, Sonja Schrepfer
<span title="2017-01-15">2017</span> <i title="MyJove Corporation"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/fun2ww7r2rhm5k7oxcmmrgntwi" style="color: black;">Journal of Visualized Experiments</a> </i> &nbsp;
Bypass grafting is an established treatment method for coronary artery disease. Graft patency continues to be the Achilles heel of saphenous vein grafts. Research models for bypass graft failure are essential for a better understanding of pathobiological and pathophysiological processes during graft patency loss. Large animal models, such as pigs or sheep, resemble human anatomical structures but require special facilities and equipment. This video describes a rat vein interposition model to
more &raquo; ... estigate vein graft patency loss. Rats are inexpensive and easy to handle. Compared to mouse models, the convenient size of rats permits better operability and enables a sufficient amount of material to be obtained for further diverse analysis. In brief, the inferior epigastric vein of a donor rat is harvested and used to replace a segment of the femoral artery. Anastomosis is conducted via single stitches and sealed with fibrin glue. Graft patency can be monitored non-invasively using duplex sonography. Myointimal hyperplasia, which is the main cause for graft patency loss, develops progressively over time and can be calculated from histological cross sections.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3791/54839">doi:10.3791/54839</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28117809">pmid:28117809</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5352261/">pmcid:PMC5352261</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/cytawx2tovao5a7xkstoppel7u">fatcat:cytawx2tovao5a7xkstoppel7u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200207175203/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5352261&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/76/75/76757f99d3cbe815f7c91da652cb6f2c363099d5.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3791/54839"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352261" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Sustainable Energy Management in Data Centers through Collaboration [chapter]

Sonja Klingert, Andreas Berl, Michael Beck, Radu Serban, Marco di Girolamo, Giovanni Giuliani, Hermann de Meer, Alfons Salden
<span title="">2012</span> <i title="Springer Berlin Heidelberg"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2w3awgokqne6te4nvlofavy5a4" style="color: black;">Lecture Notes in Computer Science</a> </i> &nbsp;
In the current decade of rapid expansion of ubiquitous data storage and cloud computing services, the demand for data centre services has seen an enormous increase which is resulting in a continuously rising pressure on the environment in terms of energy consumption and greenhouse gas (GHG) emissions. The recently started project, All4Green, explores potential ICT solutions for collaboration amongst data centers, energy providers, and end-users in order to enable energy providers to save CO2
more &raquo; ... ssions at the very source of energy conversion. This paper presents an overview of objectives and concepts of the research, discussing the so-called data centers' eco-system, the technical approach to collaboration and GreenSLAs as economic incentives.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/978-3-642-33645-4_2">doi:10.1007/978-3-642-33645-4_2</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3t6hcrhicnbfdicamvhek2i4qi">fatcat:3t6hcrhicnbfdicamvhek2i4qi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170829012434/http://fim.uni-passau.de/fileadmin/files/lehrstuhl/meer/publications/pdf/Klingert2012a.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/62/e5/62e5c3a2a8fba802ca439962cb893e468789ecf7.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/978-3-642-33645-4_2"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a>
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