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Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia

Michael Ewers, Reisa A. Sperling, William E. Klunk, Michael W. Weiner, Harald Hampel
2011 Trends in Neurosciences  
Recent studies that have identified AD-like structural and functional brain changes in elderly people who are cognitively within the normal range or who have mild cognitive impairment (MCI) are discussed  ...  In this Review, we discuss various neuroimaging measures that are proving to have potential value as biomarkers of AD pathology for the detection and prediction of AD before the onset of dementia.  ...  award 08/IN.1/ B1846 (to HH), the "Landesoffensive zur Entwicklung wissenschaftlich-ökonomischer Exzellenz" (LOEWE)  ... 
doi:10.1016/j.tins.2011.05.005 pmid:21696834 pmcid:PMC3275347 fatcat:6dk62eqplrhlvckqy2c7cwcqdm

Exercise-Related Changes of Networks in Aging and Mild Cognitive Impairment Brain

Pei Huang, Rong Fang, Bin-Yin Li, Sheng-Di Chen
2016 Frontiers in Aging Neuroscience  
Aging and mild cognitive impairment (MCI) are accompanied by decline of cognitive functions.  ...  Small decreases in the conversion rate of MCI to AD might significantly reduce the prevalence of dementia. Thus, it is important to intervene at the preclinical stage.  ...  This work was supported by grants from the National Natural Science Foundation of China (91332107, 30872729, 30971031, 81400888) and The Training and Financial Program for Young Doctors of Shanghai (  ... 
doi:10.3389/fnagi.2016.00047 pmid:27014055 pmcid:PMC4779936 fatcat:ghqcar5pzrc6fh4gefvsyteui4

Functional network disruption in the degenerative dementias

Michela Pievani, Willem de Haan, Tao Wu, William W Seeley, Giovanni B Frisoni
2011 Lancet Neurology  
These network abnormalities are somewhat specifi c to the clinical syndromes and, in Alzheimer's disease and frontotemporal dementia, network disruption tracks the pattern of pathological changes.  ...  A better understanding of network disruption in the neurodegenerative dementias might help bridge the gap between molecular changes, pathological changes, and symptoms.  ...  ", "mild cognitive impairment", "Parkinson", "Lewy bodies dementia", "stroke", and "tumour" from 1986 until June, 2011.  ... 
doi:10.1016/s1474-4422(11)70158-2 pmid:21778116 pmcid:PMC3219874 fatcat:filrmsouujckzp3evyfj7l7ngi

Predicting the transition from normal aging to Alzheimer's disease: A statistical mechanistic evaluation of FDG-PET data

Marco Pagani, Alessandro Giuliani, Johanna Öberg, Andrea Chincarini, Silvia Morbelli, Andrea Brugnolo, Dario Arnaldi, Agnese Picco, Matteo Bauckneht, Ambra Buschiazzo, Gianmario Sambuceti, Flavio Nobili
2016 NeuroImage  
This paved the way to the quantitative assessment of the functional networking status in individual patients.  ...  We demonstrated for the first time the reliability of a single global index of order in discriminating groups of cognitively impaired patients with different clinical outcome.  ...  Acknowledgements The authors wish to thank Professor Stone-Elander for the help in English editing.  ... 
doi:10.1016/j.neuroimage.2016.07.043 pmid:27453158 fatcat:qvqf5gzlqfei5iiussemus4wl4

Functional neuroimaging in subjective cognitive decline: current status and a research path forward

Raymond P. Viviano, Jessica S. Damoiseaux
2020 Alzheimer's Research & Therapy  
Although healthy older adults with subjective cognitive decline may function normally, perceived worsening may indicate incipient dementia and predict future deterioration.  ...  Thus, disorder-agnostic brain measures could be useful to track the trajectory of decline, and functional neuroimaging in particular may be sensitive to detect incipient dementia and have the ability to  ...  Salience network gray matter atrophy occurs at a greater rate in cognitively unimpaired aging than the rest of the brain, and atrophy is even greater in mild cognitive impairment and dementia, and this  ... 
doi:10.1186/s13195-020-00591-9 pmid:32151277 fatcat:mefmeuwjojf2nkb3yuo2yisoqi

Disrupted Network Topology in Patients with Stable and Progressive Mild Cognitive Impairment and Alzheimer's Disease

Joana B. Pereira, Mite Mijalkov, Ehsan Kakaei, Patricia Mecocci, Bruno Vellas, Magda Tsolaki, Iwona Kłoszewska, Hilka Soininen, Christian Spenger, Simmon Lovestone, Andrew Simmons, Lars-Olof Wahlund (+2 others)
2016 Cerebral Cortex  
However, the alterations that occur in network topology during the prodromal stages of AD, particularly in patients with stable mild cognitive impairment (MCI) and those that show a slow or faster progression  ...  to dementia, are still poorly understood.  ...  Funding This study was supported by InnoMed, (Innovative Medicines in Europe) an Integrated Project funded by the European Union of the Sixth Framework program priority FP6-2004-LIFESCIHEALTH-5, Life Sciences  ... 
doi:10.1093/cercor/bhw128 pmid:27178195 pmcid:PMC4961019 fatcat:ml7psqk7sbfehjnrhqjskswaki

Functional Neural Correlates of Anosognosia in Mild Cognitive Impairment and Alzheimer's Disease: a Systematic Review

Jaime D. Mondragón, Natasha M. Maurits, Peter P. De Deyn
2019 Neuropsychology Review  
of anosognosia in mild cognitive impairment (MCI) and Alzheimer's disease (AD).  ...  Reduced within and between network connectivity is observed in the default mode network regions of AD patients with anosognosia compared to AD patients without anosognosia and controls.  ...  This research did not receive any specific grant from funding agencies in the commercial, or not-for-profit sectors.  ... 
doi:10.1007/s11065-019-09410-x pmid:31161466 pmcid:PMC6560017 fatcat:owstbdvjnjbcxo5ojsf4mpdndq

The Importance of the Validation of M/EEG With Current Biomarkers in Alzheimer's Disease

Fernando Maestú, Pablo Cuesta, Omar Hasan, Alberto Fernandéz, Michael Funke, Paul E. Schulz
2019 Frontiers in Human Neuroscience  
However, in spite of its added value they are not part of the standard of care in clinical practice in dementia.  ...  In this paper we review what these neurophysiological techniques can add to the early diagnosis of AD, whether results in both modalities are related to each other or not, as well as the need of its validation  ...  Predicting progression from normal cognition to mild cognitive impairment for individuals at 5 years.  ... 
doi:10.3389/fnhum.2019.00017 pmid:30792632 pmcid:PMC6374629 fatcat:p5czybkozbf3nortlse5yhaije

Brain Connectivity and Graph Theory Analysis in Alzheimer's and Parkinson's Disease: The Contribution of Electrophysiological Techniques

Francesca Miraglia, Fabrizio Vecchio, Chiara Pappalettera, Lorenzo Nucci, Maria Cotelli, Elda Judica, Florinda Ferreri, Paolo Maria Rossini
2022 Brain Sciences  
In recent years, applications of the network science to electrophysiological data have increased as electrophysiological techniques are not only relatively low cost, largely available on the territory  ...  The aim of the present review is to provide an overview of the most recent applications of the graph theory to electrophysiological data in the two by far most frequent neurodegenerative disorders, Alzheimer's  ...  Abbreviations: EEG: electroen- cephalography; MEG: magnetoencephalography; PL: path length; C: clustering coefficient; SW: small-world index; PD-MCI: Parkinson disease with mild cognitive impairments.  ... 
doi:10.3390/brainsci12030402 pmid:35326358 pmcid:PMC8946843 fatcat:dxh4dqkrijei3hjgsqaqpywi6a

Longitudinal change in hippocampal and dorsal anterior insulae functional connectivity in subjective cognitive decline

Raymond P. Viviano, Jessica S. Damoiseaux
2021 Alzheimer's Research & Therapy  
in connectivity between salience and default mode network components.  ...  Results We found that individuals who reported a greater degree of subjective cognitive decline showed a larger subsequent decrease in connectivity between components of the default mode network and increase  ...  Acknowledgements The authors would like to thank Dr. Ana Daugherty for guidance on applying model constraints to structural equation models.  ... 
doi:10.1186/s13195-021-00847-y pmid:34059109 fatcat:5puu5vj4izfs7lgpa7cwp2kdxy

Progressive Disintegration of Brain Networking from Normal Aging to Alzheimer Disease: Analysis of Independent Components of 18 F-FDG PET Data

Marco Pagani, Alessandro Giuliani, Johanna Öberg, Fabrizio De Carli, Silvia Morbelli, Nicola Girtler, Dario Arnaldi, Jennifer Accardo, Matteo Bauckneht, Francesca Bongioanni, Andrea Chincarini, Gianmario Sambuceti (+2 others)
2017 Journal of Nuclear Medicine  
Selective breakdown of brain networks during progression from normal aging to Alzheimer disease dementia (AD) has also been observed.  ...  Methods: We implemented independentcomponent analysis of 18 F-FDG PET data in 5 groups of subjects with cognitive states ranging from normal aging to AD-including mild cognitive impairment (MCI) not converting  ...  Application of the latter technique to datasets including subjects ranging from normally aging individuals to patients with mild cognitive impairment (MCI) or Alzheimer disease dementia (AD) has revealed  ... 
doi:10.2967/jnumed.116.184309 pmid:28280223 fatcat:nsevuug7hjhitcmibmdeqvqspm

The Altered Reconfiguration Pattern of Brain Modular Architecture Regulates Cognitive Function in Cerebral Small Vessel Disease

Renyuan Liu, Haifeng Chen, Ruomeng Qin, Yucheng Gu, Xin Chen, Junhui Zou, YongCheng Jiang, Weikai Li, Feng Bai, Bing Zhang, Xiaoying Wang, Yun Xu
2019 Frontiers in Neurology  
Results: We identified four modules corresponding to the default mode network (DMN), executive control network (ECN), sensorimotor network and visual network.  ...  Methods: We recruited 25 cases of SVD without cognitive impairment (SVD-NCI) and 24 cases of SVD with mild cognitive impairment (SVD-MCI).  ...  HC, healthy control; SVD, small vessel disease; NCI, non-cognitive impairment; MCI, mild cognitive impairment; DMN, default mode network; ECN, executive control network; SMN, sensorimotor network; VN,  ... 
doi:10.3389/fneur.2019.00324 pmid:31024423 pmcid:PMC6461194 fatcat:z2d4fu6wvvce5ov6lrt7tzicpm

Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease

Xiaoqi Wang, Weijie Huang, Li Su, Yue Xing, Frank Jessen, Yu Sun, Ni Shu, Ying Han
2020 Molecular Neurodegeneration  
with patients with mild cognitive impairment (MCI) and dementia due to AD.  ...  In this review, we summarize the main imaging features and key findings regarding SCD related to AD, from local and regional data to connectivity-based imaging measures, with the aim of delineating a multimodal  ...  XW and WH contributed equally to search literature, tabulate the results and write the manuscript. LS and YX revised and provided critical input to the manuscript.  ... 
doi:10.1186/s13024-020-00395-3 pmid:32962744 pmcid:PMC7507636 fatcat:g5pbhodeebbjdbafie2zjhxc3q

The Default Mode Network may be the Key Substrate of Depressive Symptom-Related Cognitive Changes

Donald R. Royall, Raymond F. Palmer, Eric D. Vidoni, Robyn A. Honea
2013 Journal of Alzheimer's Disease  
DEPCOG is strongly associated with the cognitive correlates of functional status (δ), which we previously associated with elements of the Default Mode Network (DMN).  ...  These findings suggest that the cognitive correlates of depressive symptoms, even in the absence of a major depressive episode, may contribute to dementia in their own right, and could be responsible for  ...  The sponsor had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.  ... 
doi:10.3233/jad-121639 pmid:23254633 pmcid:PMC3640836 fatcat:4boklhehnrfcfiibwj4aloz6hu

Neurophysiological Hallmarks of Neurodegenerative Cognitive Decline: The Study of Brain Connectivity as A Biomarker of Early Dementia

Paolo Maria Rossini, Francesca Miraglia, Francesca Alù, Maria Cotelli, Florinda Ferreri, Riccardo Di Iorio, Francesco Iodice, Fabrizio Vecchio
2020 Journal of Personalized Medicine  
Mild cognitive impairment (MCI) is an intermediate stage between dementia and normal brain aging.  ...  It is therefore extremely important to have biomarkers able to identify—in association with neuropsychological tests—prodromal-to-dementia MCI subjects as early as possible.  ...  ); frontal network (FN); default mode network (DMN).  ... 
doi:10.3390/jpm10020034 pmid:32365890 pmcid:PMC7354555 fatcat:srfn4n6ohnhovcxql26exo7vly
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