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Current monitoring and innovative predictive modeling to improve care in the pediatric cardiac intensive care unit
2018
Translational Pediatrics
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occurs in a complex biological system (38) . ...
This process is unique and beneficial in its ability to continuously and in real-time calculate the risk of deterioration for a certain patient. ...
doi:10.21037/tp.2018.04.03
pmid:29770293
pmcid:PMC5938248
fatcat:zaqicha6cjfvtearmfrsyo76sm
Long-range Fourier domain optical coherence tomography of the pediatric subglottis
2015
International Journal of Pediatric Otorhinolaryngology
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This technology offers a safe and practical means for in vivo evaluation of lower airway microanatomy in intubated pediatric patients. ...
Images were analyzed for anatomical landmarks and subepithelial histology. Volumetric image sets were rendered into virtual 3D airway models in Mimics software. ...
We wish to thank the patients and families for their cooperation with this study. We also thank the medical staff at Children's Hospital of Orange County for their assistance. ...
doi:10.1016/j.ijporl.2014.11.019
pmid:25532671
pmcid:PMC4297587
fatcat:ml52fy4lgffezdsplmz34ab7xi
Whole-body magnetic resonance imaging in children: state of the art
2015
Radiologia Brasileira
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In pediatrics, it is utilized for both oncologic and non-oncologic indications such as screening and diagnosis of tumors in patients with genetic syndromes, evaluation of disease extent and staging, evaluation ...
It is a rapid and sensitive method, particularly in pediatrics, for detecting and monitoring multifocal lesions in the body as a whole. ...
Additionally, risk for nephrogenic systemic fibrosis in pediatric patients should not be ignored (3, 22) . ...
doi:10.1590/0100-3984.2014.0005
pmid:25987752
pmcid:PMC4433302
fatcat:n2uw4algazexddwjnk5ifzi67a
Meta-analysis of microarray data using a pathway-based approach identifies a 37-gene expression signature for systemic lupus erythematosus in human peripheral blood mononuclear cells
2011
BMC Medicine
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The views presented in this article do not necessarily reflect those of the US Food and Drug Administration. ...
Of all data sets, only data generated with oligonucleotide microarrays were selected for the metaanalysis described in this article. ...
enriched biological pathways were identified using IPA software (Table 3) . ...
doi:10.1186/1741-7015-9-65
pmid:21624134
pmcid:PMC3126731
fatcat:azeedcf6x5gf5nymscxij7r4qm
Molecular Analysis of Central Nervous System Disease Spectrum in Childhood Acute Lymphoblastic Leukemia
2016
Clinical Medicine Insights: Oncology
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Pathway analysis revealed molecular networks and biological pathways dysregulated in response to CNS disease involvement. ...
The identified pathways included the ILK, WNT, B-cell receptor, AMPK, ERK5, and JAK signaling pathways. ...
Their study evaluated leukemic gene expression profiles from the bone marrow of 17 CNSpositive and 26 CNS-negative patients who were matched for risk factors associated with CNS disease involvement. ...
doi:10.4137/cmo.s18180
pmid:26997880
pmcid:PMC4792199
fatcat:lgmhoyeyercuxe2c6tnzeg74kq
Pediatric Temporomandibular Articulation Ankylosis: OPG and RANKL Gene Expression Analysis
2020
Orthopedic Research Online Journal
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The support from the Clinical Research Center, Instituto Nacional de Traumatologia e Ortopedia (INTO) and the Carlos Chagas Filho Foundation for Research Support in the State of Rio de Janeiro (FAPERJ) ...
for research assistance. ...
Processing of biological samples All tissue samples collected were sent to the Jamil Haddad National Institute of Traumatology and Orthopedics (INTO) Clinical Research Center for immediate processing by ...
doi:10.31031/oproj.2020.07.000671
fatcat:umxqu56x2jbbvka2fpx665iw4e
BIG DATA ANALYTICS IN PHARMACOVIGILANCE - A GLOBAL TREND
2021
Asian Journal of Pharmaceutical and Clinical Research
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Analysis of big data in pharmacovigilance is useful for early raising of safety alerts, line listing them for signal detection of drugs and vaccines, and also for their validation. ...
This data are usually collected from doctors and pharmacists in a health-care facility. ...
Similarly, it has also launched other program in connection with the Center for Biologics Evaluation and Research (CBER) focusing surveillance efforts within the sentinel system for vaccine safety, using ...
doi:10.22159/ajpcr.2021.v14i10.42765
fatcat:mt62qbonkjfp3hcl7mnqxmq6r4
Optimization of Image Quality and Organ Absorbed Dose for Pediatric Chest X-Ray Examination: In-House Developed Chest Phantom Study
2022
Radiology Research and Practice
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Briefly, an in-house developed pediatric chest phantom was constructed. ...
This study aimed to identify proper exposure techniques to maintain optimal diagnostic image quality with minimum radiation dose for anteroposterior chest X-ray projection in pediatric patients. ...
Udomsit Snanpanich for their help and suggestion in the phantom construction. anks are due to Pitsanuvej Hospital, Phisanuloke, ailand for providing the CT scanner to obtain CT data. is research study ...
doi:10.1155/2022/3482458
pmid:35469151
pmcid:PMC9034961
fatcat:gyrvg2tbuzaqjhp7ywuxrhqnam
Genetic Influences on Behavioral Outcomes After Childhood TBI: A Novel Systems Biology-Informed Approach
2019
Frontiers in Genetics
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A mixture of biologic pathways and processes are associated with behavioral recovery, specifically genes associated with cell death, inflammatory response, neurotransmitter signaling, and brain development ...
Results: Systems biology methodology identified neuronal systems and neurotransmitter signaling (Glutamate receptor, dopamine, serotonin, and calcium signaling), inflammatory response, cell death, immune ...
Enriched biological processes and pathways included neuronal systems and neurotransmitter signaling (Glutamate receptor, dopamine, serotonin, and calcium signaling), inflammatory response, cell death, ...
doi:10.3389/fgene.2019.00481
pmid:31191606
pmcid:PMC6540783
fatcat:viotqo77ofc33ovgyulufrsck4
Transforming Growth Factor Beta 1: Possible Involvement with Acute Lymphoblastic Leukemia Prognosis in Pediatric Patients
2020
Clinical Oncology and Research
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The present study evaluated polymorphisms of the TGFB1 promoter region and plasma levels of TGFB1 in 104 ALL patients and 115 controls. ...
Both polymorphisms were not associated with ALL susceptibility or risk of relapse and their different genotypes did not alter TGFB1 plasma levels. ...
Fundação Araucária do Paraná, Secretaria da Ciência, Tecnologia e Ensino Superior (SETI), Fundo Estadual para a Infância e Adolescência (FIA/PR), Secretaria da Família e Desenvolvimento Social (SEDS) and ...
doi:10.31487/j.cor.2020.09.11
fatcat:k23kudpr7zcqhat22rzre3iqby
Multiplexed Bead Immunoassays: Advantages and Limitations in Pediatrics
[chapter]
2012
Advances in Immunoassay Technology
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Therefore, the establishment of reference values for the pediatric population and the improvement in the detection of those parameters present in a low concentration in samples constitute new challenges ...
for both, the investigators and the MBIA manufacturers. ...
Julie Ann Chowen for English revision and critical review of the manuscript. ...
doi:10.5772/36024
fatcat:cxgx2bzqkvghngpktz64cb5cqi
Integrative Analysis of MicroRNA-Mediated Gene Signatures and Pathways Modulating White Blood Cell Count in Childhood Acute Lymphoblastic Leukemia
2017
Biomarker Insights
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Here, we analyzed miRNAs and gene expression data from pediatric patients with ALL to identify a signature of miRNAs involved in ALL and their mRNA target genes, molecular networks, and biological pathways ...
In addition, we identified molecular networks and biological pathways, among them PI3/AKT, JAK/STAT, IL-17, TGF-β, apoptosis, IL-15, STAT3, IGF-1, FGF, mTOR, VEGF, NF-kB, and P53 signaling pathways, enriched ...
The analysis revealed that target and nontarget genes are functionally related and involved in similar biological processes. ...
doi:10.1177/1177271917702895
pmid:28469402
pmcid:PMC5397277
fatcat:pdnqniyfqbbkdkyz7hcgzpvfgy
The distinguishable DNA whole genome methylation profile of 2 cases of pediatric precursor B acute lymphoblastic leukaemia (BCP ALL) with prodromal, preleukemic phase: A case report
2018
Medicine
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The biological implication of this observation remains unclear, with many differentially methylated loci involved in many processes like neurogenesis, cell projection organization and adhesion along with ...
leucocyte activation and apoptosis. ...
The genes were enriched in many GO biological processes which were summarized with the software package Revigo [26] to allow for the detection of their major categories (Table 1) . ...
doi:10.1097/md.0000000000012763
pmid:30334962
pmcid:PMC6211912
fatcat:e33iuavdancfdbgnb4lxsokcom
Differential expression of the nuclear-encoded mitochondrial transcriptome in pediatric septic shock
2014
Critical Care
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Increasing evidence supports a role for mitochondrial dysfunction in organ injury and immune dysregulation in sepsis. ...
The nuclear genome may be an important mechanism contributing to alterations in mitochondrial bioenergetic function and outcomes in pediatric sepsis. ...
The NIH had no role in the design, collection, analysis, and interpretation of data, writing of the manuscript, or the decision to submit this manuscript for publication. ...
doi:10.1186/s13054-014-0623-9
pmid:25410281
pmcid:PMC4247726
fatcat:2d6ttrvngzddremodzllit5pj4
Differential expression of the nuclear-encoded mitochondrial transcriptome in pediatric septic shock
2014
Critical Care
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Increasing evidence supports a role for mitochondrial dysfunction in organ injury and immune dysregulation in sepsis. ...
The nuclear genome may be an important mechanism contributing to alterations in mitochondrial bioenergetic function and outcomes in pediatric sepsis. ...
The NIH had no role in the design, collection, analysis, and interpretation of data, writing of the manuscript, or the decision to submit this manuscript for publication. ...
doi:10.1186/preaccept-2292040841290621
pmid:25410281
pmcid:PMC4247726
fatcat:dw37gey43vbezcoxkhhsd4a5ge
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