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Smooth Orchestrators [chapter]

Cosimo Laneve, Luca Padovani
2006 Lecture Notes in Computer Science  
A smooth orchestrator is a process with several alternative branches, every one defining synchronizations among co-located channels.  ...  Smooth orchestrators may be created in one location and migrated to a different one, still not manifesting problems that usually afflict generic mobile agents.  ...  The implementation of smooth orchestrators Smooth orchestrators are small pieces of code that may migrate over the network for reaching the location where they execute.  ... 
doi:10.1007/11690634_3 fatcat:u3cpjouwezb4xisfsub47drs2y

Orchestration of vascular smooth muscle cell plasticity using epigenetic therapy

Thomas Thum
2022 European Heart Journal  
This editorial refers to 'The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell-monocyte crosstalk and protects against atherosclerosis via the NF-κB pathway', by F.M.  ...  Orchestration or misorchestration of vascular signalling pathways can lead to vascular homeostasis or development of early atherosclerosis, respectively.  ...  Excitingly, smooth muscle cell-based inactivation of DOT1L significantly reduced the progression of atherosclerosis in ApoE −/− mice fed a high-fat diet.  ... 
doi:10.1093/eurheartj/ehac200 pmid:35452116 fatcat:npw3t7njufbitou4gu4nfvqqge

MicroRNAs orchestrating senescence of endothelial and vascular smooth muscle cells

Ornella Colpani, Gaia Spinetti
2019 Vascular Biology  
In this short review, we describe the main features of senescence of endothelial and smooth muscle cells and focus on the role non-coding RNAs of the microRNAs class in controlling this process.  ...  Figure 1 Aging-associated phenotypes of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs).  ...  Both endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) are affected by acquiring a senescent phenotype with distinct characteristics as briefly described below (Fig. 1 ).  ... 
doi:10.1530/vb-19-0017 pmid:32923957 pmcid:PMC7439843 fatcat:yv3re2zfnzhgjoceuwsonmuzpe

UHRF1 epigenetically orchestrates smooth muscle cell plasticity in arterial disease

Leonardo Elia, Paolo Kunderfranco, Pierluigi Carullo, Marco Vacchiano, Floriana Maria Farina, Ignacio Fernando Hall, Stefano Mantero, Cristina Panico, Roberto Papait, Gianluigi Condorelli, Manuela Quintavalle
2018 Journal of Clinical Investigation  
Adult vascular smooth muscle cells (VSMCs) dedifferentiate in response to extracellular cues such as vascular damage and inflammation.  ...  UHRF1 epigenetically orchestrates smooth muscle cell plasticity in arterial disease ited luciferase activity when the reporter construct included the WT but not the mutated (mt) putative microRNA seed  ...  Ang-II infusion (Sigma-Aldrich, catalog A9525; 1,000 ng/ Taken together, our data not only show that Uhrf1 orchestrates the VSMC phenotype but also suggest that UHRF1 is a potential target for therapeutic  ... 
doi:10.1172/jci96121 pmid:29558369 pmcid:PMC5983314 fatcat:zykr4rmotnasdmxvrxq53jjrzi

Smooth Muscle Cells Orchestrate the Endothelial Cell Response to Flow and Injury

M. Balcells, J. Martorell, C. Olive, M. Santacana, V. Chitalia, A. A. Cardoso, E. R. Edelman
2010 Circulation  
Key Words: blood flow Ⅲ endothelium Ⅲ mammalian target of rapamycin (mTOR) Ⅲ molecular biology Ⅲ muscle, smooth Ⅲ signal transduction Ⅲ stents  ...  Background-Local modulation of vascular mammalian target of rapamycin (mTOR) signaling reduces smooth muscle cell (SMC) proliferation after endovascular interventions but may be associated with endothelial  ...  Phenotypic and functional characterization of endothelial and smooth muscle cells seeded on fibronectin coated tubes Endothelial (EC) and smooth muscle cell (SMC) coverage was determined using a MATLAB  ... 
doi:10.1161/circulationaha.109.877282 pmid:20458015 pmcid:PMC2887340 fatcat:cbijthmmxjgxzjfcpjlr5rpqsm

Mitochondria can orchestrate sex differences in cell fate of vascular smooth muscle cells from rats

E. Straface, R. Vona, I. Campesi, F. Franconi
2015 Biology of Sex Differences  
Conclusions: Our results suggest that (i) mitochondria, being producers of ROS, can orchestrate sex differences in cell fate of VSMC and (ii) mitochondrial dysfunction may be a significant mechanism by  ...  In basal conditions, vascular smooth muscle cells freshly isolated from aortas of male and female rats display marked sex differences in terms of redox balance and susceptibility to ultraviolet radiation-induced  ...  Abbreviations Cyt c: cytochrome c; FVSMC: vascular smooth muscle cells isolated from female rats; IAPs: inhibitors of apoptosis protein; MMP: mitochondrial membrane potential; MVSMC: vascular smooth muscle  ... 
doi:10.1186/s13293-015-0051-9 pmid:26677409 pmcid:PMC4681081 fatcat:cpfy3zraavbthk3q2titognfdu

Vascular Smooth Muscle Cells Orchestrate the Assembly of Type I Collagen via α2β1 Integrin, RhoA, and Fibronectin Polymerization

Shaohua Li, Caroline Van Den Diepstraten, Sudhir J. D'souza, Bosco M.C. Chan, J. Geoffrey Pickering
2003 American Journal of Pathology  
To determine whether vascular smooth muscle cells (SMCs) impact the formation of collagen fibrils, we microscopically tracked the conversion of soluble to insoluble collagen in human SMC cultures, using  ...  The major source of type I collagen in the vasculature is vascular smooth muscle cells (SMCs).  ...  SMCs orchestrated the formation of a robust fibril network at concentrations of precursor well Figure 5 .  ... 
doi:10.1016/s0002-9440(10)63464-5 pmid:12937145 pmcid:PMC1868248 fatcat:u6vu6zcxzvbp3naaunk47q5mcu

Cytosolic Hsp60 orchestrates the survival and inflammatory responses of vascular smooth muscle cells in injured aortic vessels

Boae Choi, Mina Choi, Charny Park, Eun Kyung Lee, Dong Hoon Kang, Doo Jae Lee, Jae Yoon Yeom, Yeonjoo Jung, Jaesang Kim, Sanghyuk Lee, Sang Won Kang
2015 Cardiovascular Research  
Aims Pro-inflammatory response of vascular smooth muscle cells (VSMCs) is triggered by endothelial damage and a causative step for thrombosis and neointimal thickening in the injured arterial vessels.  ...  The tissue sections of the injured carotid vessels were subjected to the IF staining for a-smooth muscle actin and TUNEL staining.  ...  Introduction Endothelial layer in the arterial vessels protects the differentiated vascular smooth muscle cells (VSMCs) from the blood-origin harmful substances, such as cigarette smoke, microbial derivatives  ... 
doi:10.1093/cvr/cvv130 pmid:25870185 fatcat:yiwd66jo6vcxhbpvxz3h4twcnu

Page 889 of New Outlook Vol. 60, Issue 14 [page]

1898 New Outlook  
Address “hj ANGELUS ORCHESTRAL -f f ALONE » 7/Z Mi — WS  ...  We offer fine old violins possess- ing a smooth and mellow tone, dated 1570 to 1810, from $25 upward; Artists’ violins from $50 to $250.  ... 

Nurses Keeping Patients Safe By Managing Risk in Perioperative Settings: A Classic Grounded Theory Study

Brid O'Brien, Tom Andrews, Eileen Savage
2019 Journal of Nursing Management  
Nurses achieve this through four categories: macro orchestrating, locational orchestrating, situational orchestrating and being in the know.  ...  Orchestrating is fundamental in promoting safety and minimizing risk of errors and adverse events in the perioperative setting.  ...  Understanding the strategy of orchestrating offers a comprehensive explanation and understanding of how nurses in the perioperative setting ensure that error and adverse events are minimised.  ... 
doi:10.1111/jonm.12829 pmid:31306522 fatcat:bqwyh44oojg5ddftic2ry5wlom

CCN2: A novel conductor in orchestration of orofacial tissue development and remodeling

Akira Yamaguchi
2012 Japanese Dental Science Review  
CCN2 is expressed in not only a variety of cells, including fibroblasts, endothelial cells, chondrocytes, osteoblasts, and smooth muscles under physiological conditions but also some inflammatory cells  ...  The execution of specific functions during development and remodeling in various tissues requires an ingenious conductor that orchestrates the molecules involved in these processes.  ... 
doi:10.1016/j.jdsr.2012.06.003 fatcat:hfikemgsbvarzetfs2na7jpsxm

Last Word on Point:Counterpoint "Release of an endothelium-derived vasoconstrictor and RhoA/Rho kinase-mediated calcium sensitization of smooth muscle cell contraction are/are not the main effectors for full and sustained HPV"

T. P. Robertson
2007 Journal of applied physiology  
Meldrum, Lahn, and Yuan and agree that HPV is most certainly a well orchestrated multi-factorial process. Subjectively, it's the endothelium, dummy! REFERENCES 1. Aaronson PI, Robertson TP, Ward JPT.  ...  Indeed, when considering potential "damage" to smooth muscle and the resultant effects on function, I would concur with Dr.  ...  Meldrum, Lahn, and Yuan and agree that HPV is most certainly a well orchestrated multi-factorial process. Subjectively, it's the endothelium, dummy!  ... 
doi:10.1152/japplphysiol.00002.2007 fatcat:kk5hzga5a5he7fpb33q7zlaiv4

Helping Educators to Orchestrate Learning Situations Involving Multiple Physical and Virtual Spaces

Juan Alberto Muñoz-Cristóbal
2013 European Conference on Technology Enhanced Learning  
However, the orchestration of such learning situations is still a challenge for teachers. Some approaches try to help teachers in these scenarios using Augmented Reality and authoring tools.  ...  This PhD thesis explores how to help teachers in the orchestration of this kind of learning situations, allowing the use of a range of existing authoring and enactment technologies, pedagogies and types  ...  AR is used to smooth transitions between physical and Web spaces, allowing to access learning artifacts from different spaces.  ... 
dblp:conf/ectel/Munoz-Cristobal13 fatcat:ulauze3z2jcb3gzzwvrtbqu6o4

Data Fusion of Observability Signals for Assisting Orchestration of Distributed Applications

Ioannis Tzanettis, Christina-Maria Androna, Anastasios Zafeiropoulos, Eleni Fotopoulou, Symeon Papavassiliou
2022 Sensors  
However, such frameworks provide information that is disjoint from the management information that is usually collected by cloud computing orchestration platforms.  ...  In this paper, we provide a modern observability approach and pilot implementation for tackling data fusion aspects in edge and cloud computing orchestration platforms.  ...  Integrated visualization capabilities in the orchestration environment. Figure 10 . 10 Figure 10. Request rate and latencies variation under the smooth workload. Figure 11 . 11 Figure 11.  ... 
doi:10.3390/s22052061 pmid:35271207 pmcid:PMC8915136 fatcat:4l4ejimuxbbz5jn53aagix6ndm

Page 410 of SMPTE Motion Imaging Journal Vol. 68, Issue 6 [page]

1959 SMPTE Motion Imaging Journal  
The louder the music, the easier will it be to make a smooth cut — even to the extent of disregarding matching orchestral timbres.  ...  Another hint towards a successful joint is provided by identical or simi- lar fullness and character of orchestration.  ... 
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