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Software Defect Prediction Based on Fuzzy Weighted Extreme Learning Machine with Relative Density Information

Shang Zheng, Jinjing Gai, Hualong Yu, Haitao Zou, Shang Gao, Daniela Briola
2020 Scientific Programming  
Finally, two algorithms were proposed to train software defect prediction models based on the weighted extreme learning machine.  ...  To identify software modules that are more likely to be defective, machine learning has been used to construct software defect prediction (SDP) models.  ...  by equation (8) , and then calculate its fuzzy membership value f(x i ) by equation (9) e benefits of identifying software defects lie in two aspects: First, once a software defect is predicted, we  ... 
doi:10.1155/2020/8852705 fatcat:5t5k7ko5c5a6fdkt6gkh2mwwly

NPAS3 variants in schizophrenia: a neuroimaging study

Denise Bernier, Georgina Macintyre, Robert Bartha, Christopher C Hanstock, David McAllindon, Diane Cox, Scot Purdon, Katherine J Aitchison, Benjamin Rusak, Philip G Tibbo
2014 BMC Medical Genetics  
The genetic data will be used to ensure a sample size of 45 participants in each genetic subgroup of patients (with and without NPAS3 variants).  ...  This research is a one-site neuroimaging component of a two-site genetic study involving patients with schizophrenia at early and later stages of illness.  ...  Despite strong support for the involvement of some genes, no defect in a single gene and no pattern of defects in a small set of genes have been identified as contributors to the majority of schizophrenia  ... 
doi:10.1186/1471-2350-15-37 pmid:24674381 pmcid:PMC3986669 fatcat:lzpnvlrpmjhbzhmcf67zdb2ysu

Time-variant 1D photonic crystals using flowing microdroplets

Zefeng Chen, Zehui Yong, Chi Wah Leung, Xuming Zhang, Yihang Chen, Helen L. W. Chan, Yu Wang
2012 Optics Express  
In this paper we propose a time-variant photonic crystal, which can be formed by a stream of wave-length-scale microdroplets flowing through a microfluidic channel.  ...  insights into time-variant optofluidic systems.  ...  Conclusion In this work, we have proposed the concept of time-variant photonic crystals, which not only offers total reconfigurability, but also introduces new features, like time-variant refractive index  ... 
doi:10.1364/oe.20.024330 pmid:23187195 fatcat:n5bjiz7hove53h4pmhatiwzkb4

Erythropoietin modulation of podocalyxin and a proposed erythroblast niche

P. Sathyanarayana, M. P. Menon, O. Bogacheva, O. Bogachev, K. Niss, W. S. Kapelle, E. Houde, J. Fang, D. M. Wojchowski
2007 Blood  
By modulating this select set of cell-surface adhesion molecules and chemokines, Epo is proposed to mobilize erythroblasts from a hypothesized stromal niche and possibly promote reticulocyte egress to  ...  This was further associated with a rapid release of PODXL ؉ reticulocytes to blood.  ...  Acknowledgments The authors thank A. Fiser and K. Miller for expert assistance in manuscript assembly.  ... 
doi:10.1182/blood-2006-11-056465 pmid:17403918 pmcid:PMC1924484 fatcat:kprcx4luprctflomnif3t6ocgu

A Synthesis of Software Evaluation Methodologies and the Proposal of a New Practical Approach

Armin Azarian, Ali Siadat
2011 Journal of Software  
We attempt to propose a new approach in order to assess and quantify the quality of the software evaluation process.  ...  The theoretical approach is based on elaborating a matrix (A n,m ) of software functionalities versus user's scenarios.  ...  There is also a large science handling the internal quality of software with metrics such as: defect density, vocabulary, length, volume, level, difficulty, effort (from Halstead) or the Cyclomatic Complexity  ... 
doi:10.4304/jsw.6.11.2271-2281 fatcat:6ayvmeez6fhsxjphxbcatck5wy

Functional BSND Variants in Essential Hypertension*

2007 American Journal of Hypertension  
Functional consequences of the identified BSND variants were examined using a heterologous expression system.  ...  Conclusions: We conclude that BSND-V43I, a common variant conferring partial loss of function, exhibits significant deviation from Hardy-Weinberg equilibrium in the Ghanaian normotensive control population  ...  All analyses were performed using Stata statistical software (StataCorp., Foster City, CA, 2005).  ... 
doi:10.1016/j.amjhyper.2007.07.003 pmid:17954364 fatcat:xyx64znxhzezplgwpas7mpkdke

Structural analysis of APOB variants, p.(Arg3527Gln), p.(Arg1164Thr) and p.(Gln4494del), causing Familial Hypercholesterolaemia provides novel insights into variant pathogenicity

J. A. Fernández-Higuero, A. Etxebarria, A. Benito-Vicente, A. C. Alves, J. L. R. Arrondo, H. Ostolaza, M. Bourbon, C. Martin
2015 Scientific Reports  
So far, only a few mutations have been reported and characterized as functionally defective in APOB 3,8-12 .  ...  (Gln4494del) variants compared with wild type. We conclude that these changes underlie the defective binding and uptake of p. (Arg1164Thr) and p.(Gln4494del) variants.  ...  It has been proposed that replacement of the Arg3527 promotes a conformational change in ApoB100 causing a rearrangement of a number of charged residues rather than loss of a single receptor-interactive  ... 
doi:10.1038/srep18184 pmid:26643808 pmcid:PMC4672294 fatcat:pg2z6tnpcnhk5j7tzi2xpmerxe

Novel Alternative Splice Variants of Mouse Cdk5rap2

Nadine Kraemer, Lina Issa-Jahns, Gerda Neubert, Ethiraj Ravindran, Shyamala Mani, Olaf Ninnemann, Angela M. Kaindl, Emanuele Buratti
2015 PLoS ONE  
A current model for the microcephaly phenotype invokes a stem cell proliferation and differentiation defect, which has moved the disease into the spotlight of stem cell biology and neurodevelopmental science  ...  Further analysis, initiated on account of a lack of a microcephaly phenotype in these mutant mice, revealed the presence of previously unknown splice variants of the Cdk5rap2 gene that are at least in  ...  of staining density and intensity in hom KO mice.  ... 
doi:10.1371/journal.pone.0136684 pmid:26322982 pmcid:PMC4556188 fatcat:niks6wen5vgplp3k6cavny276y

Novel FGFR1 Variants Are Associated with Congenital Scoliosis

Shengru Wang, Xiran Chai, Zihui Yan, Sen Zhao, Yang Yang, Xiaoxin Li, Yuchen Niu, Guanfeng Lin, Zhe Su, Zhihong Wu, Terry Jianguo Zhang, Nan Wu
2021 Genes  
, including one frameshift and three missense variants.  ...  As a result, the overall protein expressions of c.2334dupC, c.2339T>C and c.1261A>G were reduced to 43.9%, 63.4% and 77.4%, respectively.  ...  As for patient #3 with c.1107G>A, we propose that his skeletal defects are caused by other unknown genetic or environmental factors.  ... 
doi:10.3390/genes12081126 pmid:34440300 pmcid:PMC8393897 fatcat:oaumxinay5g5hincpl3qsfsw44

A catalog of SCN1A variants

Christoph Lossin
2009 Brain & development (Tokyo. 1979)  
It is possible, however, to examine Na v 1.1 mRNA indirectly by looking at a mutant's current density.  ...  All sequence analyses were done with Clone Manager 9 Professional Edition software (Scientific & Educational Software, Cary, NC).  ... 
doi:10.1016/j.braindev.2008.07.011 pmid:18804930 fatcat:nasejb5m6bafrfkqarxvvonhqa

αIIbβ3 variants defined by next-generation sequencing: Predicting variants likely to cause Glanzmann thrombasthenia

Lorena Buitrago, Augusto Rendon, Yupu Liang, Ilenia Simeoni, Ana Negri, Marta Filizola, Willem H. Ouwehand, Barry S. Coller
2015 Proceedings of the National Academy of Sciences of the United States of America  
Based on sequence conservation, MAF, and location on a complete model of αIIbβ3, we selected three novel variants that affect amino acids previously associated with GT for expression in HEK293 cells. αIIb  ...  We identified 114 novel missense variants in ITGA2B (affecting ∼11% of the amino acids) and 68 novel missense variants in ITGB3 (affecting ∼9% of the amino acids).  ...  All reported variants where reviewed and those in which the proposed GT mutant was shown to lead to a defect in receptor expression and function in a recombinant system were categorized as confirmed GT  ... 
doi:10.1073/pnas.1422238112 pmid:25827233 pmcid:PMC4403182 fatcat:acxbxnywwzcxhipdaaysh73cdu

Genome-wide localization of histone variants in Toxoplasma gondii implicates variant exchange in stage-specific gene expression

Sheila C. Nardelli, Natalie C. Silmon de Monerri, Laura Vanagas, Xiaonan Wang, Zoi Tampaki, William J. Sullivan, Sergio O. Angel, Kami Kim
2022 BMC Genomics  
Background Toxoplasma gondii is a protozoan parasite that differentiates from acute tachyzoite stages to latent bradyzoite forms in response to environmental cues that modify the epigenome.  ...  We studied the distribution of the histone variants CenH3, H3.3, H2A.X, H2A.Z and H2B.Z, by genome-wide chromatin immunoprecipitation to understand the role of variant histones in developmental transitions  ...  H2B.Z (previously known as H2BV), is a variant unique to Apicomplexa [12, 18, 19] that has been proposed to be the major histone H2B in T. gondii tachyzoites.  ... 
doi:10.1186/s12864-022-08338-6 pmid:35164683 pmcid:PMC8842566 fatcat:ssql5xjz4rax7i24h2mwizhuta

Association ofCYP2C19*2and*3Genetic Variants with Essential Hypertension in Koreans

Dong-Jik Shin, Jisun Kwon, Ah-Ram Park, Yousun Bae, Eun-Soon Shin, Sungha Park, Yangsoo Jang
2012 Yonsei medical journal  
The aim of the present study was to evaluate the association between two variants, CYP2C19* 2 (681G>A) and CYP2C19*3 (636G>A) and the development of essential hypertension (EH) in Koreans.  ...  In particular, the CYP2C19*3 defective allele may contribute to reduced risk for the development of EH.  ...  In addition, these metabolites have been proposed to play a mechanistic role in the development of high blood pressure (BP). 6 Genetic variants of CYP enzymes have been identified as one of the important  ... 
doi:10.3349/ymj.2012.53.6.1113 pmid:23074110 pmcid:PMC3481368 fatcat:zsqwn2qhxncl7kse4oecchvsdu

Histone Variant H2A.Z and RNA Polymerase II Transcription Elongation

M. S. Santisteban, M. Hang, M. M. Smith
2011 Molecular and Cellular Biology  
Nucleosomes containing histone variant H2A.Z (Htz1) serve to poise quiescent genes for activation and transcriptional initiation.  ...  Second, in the absence of Htz1, the density of nucleosome occupancy is increased over the GAL10p-VPS13 ORF and the chromatin is refractory to remodeling during active transcription.  ...  ., a Robert R. Wagner Fellowship to M.H., and grants GM28920 and GM60444 from the National Institutes of Health to M.M.S.  ... 
doi:10.1128/mcb.01346-10 pmid:21357739 pmcid:PMC3133230 fatcat:il3tuddho5gbjiambxop5jagxe

Transcriptional analysis supports the expression of human snRNA variants and reveals U2 snRNA homeostasis by an abundant U2 variant [article]

Brian Kosmyna, Varun Gupta, Charles C Query
2020 bioRxiv   pre-print
Thus, we identify transcribed snRNA variants and the sequence variation within, and propose mechanisms of transcriptional and posttranscriptional regulation of snRNA levels and pre-mRNA splicing.  ...  Homeostasis of total U2 snRNA level is maintained by altering the ratio of canonical and an abundant U2 snRNA variant.  ...  Despite being proposed at the time of the discovery of snRNA variants, such investigation into mechanisms through which variant snRNAs might regulate alternative splicing has been limited.  ... 
doi:10.1101/2020.01.24.917260 fatcat:nol7inlpwjckjn232dzla3i5uy
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