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Current monitoring and innovative predictive modeling to improve care in the pediatric cardiac intensive care unit

Mary K. Olive, Gabe E. Owens
2018 Translational Pediatrics  
occurs in a complex biological system (38) .  ...  This process is unique and beneficial in its ability to continuously and in real-time calculate the risk of deterioration for a certain patient.  ... 
doi:10.21037/tp.2018.04.03 pmid:29770293 pmcid:PMC5938248 fatcat:zaqicha6cjfvtearmfrsyo76sm

Long-range Fourier domain optical coherence tomography of the pediatric subglottis

Veronika Volgger, Giriraj K. Sharma, Joseph C. Jing, Ya-Sin A. Peaks, Anthony Chin Loy, Frances Lazarow, Alex Wang, Yueqiao Qu, Erica Su, Zhongping Chen, Gurpreet S. Ahuja, Brian J.-F. Wong
2015 International Journal of Pediatric Otorhinolaryngology  
This technology offers a safe and practical means for in vivo evaluation of lower airway microanatomy in intubated pediatric patients.  ...  Images were analyzed for anatomical landmarks and subepithelial histology. Volumetric image sets were rendered into virtual 3D airway models in Mimics software.  ...  We wish to thank the patients and families for their cooperation with this study. We also thank the medical staff at Children's Hospital of Orange County for their assistance.  ... 
doi:10.1016/j.ijporl.2014.11.019 pmid:25532671 pmcid:PMC4297587 fatcat:ml52fy4lgffezdsplmz34ab7xi

Whole-body magnetic resonance imaging in children: state of the art

Sara Reis Teixeira, Jorge Elias Junior, Marcello Henrique Nogueira-Barbosa, Marcos Duarte Guimarães, Edson Marchiori, Marcel Koenigkam Santos
2015 Radiologia Brasileira  
In pediatrics, it is utilized for both oncologic and non-oncologic indications such as screening and diagnosis of tumors in patients with genetic syndromes, evaluation of disease extent and staging, evaluation  ...  It is a rapid and sensitive method, particularly in pediatrics, for detecting and monitoring multifocal lesions in the body as a whole.  ...  Additionally, risk for nephrogenic systemic fibrosis in pediatric patients should not be ignored (3, 22) .  ... 
doi:10.1590/0100-3984.2014.0005 pmid:25987752 pmcid:PMC4433302 fatcat:n2uw4algazexddwjnk5ifzi67a

Meta-analysis of microarray data using a pathway-based approach identifies a 37-gene expression signature for systemic lupus erythematosus in human peripheral blood mononuclear cells

Dhivya Arasappan, Weida Tong, Padmaja Mummaneni, Hong Fang, Shashi Amur
2011 BMC Medicine  
The views presented in this article do not necessarily reflect those of the US Food and Drug Administration.  ...  Of all data sets, only data generated with oligonucleotide microarrays were selected for the metaanalysis described in this article.  ...  enriched biological pathways were identified using IPA software (Table 3) .  ... 
doi:10.1186/1741-7015-9-65 pmid:21624134 pmcid:PMC3126731 fatcat:azeedcf6x5gf5nymscxij7r4qm

Molecular Analysis of Central Nervous System Disease Spectrum in Childhood Acute Lymphoblastic Leukemia

Chindo Hicks, Jitsuda Sitthi-Amorn, Jessica Douglas, Ritika Ramani, Lucio Miele, Vani Vijayakumar, Cynthia Karlson, James Chipeta, Gail Megason
2016 Clinical Medicine Insights: Oncology  
Pathway analysis revealed molecular networks and biological pathways dysregulated in response to CNS disease involvement.  ...  The identified pathways included the ILK, WNT, B-cell receptor, AMPK, ERK5, and JAK signaling pathways.  ...  Their study evaluated leukemic gene expression profiles from the bone marrow of 17 CNSpositive and 26 CNS-negative patients who were matched for risk factors associated with CNS disease involvement.  ... 
doi:10.4137/cmo.s18180 pmid:26997880 pmcid:PMC4792199 fatcat:lgmhoyeyercuxe2c6tnzeg74kq

Pediatric Temporomandibular Articulation Ankylosis: OPG and RANKL Gene Expression Analysis

Valquiria Quinelato
2020 Orthopedic Research Online Journal  
The support from the Clinical Research Center, Instituto Nacional de Traumatologia e Ortopedia (INTO) and the Carlos Chagas Filho Foundation for Research Support in the State of Rio de Janeiro (FAPERJ)  ...  for research assistance.  ...  Processing of biological samples All tissue samples collected were sent to the Jamil Haddad National Institute of Traumatology and Orthopedics (INTO) Clinical Research Center for immediate processing by  ... 
doi:10.31031/oproj.2020.07.000671 fatcat:umxqu56x2jbbvka2fpx665iw4e

BIG DATA ANALYTICS IN PHARMACOVIGILANCE - A GLOBAL TREND

SWETHA RANI AITHA, SRAVANI MARPAKA, CHAKRADHAR T, BHUVANESHWARI E, SWARUPA RANI KASUKURTHI
2021 Asian Journal of Pharmaceutical and Clinical Research  
Analysis of big data in pharmacovigilance is useful for early raising of safety alerts, line listing them for signal detection of drugs and vaccines, and also for their validation.  ...  This data are usually collected from doctors and pharmacists in a health-care facility.  ...  Similarly, it has also launched other program in connection with the Center for Biologics Evaluation and Research (CBER) focusing surveillance efforts within the sentinel system for vaccine safety, using  ... 
doi:10.22159/ajpcr.2021.v14i10.42765 fatcat:mt62qbonkjfp3hcl7mnqxmq6r4

Optimization of Image Quality and Organ Absorbed Dose for Pediatric Chest X-Ray Examination: In-House Developed Chest Phantom Study

Thanyawee Pengpan, Natch Rattanarungruangchai, Juthathip Dechjaithat, Phawinee Panthim, Puntarika Siricharuwong, Ausanai Prapan, Lorenzo Faggioni
2022 Radiology Research and Practice  
Briefly, an in-house developed pediatric chest phantom was constructed.  ...  This study aimed to identify proper exposure techniques to maintain optimal diagnostic image quality with minimum radiation dose for anteroposterior chest X-ray projection in pediatric patients.  ...  Udomsit Snanpanich for their help and suggestion in the phantom construction. anks are due to Pitsanuvej Hospital, Phisanuloke, ailand for providing the CT scanner to obtain CT data. is research study  ... 
doi:10.1155/2022/3482458 pmid:35469151 pmcid:PMC9034961 fatcat:gyrvg2tbuzaqjhp7ywuxrhqnam

Genetic Influences on Behavioral Outcomes After Childhood TBI: A Novel Systems Biology-Informed Approach

Brad G. Kurowski, Amery Treble-Barna, Valentina Pilipenko, Shari L. Wade, Keith Owen Yeates, H. Gerry Taylor, Lisa J. Martin, Anil G. Jegga
2019 Frontiers in Genetics  
A mixture of biologic pathways and processes are associated with behavioral recovery, specifically genes associated with cell death, inflammatory response, neurotransmitter signaling, and brain development  ...  Results: Systems biology methodology identified neuronal systems and neurotransmitter signaling (Glutamate receptor, dopamine, serotonin, and calcium signaling), inflammatory response, cell death, immune  ...  Enriched biological processes and pathways included neuronal systems and neurotransmitter signaling (Glutamate receptor, dopamine, serotonin, and calcium signaling), inflammatory response, cell death,  ... 
doi:10.3389/fgene.2019.00481 pmid:31191606 pmcid:PMC6540783 fatcat:viotqo77ofc33ovgyulufrsck4

Transforming Growth Factor Beta 1: Possible Involvement with Acute Lymphoblastic Leukemia Prognosis in Pediatric Patients

Marla Karine Amarante, Alberto Yoichi Sakaguchi, Marla Karine Amarante, Carlos Eduardo Coral de Oliveira, Carlos Hiroji Hiroki, Fausto Celso Trigo, Maria Angelica Ehara Watanabe
2020 Clinical Oncology and Research  
The present study evaluated polymorphisms of the TGFB1 promoter region and plasma levels of TGFB1 in 104 ALL patients and 115 controls.  ...  Both polymorphisms were not associated with ALL susceptibility or risk of relapse and their different genotypes did not alter TGFB1 plasma levels.  ...  Fundação Araucária do Paraná, Secretaria da Ciência, Tecnologia e Ensino Superior (SETI), Fundo Estadual para a Infância e Adolescência (FIA/PR), Secretaria da Família e Desenvolvimento Social (SEDS) and  ... 
doi:10.31487/j.cor.2020.09.11 fatcat:k23kudpr7zcqhat22rzre3iqby

Multiplexed Bead Immunoassays: Advantages and Limitations in Pediatrics [chapter]

Emma Burgos-Ramos, Gabriel ngel, Jess Argente, Vicente Barrios
2012 Advances in Immunoassay Technology  
Therefore, the establishment of reference values for the pediatric population and the improvement in the detection of those parameters present in a low concentration in samples constitute new challenges  ...  for both, the investigators and the MBIA manufacturers.  ...  Julie Ann Chowen for English revision and critical review of the manuscript.  ... 
doi:10.5772/36024 fatcat:cxgx2bzqkvghngpktz64cb5cqi

Integrative Analysis of MicroRNA-Mediated Gene Signatures and Pathways Modulating White Blood Cell Count in Childhood Acute Lymphoblastic Leukemia

Ritika Ramani, Gail Megason, Jason Schallheim, Cynthia Karlson, Vani Vijayakumar, Srinivasan Vijayakumar, Chindo Hicks
2017 Biomarker Insights  
Here, we analyzed miRNAs and gene expression data from pediatric patients with ALL to identify a signature of miRNAs involved in ALL and their mRNA target genes, molecular networks, and biological pathways  ...  In addition, we identified molecular networks and biological pathways, among them PI3/AKT, JAK/STAT, IL-17, TGF-β, apoptosis, IL-15, STAT3, IGF-1, FGF, mTOR, VEGF, NF-kB, and P53 signaling pathways, enriched  ...  The analysis revealed that target and nontarget genes are functionally related and involved in similar biological processes.  ... 
doi:10.1177/1177271917702895 pmid:28469402 pmcid:PMC5397277 fatcat:pdnqniyfqbbkdkyz7hcgzpvfgy

The distinguishable DNA whole genome methylation profile of 2 cases of pediatric precursor B acute lymphoblastic leukaemia (BCP ALL) with prodromal, preleukemic phase: A case report

Radosław Chaber, Artur Gurgul, Grażyna Wróbel, Anna Tomoń, Sylwia Paszek, Natalia Potocka, Olga Haus, Monika Lejman, Kornelia Łach, Tomasz Szmatoła, Igor Jasielczuk, Blanka Rybka (+5 others)
2018 Medicine  
The biological implication of this observation remains unclear, with many differentially methylated loci involved in many processes like neurogenesis, cell projection organization and adhesion along with  ...  leucocyte activation and apoptosis.  ...  The genes were enriched in many GO biological processes which were summarized with the software package Revigo [26] to allow for the detection of their major categories (Table 1) .  ... 
doi:10.1097/md.0000000000012763 pmid:30334962 pmcid:PMC6211912 fatcat:e33iuavdancfdbgnb4lxsokcom

Differential expression of the nuclear-encoded mitochondrial transcriptome in pediatric septic shock

Scott L Weiss, Natalie Z Cvijanovich, Geoffrey L Allen, Neal J Thomas, Robert J Freishtat, Nick Anas, Keith Meyer, Paul A Checchia, Thomas P Shanley, Michael T Bigham, Julie Fitzgerald, Sharon Banschbach (+5 others)
2014 Critical Care  
Increasing evidence supports a role for mitochondrial dysfunction in organ injury and immune dysregulation in sepsis.  ...  The nuclear genome may be an important mechanism contributing to alterations in mitochondrial bioenergetic function and outcomes in pediatric sepsis.  ...  The NIH had no role in the design, collection, analysis, and interpretation of data, writing of the manuscript, or the decision to submit this manuscript for publication.  ... 
doi:10.1186/s13054-014-0623-9 pmid:25410281 pmcid:PMC4247726 fatcat:2d6ttrvngzddremodzllit5pj4

Differential expression of the nuclear-encoded mitochondrial transcriptome in pediatric septic shock

Scott L Weiss, Natalie Z Cvijanovich, Geoffrey L Allen, Neal J Thomas, Robert J Freishtat, Nick Anas, Keith Meyer, Paul A Checchia, Thomas P Shanley, Michael T Bigham, Julie Fitzgerald, Sharon Banschbach (+5 others)
2014 Critical Care  
Increasing evidence supports a role for mitochondrial dysfunction in organ injury and immune dysregulation in sepsis.  ...  The nuclear genome may be an important mechanism contributing to alterations in mitochondrial bioenergetic function and outcomes in pediatric sepsis.  ...  The NIH had no role in the design, collection, analysis, and interpretation of data, writing of the manuscript, or the decision to submit this manuscript for publication.  ... 
doi:10.1186/preaccept-2292040841290621 pmid:25410281 pmcid:PMC4247726 fatcat:dw37gey43vbezcoxkhhsd4a5ge
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