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Versatile Nanosystem-Based Cancer Theranostics: Design Inspiration and Predetermined Routing

Yaw Opoku-Damoah, Ruoning Wang, Jianping Zhou, Yang Ding
2016 Theranostics  
"smart" nanosystems to concurrently discharge both therapeutic and diagnostic roles.  ...  The relevance of personalized medicine, aimed at a more individualized drug therapy, has inspired research into nano-based concerted diagnosis and therapeutics (theranostics).  ...  light for "smart" release of drugs and diagnostic agents.  ... 
doi:10.7150/thno.14860 pmid:27217832 pmcid:PMC4876623 fatcat:72623cuvonabzj6znykg3ghuoy

Recent progress in drug delivery

Chong Li, Jiancheng Wang, Yiguang Wang, Huile Gao, Gang Wei, Yongzhuo Huang, Haijun Yu, Yong Gan, Yongjun Wang, Lin Mei, Huabing Chen, Haiyan Hu (+2 others)
2019 Acta Pharmaceutica Sinica B  
Drug delivery systems (DDS) are defined as methods by which drugs are delivered to desired tissues, organs, cells and subcellular organs for drug release and absorption through a variety of drug carriers  ...  It is a valuable reference for pharmaceutical scientists who want to learn more about the design of drug delivery systems.  ...  A transistor-like pH nanoprobe for tumour detection and image-guided surgery. Nat Biomed Eng 2016;1:0006. 50. Luo M, Wang H, Wang ZH, Cai HC, Lu ZG, Li Y, et al.  ... 
doi:10.1016/j.apsb.2019.08.003 pmid:31867161 pmcid:PMC6900554 fatcat:cq6tpflkbra6zl5mioqlzdtosu

Smart multifunctional drug delivery towards anticancer therapy harmonized in mesoporous nanoparticles

Seonmi Baek, Rajendra K. Singh, Dipesh Khanal, Kapil D. Patel, Eun-Jung Lee, Kam W. Leong, Wojciech Chrzanowski, Hae-Won Kim
2015 Nanoscale  
Effectiveness of the delivery of anticancer drugs and the efficacy of cancer therapy can be enhanced using smart multifunctional mesoporous nanoparticles.  ...  Acknowledgements The Faculty of Pharmacy in University of Sydney for funding to support the international honours  ...  Therefore, the combination of magnetic nanoparticles with MSNPs constitutes a promising alternative for drug delivery with a high loading capacity and target-specificity and magnetic properties for targeting  ... 
doi:10.1039/c5nr02730f pmid:26260245 fatcat:o4sslnddwraunleewxemtvgdki

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

Sabya Sachi Das, Priyanshu Bharadwaj, Muhammad Bilal, Mahmood Barani, Abbas Rahdar, Pablo Taboada, Simona Bungau, George Z. Kyzas
2020 Polymers  
, enzymes, temperature, redox values, hypoxia, glucose levels) or exogenous (light, magnetism, ultrasound, electrical pulses) for the effective biodistribution and controlled release of drugs or genes  ...  drugs, proteins, genes, nucleic acids, etc., in pharmaceutical and biomedical applications.  ...  nanosystem-based drug delivery nanosystem for cancer treatment.  ... 
doi:10.3390/polym12061397 pmid:32580366 fatcat:tah3wuq7lnecrfoghwxjigv4ou

Cyclodextrin-Modified Nanomaterials for Drug Delivery: Classification and Advances in Controlled Release and Bioavailability

Daniel Andrés Real, Karen Bolaños, Josefina Priotti, Nicolás Yutronic, Marcelo J. Kogan, Rodrigo Sierpe, Orlando Donoso-González
2021 Pharmaceutics  
The goals of this review are to give in-depth knowledge and critical appraisal of the main CD-modified or CD-based nanomaterials for drug delivery, such as lipid-based nanocarriers, natural and synthetic  ...  frameworks, Janus nanoparticles, and nanofibers.  ...  Cyclodextrin based nanoparticles for drug delivery and theranostics. Adv. Pharm. Bull. 2020, 10, 166–183.  ... 
doi:10.3390/pharmaceutics13122131 pmid:34959412 pmcid:PMC8706493 fatcat:g64vnyrhpnebveekjqq3tcqrgi

Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

María Vallet-Regí, Ferdi Schüth, Daniel Lozano, Montserrat Colilla, Miguel Manzano
2022 Chemical Society Reviews  
This review details the huge progress in the design and development of mesoporous silica nanoparticles for biomedical applications during the last two decades.  ...  Notes and references  ...  Acknowledgements The authors acknowledge financial support from The European Research Council through the ERC-2015-AdG-694160 (VERDI) project and the Spanish ''Ministerio de Ciencia e Innovacio ´n'' through  ... 
doi:10.1039/d1cs00659b pmid:35642539 pmcid:PMC9252171 fatcat:az22ohdv75g2zjxpay3bxqx43y

Single- versus Dual-Targeted Nanoparticles with Folic Acid and Biotin for Anticancer Drug Delivery

Magdalena Jurczyk, Katarzyna Jelonek, Monika Musiał-Kulik, Artur Beberok, Dorota Wrześniok, Janusz Kasperczyk
2021 Pharmaceutics  
These ligands are used in both, single- and dual-targeted systems although the latter are still a novel approach.  ...  This review presents the recent achievements in the development of single- or dual-targeted nanoparticles for anticancer drug delivery.  ...  In order to specifically target and eradicate cancer cells, there is a requirement for precise distinguishing target cells (tumour cells) from non-target cells and development of smart drug delivery platforms  ... 
doi:10.3390/pharmaceutics13030326 pmid:33802531 fatcat:khtce73yuvgjten3c3hhy57pye

Peptide-Based Drug-Delivery Systems in Biotechnological Applications: Recent Advances and Perspectives

Diego Tesauro, Antonella Accardo, Carlo Diaferia, Vittoria Milano, Jean Guillon, Luisa Ronga, Filomena Rossi
2019 Molecules  
address nanosystems toward specific targets.  ...  Recently, peptides achieved resounding success in drug delivery and in nanomedicine smart applications.  ...  Acknowledgments: Vittoria Milano thanks the Università Italo-Francese (UIF) for financial post-doc support (project Bando VINCI 2016, C4-4).  ... 
doi:10.3390/molecules24020351 pmid:30669445 pmcid:PMC6359574 fatcat:6ysin44kbfh53g5tsdxa6kkti4

Leveraging Physiology for Precision Drug Delivery

Wujin Sun, Quanyin Hu, Wenyan Ji, Grace Wright, Zhen Gu
2017 Physiological Reviews  
Pu et al. (347) demonstrated a ROS/pHresponsive nanosystem for targeted delivery of a model anti-inflammatory drug curcumin.  ...  Then we will focus on the latest drug delivery platform, nanocarriers, with cancer as a model disease to describe the physiological barriers and corresponding strategies for target drug delivery.  ... 
doi:10.1152/physrev.00015.2016 fatcat:psvehsnpi5dwpaklz3ti5sc35a

Recent advances in the preparation and application of multifunctional iron oxide and liposome-based nanosystems for multimodal diagnosis and therapy

Marzia Marciello, Juan Pellico, Irene Fernandez-Barahona, Fernando Herranz, Jesus Ruiz-Cabello, Marco Filice
2016 Interface Focus  
We also thank MINECO for grant MAT2013-47303-P, SAF2016-79593-P and for the research grant no.  ...  The CNIC is supported by the Spanish Ministry of Economy and Competitiveness (MINECO) and the Pro CNIC Foundation and by Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505).  ...  Their targeting at inflammatory cells has confirmed their virtue as effective agents for intraplaque inflammation detection and may allow targeted drug delivery and release to stabilize plaques before  ... 
doi:10.1098/rsfs.2016.0055 pmid:27920894 pmcid:PMC5071816 fatcat:3fhumsgxzfefjnr2rgupd77jrq

Porphyrin NanoMetal-Organic Frameworks as Cancer Theranostic Agents

Flávio Figueira, João Tomé, Filipe Paz
2022 Molecules  
Metal-Organic Frameworks (MOFs) are hybrid multifunctional platforms that have found remarkable applications in cancer treatment and diagnostics.  ...  clinical treatment and diagnostic theranostic tools.  ...  Noteworthy, since drugs commonly used in cancer treatment often cause side effects, MOF modulation can provide a clever drug delivery and release systems for more effective chemotherapy [66] .  ... 
doi:10.3390/molecules27103111 pmid:35630585 pmcid:PMC9147750 fatcat:ie77kj4o3famlde5ippjhgxxvy

Nanotechnology and Glycosaminoglycans: Paving the Way Forward for Ovarian Cancer Intervention

2018 International Journal of Molecular Sciences  
to act as "intelligent" drug delivery vehicles, functionalized with active targeting approaches for precision delivery of chemotherapeutics to overexpressed biomarkers on cancer cells.  ...  for glycosaminoglycans (GAGs) as a more focused extracellular molecular target.  ...  To this end, sole active targeting approaches may require additional aid of passive targeting interventions as a combination strategy for cancer drug delivery.  ... 
doi:10.3390/ijms19030731 pmid:29510526 pmcid:PMC5877592 fatcat:adcdvnyhqzdgvnfxdt2tztszfu

Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment

Piotr Gierlich, Ana I. Mata, Claire Donohoe, Rui M. M. Brito, Mathias O. Senge, Lígia C. Gomes-da-Silva
2020 Molecules  
This active targeting can be achieved by direct conjugation of the PS to a ligand with enhanced affinity for a target overexpressed on cancer cells and/or other cells of the tumor microenvironment.  ...  Photodynamic therapy (PDT) is a promising cancer treatment which involves a photosensitizer (PS), light at a specific wavelength for PS activation and oxygen, which combine to elicit cell death.  ...  Targeted drug delivery in the context of cancer is mainly achieved by two approaches: passive and active targeting.  ... 
doi:10.3390/molecules25225317 pmid:33202648 fatcat:obel6pt4hrex3bplb25yg2p5ha

Luminescent Silica Nanoparticles for Cancer Diagnosis

W. Arap, R. Pasqualini, M. Montalti, L. Petrizza, L. Prodi, E. Rampazzo, N. Zaccheroni, S. Marchio
2013 Current Medicinal Chemistry  
also a few non targeted systems have been cited and discussed for completeness.  ...  NPs constitute also a versatile platform that can allow facile multi-functionalization to perform multimodal imaging or theranostic (simultaneous diagnosis and therapy).  ...  as well, confirming no significant bowel or systemic toxicity, and no systemic detection. 85 Using a different approach, a smart targeting sensor for the tumor microenvironment was designed to be activatable  ... 
doi:10.2174/0929867311320170005 pmid:23458621 pmcid:PMC4309985 fatcat:es5fgql7dvfmlddayb57ifgcoy

Host-Guest Chemistry in Supramolecular Theranostics

Guocan Yu, Xiaoyuan Chen
2019 Theranostics  
diagnosis and specific delivery of drugs to lesion sites.  ...  The dynamic nature of the non-covalent interactions and selective host-guest complexation endow the resultant nanomaterials with intriguing properties, holding promising potentials in theranostic fields  ...  and targeted drug delivery [229] .  ... 
doi:10.7150/thno.31653 pmid:31244941 pmcid:PMC6567976 fatcat:u2kuyhdvcrfnjcnx6srameyqvu
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