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The Impact of Bioinformatics on Vaccine Design and Development [chapter]

Ribas‐Aparicio Rosa María, Castelán‐Vega Juan Arturo, Jiménez‐ Alberto Alicia, Monterrubio‐López Gloria Paulina, Aparicio‐ Ozores Gerardo
2017 Vaccines  
Several approaches have been applied to reduce the times and costs of vaccine development, mainly focusing on the selection of appropriate antigens or antigenic structures, carriers, and adjuvants.  ...  One of these approaches is the incorporation of bioinformatics methods and analyses into vaccine development.  ...  This approach to vaccine design has been used mainly to select or design peptide-based vaccines or cross-reactive antigens with the capability of generating immunity against different antigenically divergent  ... 
doi:10.5772/intechopen.69273 fatcat:zobve6c3brd4xh25dl4t5n2aau

Parkinson's Disease Recognition Using Artificial Immune System

Badra Khellat Kihel, Mohamed Benyettou
2011 Journal of Software Engineering and Applications  
This work deals the application of the artificial immune system to discriminate between healthy and people with Parkinson's disease (PWP).  ...  Taking inspiration from natural immune systems, we try to grab useful properties such as automatic recognition, memorization and adaptation.  ...  Use of Artificial Immune System Our system of pattern recognition is based on an approach of recognition by prototypes.  ... 
doi:10.4236/jsea.2011.47045 fatcat:moy7eugf2zhw5ibcghsdzq6leq

Halting the Pandemic - Vaccine and Vaccination a Realistic Path Forward

Bahman Zohuri, Elise Ooi
2021 Acta Scientific Pharmaceutical Sciences  
Recent worldwide COVID-19 pandemic, for example, has put tremendous pressure on pharmaceuticals scientists to be in quest of new drugs and vaccine to treat such deadly disease, and at this point, nobody  ...  knows what price tag has been estimated to develop such a vaccine by multi-drug companies involved with research and development of the drug.  ...  To use one example, in developing vaccines one way to accelerate development is challenge testing.  ... 
doi:10.31080/asps.2021.05.0707 fatcat:noyg4sfpbnanzbldlritzr6vgu

Towards Personalized Vaccines—Tailoring Peptide Vaccines to Demographic Groups and Individuals

2019 Med One  
However, they have been short in combating viral epidemics which are now occurring with increasing frequency; the reasons are primarily due to rapid mutations in RNA viruses.  ...  Alternative procedures are to be found in the new science of vaccinomics where peptide vaccines have come to be recognized as a strong alternative strategy.  ...  Compared with whole cell lysates or proteins, the peptide based approach has an advantage that only epitopes of interest are loaded onto the immune system instead of whole lot of irrelevant antigens that  ... 
doi:10.20900/mo.20190026 fatcat:j2cfifixebfdhd3do5bpeb6zgi

Automatic Software Repair

Martin Monperrus
2018 ACM Computing Surveys  
The uniqueness of this article is that it spans the research communities that contribute to this body of knowledge: software engineering, dependability, operating systems, programming languages, and security  ...  This article presents a survey on automatic software repair. Automatic software repair consists of automatically finding a solution to software bugs without human intervention.  ...  Debroy and Wong [33, 130] propose to use standard mutations from the mutation testing literature to fix programs.  ... 
doi:10.1145/3105906 fatcat:zbrbc6e22rdeja4vfrx7j57g5e

Computer-aided vaccine designing approach against fish pathogens Edwardsiella tarda and Flavobacterium columnare using bioinformatics softwares

Radha Mahendran, Suganya Jeyabaskar, Dinakaran Michael, Agnal Vincent Paul, Gayathri Sitharaman
2016 Drug Design, Development and Therapy  
Acknowledgment We acknowledge Vels Institute of Science, Technology, and Advanced Studies (VISTAS) for providing us with the required infrastructure and support system needed.  ...  Discussion The main aim of this study was to identify potential T-cell epitopes for designing peptide vaccines. An immunoinformatics approach was carried out to perform this study.  ...  By means of different in silico approaches, an attempt has been made in identifying potential peptides that can be used for designing a peptide vaccine.  ... 
doi:10.2147/dddt.s95691 pmid:27284239 pmcid:PMC4883809 fatcat:b43dmm6kkngg3eliugnn7ktbym

Breast cancer vaccination comes to age: impacts of bioinformatics

Sepideh Parvizpour, Jafar Razmara, Yadollah Omidi
2018 BioImpacts  
Acknowledgment The authors like to acknowledge the Research Center for Pharmaceutical Nanotechnology at Tabriz University of Medical Sciences and also the Department of Computer Science, Faculty of Mathematical  ...  Also, the authors would like to thank the Iranian Elite National Foundation "Bonyad Melli Nokhbegan" and the Iranian National Science Foundation (INSF) for the financial support (Grant No: 95005404).  ...  be an effective solution to re-stimulate the immune system.  ... 
doi:10.15171/bi.2018.25 pmid:30211082 pmcid:PMC6128970 fatcat:335r4pvynba7pijwdi3pohodju

Vaccines for Non-Viral Cancer Prevention

Cristina Bayó, Gerhard Jung, Marta Español-Rego, Francesc Balaguer, Daniel Benitez-Ribas
2021 International Journal of Molecular Sciences  
Cancer vaccines are a type of immune therapy that seeks to modulate the host's immune system to induce durable and protective immune responses against cancer-related antigens.  ...  Indeed, research focus has begun to shift to these approaches and some of them are yielding encouraging outcomes.  ...  A healthy individual with an intact immune system and a high risk of cancer would make an ideal target in this context.  ... 
doi:10.3390/ijms222010900 pmid:34681560 pmcid:PMC8535337 fatcat:tgvrkyjrtzhgrh3zlwkodybstq

Infectious disease mRNA vaccines and a review on epitope prediction for vaccine design

Xinhui Cai, Jiao Jiao Li, Tao Liu, Oliver Brian, Jinyan Li
2021 Briefings in Functional Genomics  
In addition to SARS-CoV-2 which caused the pandemic, mRNA vaccines have been developed and tested to prevent infectious diseases caused by other viruses such as Zika virus, the dengue virus, the respiratory  ...  Messenger RNA (mRNA) vaccines have recently emerged as a new type of vaccine technology, showing strong potential to combat the COVID-19 pandemic.  ...  Both used an LNP delivery system.  ... 
doi:10.1093/bfgp/elab027 pmid:34089044 fatcat:4knotvi2frfzta7k26v537psqy

Genomics and vaccine development

C G Gay, R Zuerner, J P Bannantine, H S Lillehoj, J J Zhu, R Green, P P Pastoret
2007 Rev Sci Tech Off Int Epizoot  
gain a better understanding of the molecular pathways underlying pathogen biology, the host immune system, and host-pathogen interactions.  ...  These new tools can be applied to veterinary pathogens to overcome some of the current hurdles in the discovery of highly effective vaccines for farmed livestock and poultry.  ...  Macrophages are important cells of the host immune system and play an important role in dictating the quantity and quality of immunity to microbial pathogens.  ... 
pmid:17633293 fatcat:imbknprhebfzhb2hsoce2zwwg4

Causality, Information and Biological Computation: An algorithmic software approach to life, disease and the immune system [article]

Hector Zenil, Angelika Schmidt, Jesper Tegnér
2016 arXiv   pre-print
instructions and computer programs, viruses as hacking devices, the immune system as a software debugging tool, and diseases as an information-theoretic battlefield where all these forces deploy.  ...  which to view complex diseases like cancer, approaching them afresh from a software-engineering viewpoint that casts evolution in the role of programmer, cells as computing machines, DNA and genes as  ...  Acknowledgements We wish to thank the rest of the Unit of Computational Medicine team at Karolinska Institutet, and the support of AstraZeneca, the Strategic Area Neuroscience (StratNeuro), the Foundational  ... 
arXiv:1508.06538v5 fatcat:riwssr3w6jcnhcswjegpiy5wky

A Recombinant Zika Virus Envelope Protein with Mutations in the Conserved Fusion Loop Leads to Reduced Antibody Cross-Reactivity upon Vaccination

Beatrice Sarah Berneck, Alexandra Rockstroh, Jasmin Fertey, Thomas Grunwald, Sebastian Ulbert
2020 Vaccines  
To exclude the possibility that recombinant E proteins of ZIKV might induce ADE in infections with related flaviviruses, we performed an immunization study with an insect-cell derived E protein containing  ...  Central to most vaccination approaches against flavivirus infections is the envelope (E) protein, which is the major target of neutralizing antibodies.  ...  Results We investigated an FL mutated ZIKV E protein, bearing four point mutations (Equad) on its potential to reduce cross reactivity with other flaviviruses and ADE after vaccination in comparison to  ... 
doi:10.3390/vaccines8040603 pmid:33066262 pmcid:PMC7712286 fatcat:6y5oeehr3vcgfombgyxrquqovq

Artificial Epitope-Based Immunogens in HIV-Vaccine Design [chapter]

Larisa I. Karpenko, Sergei I. Bazhan, Alexey M. Eroshkin, Denis V. Antonets, Anton N. Chikaev, Alexander A. Ilyichev
2018 Advances in HIV and AIDS Control  
In theory this approach helps cope with HIV-1 antigenic variability, focuses immune responses on protective determinants and enables to exclude from the vaccine compound adverse regions of viral proteins  ...  One of the promising approaches for designing HIV vaccines is construction of synthetic polyepitope HIV-1 immunogen using a wide range of conservative T-and B-cell epitopes of the main virus antigens.  ...  Acknowledgments This work was presented on the international conference "Vaccines & Vaccination", Moscow, September 27-October 1, 2017 sponsored by Russian Science Fund  ... 
doi:10.5772/intechopen.77031 fatcat:3geee44e6nebxds5tifbcouc4e

IDS: An Immune-Inspired Approach for the Detection of Software Design Smells

Salima Hassaine, Foutse Khomh, Yann-Gael Gueheneuc, Sylvie Hamel
2010 2010 Seventh International Conference on the Quality of Information and Communications Technology  
With our parallel, we propose a novel approach built on models of the immune system responses to pathogenic material. We show that our approach can detect more than one smell at a time.  ...  We build and test our approach on GanttProject v1.10.2 and Xerces v2.7.0, for which manually-validated and publiclyavailable smells exist.  ...  This work was partially supported by the NSERC Research Chair in Software Patterns and Patterns of Software and the FQRNT.  ... 
doi:10.1109/quatic.2010.61 dblp:conf/quatic/HassaineKGH10 fatcat:dn5m2rmhtrdilactiqfhjbqnnu

Engineering superior DNA vaccines: MHC class I single chain trimers bypass antigen processing and enhance the immune response to low affinity antigens

Lijin Li, John M. Herndon, Steven M. Truscott, Ted H. Hansen, Timothy P. Fleming, Peter Goedegebuure, William E. Gillanders
2010 Vaccine  
Disulfide trap SCT (dtSCT) have been engineered to improve peptide binding, with mutations designed to create a disulfide bond between the class I heavy chain and the peptide linker. dtSCT DNA vaccines  ...  In this study, we tested the efficacy of progressive generations of SCT DNA vaccines engineered to (1) enhance peptide binding, (2) enhance interaction with the CD8 coreceptor, and/or (3) activate CD4  ...  Q115E mutation enhances SCT interaction with CD8 co-receptor SCT are recognized as intact molecules by the immune system, providing the ability to further engineer these constructs to enhance T cell activation  ... 
doi:10.1016/j.vaccine.2009.10.096 pmid:20188246 pmcid:PMC2830906 fatcat:q4rclgmrenai7pmthbkeplhqle
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